LOCUS       NM_010312               1673 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus guanine nucleotide binding protein (G protein), beta 2
            (Gnb2), mRNA.
ACCESSION   NM_010312
VERSION     NM_010312.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1673)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1673)
  AUTHORS   Yim,Y.Y., McDonald,W.H., Betke,K.M., Kaya,A., Hyde,K., Erreger,K.,
            Gilsbach,R., Hein,L. and Hamm,H.E.
  TITLE     Specificities of Gbetagamma subunits for the SNARE complex before
            and after stimulation of alpha2a-adrenergic receptors
  JOURNAL   Sci Signal 14 (714), eabc4970 (2021)
   PUBMED   34932372
REFERENCE   3  (bases 1 to 1673)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1673)
  AUTHORS   van den Bos,E., Ambrosy,B., Horsthemke,M., Walbaum,S., Bachg,A.C.,
            Wettschureck,N., Innamorati,G., Wilkie,T.M. and Hanley,P.J.
  TITLE     Knockout mouse models reveal the contributions of G protein
            subunits to complement C5a receptor-mediated chemotaxis
  JOURNAL   J Biol Chem 295 (22), 7726-7742 (2020)
   PUBMED   32332099
REFERENCE   5  (bases 1 to 1673)
  AUTHORS   Guo,Y., He,X., Zhao,L., Liu,L., Song,H., Wang,X., Xu,J., Ju,X.,
            Guo,W. and Zhu,X.
  TITLE     Gbeta2 Regulates the Multipolar-Bipolar Transition of Newborn
            Neurons in the Developing Neocortex
  JOURNAL   Cereb Cortex 27 (6), 3414-3426 (2017)
   PUBMED   28334111
REFERENCE   6  (bases 1 to 1673)
  AUTHORS   Clark,S.G., Stern,M.J. and Horvitz,H.R.
  TITLE     C. elegans cell-signalling gene sem-5 encodes a protein with SH2
            and SH3 domains
  JOURNAL   Nature 356 (6367), 340-344 (1992)
   PUBMED   1372395
REFERENCE   7  (bases 1 to 1673)
  AUTHORS   von Weizsacker,E., Strathmann,M.P. and Simon,M.I.
  TITLE     Diversity among the beta subunits of heterotrimeric GTP-binding
            proteins: characterization of a novel beta-subunit cDNA
  JOURNAL   Biochem Biophys Res Commun 183 (1), 350-356 (1992)
   PUBMED   1543505
REFERENCE   8  (bases 1 to 1673)
  AUTHORS   Danciger,M., Farber,D.B., Peyser,M. and Kozak,C.A.
  TITLE     The gene for the beta-subunit of retinal transducin (Gnb-1) maps to
            distal mouse chromosome 4, and related sequences map to mouse
            chromosomes 5 and 8
  JOURNAL   Genomics 6 (3), 428-435 (1990)
   PUBMED   2328987
REFERENCE   9  (bases 1 to 1673)
  AUTHORS   Beru,N., McDonald,J. and Goldwasser,E.
  TITLE     Activation of the erythropoietin gene due to the proximity of an
            expressed gene
  JOURNAL   DNA 8 (4), 253-259 (1989)
   PUBMED   2766927
REFERENCE   10 (bases 1 to 1673)
  AUTHORS   Blatt,C., Eversole-Cire,P., Cohn,V.H., Zollman,S., Fournier,R.E.,
            Mohandas,L.T., Nesbitt,M., Lugo,T., Jones,D.T., Reed,R.R. et al.
  TITLE     Chromosomal localization of genes encoding guanine
            nucleotide-binding protein subunits in mouse and human
  JOURNAL   Proc Natl Acad Sci U S A 85 (20), 7642-7646 (1988)
   PUBMED   2902634
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI892088.1, AK146941.1 and BF458455.1.
            
            On Jan 27, 2018 this sequence version replaced NM_010312.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146941.1, BC062178.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                AI892088.1         205-258
            55-1655             AK146941.1         2-1602
            1656-1673           BF458455.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..1673
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 76.54 cM"
     gene            1..1673
                     /gene="Gnb2"
                     /gene_synonym="Gnb-2; Hg2c1"
                     /note="guanine nucleotide binding protein (G protein),
                     beta 2"
                     /db_xref="GeneID:14693"
                     /db_xref="MGI:MGI:95784"
     exon            1..168
                     /gene="Gnb2"
                     /gene_synonym="Gnb-2; Hg2c1"
                     /inference="alignment:Splign:2.1.0"
     exon            169..314
                     /gene="Gnb2"
                     /gene_synonym="Gnb-2; Hg2c1"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..1280
                     /gene="Gnb2"
                     /gene_synonym="Gnb-2; Hg2c1"
                     /note="guanine nucleotide-binding protein, beta-2 subunit;
                     transducin beta chain 2; g protein subunit beta-2; guanine
                     nucleotide binding protein, beta 2; heterotrimeric guanine
                     nucleotide-binding protein 2c1"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein
                     G(I)/G(S)/G(T) subunit beta-2"
                     /protein_id="NP_034442.1"
                     /db_xref="CCDS:CCDS19769.1"
                     /db_xref="GeneID:14693"
                     /db_xref="MGI:MGI:95784"
                     /translation="MSELEQLRQEAEQLRNQIRDARKACGDSTLTQITAGLDPVGRIQ
                     MRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMT
                     CAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITS
                     SGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMC
                     RQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSV
                     AFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDS
                     FLKIWN"
     exon            315..353
                     /gene="Gnb2"
                     /gene_synonym="Gnb-2; Hg2c1"
                     /inference="alignment:Splign:2.1.0"
     exon            354..460
                     /gene="Gnb2"
                     /gene_synonym="Gnb-2; Hg2c1"
                     /inference="alignment:Splign:2.1.0"
     exon            461..524
                     /gene="Gnb2"
                     /gene_synonym="Gnb-2; Hg2c1"
                     /inference="alignment:Splign:2.1.0"
     exon            525..687
                     /gene="Gnb2"
                     /gene_synonym="Gnb-2; Hg2c1"
                     /inference="alignment:Splign:2.1.0"
     exon            688..754
                     /gene="Gnb2"
                     /gene_synonym="Gnb-2; Hg2c1"
                     /inference="alignment:Splign:2.1.0"
     exon            755..956
                     /gene="Gnb2"
                     /gene_synonym="Gnb-2; Hg2c1"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1173
                     /gene="Gnb2"
                     /gene_synonym="Gnb-2; Hg2c1"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1656
                     /gene="Gnb2"
                     /gene_synonym="Gnb-2; Hg2c1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1630..1635
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnb2"
                     /gene_synonym="Gnb-2; Hg2c1"
                     /note="hexamer: CATAAA"
     polyA_site      1656
                     /gene="Gnb2"
                     /gene_synonym="Gnb-2; Hg2c1"
                     /note="major polyA site"
ORIGIN      
        1 actggcgggc gggatccctc cgctctgggg agagctgcgc tggacggttg agttggggtg
       61 actgaggaaa tccatccgcg tcgccgccgc tgccgcctcc gccgcggagg aagacaggac
      121 ctcccgcgct cctccaagcg accccttggc agagtcccac cacctcaggc ctcgggccag
      181 cggccaggag ctgcctcccc cagcccccgt cccgcggccc ccagccgccc ccaaccccgc
      241 cccacgggcc cggcgccatg agtgagctgg agcaactgag acaggaggcc gagcagctcc
      301 ggaaccagat ccgggacgcc agaaaagcat gcggggattc cacactgacc cagatcacag
      361 ctgggctgga cccagtgggg cgaattcaga tgagaacacg gaggaccctc cgtggacacc
      421 tggcaaaaat ctatgccatg cactggggga cagactcaag gctgctggtc agcgcctccc
      481 aggacggaaa gctcatcatt tgggacagct acaccactaa caaggtccac gccatccctc
      541 tgcgttcctc ctgggtcatg acctgtgcct acgccccctc agggaacttt gtggcctgtg
      601 ggggtttgga caacatctgc tccatctata gtctcaagac ccgagagggc aatgtcaggg
      661 tcagcagaga gctgcctggc cacactgggt acctgtcatg ctgccgcttc ctggacgaca
      721 accaaatcat caccagctct ggggacacca cctgtgccct gtgggacatt gagacaggcc
      781 agcagacggt ggggtttgct ggacacagtg gggatgtgat gtccctgtca ctggcccccg
      841 atggccgcac ctttgtgtca ggtgcctgtg acgcctccat caagctgtgg gatgttcggg
      901 attccatgtg ccgacagaca ttcataggtc acgagtcgga catcaatgcc gtggctttct
      961 tccccaatgg ctatgccttc accacgggat cagatgacgc cacttgtcgc ctctttgacc
     1021 tgcgggctga tcaggagctg ctcatgtatt cccacgacaa catcatctgc ggcatcacct
     1081 cggttgcctt ctcgcgcagc ggccggctgc tgctcgctgg ctacgacgac ttcaactgca
     1141 acatctggga tgccatgaag ggtgaccgtg caggtgtcct cgctggccat gataaccgtg
     1201 tgagctgcct tggggtcaca gatgatggaa tggccgtggc tacaggctcc tgggactcct
     1261 tcctcaagat ctggaactaa cctccccaac cccagatggg cccaggcagg gagcagccct
     1321 gcccatgccc acactacagg cccggagctt tggggctggg tacatgtgcc aagcctccct
     1381 ccctgggcta cagggcctcc ggtcctgctc ccatacccag gtttggttcc tctagggggg
     1441 ggcccccact gtggagataa aagtcgggga tggaatgggg gaagaggaag ggcaggaaag
     1501 ccctcaccct ttgctgccct ggggccatgg cctcacccct ctggagggcc agaggcagga
     1561 ggtggaaact ccaggggctg gcttttttaa ctggttttat tttaattttt attatatttt
     1621 cagtttttcc ataaaggaac cacttccaac tctgtaaaaa aaaaaaaaaa aaa
//
