LOCUS       NM_013530               1887 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Mus musculus guanine nucleotide binding protein (G protein), beta 3
            (Gnb3), mRNA.
ACCESSION   NM_013530
VERSION     NM_013530.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1887)
  AUTHORS   Wutikeli,H., Yu,Y., Zhang,T., Cao,J., Nawy,S. and Shen,Y.
  TITLE     Role of Elavl-like RNA-binding protein in retinal development and
            signal transduction
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1871 (1), 167518 (2025)
   PUBMED   39307290
REFERENCE   2  (bases 1 to 1887)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1887)
  AUTHORS   Norrie,J.L., Lupo,M.S., Xu,B., Al Diri,I., Valentine,M., Putnam,D.,
            Griffiths,L., Zhang,J., Johnson,D., Easton,J., Shao,Y., Honnell,V.,
            Frase,S., Miller,S., Stewart,V., Zhou,X., Chen,X. and Dyer,M.A.
  TITLE     Nucleome Dynamics during Retinal Development
  JOURNAL   Neuron 104 (3), 512-528 (2019)
   PUBMED   31493975
REFERENCE   4  (bases 1 to 1887)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1887)
  AUTHORS   Kannan,M., Bayam,E., Wagner,C., Rinaldi,B., Kretz,P.F., Tilly,P.,
            Roos,M., McGillewie,L., Bar,S., Minocha,S., Chevalier,C., Po,C.,
            Chelly,J., Mandel,J.L., Borgatti,R., Piton,A., Kinnear,C., Loos,B.,
            Adams,D.J., Herault,Y., Collins,S.C., Friant,S., Godin,J.D. and
            Yalcin,B.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     WD40-repeat 47, a microtubule-associated protein, is essential for
            brain development and autophagy
  JOURNAL   Proc Natl Acad Sci U S A 114 (44), E9308-E9317 (2017)
   PUBMED   29078390
REFERENCE   6  (bases 1 to 1887)
  AUTHORS   Force,W.R., Walter,B.N., Hession,C., Tizard,R., Kozak,C.A.,
            Browning,J.L. and Ware,C.F.
  TITLE     Mouse lymphotoxin-beta receptor. Molecular genetics, ligand
            binding, and expression
  JOURNAL   J Immunol 155 (11), 5280-5288 (1995)
   PUBMED   7594541
REFERENCE   7  (bases 1 to 1887)
  AUTHORS   Danciger,M., Chakraborti,A., Farber,D.B. and Kozak,C.A.
  TITLE     Localization of the gene for a third G protein beta-subunit to
            mouse chromosome 6 near Raf-1
  JOURNAL   Genomics 12 (4), 688-692 (1992)
   PUBMED   1572642
REFERENCE   8  (bases 1 to 1887)
  AUTHORS   von Weizsacker,E., Strathmann,M.P. and Simon,M.I.
  TITLE     Diversity among the beta subunits of heterotrimeric GTP-binding
            proteins: characterization of a novel beta-subunit cDNA
  JOURNAL   Biochem Biophys Res Commun 183 (1), 350-356 (1992)
   PUBMED   1543505
REFERENCE   9  (bases 1 to 1887)
  AUTHORS   Danciger,M., Farber,D.B., Peyser,M. and Kozak,C.A.
  TITLE     The gene for the beta-subunit of retinal transducin (Gnb-1) maps to
            distal mouse chromosome 4, and related sequences map to mouse
            chromosomes 5 and 8
  JOURNAL   Genomics 6 (3), 428-435 (1990)
   PUBMED   2328987
REFERENCE   10 (bases 1 to 1887)
  AUTHORS   Levine,M.A., Smallwood,P.M., Moen,P.T. Jr., Helman,L.J. and
            Ahn,T.G.
  TITLE     Molecular cloning of beta 3 subunit, a third form of the G protein
            beta-subunit polypeptide
  JOURNAL   Proc Natl Acad Sci U S A 87 (6), 2329-2333 (1990)
   PUBMED   2107550
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC018239.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018239.1, AK014789.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1887
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 59.17 cM"
     gene            1..1887
                     /gene="Gnb3"
                     /gene_synonym="Gnb-3; Hg2d"
                     /note="guanine nucleotide binding protein (G protein),
                     beta 3"
                     /db_xref="GeneID:14695"
                     /db_xref="MGI:MGI:95785"
     exon            1..356
                     /gene="Gnb3"
                     /gene_synonym="Gnb-3; Hg2d"
                     /inference="alignment:Splign:2.1.0"
     exon            357..443
                     /gene="Gnb3"
                     /gene_synonym="Gnb-3; Hg2d"
                     /inference="alignment:Splign:2.1.0"
     CDS             387..1409
                     /gene="Gnb3"
                     /gene_synonym="Gnb-3; Hg2d"
                     /note="transducin beta chain 3; heterotrimeric guanine
                     nucleotide-binding protein 2d"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein
                     G(I)/G(S)/G(T) subunit beta-3"
                     /protein_id="NP_038558.1"
                     /db_xref="CCDS:CCDS20532.1"
                     /db_xref="GeneID:14695"
                     /db_xref="MGI:MGI:95785"
                     /translation="MGEMEQLRQEAEQLKKQIADARKACADITLAELVSGLEVVGRVQ
                     MRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDTYTTNKVHAIPLRSSWVMT
                     CAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTS
                     SGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDYKLFISGACDASAKLWDVREGTC
                     RQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELTAYSQESIICGITSV
                     AFSLSGRLLFAGYDDFNCNVWDSLKCERVGILSGHDNRVSCLGVTADGMAVATGSWDS
                     FLKIWN"
     exon            444..482
                     /gene="Gnb3"
                     /gene_synonym="Gnb-3; Hg2d"
                     /inference="alignment:Splign:2.1.0"
     exon            483..589
                     /gene="Gnb3"
                     /gene_synonym="Gnb-3; Hg2d"
                     /inference="alignment:Splign:2.1.0"
     exon            590..653
                     /gene="Gnb3"
                     /gene_synonym="Gnb-3; Hg2d"
                     /inference="alignment:Splign:2.1.0"
     exon            654..816
                     /gene="Gnb3"
                     /gene_synonym="Gnb-3; Hg2d"
                     /inference="alignment:Splign:2.1.0"
     exon            817..883
                     /gene="Gnb3"
                     /gene_synonym="Gnb-3; Hg2d"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1085
                     /gene="Gnb3"
                     /gene_synonym="Gnb-3; Hg2d"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1302
                     /gene="Gnb3"
                     /gene_synonym="Gnb-3; Hg2d"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1846
                     /gene="Gnb3"
                     /gene_synonym="Gnb-3; Hg2d"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1820..1825
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnb3"
                     /gene_synonym="Gnb-3; Hg2d"
                     /note="hexamer: AATAAA"
     polyA_site      1841
                     /gene="Gnb3"
                     /gene_synonym="Gnb-3; Hg2d"
                     /note="major polyA site"
ORIGIN      
        1 gaccgtggaa gcacccctct atccccaccc cccttcttgt ggctgcataa gaggggtgct
       61 gctcttctct ggtccacggg cctgtttccc acccctccag gctgacctgt ctctggaagc
      121 cacatacctc ccctccctgg cctctccccc acccctgcca gctgatttca tttgcctggc
      181 gtggttgttg ctggccttac ccttccctgt cattcccccc tccctctcag tcagggccag
      241 gccaggccag ctcctctggc agcagagggg ggcaggtgac aggcaggcat cgcagctgag
      301 acagtgagga ggcgcccggg aagcggaaac ctgggagaag tccagccaga gcccaagagc
      361 cggaactacc cctcgacctg tgcaccatgg gggagatgga gcagctgagg caggaggcgg
      421 agcaactcaa gaagcagatt gctgatgcca ggaaagcctg tgcggacatc actctggctg
      481 agcttgtgtc tggcctggag gtggtgggcc gagtccagat gcggacacgg aggacattaa
      541 ggggacatct ggccaagatc tatgccatgc actgggccac tgactctaag ctgctcgtaa
      601 gtgcctcgca ggatgggaag ctgatcgtgt gggacactta taccaccaat aaggtgcatg
      661 caatcccgct gcgttcctcc tgggtcatga cctgtgccta tgcaccatca gggaactttg
      721 tggcatgtgg ggggctggac aacatgtgtt caatctacaa cctcaaatcc cgcgagggca
      781 atgtcaaggt cagccgggag ctctctgctc acacaggtta tctctcctgt tgccgcttcc
      841 tggatgacaa caacatcgtg actagctctg gggacaccac atgtgccttg tgggacattg
      901 agacaggaca gcagaagaca gtgtttgtgg gacacactgg tgactgcatg agcctggctg
      961 tgtccccaga ctacaaactc ttcatttcgg gagcttgcga tgctagcgcg aagctctggg
     1021 atgtgaggga agggacctgt cgtcagactt tcactggcca tgagtcagac atcaatgcca
     1081 tctgtttctt tcccaacggg gaggccatct gcactggctc agatgacgcc tcctgccgcc
     1141 tctttgacct gagggcagac caggaactga ctgcctattc ccaggagagc atcatctgcg
     1201 gcatcacttc agtagccttc tcgctcagtg ggcgcctgct ctttgcaggc tatgatgact
     1261 tcaactgcaa tgtctgggac tctctgaagt gcgagcgtgt aggcatactc tctggccatg
     1321 acaacagagt cagctgcctg ggggtcactg ctgacggcat ggctgtggcc actggttcct
     1381 gggacagctt cctcaaaatc tggaactgag gaggctagag gaagaggtgg gaagccacga
     1441 aggttctcag caggctcctc ctatgccccg tctccttagg gtcagtctcc tatactccag
     1501 gggccattcc tagtaaactt ccttttaaga gcaggtggga ttatgggagt gtgcctttgg
     1561 aagcatcagg gacttaaggg caagaactgc cccatttcct gccatggcct ctcctctcca
     1621 cagccctcac agcctctccc ttaataaaca agaatggacc ccttccccac cctagagtcc
     1681 tcctgggtta ccagtagcct ttgtccagat ggggaatggc cagagtgctc agcccatgac
     1741 tatggatgtg gctcctagtc tcctggcttc cttcccgccg ctttctcctt ttctgccctt
     1801 ttgttctctc ttattaccta ataaaatgta gcatcctggt acctctaaaa aaaaaaaaaa
     1861 aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
