LOCUS       NM_001081682            3625 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus guanine nucleotide binding protein (G protein), beta
            polypeptide 1-like (Gnb1l), transcript variant 1, mRNA.
ACCESSION   NM_001081682
VERSION     NM_001081682.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3625)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3625)
  AUTHORS   Paronett,E.M., Meechan,D.W., Karpinski,B.A., LaMantia,A.S. and
            Maynard,T.M.
  TITLE     Ranbp1, Deleted in DiGeorge/22q11.2 Deletion Syndrome, is a
            Microcephaly Gene That Selectively Disrupts Layer 2/3 Cortical
            Projection Neuron Generation
  JOURNAL   Cereb Cortex 25 (10), 3977-3993 (2015)
   PUBMED   25452572
REFERENCE   3  (bases 1 to 3625)
  AUTHORS   Karpinski,B.A., Maynard,T.M., Fralish,M.S., Nuwayhid,S., Zohn,I.E.,
            Moody,S.A. and LaMantia,A.S.
  TITLE     Dysphagia and disrupted cranial nerve development in a mouse model
            of DiGeorge (22q11) deletion syndrome
  JOURNAL   Dis Model Mech 7 (2), 245-257 (2014)
   PUBMED   24357327
REFERENCE   4  (bases 1 to 3625)
  AUTHORS   Maynard,T.M., Gopalakrishna,D., Meechan,D.W., Paronett,E.M.,
            Newbern,J.M. and LaMantia,A.S.
  TITLE     22q11 Gene dosage establishes an adaptive range for sonic hedgehog
            and retinoic acid signaling during early development
  JOURNAL   Hum Mol Genet 22 (2), 300-312 (2013)
   PUBMED   23077214
REFERENCE   5  (bases 1 to 3625)
  AUTHORS   Voss,A.K., Vanyai,H.K., Collin,C., Dixon,M.P., McLennan,T.J.,
            Sheikh,B.N., Scambler,P. and Thomas,T.
  TITLE     MOZ regulates the Tbx1 locus, and Moz mutation partially
            phenocopies DiGeorge syndrome
  JOURNAL   Dev Cell 23 (3), 652-663 (2012)
   PUBMED   22921202
REFERENCE   6  (bases 1 to 3625)
  AUTHORS   Merscher,S., Funke,B., Epstein,J.A., Heyer,J., Puech,A., Lu,M.M.,
            Xavier,R.J., Demay,M.B., Russell,R.G., Factor,S., Tokooya,K.,
            Jore,B.S., Lopez,M., Pandita,R.K., Lia,M., Carrion,D., Xu,H.,
            Schorle,H., Kobler,J.B., Scambler,P., Wynshaw-Boris,A.,
            Skoultchi,A.I., Morrow,B.E. and Kucherlapati,R.
  TITLE     TBX1 is responsible for cardiovascular defects in
            velo-cardio-facial/DiGeorge syndrome
  JOURNAL   Cell 104 (4), 619-629 (2001)
   PUBMED   11239417
REFERENCE   7  (bases 1 to 3625)
  AUTHORS   Gong,L., Liu,M., Jen,J. and Yeh,E.T.
  TITLE     GNB1L, a gene deleted in the critical region for DiGeorge syndrome
            on 22q11, encodes a G-protein beta-subunit-like polypeptide
  JOURNAL   Biochim Biophys Acta 1494 (1-2), 185-188 (2000)
   PUBMED   11072084
REFERENCE   8  (bases 1 to 3625)
  AUTHORS   Puech,A., Saint-Jore,B., Merscher,S., Russell,R.G., Cherif,D.,
            Sirotkin,H., Xu,H., Factor,S., Kucherlapati,R. and Skoultchi,A.I.
  TITLE     Normal cardiovascular development in mice deficient for 16 genes in
            550 kb of the velocardiofacial/DiGeorge syndrome region
  JOURNAL   Proc Natl Acad Sci U S A 97 (18), 10090-10095 (2000)
   PUBMED   10963672
REFERENCE   9  (bases 1 to 3625)
  AUTHORS   Lund,J., Chen,F., Hua,A., Roe,B., Budarf,M., Emanuel,B.S. and
            Reeves,R.H.
  TITLE     Comparative sequence analysis of 634 kb of the mouse chromosome 16
            region of conserved synteny with the human velocardiofacial
            syndrome region on chromosome 22q11.2
  JOURNAL   Genomics 63 (3), 374-383 (2000)
   PUBMED   10704284
REFERENCE   10 (bases 1 to 3625)
  AUTHORS   Lund,J., Roe,B., Chen,F., Budarf,M., Galili,N., Riblet,R.,
            Miller,R.D., Emanuel,B.S. and Reeves,R.H.
  TITLE     Sequence-ready physical map of the mouse chromosome 16 region with
            conserved synteny to the human velocardiofacial syndrome region on
            22q11.2
  JOURNAL   Mamm Genome 10 (5), 438-443 (1999)
   PUBMED   10337614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133488.30.
            
            On Oct 22, 2013 this sequence version replaced NM_001081682.1.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK087954.1, SRR9219382.1236.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               AC133488.30        67385-67523
            140-234             AC133488.30        67718-67812
            235-375             AC133488.30        109107-109247
            376-501             AC133488.30        109644-109769
            502-664             AC133488.30        112783-112945
            665-763             AC133488.30        116765-116863
            764-979             AC133488.30        121039-121254
            980-3625            AC133488.30        132707-135352
FEATURES             Location/Qualifiers
     source          1..3625
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 11.46 cM"
     gene            1..3625
                     /gene="Gnb1l"
                     /gene_synonym="ESTM55; Gm16314; Me49f07; Rtl10; Wdr14;
                     Wdvcf"
                     /note="guanine nucleotide binding protein (G protein),
                     beta polypeptide 1-like"
                     /db_xref="GeneID:13972"
                     /db_xref="MGI:MGI:1338057"
     exon            1..139
                     /gene="Gnb1l"
                     /gene_synonym="ESTM55; Gm16314; Me49f07; Rtl10; Wdr14;
                     Wdvcf"
                     /inference="alignment:Splign:2.1.0"
     exon            140..234
                     /gene="Gnb1l"
                     /gene_synonym="ESTM55; Gm16314; Me49f07; Rtl10; Wdr14;
                     Wdvcf"
                     /inference="alignment:Splign:2.1.0"
     exon            235..375
                     /gene="Gnb1l"
                     /gene_synonym="ESTM55; Gm16314; Me49f07; Rtl10; Wdr14;
                     Wdvcf"
                     /inference="alignment:Splign:2.1.0"
     exon            376..501
                     /gene="Gnb1l"
                     /gene_synonym="ESTM55; Gm16314; Me49f07; Rtl10; Wdr14;
                     Wdvcf"
                     /inference="alignment:Splign:2.1.0"
     exon            502..664
                     /gene="Gnb1l"
                     /gene_synonym="ESTM55; Gm16314; Me49f07; Rtl10; Wdr14;
                     Wdvcf"
                     /inference="alignment:Splign:2.1.0"
     exon            665..763
                     /gene="Gnb1l"
                     /gene_synonym="ESTM55; Gm16314; Me49f07; Rtl10; Wdr14;
                     Wdvcf"
                     /inference="alignment:Splign:2.1.0"
     exon            764..979
                     /gene="Gnb1l"
                     /gene_synonym="ESTM55; Gm16314; Me49f07; Rtl10; Wdr14;
                     Wdvcf"
                     /inference="alignment:Splign:2.1.0"
     exon            980..3625
                     /gene="Gnb1l"
                     /gene_synonym="ESTM55; Gm16314; Me49f07; Rtl10; Wdr14;
                     Wdvcf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1464..1469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnb1l"
                     /gene_synonym="ESTM55; Gm16314; Me49f07; Rtl10; Wdr14;
                     Wdvcf"
                     /note="hexamer: AATAAA"
     polyA_site      1489
                     /gene="Gnb1l"
                     /gene_synonym="ESTM55; Gm16314; Me49f07; Rtl10; Wdr14;
                     Wdvcf"
                     /note="major polyA site"
     regulatory      3605..3610
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnb1l"
                     /gene_synonym="ESTM55; Gm16314; Me49f07; Rtl10; Wdr14;
                     Wdvcf"
                     /note="hexamer: AATAAA"
     polyA_site      3625
                     /gene="Gnb1l"
                     /gene_synonym="ESTM55; Gm16314; Me49f07; Rtl10; Wdr14;
                     Wdvcf"
ORIGIN      
        1 ctccgcgctg gcgcgctggc gcggtgtgac cctctgcgag atggaggcct cgctgtttac
       61 ggcgcaggcg cggtgggccg aacgtgcgcg cgcagccccg cgggaaggct aacttggggc
      121 gtgcggagcg ccagagccgg tggcggtggg atcctgccct cggaagaagc ccctctgcct
      181 ggtgttctcc agcggagcct ctgatcctgg cggcccctcc tggcgcagtc ctaggactgc
      241 atttacccac atggcagccc tgttcccacc accgcctggt cccagatttg tcctccgagg
      301 cacacagtcg gctgtgaaca cgctccattt ctgcccacca tcccaagctg cagggaaccc
      361 acttctcttc tcagggtctc agaatggcct agtacatatc tggagcctac aaacaagaag
      421 aatagttacc actctaaatg gccatggggg ccagggtgta atctggctga agacactgcc
      481 acagggacac cagctcctca gccagggtcg agacctgcgg ctgtgcctgt gggacctgga
      541 ggagggcagg aacaccatca tggactcagt tcagctggac agtgtgggct tctgcagggg
      601 ctccatcctg gtcaggggac agcagtgctg gatgcttgct gtgccaggga agggcagcga
      661 cgaggttcag attctggaga tgccatccaa gacgtcagtg tgcaccctga agccggaggc
      721 cgatgccagg ccaggcatgc ccatgtgcct ggggctgtgg cagactaact ccagtctccg
      781 ccccctcctt ctggctggct atgaggatgg atcagtaacc ctgtgggaca tctcagagcg
      841 gaaggtgtgc agccaaatca cctgccatga agagcctgtc atgggcctcg acttcgactc
      901 tcagaaggcc aagggcatct ctggctctgc tgggaaggta ctggctgtct ggagtctgga
      961 cgatcagcag tccctgcagg tgaagaagac tcatgaactc accaatcctg gaattgccga
     1021 agtcaccatc cggccagacc acaagatctt agccacagca ggctgggacc atcgcatccg
     1081 tgtgtttcac tggaggacaa tgaaaccgtt agctgttctg gctttccaca gcgctcctgt
     1141 gtactgcgtg gcctttgctg ctgatggctt gcttgctgcg gggtccaagg accagcgtat
     1201 cagcatctgg tcactctacc cctgcccatg acttagctgt gggacactgc tattttactc
     1261 cagtcttgac ccagccctgt ggaagatctt caagtccctc tgaggacagc aaattgtggc
     1321 caaagatccc tggggtccac tttcttcgtg aggttctctg ttccttttgt gactgtcatt
     1381 cagatgatag acacctggca cctatagctt ggtaacaggc atgttttaga cctggttggg
     1441 tggccagact aaagatattt gacaataaat ttcccattgc caacctgaag cctcaaggtg
     1501 ggaacttccc ccaaagatct ccctgtgttc tgcacttaga gtagagcatt cagcttgccc
     1561 agcaggcctg tcatcagcct tactcggaag cagtggttct gggtgcaggt actcagcact
     1621 tggccttggg aggctgccaa tcccacagtg attatctgcc ataccctctg gcacattgtc
     1681 ccagacatgt tctgggactc ctgacatcca cgactcaggt cagcatgagg aatggatgaa
     1741 actgggctcc ttaaagaggg aggcaagtaa gagttaataa tggggtgacc aaggtggtca
     1801 gggaaggaga gatgtgtaca atgcagtata aggccagata gaagaccagg aaaggaggct
     1861 ctagcctctg acaggataag gtaaagggat agcttgtctt tcagtgaacc tgcaggaggc
     1921 aagggaaagc actctcgaca ggccacaaac tggaccttct gtagtgccca ggctgcaagc
     1981 acagccatgt ggtatatgga gtaacaaggc cttgagagtc aggagtgagc gcctgatgcc
     2041 tctttccatg tggccgacag ggaagcagcc tccgaggtag tgctgactgg ggtggaggac
     2101 tgtaaaggtg aggatgcagg tgaggagtgt ggacctcgga cctttctcct tccatcactg
     2161 ccagaaagaa tcctgtgccc cgaagagctg gggcgccccc aagtgctgcc ctgccaggca
     2221 ctgctaactt agaatcccta ctgccctttg ggcctctggt ctataactaa acactacaca
     2281 tagcctgctg aagctgaatg tgtctatgtt gaaagtgtca cagttcagcc tggtgtcccc
     2341 aagctgggga gcacacgtag gaggccagga aaggagtgtg tggtccaggt gaaatacata
     2401 tatcaagaac tatggcttgc cgccacagcg ccagggccag agagagctgg ttggattggt
     2461 ggtaagctag ttagacacag ttgaaaagat gggaactgtg tctgactaac gtacatgggg
     2521 agctgagaag ccaggtggag gaagggatcc agcggttgga agatcagaat gtggcctgtt
     2581 agggctgggt tgggaggatg tgccttttgc cccatactga gggaggcagt tgccggggga
     2641 acatcctcag agggcttcat ggtggctcct ctctgtacac ctgtgaaggc tacgacttgg
     2701 tggtaagcac ttgcacacag gaggccctgg ctccaactaa ggtcctggga tagtacaact
     2761 gcagcttcca gtttggaatc tctaactgga gtggggatca ctagctgccc cagtgggagt
     2821 gctccccgta atgggctatg gatcgggagc agccctcagc agaacctgac cgcgagagct
     2881 ggctttcctg gagtccctag aaatggcatg gatcaacttg gtccacatag gcagaagcag
     2941 tagcgagcag gccaacccac atcacaggca caggcctctt cactcccttt gaaggaagta
     3001 ccatccagac actgctcatt tttctctcag aatcccccag gggccctgcc accaccaagt
     3061 gctctatttt attaccctgg gccgggggca tgggtaggtt gattgaaggg aaattggtga
     3121 gcccatctat gagtgggaaa gataacccag ttcatctgtg gccaaaccgt gctgtgatac
     3181 ccggcagcac ggagcaatgc tgttccgtgg agtgctccag ttgtctttta ccaacacttt
     3241 tggagatgac ctcaagcctg tgtagatcaa tgtggctgcc tcaggaagcc caggactgga
     3301 agtgtcatct catacaagct ctgtccaacc ttccccacac accgggaggc cccgtctgta
     3361 catgagctgt ttcctccaca gtggaacatt ctctcctcct tccaaggaag gaggcttaca
     3421 ggactcagtt ctgagatcct caggctccct gcccagagtt acaaaaggca gtaacaattg
     3481 ctggggaaga ggacgctctc cagtggactg tctgcaagct aagccaggag ctccagggac
     3541 gcagcttctt tgagagatcc ccaggactga cctgggggat ctcagatgcc ctaaaagtta
     3601 ccccaataaa gtcattggtt cacta
//
