LOCUS       NM_010311               3534 bp    mRNA    linear   ROD 10-FEB-2024
DEFINITION  Mus musculus guanine nucleotide binding protein, alpha z subunit
            (Gnaz), transcript variant 1, mRNA.
ACCESSION   NM_010311
VERSION     NM_010311.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3534)
  AUTHORS   Schaid,M.D., Green,C.L., Peter,D.C., Gallagher,S.J., Guthery,E.,
            Carbajal,K.A., Harrington,J.M., Kelly,G.M., Reuter,A., Wehner,M.L.,
            Brill,A.L., Neuman,J.C., Lamming,D.W. and Kimple,M.E.
  TITLE     Agonist-independent Galphaz activity negatively regulates beta-cell
            compensation in a diet-induced obesity model of type 2 diabetes
  JOURNAL   J Biol Chem 296, 100056 (2021)
   PUBMED   33172888
REFERENCE   2  (bases 1 to 3534)
  AUTHORS   Vancura,P., Abdelhadi,S., Csicsely,E., Baba,K., Tosini,G.,
            Iuvone,P.M. and Spessert,R.
  TITLE     Gnaz couples the circadian and dopaminergic system to G
            protein-mediated signaling in mouse photoreceptors
  JOURNAL   PLoS One 12 (10), e0187411 (2017)
   PUBMED   29088301
  REMARK    GeneRIF: present study suggest that Gnaz links the circadian
            clockwork-via dopamine acting on D4 receptors-to G protein-mediated
            signaling in intact but not diabetic retina
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3534)
  AUTHORS   Fenske,R.J., Cadena,M.T., Harenda,Q.E., Wienkes,H.N., Carbajal,K.,
            Schaid,M.D., Laundre,E., Brill,A.L., Truchan,N.A., Brar,H.,
            Wisinski,J., Cai,J., Graham,T.E., Engin,F. and Kimple,M.E.
  TITLE     The Inhibitory G Protein alpha-Subunit, Galphaz, Promotes Type 1
            Diabetes-Like Pathophysiology in NOD Mice
  JOURNAL   Endocrinology 158 (6), 1645-1658 (2017)
   PUBMED   28419211
  REMARK    GeneRIF: Galphaz plays a key role in beta-cell signaling that
            becomes dysfunctional in the type 1 diabetes setting, accelerating
            the death of beta-cells, which promotes further accumulation of
            immune cells in the pancreatic islets, and inhibiting a restorative
            proliferative response.
REFERENCE   4  (bases 1 to 3534)
  AUTHORS   Jin,S., Martinelli,D.C., Zheng,X., Tessier-Lavigne,M. and Fan,C.M.
  TITLE     Gas1 is a receptor for sonic hedgehog to repel enteric axons
  JOURNAL   Proc Natl Acad Sci U S A 112 (1), E73-E80 (2015)
   PUBMED   25535338
REFERENCE   5  (bases 1 to 3534)
  AUTHORS   Regard,J.B., Malhotra,D., Gvozdenovic-Jeremic,J., Josey,M.,
            Chen,M., Weinstein,L.S., Lu,J., Shore,E.M., Kaplan,F.S. and Yang,Y.
  TITLE     Activation of Hedgehog signaling by loss of GNAS causes heterotopic
            ossification
  JOURNAL   Nat Med 19 (11), 1505-1512 (2013)
   PUBMED   24076664
REFERENCE   6  (bases 1 to 3534)
  AUTHORS   Zigman,J.M., Westermark,G.T., LaMendola,J. and Steiner,D.F.
  TITLE     Expression of cone transducin, Gz alpha, and other G-protein
            alpha-subunit messenger ribonucleic acids in pancreatic islets
  JOURNAL   Endocrinology 135 (1), 31-37 (1994)
   PUBMED   8013366
REFERENCE   7  (bases 1 to 3534)
  AUTHORS   Wilkie,T.M., Gilbert,D.J., Olsen,A.S., Chen,X.N., Amatruda,T.T.,
            Korenberg,J.R., Trask,B.J., de Jong,P., Reed,R.R., Simon,M.I. et
            al.
  TITLE     Evolution of the mammalian G protein alpha subunit multigene family
  JOURNAL   Nat Genet 1 (2), 85-91 (1992)
   PUBMED   1302014
  REMARK    Review article
REFERENCE   8  (bases 1 to 3534)
  AUTHORS   Strathmann,M., Wilkie,T.M. and Simon,M.I.
  TITLE     Diversity of the G-protein family: sequences from five additional
            alpha subunits in the mouse
  JOURNAL   Proc Natl Acad Sci U S A 86 (19), 7407-7409 (1989)
   PUBMED   2508088
REFERENCE   9  (bases 1 to 3534)
  AUTHORS   Fong,H.K., Yoshimoto,K.K., Eversole-Cire,P. and Simon,M.I.
  TITLE     Identification of a GTP-binding protein alpha subunit that lacks an
            apparent ADP-ribosylation site for pertussis toxin
  JOURNAL   Proc Natl Acad Sci U S A 85 (9), 3066-3070 (1988)
   PUBMED   3129724
REFERENCE   10 (bases 1 to 3534)
  AUTHORS   Tanabe,T., Nukada,T., Nishikawa,Y., Sugimoto,K., Suzuki,H.,
            Takahashi,H., Noda,M., Haga,T., Ichiyama,A., Kangawa,K. et al.
  TITLE     Primary structure of the alpha-subunit of transducin and its
            relationship to ras proteins
  JOURNAL   Nature 315 (6016), 242-245 (1985)
   PUBMED   3923359
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY291477.1, BF456902.1, BY718552.1, CX734056.1, BG089218.1,
            AC142500.23 and CD776772.1.
            
            [WARNING] On Mar 13, 2024 this sequence was replaced by
            NM_010311.5.
            
            On Dec 12, 2017 this sequence version replaced NM_010311.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK080716.1, SRR7345562.1217651.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-227               BY291477.1         1-227
            228-497             BF456902.1         130-399
            498-954             BY718552.1         144-600
            955-1114            CX734056.1         88-247              c
            1115-1509           BG089218.1         1-395
            1510-3017           AC142500.23        169395-170902
            3018-3534           CD776772.1         1-517               c
FEATURES             Location/Qualifiers
     source          1..3534
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 38.48 cM"
     gene            1..3534
                     /gene="Gnaz"
                     /gene_synonym="Gz"
                     /note="guanine nucleotide binding protein, alpha z
                     subunit"
                     /db_xref="GeneID:14687"
                     /db_xref="MGI:MGI:95780"
     exon            1..206
                     /gene="Gnaz"
                     /gene_synonym="Gz"
                     /inference="alignment:Splign:2.1.0"
     exon            207..272
                     /gene="Gnaz"
                     /gene_synonym="Gz"
                     /inference="alignment:Splign:2.1.0"
     exon            273..1479
                     /gene="Gnaz"
                     /gene_synonym="Gz"
                     /inference="alignment:Splign:2.1.0"
     CDS             757..1824
                     /gene="Gnaz"
                     /gene_synonym="Gz"
                     /note="gz-alpha; g(x) alpha chain"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein G(z) subunit
                     alpha"
                     /protein_id="NP_034441.1"
                     /db_xref="CCDS:CCDS23922.1"
                     /db_xref="GeneID:14687"
                     /db_xref="MGI:MGI:95780"
                     /translation="MGCRQSSEEKEAARRSRRIDRHLRSESQRQRREIKLLLLGTSNS
                     GKSTIVKQMKIIHSGGFNLDACKEYKPLIIYNAIDSLTRIIRALAALKIDFHNPDRAY
                     DAVQLFALTGPAESKGEITPELLGVMRRLWADPGAQACFGRSSEYHLEDNAAYYLNDL
                     ERIAAPDYIPTVEDILRSRDMTTGIVENKFTFKELTFKMVDVGGQRSERKKWIHCFEG
                     VTAIIFCVELSGYDLKLYEDNQTSRMAESLRLFDSICNNNWFINTSLILFLNKKDLLA
                     EKIRRIPLSVCFPEYKGQNTYEEAAVYIQRQFEDLNRNKETKEIYSHFTCATDTSNIQ
                     FVFDAVTDVIIQNNLKYIGLC"
     exon            1480..3519
                     /gene="Gnaz"
                     /gene_synonym="Gz"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggcgggtg gacccgcttg caggcggcgc gggagggcgg aggagggagc cagggcggcg
       61 gagcgtgtgt gccacccgcg gaccggtcac gtcctcgcgc ggccgccggc acccgcttcg
      121 tgcagaacca gggcgccaca gccctacgct cgcggccccg ccccgccggg tgcagctcga
      181 ccgacgcacg aagccgcgcc cgggagtttc aggcatttgc agggctgatg aggagtgaaa
      241 tgcaaagtcc ttcgcaagcc ttatgaaaac tggtgaaggg ccggatgcaa ggcagggagc
      301 cggagcagcc tgaggcaggg gggcctcagg gagcgctggg ccctccagcc gtgcttagaa
      361 acatcgccac agcaaccagc gagcagacag cagtagcctg ggcagacgca agcggacagc
      421 ttcctaccgt ggcagagtac agggaatgac tacggcaaat caggccacac tgctgacaag
      481 ggaggtggag tgtcactaga ggggagggtg tggtctctgc cccactgcac caagcgccat
      541 gcccacagga gaagcggtac tggggcaggg attgctctgt gacacagcct cgccccaaag
      601 ccagtgctga gcacggccgg gtcagctgcc tctctcatct gcccgtcaca ccagcccacg
      661 tttgagcatc cctcgttgtg accattctgt ttggcgaggg ggagaggcgc ccaccctgtg
      721 ttctgcatct ggggggtggc ccgctgctgc cggaccatgg gatgtcggca aagctcagag
      781 gaaaaagagg cagcgaggcg gtcccggaga attgaccgcc acctgcgctc cgaaagccag
      841 cggcagcgcc gtgaaatcaa acttctcctg ctgggcacca gcaactcggg caagagcacc
      901 atcgtcaagc agatgaagat catccacagc gggggcttca acctggacgc ctgcaaggag
      961 tacaagcccc tcatcatcta caacgccatc gactcgctga cccggatcat ccgggccctg
     1021 gctgccctca agatcgattt ccacaaccct gaccgtgcct acgacgctgt gcagctcttt
     1081 gctctgactg gcccagcaga gagcaagggt gagattacac ctgagctgct gggtgtcatg
     1141 cgacggctct gggctgaccc aggggcccag gcctgctttg gccgctctag cgagtaccac
     1201 ctggaggaca atgcagccta ctacctgaac gacctggagc gcatcgcagc gcccgactac
     1261 atccccacgg tggaggatat cctacgctcc cgggacatga ccacgggcat tgtggagaac
     1321 aagttcacct tcaaggagct taccttcaag atggtggacg tgggcgggca gaggtcagaa
     1381 cgcaaaaagt ggatccattg ctttgaaggc gtcacagcca tcatcttctg tgtggagctc
     1441 agtggctatg acctgaagct ctatgaggac aaccagacga gccggatggc ggagagcctg
     1501 cgcctctttg actccatctg caacaacaac tggttcatca acacctcgct catcctcttc
     1561 ctgaacaaga aggacctcct ggcagagaag atccggcgta tcccgctcag cgtctgcttc
     1621 ccagagtaca agggtcagaa cacgtacgag gaagccgcgg tctacatcca acgtcagttc
     1681 gaggacctca accgcaacaa ggagaccaag gagatctatt cgcacttcac ttgtgccacc
     1741 gacaccagta acatccagtt tgtgtttgac gcagtgacag atgtcatcat acagaacaat
     1801 ctcaagtaca tcggcctttg ctgaggagcc gggcgcagcc tgctcgcctg tggtgaaacc
     1861 catggggtgt cacaccccac acctcatgct cgagaggccc gacccagggg cagaaaacgg
     1921 ggcttgaaga gtgtgtcccc atcccacccc cagcctctgc cttcttggcc ccacatctct
     1981 gcaaacataa atatatttgg atagattgct aggtaggtag acacacagac acacacacag
     2041 acacacacac acacagacac acgcacgcac gcacatctgg agagggcata gttctccaga
     2101 gcgtcaaggt ttcctgaagt tttcaaaagc tgctgtcaca atttcattcc gaggccatct
     2161 tgcccctccc ccttcactct gccttcctga gttggcccca ctctgcacgg gagggagggc
     2221 ccaccttaga ctgctgggga gaggccacag ggctgggggc caggtccggc cagctgtgcc
     2281 catcgcctgg gagaaggcca gctcaccaac tgagctctgg actggggact accgctgacc
     2341 aggagggaag cctggagccg cacccgactc agccactctg cgtcacattc gtcctgtacc
     2401 taggaccgga ggaaagacgt gactgctcta accggacctc tgactaccgg tggcttttac
     2461 aaaaaaaaaa cagctaaaac gtactcagca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2521 aattaacaca ggataattag tgtcaccgtt tattccaaac taggccagct gggtttccag
     2581 cttttcttct actggtctga tgttttataa atggaaacct ggtttttctt ctctggcatc
     2641 ttcttttttt tattattttt ttaaattttt atttttggcc aaatattatg tctcacagag
     2701 ggggaaaaaa aaactacaga caatttcgga tgtgattaga tattcttttt taaatgcgga
     2761 ttttcaaaac atatttcctt tccagtgtcc cttttgtgtc tggcttgctg agtatagaag
     2821 ctgtcacctg gacgattctg ctcctcagct ccaaagaatc ctggggtcaa cgtcccaggc
     2881 cagccgcatg ggacatatgt acataggtct tcgcaatgtt ctcttgttac tggtgccgtt
     2941 ttctgcttgt tttttttttt tgttttgttt tgttttgttt tttgtttttt atttaagaga
     3001 gagaaatgtg atgtatttaa agaaggtcct ttacctagga gcgaatgaac aatagctgaa
     3061 tgtcttggta tttaaagtgt aaattatcta tggctttgcc aaatgaaggg agggggtggg
     3121 caagacatgg aactccccgg tccccacaca cttcgcaccc aatgtgggct ggggggctgc
     3181 tcagactcct gtgaaggcac agctacagtt gtggcctgaa ggaggcccag ctgggactgt
     3241 gtgctcccgg ccttctagcc ccacagccca cagacattgg tcttgagaga gccttggctg
     3301 tgtatcaatt acaaagccct gccagcaagg ggatggcacc actggagctc ttgccaaatc
     3361 actctcagcc ctgtatttgg taccggtgtg tcccaggtca atgtacagaa ctgcagccaa
     3421 ggagctaaga tgtaacagag agagagaaga gctggtgaac catataaaac tcaaaagatt
     3481 gtctacttta agaaataaaa taccctgaat ggagccaaaa aaaaaaaaaa aaaa
//
