LOCUS       NM_001348104            7939 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus guanine nucleotide binding protein (G protein), beta 4
            (Gnb4), transcript variant 3, mRNA.
ACCESSION   NM_001348104
VERSION     NM_001348104.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7939)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7939)
  AUTHORS   Wang,Q., Wang,Y., Kuo,H.C., Xie,P., Kuang,X., Hirokawa,K.E.,
            Naeemi,M., Yao,S., Mallory,M., Ouellette,B., Lesnar,P., Li,Y.,
            Ye,M., Chen,C., Xiong,W., Ahmadinia,L., El-Hifnawi,L., Cetin,A.,
            Sorensen,S.A., Harris,J.A., Zeng,H. and Koch,C.
  TITLE     Regional and cell-type-specific afferent and efferent projections
            of the mouse claustrum
  JOURNAL   Cell Rep 42 (2), 112118 (2023)
   PUBMED   36774552
REFERENCE   3  (bases 1 to 7939)
  AUTHORS   McBride,E.G., Gandhi,S.R., Kuyat,J.R., Ollerenshaw,D.R.,
            Arkhipov,A., Koch,C. and Olsen,S.R.
  TITLE     Influence of claustrum on cortex varies by area, layer, and cell
            type
  JOURNAL   Neuron 111 (2), 275-290 (2023)
   PUBMED   36368317
REFERENCE   4  (bases 1 to 7939)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   5  (bases 1 to 7939)
  AUTHORS   Lassuthova,P., Safka Brozkova,D., Neupauerova,J., Krutova,M.,
            Mazanec,R. and Seeman,P.
  TITLE     Confirmation of the GNB4 gene as causal for Charcot-Marie-Tooth
            disease by a novel de novo mutation in a Czech patient
  JOURNAL   Neuromuscul Disord 27 (1), 57-60 (2017)
   PUBMED   27908631
REFERENCE   6  (bases 1 to 7939)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   7  (bases 1 to 7939)
  AUTHORS   Saito,H., Mimmack,M., Kishimoto,J., Keverne,E.B. and Emson,P.C.
  TITLE     Expression of olfactory receptors, G-proteins and AxCAMs during the
            development and maturation of olfactory sensory neurons in the
            mouse
  JOURNAL   Brain Res Dev Brain Res 110 (1), 69-81 (1998)
   PUBMED   9733924
REFERENCE   8  (bases 1 to 7939)
  AUTHORS   Williams,C.J., Schultz,R.M. and Kopf,G.S.
  TITLE     G protein gene expression during mouse oocyte growth and
            maturation, and preimplantation embryo development
  JOURNAL   Mol Reprod Dev 44 (3), 315-323 (1996)
   PUBMED   8858601
REFERENCE   9  (bases 1 to 7939)
  AUTHORS   von Weizsacker,E., Strathmann,M.P. and Simon,M.I.
  TITLE     Diversity among the beta subunits of heterotrimeric GTP-binding
            proteins: characterization of a novel beta-subunit cDNA
  JOURNAL   Biochem Biophys Res Commun 183 (1), 350-356 (1992)
   PUBMED   1543505
REFERENCE   10 (bases 1 to 7939)
  AUTHORS   Danciger,M., Farber,D.B., Peyser,M. and Kozak,C.A.
  TITLE     The gene for the beta-subunit of retinal transducin (Gnb-1) maps to
            distal mouse chromosome 4, and related sequences map to mouse
            chromosomes 5 and 8
  JOURNAL   Genomics 6 (3), 428-435 (1990)
   PUBMED   2328987
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC130281.13.
            
            On Dec 6, 2022 this sequence version replaced NM_001348104.1.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158965.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN01164134
                                           [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AC130281.13        2754-2850
            98-344              AC130281.13        4943-5189
            345-440             AC130281.13        17149-17244
            441-479             AC130281.13        21125-21163
            480-586             AC130281.13        22906-23012
            587-650             AC130281.13        26068-26131
            651-813             AC130281.13        28016-28178
            814-880             AC130281.13        29226-29292
            881-1082            AC130281.13        29379-29580
            1083-1299           AC130281.13        31512-31728
            1300-7939           AC130281.13        34063-40702
FEATURES             Location/Qualifiers
     source          1..7939
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 15.78 cM"
     gene            1..7939
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /note="guanine nucleotide binding protein (G protein),
                     beta 4"
                     /db_xref="GeneID:14696"
                     /db_xref="MGI:MGI:104581"
     exon            1..97
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /inference="alignment:Splign:2.1.0"
     exon            98..344
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /inference="alignment:Splign:2.1.0"
     exon            345..440
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /inference="alignment:Splign:2.1.0"
     CDS             384..1406
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /note="isoform 1 is encoded by transcript variant 3;
                     guanine nucleotide-binding protein subunit beta-4;
                     transducin beta chain 4; heterotrimeric guanine
                     nucleotide-binding protein 2b"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein subunit
                     beta-4 isoform 1"
                     /protein_id="NP_001335033.1"
                     /db_xref="CCDS:CCDS17297.1"
                     /db_xref="GeneID:14696"
                     /db_xref="MGI:MGI:104581"
                     /translation="MSELEQLRQEAEQLRNQIQDARKACNDATLVQITSNMDSVGRIQ
                     MRTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMT
                     CAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDGQIITS
                     SGDTTCALWDIETGQQTTTFTGHSGDVMSLSLSPDLKTFVSGACDASSKLWDIRDGMC
                     RQSFTGHISDINAVSFFPSGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSV
                     AFSKSGRLLLAGYDDFNCSVWDALKGGRSGVLAGHDNRVSCLGVTDDGMAVATGSWDS
                     FLRIWN"
     exon            441..479
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /inference="alignment:Splign:2.1.0"
     exon            480..586
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /inference="alignment:Splign:2.1.0"
     exon            587..650
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /inference="alignment:Splign:2.1.0"
     exon            651..813
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /inference="alignment:Splign:2.1.0"
     exon            814..880
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1082
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1299
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..7939
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1584..1589
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /note="hexamer: CATAAA"
     polyA_site      1607
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /note="major polyA site"
     regulatory      2508..2513
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /note="hexamer: TATAAA"
     polyA_site      2530
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /note="major polyA site"
     polyA_site      3002
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
     polyA_site      3068
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
     regulatory      4273..4278
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /note="hexamer: AATAAA"
     polyA_site      4296
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
     regulatory      6174..6179
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /note="hexamer: AATAAA"
     polyA_site      6194
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
     regulatory      7005..7010
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /note="hexamer: AATAAA"
     polyA_site      7024
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
     regulatory      7913..7918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
                     /note="hexamer: AATAAA"
     polyA_site      7939
                     /gene="Gnb4"
                     /gene_synonym="6720453A21Rik; G(beta)4; Hg2b"
ORIGIN      
        1 gggtgtggtc gccgtcttgt gtggtggagc cagctagcgg ttcgcgaccc gcagccgggc
       61 gcccagcagt agcgcggtgg tggcggccgg gctccagtta ctgtcctatg tctttctgtc
      121 tgtctttcat ttttttcttt cttttttttt ctcttctctc tctctctctc tctctctctc
      181 tctctctctc tctctctctc tctctctctt tgtttgtttc gttttgagac agggtttctc
      241 tgtgtagttt tagctatcct ggaactccat ctatagacca agctggtctg gaaaccacag
      301 aaatctgtct gcttctgcct gctttcagag ttctgggatt aaagctcttc acttgagacg
      361 cctgagggaa accaccaggc aggatgagcg agctggagca gctgaggcag gaggctgaac
      421 agcttcggaa tcagatccag gatgctcgga aggcctgcaa tgatgccacg ctggttcaga
      481 tcacgtctaa tatggactcc gtgggccgaa tacaaatgcg aacaaggcgc acgctgcgcg
      541 gccacctcgc taagatctac gccatgcact ggggatatga ttccaggcta ctagtcagtg
      601 cttcgcaaga tggaaaatta attatttggg atagctatac gacaaataag atgcacgcca
      661 tccctctgag gtcctcctgg gtgatgacct gtgcctacgc cccgtccggg aactacgttg
      721 cctgtggagg cttggataac atctgctcca tatacaacct aaagacccga gaggggaatg
      781 tgcgggtgag ccgagaattg ccaggacaca cgggctactt gtcctgctgc cgattcttag
      841 atgatggaca aatcattaca agttcgggag acacgacttg tgctttgtgg gacattgaga
      901 ccggacagca gactacgacc ttcacgggac actcgggtga cgtgatgagc ctctcactga
      961 gtcctgactt gaagaccttt gtgtctggtg cttgtgatgc atcctcaaag ctgtgggata
     1021 tccgagatgg gatgtgtaga cagtctttca ccggacacat ctcagacatc aacgctgtca
     1081 gtttcttccc gagtggatat gcctttgcca ctggttctga tgatgccaca tgccgactct
     1141 ttgacctccg tgcagaccag gagctcctgc tatactctca tgacaatatc atctgtggca
     1201 ttacttctgt ggccttctca aagagtgggc gcctcctgtt agccggctat gacgacttca
     1261 actgcagtgt gtgggacgct ctgaaaggag gccggtcagg tgtccttgct ggtcatgaca
     1321 accgtgttag ctgcttaggt gtgactgatg acggcatggc tgtggccact ggctcctggg
     1381 acagttttct tagaatctgg aattgagtgc catattttct gttctccaat gatacctgga
     1441 gaaatccgtg ttacagccta tagctgtgag gaaaaaaaaa aaccaaccct ctaccttcta
     1501 tttgcagatg aagtttttct atggaggtga ctatatataa aaagcagcgt tcaataagct
     1561 gtagtttatt gaaactgttg tgacataaat ggtggtcaga gaaacaatca agattaagct
     1621 ccctttctgt ggtcaaaggc cagggtattc attgagtggt cgtcttgact tgaacagatt
     1681 cttgcttgtg ctcattgttt ttctgtagat tagagtgcac actttatagc agacaaccat
     1741 ttgtgtttgc cattttaagg actaccattg aactttgtat atataagaaa tgccacattt
     1801 ttaaagtgtt gtcatggaaa acaaggaagg gcctgtgata gacagaagtg atgctgtaga
     1861 ttatgtgctg tctgaaggag gtccccttgg actgtgacat tgcattttaa tctgaaagtc
     1921 cctgactgct tcgtggttag gtgactaaga ggtgaggtgg tcctgaggga cccagtggct
     1981 gttcatgcat tctttgccat gctacggatt taagtgctca ttttcagtcc tttgagggga
     2041 caggtgatat gaaggccagg ggtaaagatt tcactttgac atagggtaca ccctgaagaa
     2101 atgtcattac agtctattac attagaaacc agtagacact ggcacgtgat tttttttggt
     2161 attttaagaa gctcagccat ttgaaccatt ggaccttgct gttaattttg ccttctgaaa
     2221 tgaagtttgt agaaagtact agtatttgag aagtctgaca aaaacctgac ttgtctctgc
     2281 atctggagac acttgcctgg tgttctctgt aatgggagga aacagtgtct caccttctaa
     2341 catttgagaa atgtaaactc atccattcaa ctggcacaaa tatatgtatg atttatatgt
     2401 cacacataca tatgtgtgtg tgtgtgtata tatatacaca catatacaca tatatatgat
     2461 ggctttgtga attgtgtaat gtaaaatcta tgtaatgtaa aaacaggtat aaactatttg
     2521 tacccttgaa cttttacttt tccatttttg cggtgctgcc gaaatctagg ccttgtgccc
     2581 actagccaag tgctgtactt agtacagccc tagctcctca gatccaagct ttctgctgcc
     2641 ctgtagtatt gttctccgta gtatgatgta gtcaaggagc ttactacaaa gctagtctag
     2701 agttgaccac tcctagagcc taaaacattg tttcaaaggg gctcagctgg cagcaaagat
     2761 gtgccaactg ttcagtagtg tctgtcactg ggatgtcccg cctcctaacg gaacagacag
     2821 ctctcctctt cagttctctc ctgtagattc aaatgattga cagtaacaga ctgttatgtc
     2881 ttgctggtgc cgtctccttg ggttacttgg atgtatacaa acacattgta aagctgctgt
     2941 ctagcagttt ctgtgttaaa gttgatcacc tgtaactgta accttaatac ttccaaactg
     3001 aacctgtgag ttttcatcct tgtactgtga atgtgcccat gtacataaca gctgtgatca
     3061 gaccagcatc ccttttgttt atgaaaatca attgatctta atacagtggg aagacccttc
     3121 gcccacacag ctctagggtc cgacctgacc agggcagaaa gggaatgaaa aacagacaca
     3181 cacaggaaag ctggggttgg gtagactgga cattgatgga gaaaccagca cccagaaact
     3241 cagagtttat tccatggaga agcacaaaga ggcagtgctg ttgtatacag ataaaaaagg
     3301 aggaaacatc cgaggtatac tgctggatca aggagacagg tttagccaat ctcttcaaga
     3361 gcagtcccca tatgtaggga agcaatcctc aggctgtaaa tatcaggatg gggctcaggg
     3421 agctaaggta cacatgttct acacatacca tcaacactca tgctcaaccc agggggactc
     3481 tgccattctc gtgggtctaa ggtaagggtc cgtgataggg cagtcactct ggatgtcctc
     3541 tgctccctac aggatagagg tgaactgaga tacagtatcg aagagaaaca gaccatcgtg
     3601 gcaggtgtga atgtgtacct taatccttaa tttgcgggac ccctttgccc ttgtctattg
     3661 tgcactaggg agtgctctca aatagggcac gaaaagaaaa cctgacggtg ctgaatgaag
     3721 tctagccttc cttgtacctc tgcccagaaa gttctatcgc tgggttgtat ctgctgcctg
     3781 cccaccccag ccaagagctg aggcgcatga gaggatcctg agcatcccca gaagggtgtg
     3841 tctgctgtgt ggctcagaat tcatactaaa acctcgctca aaactaagga aaaaaaaacc
     3901 ataacaaaaa acctcgctca aaacagcatt tctattaggt ataaaggggg cttaatgtgg
     3961 ggtagagtgc ttgcaacgca aggccctggg ttcagtccct agctctgtgt gtgtgtatgt
     4021 gtgtatagtc atactaaaag aattctatgg tcctaaatat tttaaaatgt tacttacggc
     4081 tggagagatg gatcagcagt taaaaacagg tgtcactctt gtagaagacc tggatttgag
     4141 tcccagcatc cacatggcag ctcaaactgt ctgttgcttc agtcccagga tatctgactt
     4201 cctcacccac atacatacat gcaggcaaaa catccataca cttaaaatgt tttaaaaggg
     4261 agctcctttg ttaataaaag tttgcatgga acagaacttg aaggtttccc ttaatatgta
     4321 tctggagaga aaccatgatg accgtggcta actgcacaca gcgccactgc tgacaagaag
     4381 ttgctttctc atggttggtg tctttagggt ttctctgcag ttcctgccgt ggttaaatac
     4441 attggcttgc tggagagttc ctgaaattag cctgcataat gtgccttagc aggttgatgc
     4501 ataacatcag acaaaagttg tccttcagat tggcaagatt tgtaacattt ttgctgtgac
     4561 tcctgccctg gcctctagct tggtctacag gcagatgcca gtgtgccact ctgccaagaa
     4621 tactgtagta ctgtaaaggc acaagttctc tcctaaagca atgtgaccac catttggttg
     4681 agtaaacacc ccaaaatgct gctcagcaaa gacatcacta tctcccttaa gatgaacaag
     4741 cttcattttg gcagctgtga tagatcccag gtccctttct agcaaacact ttaagtcatg
     4801 acacacatgt actgtattac aaactcatga aagcaaagtg ttggggcctg tcacttcaag
     4861 agcaaaagtc taaagtggct gtcatttagt agcacagtgt ttctggaatg ctaaagaatt
     4921 ttaacctatt aaaggagaaa tgaagatagg tgtggcaatg catgcttgtt atccttcacc
     4981 tgggaggcta acacagtgca gagctgaggc cagctcgtca aggctatcag atgggaactt
     5041 tatcccagag gctgagtagt caagtctgct tagtgttatt acacaggacc tgagtttagt
     5101 tcccatttca ggtggctaac aactgccttt aacttcaagg gatccaaagc cctcctcagg
     5161 cacctgtacc cacatagttt aaaaagaatc cttttctttt aaaaggaaaa aaacccttta
     5221 ttttaataaa aagtaatttt attgctgaaa gtactctcta atcttgttgc tgttttaaac
     5281 ttagtagtaa aacttaagac atcatttcag aagtgaaacc atccagggaa attatctgga
     5341 tatgaacgtc ttagattttg aactgcaatg tgctttgtta ctgactagct taggaaaagc
     5401 tgaatatgca atcccccaga taggcctgcc tgtcatcatt tcatagggaa catactttta
     5461 gaatctgcac atcacacgag gcttgtacaa atacttacat actgtgttcg ggtgctgatt
     5521 ctctggccac tgtggaaagc atactgttgt aaaatgacat cttagccagt tagaaatgta
     5581 aaagccaccc accggggagt gtcctttata gggagactgt cttaaattag actggaaagt
     5641 gaagcacaca gcagactcac ttctgcttct catttgttac aacaggtact caacagatgt
     5701 ctacccccaa actaaatagc tggttttgta aagcaggtgt aacaatgtag cattatgaga
     5761 aaaatacttg tttcaactag tatgaaatgt atccaacaga ctcttccata gcaactgggc
     5821 gtaactagga cttccgtggt tcagcagcag ggtgtcccgt ccttttctgt ctttatgcaa
     5881 ttgtgctctt gagtatcctt gtctcgctga aggcactgat agcccacacc tcaagtgtgc
     5941 ctttaagcct gactgagtat ttctctatga ggtatcttgg aggcattttt ctcctcctaa
     6001 aataagttcc aacacatgaa gccaactgac tgaatgccag ccatgcctaa agcttaacta
     6061 tagaagctgg ggacttatgc catggttcac agtattctga ggcatgacag gtacacccct
     6121 ctatctgtac agttgcttgt gaaatactgt tgcagcaagc tcatactgta atcaataaag
     6181 tgcttttcac catggctcac tgtaccttgt tttaagtcaa attttagtaa gatttaaaaa
     6241 gttatgccct ggaactaaac tcaggttcag tactttaatg gtcagctctg cttcctgtgt
     6301 ttaaatactg atcttccttc tcttcttcct cctgctcctc ctccttttcc tcccccttca
     6361 taaaaagggg cagtaaggga gagattgagt attattgatc caaagctagc ttttacttta
     6421 ttgttaaagg gtacagattt ctcatttata agtaaaccat ccctgtgggg cacgagagcc
     6481 aggtttataa tctagtactt gggagactga gagaagcagg aggatcccaa gtttgaggct
     6541 agctttgcct ccatgagaag accctgcctc aaaagaaaca cccttctcct gtagctccct
     6601 tagcgatata ttcttaaaag tcaaaagtct taaaaatacc atagatttta atttttttta
     6661 aatatccatt ttttcttaga tttatttatt ttatgtgagt acactgtagc tgtcttcaga
     6721 cacaccagaa gagggcattg gatcccatta cagatagttg tgagtcacca tgtggttgct
     6781 gggaattaaa ctcaggacct ctggaagagc agccagtgct cttaacctct gagccatttc
     6841 tccagcccaa tcacataaga tttttaaata cttgtattta ttatcacatt gcagttttaa
     6901 gattaacaat taagatttta agtttgtatt ccaggtcgag cccaccctga tctacagagc
     6961 aagttccagg atggccaggg atacacagag aaccctgtct tgaaaataaa ccaaaggtag
     7021 aggatgtttg tattagttct gtttagggaa tcctcctggc tcagtgctta tcagctgcac
     7081 aactaccatg gaagacttct caaactgtgc tcctgacagt ggtgagccag gcatctcaca
     7141 ctttctgtga ctgggcaaag gcactattat acagtgtatg tacaatagta ctacagcaca
     7201 gtgacaggac ctcatgtgag agcttacacg actaccatga aaatatctga agggagtgga
     7261 aaacagtcac taactgagat aaatgctata tttaccaact aataggcgga taggtttatt
     7321 ttcatcttgc aagcttgcat acttataaaa atgttttgta aaaagtttaa gatcatacaa
     7381 agtttataaa tactgtaaac atacacagta aatcatcaag tatgtgtgta gcaactaatc
     7441 agtaaccgtc atgattacag tctgtaatgc acgagcctac cagtggcagg cgcactcttg
     7501 tctggtaaaa gagctagtgt ctgcatttca acactccatg ctcaacaccc gtaacttctg
     7561 aacttcatca gctggctcta cattcttaat cagtgaggaa agcattctgg actacagata
     7621 ctggcttgca gacttcagag tacactggga cagacttgaa gcttgctgca gaccccaaac
     7681 ttgattcata ccttgttgag aatctacacc ttacaaatct ttacaagttt aaaaataatg
     7741 ttgacaatcc cgggagcaaa cccagagaac caagctgtag ctggctaatt atgtgctcca
     7801 agtaactgtg taacctaggt tagcagacct caattctaga tactactttt tcatgtacta
     7861 ttcacccagt cccacttggt tgcctgtacc atttggggga ctaaaaatca gcaataaaag
     7921 caaaaggtag tcacatgga
//
