LOCUS       NP_032165                359 aa            linear   ROD 27-APR-2025
DEFINITION  guanine nucleotide-binding protein G(q) subunit alpha [Mus
            musculus].
ACCESSION   NP_032165 XP_915995
VERSION     NP_032165.3
DBSOURCE    REFSEQ: accession NM_008139.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 359)
  AUTHORS   Zhu,P., Bi,X., Su,D., Li,X., Chen,Y., Song,Z., Zhao,L., Wang,Y.,
            Xu,S. and Wu,X.
  TITLE     Transcription repression of estrogen receptor alpha by
            ghrelin/Gq/11/YAP signaling in granulosa cells promotes polycystic
            ovary syndrome
  JOURNAL   Hum Cell 37 (6), 1663-1678 (2024)
   PUBMED   39225978
  REMARK    GeneRIF: Transcription repression of estrogen receptor alpha by
            ghrelin/Gq/11/YAP signaling in granulosa cells promotes polycystic
            ovary syndrome.
REFERENCE   2  (residues 1 to 359)
  AUTHORS   Wang,K.Y., Gao,M.X., Qi,H.B., An,W.T., Lin,J.Y., Ning,S.L.,
            Yang,F., Xiao,P., Cheng,J., Pan,W., Cheng,Q.X., Wang,J., Fang,L.,
            Sun,J.P. and Yu,X.
  TITLE     Differential contributions of G protein- or arrestin
            subtype-mediated signalling underlie urocortin 3-induced
            somatostatin secretion in pancreatic delta cells
  JOURNAL   Br J Pharmacol 181 (15), 2600-2621 (2024)
   PUBMED   38613153
REFERENCE   3  (residues 1 to 359)
  AUTHORS   Zhang,L., He,Y., Zhang,M., Zhang,J., Zhuang,W., Sun,Y., Chen,X.,
            Fu,H., Tang,X. and Shi,G.
  TITLE     Heterozygous Gnaq deficiency enhances Ifi202b/IFI16 and NF-kappaB
            activation in endothelial cells and exacerbates lupus nephritis
            pathology
  JOURNAL   iScience 27 (8), 110350 (2024)
   PUBMED   39108722
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 359)
  AUTHORS   Izquierdo-Villalba,I., Mirra,S., Manso,Y., Parcerisas,A., Rubio,J.,
            Del Valle,J., Gil-Bea,F.J., Ulloa,F., Herrero-Lorenzo,M.,
            Verdaguer,E., Beninca,C., Castro-Torres,R.D., Rebollo,E.,
            Marfany,G., Auladell,C., Navarro,X., Enriquez,J.A., Lopez de
            Munain,A., Soriano,E. and Aragay,A.M.
  TITLE     A mammalian-specific Alex3/Galphaq protein complex regulates
            mitochondrial trafficking, dendritic complexity, and neuronal
            survival
  JOURNAL   Sci Signal 17 (822), eabq1007 (2024)
   PUBMED   38320000
  REMARK    GeneRIF: A mammalian-specific Alex3/Galphaq protein complex
            regulates mitochondrial trafficking, dendritic complexity, and
            neuronal survival.
REFERENCE   5  (residues 1 to 359)
  AUTHORS   Falzone,M.E. and MacKinnon,R.
  TITLE     The mechanism of Galphaq regulation of PLCbeta3-catalyzed PIP2
            hydrolysis
  JOURNAL   Proc Natl Acad Sci U S A 120 (48), e2315011120 (2023)
   PUBMED   37991948
REFERENCE   6  (residues 1 to 359)
  AUTHORS   Walensky,L.D. and Snyder,S.H.
  TITLE     Inositol 1,4,5-trisphosphate receptors selectively localized to the
            acrosomes of mammalian sperm
  JOURNAL   J Cell Biol 130 (4), 857-869 (1995)
   PUBMED   7642703
REFERENCE   7  (residues 1 to 359)
  AUTHORS   Rambhatla,L., Patel,B., Dhanasekaran,N. and Latham,K.E.
  TITLE     Analysis of G protein alpha subunit mRNA abundance in
            preimplantation mouse embryos using a rapid, quantitative RT-PCR
            approach
  JOURNAL   Mol Reprod Dev 41 (3), 314-324 (1995)
   PUBMED   8588930
REFERENCE   8  (residues 1 to 359)
  AUTHORS   Wedegaertner,P.B., Chu,D.H., Wilson,P.T., Levis,M.J. and
            Bourne,H.R.
  TITLE     Palmitoylation is required for signaling functions and membrane
            attachment of Gq alpha and Gs alpha
  JOURNAL   J Biol Chem 268 (33), 25001-25008 (1993)
   PUBMED   8227063
REFERENCE   9  (residues 1 to 359)
  AUTHORS   Wilkie,T.M., Gilbert,D.J., Olsen,A.S., Chen,X.N., Amatruda,T.T.,
            Korenberg,J.R., Trask,B.J., de Jong,P., Reed,R.R., Simon,M.I. et
            al.
  TITLE     Evolution of the mammalian G protein alpha subunit multigene family
  JOURNAL   Nat Genet 1 (2), 85-91 (1992)
   PUBMED   1302014
  REMARK    Review article
REFERENCE   10 (residues 1 to 359)
  AUTHORS   Strathmann,M. and Simon,M.I.
  TITLE     G protein diversity: a distinct class of alpha subunits is present
            in vertebrates and invertebrates
  JOURNAL   Proc Natl Acad Sci U S A 87 (23), 9113-9117 (1990)
   PUBMED   2123549
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102062.9, AC125202.3 and AC126031.2.
            
            On Jan 10, 2006 this sequence version replaced NP_032165.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147393.1, BC057583.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..359
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 11.01 cM"
     Protein         1..359
                     /product="guanine nucleotide-binding protein G(q) subunit
                     alpha"
                     /calculated_mol_wt=42027
     Region          40..353
                     /region_name="G-alpha"
                     /note="Alpha subunit of G proteins (guanine nucleotide
                     binding); cd00066"
                     /db_xref="CDD:206639"
     Region          41..54
                     /region_name="G1 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01230"
                     /note="propagated from UniProtKB/Swiss-Prot (P21279.4)"
     Site            order(46,51..53,186,205,208,274..275,277,330..331)
                     /site_type="other"
                     /note="GTP/Mg2+ binding site [chemical binding]"
                     /db_xref="CDD:206639"
     Site            46..53
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:206639"
     Site            order(47..49,77,81,85,88,91..92,110,113,154,183,208,216,
                     220)
                     /site_type="active"
                     /note="GoLoco binding site [active]"
                     /db_xref="CDD:206639"
     Region          178..186
                     /region_name="G2 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01230"
                     /note="propagated from UniProtKB/Swiss-Prot (P21279.4)"
     Site            181..189
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206639"
     Site            186
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206639"
     Site            order(187,189,191,202,204,208..210,212,215..216,218..221)
                     /site_type="other"
                     /note="beta - gamma complex interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:206639"
     Site            order(189,214,217..218,221)
                     /site_type="other"
                     /note="adenylyl cyclase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:206639"
     Region          201..210
                     /region_name="G3 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01230"
                     /note="propagated from UniProtKB/Swiss-Prot (P21279.4)"
     Site            205..208
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206639"
     Site            206..222
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:206639"
     Region          270..277
                     /region_name="G4 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01230"
                     /note="propagated from UniProtKB/Swiss-Prot (P21279.4)"
     Site            274..277
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206639"
     Site            order(322..333,335..338)
                     /site_type="active"
                     /note="putative receptor binding site [active]"
                     /db_xref="CDD:206639"
     Region          329..334
                     /region_name="G5 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01230"
                     /note="propagated from UniProtKB/Swiss-Prot (P21279.4)"
     Site            330..332
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:206639"
     CDS             1..359
                     /gene="Gnaq"
                     /gene_synonym="1110005L02Rik; 6230401I02Rik; Dsk1; Dsk10;
                     Galphaq; Gq; GqI"
                     /coded_by="NM_008139.6:643..1722"
                     /db_xref="CCDS:CCDS29684.1"
                     /db_xref="GeneID:14682"
                     /db_xref="MGI:MGI:95776"
ORIGIN      
        1 mtlesimacc lseeakearr indeierqlr rdkrdarrel kllllgtges gkstfikqmr
       61 iihgsgysde dkrgftklvy qniftamqam iramdtlkip ykyehnkaha qlvrevdvek
      121 vsafenpyvd aikslwndpg iqecydrrre yqlsdstkyy lndldrvadp sylptqqdvl
      181 rvrvpttgii eypfdlqsvi frmvdvggqr serrkwihcf envtsimflv alseydqvlv
      241 esdnenrmee skalfrtiit ypwfqnssvi lflnkkdlle ekimyshlvd yfpeydgpqr
      301 daqaarefil kmfvdlnpds dkiiyshftc atdtenirfv faavkdtilq lnlkeynlv
//
