LOCUS       NM_001077510            1789 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus GNAS complex locus (Gnas), transcript variant 8, mRNA.
ACCESSION   NM_001077510
VERSION     NM_001077510.5
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1789)
  AUTHORS   Ben-Shaanan,T.L., Knopper,K., Duan,L., Liu,R., Taglinao,H., Xu,Y.,
            An,J., Plikus,M.V. and Cyster,J.G.
  TITLE     Dermal TRPV1 innervations engage a macrophage- and
            fibroblast-containing pathway to activate hair growth in mice
  JOURNAL   Dev Cell 59 (21), 2818-2833 (2024)
   PUBMED   38851191
REFERENCE   2  (bases 1 to 1789)
  AUTHORS   Liu,L., El,K., Dattaroy,D., Barella,L.F., Cui,Y., Gray,S.M.,
            Guedikian,C., Chen,M., Weinstein,L.S., Knuth,E., Jin,E.,
            Merrins,M.J., Roman,J., Kaestner,K.H., Doliba,N., Campbell,J.E. and
            Wess,J.
  TITLE     Intra-islet alpha-cell Gs signaling promotes glucagon release
  JOURNAL   Nat Commun 15 (1), 5129 (2024)
   PUBMED   38879678
  REMARK    Erratum:[Nat Commun. 2024 Jul 29;15(1):6383. doi:
            10.1038/s41467-024-50810-2.. PMID: 39075062]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1789)
  AUTHORS   Tang,C., Zhong,C., Zhu,J., Yuan,F., Yang,J., Xu,Y. and Ma,C.
  TITLE     GNAS mutations suppress cell invasion by activating MEG3 in growth
            hormone-secreting pituitary adenoma
  JOURNAL   Oncol Res 32 (6), 1079-1091 (2024)
   PUBMED   38827318
  REMARK    GeneRIF: GNAS mutations suppress cell invasion by activating MEG3
            in growth hormone-secreting pituitary adenoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1789)
  AUTHORS   Plagge,A., Isles,A.R., Gordon,E., Humby,T., Dean,W., Gritsch,S.,
            Fischer-Colbrie,R., Wilkinson,L.S. and Kelsey,G.
  TITLE     Imprinted Nesp55 influences behavioral reactivity to novel
            environments
  JOURNAL   Mol Cell Biol 25 (8), 3019-3026 (2005)
   PUBMED   15798190
  REMARK    GeneRIF: Maternally expressed Nesp55 plays a role in controlling
            exploratory behavior.
REFERENCE   5  (bases 1 to 1789)
  AUTHORS   Abramowitz,J., Grenet,D., Birnbaumer,M., Torres,H.N. and
            Birnbaumer,L.
  TITLE     XLalphas, the extra-long form of the alpha-subunit of the Gs G
            protein, is significantly longer than suspected, and so is its
            companion Alex
  JOURNAL   Proc Natl Acad Sci U S A 101 (22), 8366-8371 (2004)
   PUBMED   15148396
  REMARK    GeneRIF: Data report that the XL exon of Gsalpha is longer than
            presumed and contributes an additional 364 codons to XLalphas.
REFERENCE   6  (bases 1 to 1789)
  AUTHORS   Wroe,S.F., Kelsey,G., Skinner,J.A., Bodle,D., Ball,S.T.,
            Beechey,C.V., Peters,J. and Williamson,C.M.
  TITLE     An imprinted transcript, antisense to Nesp, adds complexity to the
            cluster of imprinted genes at the mouse Gnas locus
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3342-3346 (2000)
   PUBMED   10716699
REFERENCE   7  (bases 1 to 1789)
  AUTHORS   Peters,J., Wroe,S.F., Wells,C.A., Miller,H.J., Bodle,D.,
            Beechey,C.V., Williamson,C.M. and Kelsey,G.
  TITLE     A cluster of oppositely imprinted transcripts at the Gnas locus in
            the distal imprinting region of mouse chromosome 2
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3830-3835 (1999)
   PUBMED   10097123
  REMARK    GeneRIF: Gnas gene exhibits a complex imprinted pattern, giving
            rise to transcripts that are maternally, paternally, or
            biallelically expressed.
REFERENCE   8  (bases 1 to 1789)
  AUTHORS   Tachibana,M., Wilcox,E., Yokotani,N., Schneider,M. and Fex,J.
  TITLE     Selective amplification and partial sequencing of cDNAs encoding G
            protein alpha subunits from cochlear tissues
  JOURNAL   Hear Res 62 (1), 82-88 (1992)
   PUBMED   1429253
REFERENCE   9  (bases 1 to 1789)
  AUTHORS   Wilkie,T.M., Gilbert,D.J., Olsen,A.S., Chen,X.N., Amatruda,T.T.,
            Korenberg,J.R., Trask,B.J., de Jong,P., Reed,R.R., Simon,M.I. et
            al.
  TITLE     Evolution of the mammalian G protein alpha subunit multigene family
  JOURNAL   Nat Genet 1 (2), 85-91 (1992)
   PUBMED   1302014
  REMARK    Review article
REFERENCE   10 (bases 1 to 1789)
  AUTHORS   MacMillan,P.
  TITLE     Women of the world, unite
  JOURNAL   Nurs Times 75 (33), 1391-1392 (1979)
   PUBMED   257483
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL593857.10, AK159563.1,
            BU054033.1, DV057819.1 and BC062654.1.
            
            On Jun 6, 2018 this sequence version replaced NM_001077510.4.
            
            Summary: This locus has a highly complex imprinted expression
            pattern. It gives rise to maternally, paternally, and biallelically
            expressed transcripts that are derived from four alternative
            promoters and 5' exons. Some transcripts contain a differentially
            methylated region (DMR) at their 5' exons, which is commonly found
            in imprinted genes and correlates with transcript expression. This
            gene has an antisense transcript. One of the transcripts produced
            from this locus, and the antisense transcript, are both paternally
            expressed noncoding RNAs, and may regulate imprinting in this
            region. In addition, one of the transcripts contains a second
            overlapping ORF, which encodes a structurally unrelated protein -
            Alex. Alternative splicing of downstream exons is also observed,
            which results in different forms of the stimulatory G-protein alpha
            subunit, a key element of the classical signal transduction pathway
            linking receptor-ligand interactions with the activation of
            adenylyl cyclase and a variety of cellular reponses. Additional
            transcript variants have been found for this gene, but the
            full-length nature and/or biological validity of some variants have
            not been determined. [provided by RefSeq, Jun 2015].
            
            Transcript Variant: This variant (8) is biallelically expressed. It
            lacks an internal exon and uses an alternate splice site, compared
            to variant 7. It encodes the isoform GNASS, also known as alpha-S1,
            which lacks an internal segment and has two amino acids different,
            compared to isoform GNASL.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061496.1, AK147051.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene :: PMID: 10097123, 11056047
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AL593857.10        186165-186247
            84-262              AK159563.1         2-180
            263-501             BU054033.1         1-239
            502-888             DV057819.1         189-575
            889-951             BU054033.1         669-731
            952-1789            BC062654.1         3066-3903
FEATURES             Location/Qualifiers
     source          1..1789
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 97.89 cM"
     gene            1..1789
                     /gene="Gnas"
                     /gene_synonym="5530400H20Rik; A930027G11Rik;
                     C130027O20Rik; Galphas; Gnas1; Gnasxl; GPSA; Gs-alpha;
                     Gsa; GSP; Nesp; Nesp55; Nespl; Oed-Sml; Oedsml; P1; P2;
                     P3; PHP1A; PHP1B; POH; SCG6"
                     /note="GNAS complex locus"
                     /db_xref="GeneID:14683"
                     /db_xref="MGI:MGI:95777"
     exon            1..429
                     /gene="Gnas"
                     /gene_synonym="5530400H20Rik; A930027G11Rik;
                     C130027O20Rik; Galphas; Gnas1; Gnasxl; GPSA; Gs-alpha;
                     Gsa; GSP; Nesp; Nesp55; Nespl; Oed-Sml; Oedsml; P1; P2;
                     P3; PHP1A; PHP1B; POH; SCG6"
                     /inference="alignment:Splign:2.1.0"
     CDS             291..1433
                     /gene="Gnas"
                     /gene_synonym="5530400H20Rik; A930027G11Rik;
                     C130027O20Rik; Galphas; Gnas1; Gnasxl; GPSA; Gs-alpha;
                     Gsa; GSP; Nesp; Nesp55; Nespl; Oed-Sml; Oedsml; P1; P2;
                     P3; PHP1A; PHP1B; POH; SCG6"
                     /note="isoform GNASS is encoded by transcript variant 8;
                     protein ALEX; neuroendocrine secretory protein 55; GNAS
                     (guanine nucleotide binding protein, alpha stimulating)
                     complex locus; secretogranin VI; Gs alpha subunit;
                     stimulatory G-protein alpha subunit; extra large alphas
                     protein; alternative gene product encoded by XL-exon;
                     adenylate cyclase-stimulating G alpha protein"
                     /codon_start=1
                     /product="protein GNAS isoform GNASS"
                     /protein_id="NP_001070978.1"
                     /db_xref="CCDS:CCDS38357.1"
                     /db_xref="GeneID:14683"
                     /db_xref="MGI:MGI:95777"
                     /translation="MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLL
                     LLGAGESGKSTIVKQMRILHVNGFNGDSEKATKVQDIKNNLKEAIETIVAAMSNLVPP
                     VELANPENQFRVDYILSVMNVPNFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDC
                     AQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERR
                     KWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILF
                     LNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRI
                     STASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL"
     exon            430..502
                     /gene="Gnas"
                     /gene_synonym="5530400H20Rik; A930027G11Rik;
                     C130027O20Rik; Galphas; Gnas1; Gnasxl; GPSA; Gs-alpha;
                     Gsa; GSP; Nesp; Nesp55; Nespl; Oed-Sml; Oedsml; P1; P2;
                     P3; PHP1A; PHP1B; POH; SCG6"
                     /inference="alignment:Splign:2.1.0"
     exon            503..560
                     /gene="Gnas"
                     /gene_synonym="5530400H20Rik; A930027G11Rik;
                     C130027O20Rik; Galphas; Gnas1; Gnasxl; GPSA; Gs-alpha;
                     Gsa; GSP; Nesp; Nesp55; Nespl; Oed-Sml; Oedsml; P1; P2;
                     P3; PHP1A; PHP1B; POH; SCG6"
                     /inference="alignment:Splign:2.1.0"
     exon            561..680
                     /gene="Gnas"
                     /gene_synonym="5530400H20Rik; A930027G11Rik;
                     C130027O20Rik; Galphas; Gnas1; Gnasxl; GPSA; Gs-alpha;
                     Gsa; GSP; Nesp; Nesp55; Nespl; Oed-Sml; Oedsml; P1; P2;
                     P3; PHP1A; PHP1B; POH; SCG6"
                     /inference="alignment:Splign:2.1.0"
     exon            681..778
                     /gene="Gnas"
                     /gene_synonym="5530400H20Rik; A930027G11Rik;
                     C130027O20Rik; Galphas; Gnas1; Gnasxl; GPSA; Gs-alpha;
                     Gsa; GSP; Nesp; Nesp55; Nespl; Oed-Sml; Oedsml; P1; P2;
                     P3; PHP1A; PHP1B; POH; SCG6"
                     /inference="alignment:Splign:2.1.0"
     exon            779..833
                     /gene="Gnas"
                     /gene_synonym="5530400H20Rik; A930027G11Rik;
                     C130027O20Rik; Galphas; Gnas1; Gnasxl; GPSA; Gs-alpha;
                     Gsa; GSP; Nesp; Nesp55; Nespl; Oed-Sml; Oedsml; P1; P2;
                     P3; PHP1A; PHP1B; POH; SCG6"
                     /inference="alignment:Splign:2.1.0"
     exon            834..907
                     /gene="Gnas"
                     /gene_synonym="5530400H20Rik; A930027G11Rik;
                     C130027O20Rik; Galphas; Gnas1; Gnasxl; GPSA; Gs-alpha;
                     Gsa; GSP; Nesp; Nesp55; Nespl; Oed-Sml; Oedsml; P1; P2;
                     P3; PHP1A; PHP1B; POH; SCG6"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1087
                     /gene="Gnas"
                     /gene_synonym="5530400H20Rik; A930027G11Rik;
                     C130027O20Rik; Galphas; Gnas1; Gnasxl; GPSA; Gs-alpha;
                     Gsa; GSP; Nesp; Nesp55; Nespl; Oed-Sml; Oedsml; P1; P2;
                     P3; PHP1A; PHP1B; POH; SCG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1218
                     /gene="Gnas"
                     /gene_synonym="5530400H20Rik; A930027G11Rik;
                     C130027O20Rik; Galphas; Gnas1; Gnasxl; GPSA; Gs-alpha;
                     Gsa; GSP; Nesp; Nesp55; Nespl; Oed-Sml; Oedsml; P1; P2;
                     P3; PHP1A; PHP1B; POH; SCG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1286
                     /gene="Gnas"
                     /gene_synonym="5530400H20Rik; A930027G11Rik;
                     C130027O20Rik; Galphas; Gnas1; Gnasxl; GPSA; Gs-alpha;
                     Gsa; GSP; Nesp; Nesp55; Nespl; Oed-Sml; Oedsml; P1; P2;
                     P3; PHP1A; PHP1B; POH; SCG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1789
                     /gene="Gnas"
                     /gene_synonym="5530400H20Rik; A930027G11Rik;
                     C130027O20Rik; Galphas; Gnas1; Gnasxl; GPSA; Gs-alpha;
                     Gsa; GSP; Nesp; Nesp55; Nespl; Oed-Sml; Oedsml; P1; P2;
                     P3; PHP1A; PHP1B; POH; SCG6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1733..1738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnas"
                     /gene_synonym="5530400H20Rik; A930027G11Rik;
                     C130027O20Rik; Galphas; Gnas1; Gnasxl; GPSA; Gs-alpha;
                     Gsa; GSP; Nesp; Nesp55; Nespl; Oed-Sml; Oedsml; P1; P2;
                     P3; PHP1A; PHP1B; POH; SCG6"
                     /note="hexamer: AATAAA"
     polyA_site      1763
                     /gene="Gnas"
                     /gene_synonym="5530400H20Rik; A930027G11Rik;
                     C130027O20Rik; Galphas; Gnas1; Gnasxl; GPSA; Gs-alpha;
                     Gsa; GSP; Nesp; Nesp55; Nespl; Oed-Sml; Oedsml; P1; P2;
                     P3; PHP1A; PHP1B; POH; SCG6"
                     /note="major polyA site"
     regulatory      1766..1771
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnas"
                     /gene_synonym="5530400H20Rik; A930027G11Rik;
                     C130027O20Rik; Galphas; Gnas1; Gnasxl; GPSA; Gs-alpha;
                     Gsa; GSP; Nesp; Nesp55; Nespl; Oed-Sml; Oedsml; P1; P2;
                     P3; PHP1A; PHP1B; POH; SCG6"
                     /note="hexamer: AATAAA"
     regulatory      1773..1778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnas"
                     /gene_synonym="5530400H20Rik; A930027G11Rik;
                     C130027O20Rik; Galphas; Gnas1; Gnasxl; GPSA; Gs-alpha;
                     Gsa; GSP; Nesp; Nesp55; Nespl; Oed-Sml; Oedsml; P1; P2;
                     P3; PHP1A; PHP1B; POH; SCG6"
                     /note="hexamer: ATTAAA"
     polyA_site      1784
                     /gene="Gnas"
                     /gene_synonym="5530400H20Rik; A930027G11Rik;
                     C130027O20Rik; Galphas; Gnas1; Gnasxl; GPSA; Gs-alpha;
                     Gsa; GSP; Nesp; Nesp55; Nespl; Oed-Sml; Oedsml; P1; P2;
                     P3; PHP1A; PHP1B; POH; SCG6"
                     /note="major polyA site"
     polyA_site      1789
                     /gene="Gnas"
                     /gene_synonym="5530400H20Rik; A930027G11Rik;
                     C130027O20Rik; Galphas; Gnas1; Gnasxl; GPSA; Gs-alpha;
                     Gsa; GSP; Nesp; Nesp55; Nespl; Oed-Sml; Oedsml; P1; P2;
                     P3; PHP1A; PHP1B; POH; SCG6"
                     /note="major polyA site"
ORIGIN      
        1 ctcgccgccg tcgcctccgc ctccccccgc tcccccgccc gccgcggcgc ttttgggtcg
       61 gggcggcggg cccgggccga ggcaataaga gcggcggcgg cggcggcggc ggcagcagct
      121 cccgcggctc ctgctctgct ccgcctcggc cccggagcga ggggcggaga gccgcgcgct
      181 tgccttagtc cgagccgcca ccctccccgc gttccccgct ttcccggccc gcccgaggcc
      241 gcccgccccg tccccgccgc cccgcagccc ggccgcgccc cgccgccgcc atgggctgcc
      301 tcggcaacag taagaccgag gaccagcgca acgaggagaa ggcgcagcgc gaggccaaca
      361 aaaagatcga gaagcagctg cagaaggaca agcaggtcta ccgggccacg caccgcctgc
      421 tgctgctggg tgctggagag tctggcaaaa gcaccattgt gaagcagatg aggatcctgc
      481 atgttaatgg gtttaacgga gatagtgaga aggccactaa agtgcaggac atcaaaaaca
      541 acctgaagga ggccattgaa accattgtgg ccgccatgag caacctggtg ccccctgtgg
      601 agctggccaa ccctgagaac cagttcagag tggactacat tctgagcgtg atgaacgtgc
      661 cgaactttga cttcccacct gaattctatg agcatgccaa ggctctgtgg gaggatgagg
      721 gagtgcgtgc ctgctacgag cgctccaatg agtaccagct gattgactgt gcccagtact
      781 tcctggacaa gattgatgtg atcaagcagg ccgactacgt gccaagtgac caggacctgc
      841 ttcgctgccg tgtcctgacc tctggaatct ttgagaccaa gttccaggtg gacaaagtca
      901 acttccacat gttcgatgtg ggcggccagc gcgatgagcg ccgcaagtgg atccagtgct
      961 tcaatgatgt gactgccatc atcttcgtgg tggccagcag cagctacaac atggtcattc
     1021 gggaggacaa ccagactaac cgcctgcagg aggctctgaa cctcttcaag agcatctgga
     1081 acaacagatg gctgcgcacc atctctgtga ttctcttcct caacaagcaa gacctgcttg
     1141 ctgagaaagt cctcgctggc aaatcgaaga ttgaggacta ctttccagag ttcgctcgct
     1201 acaccactcc tgaggatgcg actcccgagc cgggagagga cccacgcgtg acccgggcca
     1261 agtacttcat tcgggatgag tttctgagaa tcagcactgc tagtggagat gggcgccact
     1321 actgctaccc tcactttacc tgcgccgtgg acactgagaa catccgccgt gtcttcaacg
     1381 actgccgtga catcatccag cgcatgcatc tccgccaata cgagctgctc taagaaggga
     1441 acacccaaat ttaattcagc cttaagcaca attaattaag agtgaaacgt aattgtacaa
     1501 gcagttggtc acccaccata gggcatgatc aacaccgcaa cctttccttt ttcccccagt
     1561 gattctgaaa aacccctctt cccttcagct tgcttagatg ttccaaattt agtaagctta
     1621 aggcggccta cagaagaaaa agaaaaaaaa ggccacaaaa gttccctctc actttcagta
     1681 aataaaataa aagcagcaac agaaataaag aaataaatga aattcaaaat gaaataaata
     1741 ttgtgttgtg cagcattaaa aaatcaataa aaattaaaaa tgagcaaaa
//
