LOCUS       NM_008142               3143 bp    mRNA    linear   ROD 18-DEC-2022
DEFINITION  Mus musculus guanine nucleotide binding protein (G protein), beta 1
            (Gnb1), transcript variant 1, mRNA.
ACCESSION   NM_008142
VERSION     NM_008142.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3143)
  AUTHORS   Ruengsinpinya L, Murakami T, Nakamura E, Takahata Y, Hata K,
            Nakaminami Y, Okae H and Nishimura R.
  TITLE     G protein subunit beta1 is an important mediator of the late stage
            of endochondral ossification
  JOURNAL   Biochem Biophys Res Commun 533 (1), 90-96 (2020)
   PUBMED   32928505
  REMARK    GeneRIF: G protein subunit beta1 is an important mediator of the
            late stage of endochondral ossification.
REFERENCE   2  (bases 1 to 3143)
  AUTHORS   van den Bos E, Ambrosy B, Horsthemke M, Walbaum S, Bachg AC,
            Wettschureck N, Innamorati G, Wilkie TM and Hanley PJ.
  TITLE     Knockout mouse models reveal the contributions of G protein
            subunits to complement C5a receptor-mediated chemotaxis
  JOURNAL   J Biol Chem 295 (22), 7726-7742 (2020)
   PUBMED   32332099
REFERENCE   3  (bases 1 to 3143)
  AUTHORS   Murakami T, Ruengsinpinya L, Nakamura E, Takahata Y, Hata K, Okae
            H, Taniguchi S, Takahashi M and Nishimura R.
  TITLE     Cutting Edge: G Protein Subunit beta 1 Negatively Regulates NLRP3
            Inflammasome Activation
  JOURNAL   J Immunol 202 (7), 1942-1947 (2019)
   PUBMED   30777924
  REMARK    GeneRIF: This study indicates that GNB1 negatively regulates NLRP3
            inflammasome activation
REFERENCE   4  (bases 1 to 3143)
  AUTHORS   Zurawski Z, Thompson Gray AD, Brady LJ, Page B, Church E, Harris
            NA, Dohn MR, Yim YY, Hyde K, Mortlock DP, Jones CK, Winder DG,
            Alford S and Hamm HE.
  TITLE     Disabling the Gbetagamma-SNARE interaction disrupts GPCR-mediated
            presynaptic inhibition, leading to physiological and behavioral
            phenotypes
  JOURNAL   Sci Signal 12 (569) (2019)
   PUBMED   30783011
  REMARK    GeneRIF: Data show that synaptosome associated protein 25
            (SNAP25)Delta3 mutation has a twofold reduction in GTP-binding
            protein beta/gamma (Gbetagamma) binding.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3143)
  AUTHORS   Pradhan S, Khatlani T, Nairn AC and Vijayan KV.
  TITLE     The heterotrimeric G protein Gbeta1 interacts with the catalytic
            subunit of protein phosphatase 1 and modulates G protein-coupled
            receptor signaling in platelets
  JOURNAL   J Biol Chem 292 (32), 13133-13142 (2017)
   PUBMED   28615442
  REMARK    GeneRIF: Data, including data from studies using
            transgenic/knockout mice, suggest that Ppp1ca and Gnb1 interact in
            quiescent platelets; then, Ppp1ca and Plcb3 interact during
            platelet aggregation; thus, Gnb1 enlists Ppp1ca to modulate G
            protein-coupled receptor signaling. (Ppp1ca = protein phosphatase
            1, catalytic subunit alpha; Gnb1 = guanine nucleotide-binding
            protein, subunit beta-1; Plcb3 = phospholipase C, subunit beta-3)
REFERENCE   6  (bases 1 to 3143)
  AUTHORS   Danciger M, Chakraborti A, Farber DB and Kozak CA.
  TITLE     Localization of the gene for a third G protein beta-subunit to
            mouse chromosome 6 near Raf-1
  JOURNAL   Genomics 12 (4), 688-692 (1992)
   PUBMED   1572642
REFERENCE   7  (bases 1 to 3143)
  AUTHORS   von Weizsacker E, Strathmann MP and Simon MI.
  TITLE     Diversity among the beta subunits of heterotrimeric GTP-binding
            proteins: characterization of a novel beta-subunit cDNA
  JOURNAL   Biochem Biophys Res Commun 183 (1), 350-356 (1992)
   PUBMED   1543505
REFERENCE   8  (bases 1 to 3143)
  AUTHORS   McFarlane-Anderson N, Bailly J and Begin-Heick N.
  TITLE     Levels of G-proteins in liver and brain of lean and obese (ob/ob)
            mice
  JOURNAL   Biochem J 282 (Pt 1) (Pt 1), 15-23 (1992)
   PUBMED   1540129
REFERENCE   9  (bases 1 to 3143)
  AUTHORS   Danciger M, Farber DB, Peyser M and Kozak CA.
  TITLE     The gene for the beta-subunit of retinal transducin (Gnb-1) maps to
            distal mouse chromosome 4, and related sequences map to mouse
            chromosomes 5 and 8
  JOURNAL   Genomics 6 (3), 428-435 (1990)
   PUBMED   2328987
REFERENCE   10 (bases 1 to 3143)
  AUTHORS   Blatt C, Eversole-Cire P, Cohn VH, Zollman S, Fournier RE, Mohandas
            LT, Nesbitt M, Lugo T, Jones DT, Reed RR et al.
  TITLE     Chromosomal localization of genes encoding guanine
            nucleotide-binding protein subunits in mouse and human
  JOURNAL   Proc Natl Acad Sci U S A 85 (20), 7642-7646 (1988)
   PUBMED   2902634
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL670227.7, AK163844.1 and AL627405.17.
            
            [WARNING] On May 9, 2023 this sequence was replaced by NM_008142.5.
            
            On May 8, 2009 this sequence version replaced NM_008142.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1-3 encode the same the protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK163844.1, SRR11927937.5020533.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AL670227.7         208221-208232
            13-1688             AK163844.1         2-1677
            1689-3143           AL627405.17        56252-57706
FEATURES             Location/Qualifiers
     source          1..3143
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 86.17 cM"
     gene            1..3143
                     /gene="Gnb1"
                     /gene_synonym="Gnb-1; Hg2a"
                     /note="guanine nucleotide binding protein (G protein),
                     beta 1"
                     /db_xref="GeneID:14688"
                     /db_xref="MGI:MGI:95781"
     exon            1..220
                     /gene="Gnb1"
                     /gene_synonym="Gnb-1; Hg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            221..269
                     /gene="Gnb1"
                     /gene_synonym="Gnb-1; Hg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            270..366
                     /gene="Gnb1"
                     /gene_synonym="Gnb-1; Hg2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             310..1332
                     /gene="Gnb1"
                     /gene_synonym="Gnb-1; Hg2a"
                     /note="transducin beta chain 1; guanine nucleotide binding
                     protein, beta 1; heterotrimeric guanine nucleotide-binding
                     protein 2a"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein
                     G(I)/G(S)/G(T) subunit beta-1"
                     /protein_id="NP_032168.1"
                     /db_xref="CCDS:CCDS19030.1"
                     /db_xref="GeneID:14688"
                     /db_xref="MGI:MGI:95781"
                     /translation="MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQ
                     MRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMT
                     CAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTS
                     SGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMC
                     RQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSV
                     SFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDS
                     FLKIWN"
     exon            367..405
                     /gene="Gnb1"
                     /gene_synonym="Gnb-1; Hg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            406..512
                     /gene="Gnb1"
                     /gene_synonym="Gnb-1; Hg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            513..576
                     /gene="Gnb1"
                     /gene_synonym="Gnb-1; Hg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            577..739
                     /gene="Gnb1"
                     /gene_synonym="Gnb-1; Hg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            740..806
                     /gene="Gnb1"
                     /gene_synonym="Gnb-1; Hg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            807..1008
                     /gene="Gnb1"
                     /gene_synonym="Gnb-1; Hg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1225
                     /gene="Gnb1"
                     /gene_synonym="Gnb-1; Hg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1341
                     /gene="Gnb1"
                     /gene_synonym="Gnb-1; Hg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..3143
                     /gene="Gnb1"
                     /gene_synonym="Gnb-1; Hg2a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaggggccg ccgcgcccat cctgatggct ggaggcgtct gaggggcgga cggcgacggc
       61 ggcggcggcg gcggcggtgg cgggcgcggg cggcgagggc agcggggctg ggactggaac
      121 agccgccgcg cggacccgac cagcctcgcc gactcctgcc cgcaggccgc gagcgcgacg
      181 accaggcggc ggcgtgggcg ccagaccggg cgagggcgag atagacttac atgtgtggga
      241 aaccagacca gaaacacttc tgagtcaaga gcttggattc tgaagtgtgg aaagcactga
      301 gacgtgaaga tgagtgaact tgaccagctg cggcaggagg ccgagcaact gaagaaccaa
      361 attagagatg ctcgtaaagc gtgtgccgat gcgactcttt ctcagatcac aaacaatatt
      421 gatccagtgg gaagaatcca aatgcggacc aggagaacac tgagggggca tctggcaaag
      481 atttatgcca tgcactgggg cacagactca aggctccttg tcagcgcctc tcaggatgga
      541 aaactcatca tctgggacag ttataccaca aacaaggttc atgccatccc tctgcgctcc
      601 tcttgggtca tgacctgcgc atacgctcct tctgggaatt atgtggcctg tggtggcctg
      661 gataacatct gctccattta caacctgaaa actcgtgaag ggaatgtgcg tgtgagtcgt
      721 gagctggcgg gacacacagg ttatctgtcc tgttgccggt tcctggatga caatcagata
      781 gttaccagtt ctggagacac cacatgtgcc ctgtgggaca tcgagactgg ccagcagaca
      841 accacattta ctggacacac tggagatgtc atgagcctgt ctcttgctcc tgacaccaga
      901 ctgtttgtct ctggtgcttg tgatgcttca gccaagctct gggatgtccg agaagggatg
      961 tgccggcaga cctttacagg acacgagtct gacatcaatg ccatatgttt ctttcccaat
     1021 ggcaatgcct ttgccactgg ctcagacgat gccacatgca ggctgtttga cctccgtgca
     1081 gaccaggagc tcatgaccta ctcccatgac aacattatct gtggtatcac atctgtttcc
     1141 ttctccaaga gtggccgcct cctccttgct gggtatgatg acttcaactg taatgtctgg
     1201 gatgcactca aagctgacag agcaggtgtc ttagctggac acgacaaccg agtcagctgc
     1261 ttgggggtga ctgatgatgg catggctgtg gcaacagggt cctgggacag cttcctcaag
     1321 atctggaact aaagccagga gcagcaggtg gatggatgcc atggcgactg gaagaccatt
     1381 ccaaccttga atcgttacag cgatagcata tcctatccaa ccatactaac gtggacaccc
     1441 acacctcccc tcagaacttc aaaagggcaa gatctttttt ccttcactta ttgctgaaac
     1501 caagagcaca attcccatta agagaaggat ctctgtgctg taaactaaac aaattgtgca
     1561 ttttttctgg ggccattgtt tttggtttat tttgttattt tgttttgttt ttgttttttt
     1621 ggtttcattt tgttttgggt tggtccaatt ttaaaaggaa atactacaat aaaaatgtta
     1681 accagaaggt aaccctgagt gtgattgtga gagagacacg cctttttact agttcatttg
     1741 catttaaatc agtgatcctg ttctgtggca ttcatgaaaa acaagttgaa gaatttgttt
     1801 atctggaatt gtttctaaat ataagtcatt tgtagcaaga ctttggaagc attctttctt
     1861 aaacatattc ctttatgttc agtagttaag agaaccaggg cccacggcgg tctctgactt
     1921 gtcactgatg tttttttttt ttttgtccct ggcttgcttt tttttttttt tttttttttt
     1981 tttttgtctc atgtcacaga tgactgtttc gcacaaacac agcatagtgg aagaaaaaat
     2041 ttcagaagca aagtagccaa gcacatgtta ggatggccac gaatgcttgg tcagagtcct
     2101 tccttccctt gctcagcagc ggacttactc ccagcgcctt ccctccctcc tgtccctcct
     2161 gtcccctcac tgtccacttt ctgttctttc cttgggtttc ctgtgaagtt ggagggacgt
     2221 ttgtagtcat gtgacactag ccgtcctgcc cctgctgtca gagatttttt tctccagaga
     2281 ggtgcctgtc ctgtgcttgg atagtcagtt ggttatttgt gtatgaaaca atgtacaaat
     2341 caatgttttg aaaataatga tctcagactt tctaagttaa attttaaaca atttgattgt
     2401 ttgccatatt gggtggggtt actcttagaa tcgcatgctg tagaaatgct ctaaagtgca
     2461 tataggactc agtccttaga tgttcttttt attttaagaa ataacctctt caagttgtaa
     2521 ccgtggcggc tttgtccatt actgttgcta ttctgcacac atatcggaag cagcaagcgc
     2581 tttacacact tgagtagtgg gataagtcac tgttttcttt acaaaacaaa acagtcctgt
     2641 tgggaatgat tgctgttgga ttctggaagg gaggggaaag ctgctctgct gcctctttgc
     2701 cacttcctgg aagccttcct ccctggaaga acagcctttt gcatctgagg cgaccatttt
     2761 tacaccatgc agatcttcgt ggttatcatc tcaaagccat gttcagcagc agcgtttgga
     2821 cagcagtgtt ctgtgggccc tcccctcccc catatcctgc accccctcat agcagtagtg
     2881 gcttcgccat tctgttttct gcagtgtcct gtacaaaact gtgctgtgac tgtgcggtag
     2941 gcctggacat ggcaaagaga atacagcgaa gccccttctc ttcctaccaa acaactctgt
     3001 agagctctct gcaccctgta cccttttcac cttttgtatt taattttaaa gtcagtgtac
     3061 tgcaaggagg ctggatgcaa gatagatact atattaaact gtactgttat ttaagatgta
     3121 ataaagcagt ttgacatgag gga
//
