LOCUS       NM_001081143            1174 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus G protein subunit alpha transducin 3 (Gnat3), mRNA.
ACCESSION   NM_001081143 XM_144196
VERSION     NM_001081143.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1174)
  AUTHORS   Ohmoto,M., Jyotaki,M., Yee,K.K. and Matsumoto,I.
  TITLE     A Transcription Factor Etv1/Er81 Is Involved in the Differentiation
            of Sweet, Umami, and Sodium Taste Cells
  JOURNAL   eNeuro 10 (4) (2023)
   PUBMED   37045597
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1174)
  AUTHORS   Hoffman,M.T., Kemp,S.B., Salas-Escabillas,D.J., Zhang,Y.,
            Steele,N.G., The,S., Long,D., Benitz,S., Yan,W., Margolskee,R.F.,
            Bednar,F., Pasca di Magliano,M., Wen,H.J. and Crawford,H.C.
  TITLE     The Gustatory Sensory G-Protein GNAT3 Suppresses Pancreatic Cancer
            Progression in Mice
  JOURNAL   Cell Mol Gastroenterol Hepatol 11 (2), 349-369 (2021)
   PUBMED   32882403
  REMARK    GeneRIF: The Gustatory Sensory G-Protein GNAT3 Suppresses
            Pancreatic Cancer Progression in Mice.
REFERENCE   3  (bases 1 to 1174)
  AUTHORS   Zheng,X., Tizzano,M., Redding,K., He,J., Peng,X., Jiang,P., Xu,X.,
            Zhou,X. and Margolskee,R.F.
  TITLE     Gingival solitary chemosensory cells are immune sentinels for
            periodontitis
  JOURNAL   Nat Commun 10 (1), 4496 (2019)
   PUBMED   31582750
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1174)
  AUTHORS   Fan,D., Chettouh,Z., Consalez,G.G. and Brunet,J.F.
  TITLE     Taste bud formation depends on taste nerves
  JOURNAL   Elife 8, e49226 (2019)
   PUBMED   31570121
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1174)
  AUTHORS   Cherenkov,I.A., Sergeyev,V.G., Nikityuk,D.B. and Chychkov,V.M.
  TITLE     Histotopography of alpha-Gustdusin- and T2R3-Expressing Lymphocytes
            in Mouse Spleen
  JOURNAL   Bull Exp Biol Med 167 (6), 801-804 (2019)
   PUBMED   31656004
  REMARK    GeneRIF: Spleen lymphocytes with gustducin signaling may be
            involved in T-dependent immune response to the blood bacterial
            polysaccharides.
REFERENCE   6  (bases 1 to 1174)
  AUTHORS   Margolskee,R.F.
  TITLE     Molecular mechanisms of bitter and sweet taste transduction
  JOURNAL   J Biol Chem 277 (1), 1-4 (2002)
   PUBMED   11696554
  REMARK    Review article
REFERENCE   7  (bases 1 to 1174)
  AUTHORS   Ruiz-Avila,L., Wong,G.T., Damak,S. and Margolskee,R.F.
  TITLE     Dominant loss of responsiveness to sweet and bitter compounds
            caused by a single mutation in alpha -gustducin
  JOURNAL   Proc Natl Acad Sci U S A 98 (15), 8868-8873 (2001)
   PUBMED   11447270
REFERENCE   8  (bases 1 to 1174)
  AUTHORS   Huang,L., Shanker,Y.G., Dubauskaite,J., Zheng,J.Z., Yan,W.,
            Rosenzweig,S., Spielman,A.I., Max,M. and Margolskee,R.F.
  TITLE     Ggamma13 colocalizes with gustducin in taste receptor cells and
            mediates IP3 responses to bitter denatonium
  JOURNAL   Nat Neurosci 2 (12), 1055-1062 (1999)
   PUBMED   10570481
REFERENCE   9  (bases 1 to 1174)
  AUTHORS   Ringstedt,T., Ibanez,C.F. and Nosrat,C.A.
  TITLE     Role of brain-derived neurotrophic factor in target invasion in the
            gustatory system
  JOURNAL   J Neurosci 19 (9), 3507-3518 (1999)
   PUBMED   10212310
REFERENCE   10 (bases 1 to 1174)
  AUTHORS   Wong,G.T., Gannon,K.S. and Margolskee,R.F.
  TITLE     Transduction of bitter and sweet taste by gustducin
  JOURNAL   Nature 381 (6585), 796-800 (1996)
   PUBMED   8657284
  REMARK    Erratum:[Nature 1996 Oct 10;383(6600):557]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC129572.6.
            
            On Feb 6, 2007 this sequence version replaced XM_144196.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC147449.1, AK040065.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-227               AC129572.6         88750-88976         c
            228-270             AC129572.6         65067-65109         c
            271-412             AC129572.6         60086-60227         c
            413-570             AC129572.6         51735-51892         c
            571-699             AC129572.6         47657-47785         c
            700-829             AC129572.6         36185-36314         c
            830-983             AC129572.6         35842-35995         c
            984-1174            AC129572.6         31878-32068         c
FEATURES             Location/Qualifiers
     source          1..1174
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 8.14 cM"
     gene            1..1174
                     /gene="Gnat3"
                     /gene_synonym="Ggust; Gtn; Hg1e"
                     /note="G protein subunit alpha transducin 3"
                     /db_xref="GeneID:242851"
                     /db_xref="MGI:MGI:3588268"
     exon            1..227
                     /gene="Gnat3"
                     /gene_synonym="Ggust; Gtn; Hg1e"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..1174
                     /gene="Gnat3"
                     /gene_synonym="Ggust; Gtn; Hg1e"
                     /EC_number="2.3.1.4"
                     /note="gustducin alpha-3 chain; alpha-gustducin;
                     heterotrimeric guanine nucleotide-binding protein 1e;
                     guanine nucleotide binding protein, alpha transducing 3"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein G(t) subunit
                     alpha-3"
                     /protein_id="NP_001074612.1"
                     /db_xref="CCDS:CCDS39017.1"
                     /db_xref="GeneID:242851"
                     /db_xref="MGI:MGI:3588268"
                     /translation="MGSGISSESKESARRSKELEKKLQEDAERDARTVKLLLLGAGES
                     GKSTIVKQMKIIHKNGYSKQECMEFKAVIYSNTLQSILAIVKAMATLGIDYVNPRSRE
                     DQEQLHSMANTLEDGDMTPQLAEIIKRLWGDPGIQACFERASEYQLNDSAAYYLNDLD
                     RLTAPGYVPNEQDVLHSRVKTTGIIETQFSFKDLNFRMFDVGGQRSERKKWIHCFEGV
                     TCIIFCAALSAYDMVLVEDEEVNRMHESLHLFNSICNHKYFATTSIVLFLNKKDLFQE
                     KVAKVHLSICFPEYTGPNTFEDAGNYIKNQFLDLNLKKEDKEIYSHMTCATDTQNVKF
                     VFDAVTDIIIKENLKDCGLF"
     exon            228..270
                     /gene="Gnat3"
                     /gene_synonym="Ggust; Gtn; Hg1e"
                     /inference="alignment:Splign:2.1.0"
     exon            271..412
                     /gene="Gnat3"
                     /gene_synonym="Ggust; Gtn; Hg1e"
                     /inference="alignment:Splign:2.1.0"
     exon            413..570
                     /gene="Gnat3"
                     /gene_synonym="Ggust; Gtn; Hg1e"
                     /inference="alignment:Splign:2.1.0"
     exon            571..699
                     /gene="Gnat3"
                     /gene_synonym="Ggust; Gtn; Hg1e"
                     /inference="alignment:Splign:2.1.0"
     exon            700..829
                     /gene="Gnat3"
                     /gene_synonym="Ggust; Gtn; Hg1e"
                     /inference="alignment:Splign:2.1.0"
     exon            830..983
                     /gene="Gnat3"
                     /gene_synonym="Ggust; Gtn; Hg1e"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1174
                     /gene="Gnat3"
                     /gene_synonym="Ggust; Gtn; Hg1e"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgcctgtt gtagcgagca ccgctcatat gtcctatatc taaactacag ctgtgctccg
       61 tgtttgaaaa gtttgagcaa atcaactgcc cagccactaa catcaaaaga tgggaagtgg
      121 aattagttca gagagcaagg aatcagccag aaggtccaaa gaactggaga agaagcttca
      181 ggaggatgct gagcgggatg caagaactgt gaagttactg ctactaggag caggtgaatc
      241 tgggaaaagc actattgtta aacaaatgaa gatcatccat aagaatggtt acagcaaaca
      301 agaatgcatg gagtttaaag cagtgattta cagtaacaca ttgcagtcca tcctagctat
      361 tgtgaaagcc atggctacac tggggattga ttatgtcaat cctaggagcc gagaggacca
      421 agaacaactt cactcaatgg caaatacact agaagatggt gatatgactc cacagctggc
      481 tgaaatcatt aaacgactgt ggggggatcc aggaatccaa gcctgctttg aaagggcatc
      541 tgaataccag ctcaatgact ctgcagctta ctaccttaat gacttagaca gactcacagc
      601 ccctgggtac gtgccaaatg agcaagatgt tctacattcc cgggtgaaaa ccactggtat
      661 cattgaaact caattctcct ttaaagactt gaacttcaga atgtttgatg taggtggcca
      721 gagatcagag agaaaaaaat ggatccactg ctttgaagga gtcacctgca ttatattttg
      781 cgcagcgcta agtgcctatg acatggtgct tgtagaagat gaggaggtga acagaatgca
      841 tgaaagtctt cacctgttta acagcatatg taatcataag tacttcgcaa ccacctccat
      901 tgttctgttt cttaacaaga aagatctctt ccaggagaaa gtggctaagg tgcacctcag
      961 catttgcttt ccagaatata ctggaccaaa cacatttgaa gatgcaggga actacatcaa
     1021 gaaccagttt ctagacctga acttaaaaaa agaagataag gaaatctatt ctcacatgac
     1081 ctgtgctact gacacacaaa atgtcaaatt tgtgtttgat gcagtgacag atataataat
     1141 aaaagagaac ctcaaagact gtgggctctt ctga
//
