LOCUS       NM_008140               2296 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus G protein subunit alpha transducin 1 (Gnat1), mRNA.
ACCESSION   NM_008140
VERSION     NM_008140.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2296)
  AUTHORS   Housset,M., Filion,D., Cortes,N., Vali,H., Mandato,C.A.,
            Casanova,C. and Cayouette,M.
  TITLE     Identification of a non-canonical planar cell polarity pathway
            triggered by light in the developing mouse retina
  JOURNAL   Dev Cell 60 (3), 447-458 (2025)
   PUBMED   39561777
REFERENCE   2  (bases 1 to 2296)
  AUTHORS   Fitzpatrick,M.J., Krizan,J., Hsiang,J.C., Shen,N. and
            Kerschensteiner,D.
  TITLE     A pupillary contrast response in mice and humans: Neural mechanisms
            and visual functions
  JOURNAL   Neuron 112 (14), 2404-2422 (2024)
   PUBMED   38697114
REFERENCE   3  (bases 1 to 2296)
  AUTHORS   Biswas,S., Shahriar,S., Bachay,G., Arvanitis,P., Jamoul,D.,
            Brunken,W.J. and Agalliu,D.
  TITLE     Glutamatergic neuronal activity regulates angiogenesis and
            blood-retinal barrier maturation via Norrin/beta-catenin signaling
  JOURNAL   Neuron 112 (12), 1978-1996 (2024)
   PUBMED   38599212
REFERENCE   4  (bases 1 to 2296)
  AUTHORS   Bassetto,M., Kolesnikov,A.V., Lewandowski,D., Kiser,J.Z.,
            Halabi,M., Einstein,D.E., Choi,E.H., Palczewski,K., Kefalov,V.J.
            and Kiser,P.D.
  TITLE     Dominant role for pigment epithelial CRALBP in supplying visual
            chromophore to photoreceptors
  JOURNAL   Cell Rep 43 (5), 114143 (2024)
   PUBMED   38676924
REFERENCE   5  (bases 1 to 2296)
  AUTHORS   Morshedian,A., Jiang,Z., Radu,R.A., Fain,G.L. and Sampath,A.P.
  TITLE     Genetic manipulation of rod-cone differences in mouse retina
  JOURNAL   PLoS One 19 (5), e0300584 (2024)
   PUBMED   38709779
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2296)
  AUTHORS   Wilkie,T.M., Gilbert,D.J., Olsen,A.S., Chen,X.N., Amatruda,T.T.,
            Korenberg,J.R., Trask,B.J., de Jong,P., Reed,R.R., Simon,M.I. et
            al.
  TITLE     Evolution of the mammalian G protein alpha subunit multigene family
  JOURNAL   Nat Genet 1 (2), 85-91 (1992)
   PUBMED   1302014
  REMARK    Review article
REFERENCE   7  (bases 1 to 2296)
  AUTHORS   Eng,C.M., Kozak,C.A., Beaudet,A.L. and Zoghbi,H.Y.
  TITLE     Mapping of multiple subunits of the neuronal nicotinic
            acetylcholine receptor to chromosome 15 in man and chromosome 9 in
            mouse
  JOURNAL   Genomics 9 (2), 278-282 (1991)
   PUBMED   2004777
REFERENCE   8  (bases 1 to 2296)
  AUTHORS   Drivas,G., Massey,R., Chang,H.Y., Rush,M.G. and D'Eustachio,P.
  TITLE     Ras-like genes and gene families in the mouse
  JOURNAL   Mamm Genome 1 (2), 112-117 (1991)
   PUBMED   1686838
REFERENCE   9  (bases 1 to 2296)
  AUTHORS   Strathmann,M., Wilkie,T.M. and Simon,M.I.
  TITLE     Alternative splicing produces transcripts encoding two forms of the
            alpha subunit of GTP-binding protein Go
  JOURNAL   Proc Natl Acad Sci U S A 87 (17), 6477-6481 (1990)
   PUBMED   1697681
REFERENCE   10 (bases 1 to 2296)
  AUTHORS   Jones,D.T. and Reed,R.R.
  TITLE     Golf: an olfactory neuron specific-G protein involved in odorant
            signal transduction
  JOURNAL   Science 244 (4906), 790-795 (1989)
   PUBMED   2499043
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK149254.1, BC022793.1 and BE950709.1.
            
            On Jun 19, 2018 this sequence version replaced NM_008140.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058810.1, SRR9219382.196165.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AK149254.1         2-43
            43-2250             BC022793.1         1-2208
            2251-2296           BE950709.1         1-46                c
FEATURES             Location/Qualifiers
     source          1..2296
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 58.86 cM"
     gene            1..2296
                     /gene="Gnat1"
                     /gene_synonym="Gnat-1; Hg1f; Ird1; Ird2; irdc; irdr;
                     Tralpha; transducin"
                     /note="G protein subunit alpha transducin 1"
                     /db_xref="GeneID:14685"
                     /db_xref="MGI:MGI:95778"
     exon            1..192
                     /gene="Gnat1"
                     /gene_synonym="Gnat-1; Hg1f; Ird1; Ird2; irdc; irdr;
                     Tralpha; transducin"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1139
                     /gene="Gnat1"
                     /gene_synonym="Gnat-1; Hg1f; Ird1; Ird2; irdc; irdr;
                     Tralpha; transducin"
                     /note="transducin alpha-1 chain; heterotrimeric guanine
                     nucleotide-binding protein 1f; guanine nucleotide binding
                     protein, alpha transducing 1"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein G(t) subunit
                     alpha-1"
                     /protein_id="NP_032166.1"
                     /db_xref="CCDS:CCDS23504.1"
                     /db_xref="GeneID:14685"
                     /db_xref="MGI:MGI:95778"
                     /translation="MGAGASAEEKHSRELEKKLKEDAEKDARTVKLLLLGAGESGKST
                     IVKQMKIIHQDGYSLEECLEFIAIIYGNTLQSILAIVRAMTTLNIQYGDSARQDDARK
                     LMHMADTIEEGTMPKEMSDIIQRLWKDSGIQACFDRASEYQLNDSAGYYLSDLERLVT
                     PGYVPTEQDVLRSRVKTTGIIETQFSFKDLNFRMFDVGGQRSERKKWIHCFEGVTCII
                     FIAALSAYDMVLVEDDEVNRMHESLHLFNSICNHRYFATTSIVLFLNKKDVFSEKIKK
                     AHLSICFPDYDGPNTYEDAGNYIKVQFLELNMRRDVKEIYSHMTCATDTQNVKFVFDA
                     VTDIIIKENLKDCGLF"
     exon            193..235
                     /gene="Gnat1"
                     /gene_synonym="Gnat-1; Hg1f; Ird1; Ird2; irdc; irdr;
                     Tralpha; transducin"
                     /inference="alignment:Splign:2.1.0"
     exon            236..377
                     /gene="Gnat1"
                     /gene_synonym="Gnat-1; Hg1f; Ird1; Ird2; irdc; irdr;
                     Tralpha; transducin"
                     /inference="alignment:Splign:2.1.0"
     exon            378..535
                     /gene="Gnat1"
                     /gene_synonym="Gnat-1; Hg1f; Ird1; Ird2; irdc; irdr;
                     Tralpha; transducin"
                     /inference="alignment:Splign:2.1.0"
     exon            536..664
                     /gene="Gnat1"
                     /gene_synonym="Gnat-1; Hg1f; Ird1; Ird2; irdc; irdr;
                     Tralpha; transducin"
                     /inference="alignment:Splign:2.1.0"
     exon            665..794
                     /gene="Gnat1"
                     /gene_synonym="Gnat-1; Hg1f; Ird1; Ird2; irdc; irdr;
                     Tralpha; transducin"
                     /inference="alignment:Splign:2.1.0"
     exon            795..948
                     /gene="Gnat1"
                     /gene_synonym="Gnat-1; Hg1f; Ird1; Ird2; irdc; irdr;
                     Tralpha; transducin"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1140
                     /gene="Gnat1"
                     /gene_synonym="Gnat-1; Hg1f; Ird1; Ird2; irdc; irdr;
                     Tralpha; transducin"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..2287
                     /gene="Gnat1"
                     /gene_synonym="Gnat-1; Hg1f; Ird1; Ird2; irdc; irdr;
                     Tralpha; transducin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2232..2237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnat1"
                     /gene_synonym="Gnat-1; Hg1f; Ird1; Ird2; irdc; irdr;
                     Tralpha; transducin"
                     /note="hexamer: AATAAA"
     polyA_site      2250
                     /gene="Gnat1"
                     /gene_synonym="Gnat-1; Hg1f; Ird1; Ird2; irdc; irdr;
                     Tralpha; transducin"
                     /note="major polyA site"
ORIGIN      
        1 agttgattgt tggctttggg gccagaaggt cgtctgagga ggccggggag gctgcctacc
       61 ctgtcccttt gcctgctgct gggaccatgg gggctggggc cagcgctgag gagaagcact
      121 ccagagagct ggagaagaag ctgaaagagg atgctgagaa ggatgcccgc actgtgaaac
      181 tgctgcttct gggtgccggt gaatccggga agagcactat tgtcaaacag atgaagatta
      241 tccaccagga cgggtattcg ctggaggaat gcctcgagtt cattgccatc atctacggca
      301 acactctgca gtccatcctg gccatcgttc gggctatgac cacgctcaac attcagtatg
      361 gagattcagc ccggcaggat gatgcccgga agctcatgca catggcagat actattgagg
      421 aaggcacaat gcccaaggag atgtcagaca tcattcagcg cttgtggaag gactcgggta
      481 tccaagcttg ctttgaccga gcctcagaat accagctcaa tgactccgcc ggctactatc
      541 tctcagacct agagcgtctg gtgactccag gatatgtgcc cactgagcag gacgtgttgc
      601 gttctcgtgt caaaaccact ggtattatcg agactcaatt ctccttcaag gacctcaact
      661 tcagaatgtt cgatgtgggc gggcagcgtt ccgagcgcaa aaagtggatc cactgctttg
      721 agggtgtgac gtgcatcatt ttcatcgctg cgctgagcgc ttacgacatg gtgctggtgg
      781 aggacgacga agtgaaccga atgcacgaga gcctgcacct gttcaacagc atctgcaatc
      841 atcgctactt cgccacaacg tctatcgtgc tcttcctcaa caagaaggac gttttctccg
      901 agaagataaa aaaggcacac ctcagcatct gcttccccga ctacgatgga cctaacactt
      961 acgaggatgc cggcaactac atcaaagtgc agttcctgga gcttaacatg cgacgtgatg
     1021 tgaaggagat ctattcccac atgacgtgcg ctaccgacac acagaacgtc aagtttgtct
     1081 ttgacgctgt caccgacatt atcatcaagg agaacctcaa agactgcggg ctcttctgag
     1141 gtacctgaat tcaggtgtgt ctcttgccct gagattctgt agccctgcag ccctgtagcc
     1201 ctgtagtccc ctcaaatacc gtcctttcca caagctgctg ctcttgtagc cacacaccca
     1261 aaggcatgag gcttgcagtg cagaccctcc cccaagtacc caactcgacc ctgcttttca
     1321 ccgcctggct gcactggcct cttggaccta cagcagccag cctgagctag gacacctcag
     1381 gacttgggac agctggaact cacagtgact cagcagtgcc ctagtgaccc gtctgtctcc
     1441 agcctcttct gctaccccca gcagcagcag cagctcacca gcagatcccc attccacaaa
     1501 cagccctccc tcaccagttt ccacgaagga cttgaggtat ccctccctca agcagtaggc
     1561 cggtccagcc tgctacctgc atatgacaag tccaacacgt gtccacccag tggttagtga
     1621 ctgtccctcc cagtagcctg aggactccaa agtccaagct ctggtttttg aagcctcgta
     1681 tagagaagtg agtgactttg acgtgggtgc cagggaaaga aagacacaag ccaaacccat
     1741 tcccgaacat cagactcagg gtttctccag tcccttctcc ctctgggtct tgcccctctg
     1801 tccttggaca cttccacacc acacctcatc cacccacaca caatactcag ggctggctgg
     1861 tcaaggtatg ctgtattgaa ggagggtatt attgacatag ctatgaccaa taatgaagcc
     1921 atgctgaggg gtggctcaga gcagagtcca acccctattg atcaaccatg ggcaaagaat
     1981 atcccatgtg aggttacagg caattccatg tgaccatgtt gtccctcctg attcagggcc
     2041 cattccttag gagggagaac tgaaaaccag gcctaaacca ttagagacaa tgtcccccaa
     2101 cccccagcca cttctacaac ctttgcttaa gcctgtggac cagagccagt gctgctggaa
     2161 gaggcaagat gcttctggac agcaagacta gggcacaacc tctccctccc ttagctagct
     2221 gcagactcag caataaacct ttgcaccaga tctgctgtcc ttccttgggt cggcggggga
     2281 aactcaaaaa aaaaaa
//
