LOCUS       NM_008141               1796 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus G protein subunit alpha transducin 2 (Gnat2), mRNA.
ACCESSION   NM_008141
VERSION     NM_008141.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1796)
  AUTHORS   Housset,M., Filion,D., Cortes,N., Vali,H., Mandato,C.A.,
            Casanova,C. and Cayouette,M.
  TITLE     Identification of a non-canonical planar cell polarity pathway
            triggered by light in the developing mouse retina
  JOURNAL   Dev Cell 60 (3), 447-458 (2025)
   PUBMED   39561777
REFERENCE   2  (bases 1 to 1796)
  AUTHORS   Fitzpatrick,M.J., Krizan,J., Hsiang,J.C., Shen,N. and
            Kerschensteiner,D.
  TITLE     A pupillary contrast response in mice and humans: Neural mechanisms
            and visual functions
  JOURNAL   Neuron 112 (14), 2404-2422 (2024)
   PUBMED   38697114
REFERENCE   3  (bases 1 to 1796)
  AUTHORS   Kane,E., Mak,T.C.S. and Latreille,M.
  TITLE     MicroRNA-7 regulates endocrine progenitor delamination and
            endocrine cell mass in developing pancreatic islets
  JOURNAL   iScience 27 (7), 110332 (2024)
   PUBMED   39055950
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1796)
  AUTHORS   Touahri,Y., Hanna,J., Tachibana,N., Okawa,S., Liu,H., David,L.A.,
            Olender,T., Vasan,L., Pak,A., Mehta,D.N., Chinchalongporn,V.,
            Balakrishnan,A., Cantrup,R., Dixit,R., Mattar,P., Saleh,F.,
            Ilnytskyy,Y., Murshed,M., Mains,P.E., Kovalchuk,I., Lefebvre,J.L.,
            Leong,H.S., Cayouette,M., Wang,C., Del Sol,A., Brand,M., Reese,B.E.
            and Schuurmans,C.
  TITLE     Pten regulates endocytic trafficking of cell adhesion and Wnt
            signaling molecules to pattern the retina
  JOURNAL   Cell Rep 43 (4), 114005 (2024)
   PUBMED   38551961
REFERENCE   5  (bases 1 to 1796)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 1796)
  AUTHORS   Zigman,J.M., Westermark,G.T., LaMendola,J. and Steiner,D.F.
  TITLE     Expression of cone transducin, Gz alpha, and other G-protein
            alpha-subunit messenger ribonucleic acids in pancreatic islets
  JOURNAL   Endocrinology 135 (1), 31-37 (1994)
   PUBMED   8013366
REFERENCE   7  (bases 1 to 1796)
  AUTHORS   Wilkie,T.M., Gilbert,D.J., Olsen,A.S., Chen,X.N., Amatruda,T.T.,
            Korenberg,J.R., Trask,B.J., de Jong,P., Reed,R.R., Simon,M.I. et
            al.
  TITLE     Evolution of the mammalian G protein alpha subunit multigene family
  JOURNAL   Nat Genet 1 (2), 85-91 (1992)
   PUBMED   1302014
  REMARK    Review article
REFERENCE   8  (bases 1 to 1796)
  AUTHORS   Jones,D.T. and Reed,R.R.
  TITLE     Golf: an olfactory neuron specific-G protein involved in odorant
            signal transduction
  JOURNAL   Science 244 (4906), 790-795 (1989)
   PUBMED   2499043
REFERENCE   9  (bases 1 to 1796)
  AUTHORS   Blatt,C., Eversole-Cire,P., Cohn,V.H., Zollman,S., Fournier,R.E.,
            Mohandas,L.T., Nesbitt,M., Lugo,T., Jones,D.T., Reed,R.R. et al.
  TITLE     Chromosomal localization of genes encoding guanine
            nucleotide-binding protein subunits in mouse and human
  JOURNAL   Proc Natl Acad Sci U S A 85 (20), 7642-7646 (1988)
   PUBMED   2902634
REFERENCE   10 (bases 1 to 1796)
  AUTHORS   Lochrie,M.A., Hurley,J.B. and Simon,M.I.
  TITLE     Sequence of the alpha subunit of photoreceptor G protein:
            homologies between transducin, ras, and elongation factors
  JOURNAL   Science 228 (4695), 96-99 (1985)
   PUBMED   3856323
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671854.14, BC016272.1 and BC085102.1.
            
            On Aug 14, 2013 this sequence version replaced NM_008141.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016272.1, SRR9219381.47087.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AL671854.14        36442-36443
            3-1631              BC016272.1         1-1629
            1632-1796           BC085102.1         2379-2543
FEATURES             Location/Qualifiers
     source          1..1796
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.83 cM"
     gene            1..1796
                     /gene="Gnat2"
                     /gene_synonym="Gnat-2; Gt-2; Hg1d; Tcalpha"
                     /note="G protein subunit alpha transducin 2"
                     /db_xref="GeneID:14686"
                     /db_xref="MGI:MGI:95779"
     exon            1..28
                     /gene="Gnat2"
                     /gene_synonym="Gnat-2; Gt-2; Hg1d; Tcalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            29..201
                     /gene="Gnat2"
                     /gene_synonym="Gnat-2; Gt-2; Hg1d; Tcalpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1148
                     /gene="Gnat2"
                     /gene_synonym="Gnat-2; Gt-2; Hg1d; Tcalpha"
                     /note="transducin alpha-2 chain; heterotrimeric guanine
                     nucleotide-binding protein 1d; guanine nucleotide binding
                     protein, alpha transducing 2"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein G(t) subunit
                     alpha-2"
                     /protein_id="NP_032167.1"
                     /db_xref="CCDS:CCDS17750.1"
                     /db_xref="GeneID:14686"
                     /db_xref="MGI:MGI:95779"
                     /translation="MGSGISAEDKELARRSKELEKKLQEDADKEAKTVKLLLLGAGES
                     GKSTIVKQMKIIHQDGYSPEECLEFKSVIYGNVLQSILAIIRAMSTLGIDYAEPSCAD
                     AGRQLNNLADSTEEGTMPPELVDVIRKLWKDGGVQACFDRAAEFQLNDSASYYLNQLD
                     RITDPNYLPNEQDVLRSRVKTTGIIETKFSVKDLNFRMFDVGGQRSERKKWIHCFEGV
                     TCIIFCAALSAYDMVLVEDDEVNRMHESLHLFNSICNHKFFAATSIVLFLNKKDLFEE
                     KIKKVHLSICFPEYDGNNSYEDAGNYIKSQFLDLNMRKDVKEIYSHMTCATDTQNVKF
                     VFDAVTDIIIKENLKDCGLF"
     exon            202..244
                     /gene="Gnat2"
                     /gene_synonym="Gnat-2; Gt-2; Hg1d; Tcalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            245..386
                     /gene="Gnat2"
                     /gene_synonym="Gnat-2; Gt-2; Hg1d; Tcalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            387..544
                     /gene="Gnat2"
                     /gene_synonym="Gnat-2; Gt-2; Hg1d; Tcalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            545..673
                     /gene="Gnat2"
                     /gene_synonym="Gnat-2; Gt-2; Hg1d; Tcalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            674..803
                     /gene="Gnat2"
                     /gene_synonym="Gnat-2; Gt-2; Hg1d; Tcalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            804..957
                     /gene="Gnat2"
                     /gene_synonym="Gnat-2; Gt-2; Hg1d; Tcalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1775
                     /gene="Gnat2"
                     /gene_synonym="Gnat-2; Gt-2; Hg1d; Tcalpha"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1751..1756
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnat2"
                     /gene_synonym="Gnat-2; Gt-2; Hg1d; Tcalpha"
                     /note="hexamer: ATTAAA"
     polyA_site      1775
                     /gene="Gnat2"
                     /gene_synonym="Gnat-2; Gt-2; Hg1d; Tcalpha"
                     /note="major polyA site"
ORIGIN      
        1 cagctcgggt aaggagtctc aaggcaagat aggaaaaatt taagagccag agggaacgtc
       61 ccttctcaga ggagacagca gaaatgggga gtggcatcag tgctgaggac aaagaacttg
      121 ccaggaggtc caaggagctg gagaagaagc tgcaggagga tgctgacaag gaagccaaga
      181 ctgtcaagct gctgttgctc ggtgcgggcg agtcagggaa gagcactatc gtcaaacaga
      241 tgaagatcat tcaccaggat ggctactcac ccgaagagtg cctagagttc aagtctgtca
      301 tctatgggaa cgtgctgcag tccatcctgg ccatcatcag agccatgtcc acactaggca
      361 ttgactatgc agagccaagc tgtgcggatg ccgggagaca gctcaacaac ctggctgact
      421 ccaccgagga ggggaccatg cctcctgagt tggtggacgt catcaggaag ttgtggaagg
      481 acggtggagt tcaagcctgc tttgacagag ctgcagagtt ccagctcaat gactcggcat
      541 cttactacct gaaccagctg gaccggatta cagaccctaa ctacctccct aacgagcagg
      601 acgtgcttcg atccagagtc aagacaacag gcatcatcga gaccaagttt tctgttaaag
      661 atttgaattt caggatgttt gatgtgggag ggcagagatc agagaggaag aaatggatcc
      721 actgcttcga gggagtcacc tgcatcattt tctgtgcggc cctcagtgcc tacgacatgg
      781 tgctggtgga ggatgacgaa gtgaatcgca tgcacgagtc tttgcatctg ttcaacagca
      841 tctgcaacca caagttcttt gcggctacgt ccatcgttct ctttctcaac aagaaggacc
      901 tctttgagga aaaaattaag aaagtccacc tcagtatctg ttttccggag tatgacggaa
      961 acaactccta tgaggatgcc gggaattata tcaagagtca gttccttgac ctcaacatga
     1021 ggaaagatgt caaagaaatc tacagtcaca tgacctgtgc tacagacaca cagaacgtca
     1081 aattcgtgtt cgatgcagtt acagacatca tcatcaaaga aaacctcaag gactgtgggc
     1141 tcttttaatg ctcagttcct cgaatataca ttctataagc aagcttagaa tctgaggctt
     1201 catgcagaaa attagttcgc atgtaccaga atgtgtcaaa tcagcccatc ctgttggtga
     1261 tagagaaggc atgctcagga ctgttagcag tgtggccagt tcactgtaac gaaggcatgg
     1321 ccagcgaccc taacgcccag gttccaaggc tggttctgtt tagtataaga acagaaaagc
     1381 ttcatttctc cgatgcagaa gtcccagtct gtatgatgaa ggtaacttcc ctgcctactt
     1441 cacagggtca ctctgaagag cacagaccta actgaagggg aggcccaggg tagctggctg
     1501 ctgtggttgg ccacagaaag cggccatgac agctgcctga tggactacca tacttggtta
     1561 ttagaagaaa ccaccccaaa gcctaacagc aagccttcct tacgttgagc gataaagtat
     1621 taaaaattaa acctgcccct gtggttttac tggtcctatg tgtgtgcctc agctcagaga
     1681 cccagattac aggagagaag atgcgagcct gcttatttct aaggaactca ctcaaaaagt
     1741 gatcatcttt attaaaaaca attttccctc tcccaaaaaa aaaaaaaaaa aaaaaa
//
