LOCUS       NM_013531               7692 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus guanine nucleotide binding protein (G protein), beta 4
            (Gnb4), transcript variant 1, mRNA.
ACCESSION   NM_013531
VERSION     NM_013531.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7692)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7692)
  AUTHORS   Wang,Q., Wang,Y., Kuo,H.C., Xie,P., Kuang,X., Hirokawa,K.E.,
            Naeemi,M., Yao,S., Mallory,M., Ouellette,B., Lesnar,P., Li,Y.,
            Ye,M., Chen,C., Xiong,W., Ahmadinia,L., El-Hifnawi,L., Cetin,A.,
            Sorensen,S.A., Harris,J.A., Zeng,H. and Koch,C.
  TITLE     Regional and cell-type-specific afferent and efferent projections
            of the mouse claustrum
  JOURNAL   Cell Rep 42 (2), 112118 (2023)
   PUBMED   36774552
REFERENCE   3  (bases 1 to 7692)
  AUTHORS   McBride,E.G., Gandhi,S.R., Kuyat,J.R., Ollerenshaw,D.R.,
            Arkhipov,A., Koch,C. and Olsen,S.R.
  TITLE     Influence of claustrum on cortex varies by area, layer, and cell
            type
  JOURNAL   Neuron 111 (2), 275-290 (2023)
   PUBMED   36368317
REFERENCE   4  (bases 1 to 7692)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   5  (bases 1 to 7692)
  AUTHORS   Lassuthova,P., Safka Brozkova,D., Neupauerova,J., Krutova,M.,
            Mazanec,R. and Seeman,P.
  TITLE     Confirmation of the GNB4 gene as causal for Charcot-Marie-Tooth
            disease by a novel de novo mutation in a Czech patient
  JOURNAL   Neuromuscul Disord 27 (1), 57-60 (2017)
   PUBMED   27908631
REFERENCE   6  (bases 1 to 7692)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   7  (bases 1 to 7692)
  AUTHORS   Saito,H., Mimmack,M., Kishimoto,J., Keverne,E.B. and Emson,P.C.
  TITLE     Expression of olfactory receptors, G-proteins and AxCAMs during the
            development and maturation of olfactory sensory neurons in the
            mouse
  JOURNAL   Brain Res Dev Brain Res 110 (1), 69-81 (1998)
   PUBMED   9733924
REFERENCE   8  (bases 1 to 7692)
  AUTHORS   Williams,C.J., Schultz,R.M. and Kopf,G.S.
  TITLE     G protein gene expression during mouse oocyte growth and
            maturation, and preimplantation embryo development
  JOURNAL   Mol Reprod Dev 44 (3), 315-323 (1996)
   PUBMED   8858601
REFERENCE   9  (bases 1 to 7692)
  AUTHORS   von Weizsacker,E., Strathmann,M.P. and Simon,M.I.
  TITLE     Diversity among the beta subunits of heterotrimeric GTP-binding
            proteins: characterization of a novel beta-subunit cDNA
  JOURNAL   Biochem Biophys Res Commun 183 (1), 350-356 (1992)
   PUBMED   1543505
REFERENCE   10 (bases 1 to 7692)
  AUTHORS   Danciger,M., Farber,D.B., Peyser,M. and Kozak,C.A.
  TITLE     The gene for the beta-subunit of retinal transducin (Gnb-1) maps to
            distal mouse chromosome 4, and related sequences map to mouse
            chromosomes 5 and 8
  JOURNAL   Genomics 6 (3), 428-435 (1990)
   PUBMED   2328987
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC130281.13.
            
            On Dec 5, 2022 this sequence version replaced NM_013531.5.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036816.1, AK152227.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AC130281.13        2754-2850
            98-193              AC130281.13        17149-17244
            194-232             AC130281.13        21125-21163
            233-339             AC130281.13        22906-23012
            340-403             AC130281.13        26068-26131
            404-566             AC130281.13        28016-28178
            567-633             AC130281.13        29226-29292
            634-835             AC130281.13        29379-29580
            836-1052            AC130281.13        31512-31728
            1053-7692           AC130281.13        34063-40702
FEATURES             Location/Qualifiers
     source          1..7692
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 15.78 cM"
     gene            1..7692
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /note="guanine nucleotide binding protein (G protein),
                     beta 4"
                     /db_xref="GeneID:14696"
                     /db_xref="MGI:MGI:104581"
     exon            1..97
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /inference="alignment:Splign:2.1.0"
     exon            98..193
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1159
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /note="isoform 1 is encoded by transcript variant 1;
                     guanine nucleotide-binding protein subunit beta-4;
                     transducin beta chain 4; heterotrimeric guanine
                     nucleotide-binding protein 2b"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein subunit
                     beta-4 isoform 1"
                     /protein_id="NP_038559.2"
                     /db_xref="CCDS:CCDS17297.1"
                     /db_xref="GeneID:14696"
                     /db_xref="MGI:MGI:104581"
                     /translation="MSELEQLRQEAEQLRNQIQDARKACNDATLVQITSNMDSVGRIQ
                     MRTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMT
                     CAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDGQIITS
                     SGDTTCALWDIETGQQTTTFTGHSGDVMSLSLSPDLKTFVSGACDASSKLWDIRDGMC
                     RQSFTGHISDINAVSFFPSGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSV
                     AFSKSGRLLLAGYDDFNCSVWDALKGGRSGVLAGHDNRVSCLGVTDDGMAVATGSWDS
                     FLRIWN"
     exon            194..232
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /inference="alignment:Splign:2.1.0"
     exon            233..339
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /inference="alignment:Splign:2.1.0"
     exon            340..403
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /inference="alignment:Splign:2.1.0"
     exon            404..566
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /inference="alignment:Splign:2.1.0"
     exon            567..633
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /inference="alignment:Splign:2.1.0"
     exon            634..835
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /inference="alignment:Splign:2.1.0"
     exon            836..1052
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..7692
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1337..1342
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /note="hexamer: CATAAA"
     polyA_site      1360
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /note="major polyA site"
     regulatory      2261..2266
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /note="hexamer: TATAAA"
     polyA_site      2283
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /note="major polyA site"
     polyA_site      2755
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
     polyA_site      2821
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
     regulatory      4026..4031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /note="hexamer: AATAAA"
     polyA_site      4049
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
     regulatory      5927..5932
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /note="hexamer: AATAAA"
     polyA_site      5947
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
     regulatory      6758..6763
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /note="hexamer: AATAAA"
     polyA_site      6777
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
     regulatory      7666..7671
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /note="hexamer: AATAAA"
     polyA_site      7692
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
ORIGIN      
        1 gggtgtggtc gccgtcttgt gtggtggagc cagctagcgg ttcgcgaccc gcagccgggc
       61 gcccagcagt agcgcggtgg tggcggccgg gctccagctc ttcacttgag acgcctgagg
      121 gaaaccacca ggcaggatga gcgagctgga gcagctgagg caggaggctg aacagcttcg
      181 gaatcagatc caggatgctc ggaaggcctg caatgatgcc acgctggttc agatcacgtc
      241 taatatggac tccgtgggcc gaatacaaat gcgaacaagg cgcacgctgc gcggccacct
      301 cgctaagatc tacgccatgc actggggata tgattccagg ctactagtca gtgcttcgca
      361 agatggaaaa ttaattattt gggatagcta tacgacaaat aagatgcacg ccatccctct
      421 gaggtcctcc tgggtgatga cctgtgccta cgccccgtcc gggaactacg ttgcctgtgg
      481 aggcttggat aacatctgct ccatatacaa cctaaagacc cgagagggga atgtgcgggt
      541 gagccgagaa ttgccaggac acacgggcta cttgtcctgc tgccgattct tagatgatgg
      601 acaaatcatt acaagttcgg gagacacgac ttgtgctttg tgggacattg agaccggaca
      661 gcagactacg accttcacgg gacactcggg tgacgtgatg agcctctcac tgagtcctga
      721 cttgaagacc tttgtgtctg gtgcttgtga tgcatcctca aagctgtggg atatccgaga
      781 tgggatgtgt agacagtctt tcaccggaca catctcagac atcaacgctg tcagtttctt
      841 cccgagtgga tatgcctttg ccactggttc tgatgatgcc acatgccgac tctttgacct
      901 ccgtgcagac caggagctcc tgctatactc tcatgacaat atcatctgtg gcattacttc
      961 tgtggccttc tcaaagagtg ggcgcctcct gttagccggc tatgacgact tcaactgcag
     1021 tgtgtgggac gctctgaaag gaggccggtc aggtgtcctt gctggtcatg acaaccgtgt
     1081 tagctgctta ggtgtgactg atgacggcat ggctgtggcc actggctcct gggacagttt
     1141 tcttagaatc tggaattgag tgccatattt tctgttctcc aatgatacct ggagaaatcc
     1201 gtgttacagc ctatagctgt gaggaaaaaa aaaaaccaac cctctacctt ctatttgcag
     1261 atgaagtttt tctatggagg tgactatata taaaaagcag cgttcaataa gctgtagttt
     1321 attgaaactg ttgtgacata aatggtggtc agagaaacaa tcaagattaa gctccctttc
     1381 tgtggtcaaa ggccagggta ttcattgagt ggtcgtcttg acttgaacag attcttgctt
     1441 gtgctcattg tttttctgta gattagagtg cacactttat agcagacaac catttgtgtt
     1501 tgccatttta aggactacca ttgaactttg tatatataag aaatgccaca tttttaaagt
     1561 gttgtcatgg aaaacaagga agggcctgtg atagacagaa gtgatgctgt agattatgtg
     1621 ctgtctgaag gaggtcccct tggactgtga cattgcattt taatctgaaa gtccctgact
     1681 gcttcgtggt taggtgacta agaggtgagg tggtcctgag ggacccagtg gctgttcatg
     1741 cattctttgc catgctacgg atttaagtgc tcattttcag tcctttgagg ggacaggtga
     1801 tatgaaggcc aggggtaaag atttcacttt gacatagggt acaccctgaa gaaatgtcat
     1861 tacagtctat tacattagaa accagtagac actggcacgt gatttttttt ggtattttaa
     1921 gaagctcagc catttgaacc attggacctt gctgttaatt ttgccttctg aaatgaagtt
     1981 tgtagaaagt actagtattt gagaagtctg acaaaaacct gacttgtctc tgcatctgga
     2041 gacacttgcc tggtgttctc tgtaatggga ggaaacagtg tctcaccttc taacatttga
     2101 gaaatgtaaa ctcatccatt caactggcac aaatatatgt atgatttata tgtcacacat
     2161 acatatgtgt gtgtgtgtgt atatatatac acacatatac acatatatat gatggctttg
     2221 tgaattgtgt aatgtaaaat ctatgtaatg taaaaacagg tataaactat ttgtaccctt
     2281 gaacttttac ttttccattt ttgcggtgct gccgaaatct aggccttgtg cccactagcc
     2341 aagtgctgta cttagtacag ccctagctcc tcagatccaa gctttctgct gccctgtagt
     2401 attgttctcc gtagtatgat gtagtcaagg agcttactac aaagctagtc tagagttgac
     2461 cactcctaga gcctaaaaca ttgtttcaaa ggggctcagc tggcagcaaa gatgtgccaa
     2521 ctgttcagta gtgtctgtca ctgggatgtc ccgcctccta acggaacaga cagctctcct
     2581 cttcagttct ctcctgtaga ttcaaatgat tgacagtaac agactgttat gtcttgctgg
     2641 tgccgtctcc ttgggttact tggatgtata caaacacatt gtaaagctgc tgtctagcag
     2701 tttctgtgtt aaagttgatc acctgtaact gtaaccttaa tacttccaaa ctgaacctgt
     2761 gagttttcat ccttgtactg tgaatgtgcc catgtacata acagctgtga tcagaccagc
     2821 atcccttttg tttatgaaaa tcaattgatc ttaatacagt gggaagaccc ttcgcccaca
     2881 cagctctagg gtccgacctg accagggcag aaagggaatg aaaaacagac acacacagga
     2941 aagctggggt tgggtagact ggacattgat ggagaaacca gcacccagaa actcagagtt
     3001 tattccatgg agaagcacaa agaggcagtg ctgttgtata cagataaaaa aggaggaaac
     3061 atccgaggta tactgctgga tcaaggagac aggtttagcc aatctcttca agagcagtcc
     3121 ccatatgtag ggaagcaatc ctcaggctgt aaatatcagg atggggctca gggagctaag
     3181 gtacacatgt tctacacata ccatcaacac tcatgctcaa cccaggggga ctctgccatt
     3241 ctcgtgggtc taaggtaagg gtccgtgata gggcagtcac tctggatgtc ctctgctccc
     3301 tacaggatag aggtgaactg agatacagta tcgaagagaa acagaccatc gtggcaggtg
     3361 tgaatgtgta ccttaatcct taatttgcgg gacccctttg cccttgtcta ttgtgcacta
     3421 gggagtgctc tcaaataggg cacgaaaaga aaacctgacg gtgctgaatg aagtctagcc
     3481 ttccttgtac ctctgcccag aaagttctat cgctgggttg tatctgctgc ctgcccaccc
     3541 cagccaagag ctgaggcgca tgagaggatc ctgagcatcc ccagaagggt gtgtctgctg
     3601 tgtggctcag aattcatact aaaacctcgc tcaaaactaa ggaaaaaaaa accataacaa
     3661 aaaacctcgc tcaaaacagc atttctatta ggtataaagg gggcttaatg tggggtagag
     3721 tgcttgcaac gcaaggccct gggttcagtc cctagctctg tgtgtgtgta tgtgtgtata
     3781 gtcatactaa aagaattcta tggtcctaaa tattttaaaa tgttacttac ggctggagag
     3841 atggatcagc agttaaaaac aggtgtcact cttgtagaag acctggattt gagtcccagc
     3901 atccacatgg cagctcaaac tgtctgttgc ttcagtccca ggatatctga cttcctcacc
     3961 cacatacata catgcaggca aaacatccat acacttaaaa tgttttaaaa gggagctcct
     4021 ttgttaataa aagtttgcat ggaacagaac ttgaaggttt cccttaatat gtatctggag
     4081 agaaaccatg atgaccgtgg ctaactgcac acagcgccac tgctgacaag aagttgcttt
     4141 ctcatggttg gtgtctttag ggtttctctg cagttcctgc cgtggttaaa tacattggct
     4201 tgctggagag ttcctgaaat tagcctgcat aatgtgcctt agcaggttga tgcataacat
     4261 cagacaaaag ttgtccttca gattggcaag atttgtaaca tttttgctgt gactcctgcc
     4321 ctggcctcta gcttggtcta caggcagatg ccagtgtgcc actctgccaa gaatactgta
     4381 gtactgtaaa ggcacaagtt ctctcctaaa gcaatgtgac caccatttgg ttgagtaaac
     4441 accccaaaat gctgctcagc aaagacatca ctatctccct taagatgaac aagcttcatt
     4501 ttggcagctg tgatagatcc caggtccctt tctagcaaac actttaagtc atgacacaca
     4561 tgtactgtat tacaaactca tgaaagcaaa gtgttggggc ctgtcacttc aagagcaaaa
     4621 gtctaaagtg gctgtcattt agtagcacag tgtttctgga atgctaaaga attttaacct
     4681 attaaaggag aaatgaagat aggtgtggca atgcatgctt gttatccttc acctgggagg
     4741 ctaacacagt gcagagctga ggccagctcg tcaaggctat cagatgggaa ctttatccca
     4801 gaggctgagt agtcaagtct gcttagtgtt attacacagg acctgagttt agttcccatt
     4861 tcaggtggct aacaactgcc tttaacttca agggatccaa agccctcctc aggcacctgt
     4921 acccacatag tttaaaaaga atccttttct tttaaaagga aaaaaaccct ttattttaat
     4981 aaaaagtaat tttattgctg aaagtactct ctaatcttgt tgctgtttta aacttagtag
     5041 taaaacttaa gacatcattt cagaagtgaa accatccagg gaaattatct ggatatgaac
     5101 gtcttagatt ttgaactgca atgtgctttg ttactgacta gcttaggaaa agctgaatat
     5161 gcaatccccc agataggcct gcctgtcatc atttcatagg gaacatactt ttagaatctg
     5221 cacatcacac gaggcttgta caaatactta catactgtgt tcgggtgctg attctctggc
     5281 cactgtggaa agcatactgt tgtaaaatga catcttagcc agttagaaat gtaaaagcca
     5341 cccaccgggg agtgtccttt atagggagac tgtcttaaat tagactggaa agtgaagcac
     5401 acagcagact cacttctgct tctcatttgt tacaacaggt actcaacaga tgtctacccc
     5461 caaactaaat agctggtttt gtaaagcagg tgtaacaatg tagcattatg agaaaaatac
     5521 ttgtttcaac tagtatgaaa tgtatccaac agactcttcc atagcaactg ggcgtaacta
     5581 ggacttccgt ggttcagcag cagggtgtcc cgtccttttc tgtctttatg caattgtgct
     5641 cttgagtatc cttgtctcgc tgaaggcact gatagcccac acctcaagtg tgcctttaag
     5701 cctgactgag tatttctcta tgaggtatct tggaggcatt tttctcctcc taaaataagt
     5761 tccaacacat gaagccaact gactgaatgc cagccatgcc taaagcttaa ctatagaagc
     5821 tggggactta tgccatggtt cacagtattc tgaggcatga caggtacacc cctctatctg
     5881 tacagttgct tgtgaaatac tgttgcagca agctcatact gtaatcaata aagtgctttt
     5941 caccatggct cactgtacct tgttttaagt caaattttag taagatttaa aaagttatgc
     6001 cctggaacta aactcaggtt cagtacttta atggtcagct ctgcttcctg tgtttaaata
     6061 ctgatcttcc ttctcttctt cctcctgctc ctcctccttt tcctccccct tcataaaaag
     6121 gggcagtaag ggagagattg agtattattg atccaaagct agcttttact ttattgttaa
     6181 agggtacaga tttctcattt ataagtaaac catccctgtg gggcacgaga gccaggttta
     6241 taatctagta cttgggagac tgagagaagc aggaggatcc caagtttgag gctagctttg
     6301 cctccatgag aagaccctgc ctcaaaagaa acacccttct cctgtagctc ccttagcgat
     6361 atattcttaa aagtcaaaag tcttaaaaat accatagatt ttaatttttt ttaaatatcc
     6421 attttttctt agatttattt attttatgtg agtacactgt agctgtcttc agacacacca
     6481 gaagagggca ttggatccca ttacagatag ttgtgagtca ccatgtggtt gctgggaatt
     6541 aaactcagga cctctggaag agcagccagt gctcttaacc tctgagccat ttctccagcc
     6601 caatcacata agatttttaa atacttgtat ttattatcac attgcagttt taagattaac
     6661 aattaagatt ttaagtttgt attccaggtc gagcccaccc tgatctacag agcaagttcc
     6721 aggatggcca gggatacaca gagaaccctg tcttgaaaat aaaccaaagg tagaggatgt
     6781 ttgtattagt tctgtttagg gaatcctcct ggctcagtgc ttatcagctg cacaactacc
     6841 atggaagact tctcaaactg tgctcctgac agtggtgagc caggcatctc acactttctg
     6901 tgactgggca aaggcactat tatacagtgt atgtacaata gtactacagc acagtgacag
     6961 gacctcatgt gagagcttac acgactacca tgaaaatatc tgaagggagt ggaaaacagt
     7021 cactaactga gataaatgct atatttacca actaataggc ggataggttt attttcatct
     7081 tgcaagcttg catacttata aaaatgtttt gtaaaaagtt taagatcata caaagtttat
     7141 aaatactgta aacatacaca gtaaatcatc aagtatgtgt gtagcaacta atcagtaacc
     7201 gtcatgatta cagtctgtaa tgcacgagcc taccagtggc aggcgcactc ttgtctggta
     7261 aaagagctag tgtctgcatt tcaacactcc atgctcaaca cccgtaactt ctgaacttca
     7321 tcagctggct ctacattctt aatcagtgag gaaagcattc tggactacag atactggctt
     7381 gcagacttca gagtacactg ggacagactt gaagcttgct gcagacccca aacttgattc
     7441 ataccttgtt gagaatctac accttacaaa tctttacaag tttaaaaata atgttgacaa
     7501 tcccgggagc aaacccagag aaccaagctg tagctggcta attatgtgct ccaagtaact
     7561 gtgtaaccta ggttagcaga cctcaattct agatactact ttttcatgta ctattcaccc
     7621 agtcccactt ggttgcctgt accatttggg ggactaaaaa tcagcaataa aagcaaaagg
     7681 tagtcacatg ga
//
