LOCUS       NM_177137               5654 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus guanine nucleotide binding protein, alpha stimulating,
            olfactory type (Gnal), transcript variant 2, mRNA.
ACCESSION   NM_177137
VERSION     NM_177137.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5654)
  AUTHORS   Millett,M., Heuberger,A., Martin Castosa,E., Comite,A., Wagner,P.,
            Hall,D., Gallardo,I., Chambers,N.E., Wagner,L., Reinhardt,J. and
            Moehle,M.S.
  TITLE     Neuron specific quantitation of Galphaolf expression and signaling
            in murine brain tissue
  JOURNAL   Brain Res 1842, 149105 (2024)
   PUBMED   38960060
  REMARK    GeneRIF: Neuron specific quantitation of Galphaolf expression and
            signaling in murine brain tissue.
REFERENCE   2  (bases 1 to 5654)
  AUTHORS   Aissa,H.B., Sala,R.W., Georgescu Margarint,E.L., Frontera,J.L.,
            Varani,A.P., Menardy,F., Pelosi,A., Herve,D., Lena,C. and Popa,D.
  TITLE     Functional abnormalities in the cerebello-thalamic pathways in a
            mouse model of DYT25 dystonia
  JOURNAL   Elife 11, e79135 (2022)
   PUBMED   35699413
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5654)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5654)
  AUTHORS   Melis,C., Beauvais,G., Muntean,B.S., Cirnaru,M.D., Otrimski,G.,
            Creus-Muncunill,J., Martemyanov,K.A., Gonzalez-Alegre,P. and
            Ehrlich,M.E.
  TITLE     Striatal Dopamine Induced ERK Phosphorylation Is Altered in Mouse
            Models of Monogenic Dystonia
  JOURNAL   Mov Disord 36 (5), 1147-1157 (2021)
   PUBMED   33458877
REFERENCE   5  (bases 1 to 5654)
  AUTHORS   Nagai,M.H., Xavier,V.P.S., Gutiyama,L.M., Machado,C.F., Reis,A.H.,
            Donnard,E.R., Galante,P.A.F., Abreu,J.G., Festuccia,W.T. and
            Malnic,B.
  TITLE     Depletion of Ric-8B leads to reduced mTORC2 activity
  JOURNAL   PLoS Genet 16 (5), e1008255 (2020)
   PUBMED   32392211
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5654)
  AUTHORS   Williams,C.J., Schultz,R.M. and Kopf,G.S.
  TITLE     G protein gene expression during mouse oocyte growth and
            maturation, and preimplantation embryo development
  JOURNAL   Mol Reprod Dev 44 (3), 315-323 (1996)
   PUBMED   8858601
REFERENCE   7  (bases 1 to 5654)
  AUTHORS   Justice,M.J., Gilbert,D.J., Kinzler,K.W., Vogelstein,B.,
            Buchberg,A.M., Ceci,J.D., Matsuda,Y., Chapman,V.M., Patriotis,C.,
            Makris,A. et al.
  TITLE     A molecular genetic linkage map of mouse chromosome 18 reveals
            extensive linkage conservation with human chromosomes 5 and 18
  JOURNAL   Genomics 13 (4), 1281-1288 (1992)
   PUBMED   1354644
REFERENCE   8  (bases 1 to 5654)
  AUTHORS   Wilkie,T.M., Gilbert,D.J., Olsen,A.S., Chen,X.N., Amatruda,T.T.,
            Korenberg,J.R., Trask,B.J., de Jong,P., Reed,R.R., Simon,M.I. et
            al.
  TITLE     Evolution of the mammalian G protein alpha subunit multigene family
  JOURNAL   Nat Genet 1 (2), 85-91 (1992)
   PUBMED   1302014
  REMARK    Review article
REFERENCE   9  (bases 1 to 5654)
  AUTHORS   Strathmann,M., Wilkie,T.M. and Simon,M.I.
  TITLE     Diversity of the G-protein family: sequences from five additional
            alpha subunits in the mouse
  JOURNAL   Proc Natl Acad Sci U S A 86 (19), 7407-7409 (1989)
   PUBMED   2508088
REFERENCE   10 (bases 1 to 5654)
  AUTHORS   Jones,D.T. and Reed,R.R.
  TITLE     Golf: an olfactory neuron specific-G protein involved in odorant
            signal transduction
  JOURNAL   Science 244 (4906), 790-795 (1989)
   PUBMED   2499043
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK035952.1, BC078439.1 and AC140336.2.
            
            On Dec 24, 2013 this sequence version replaced NM_177137.4.
            
            Transcript Variant: This variant (2) represents the longer
            transcript and encodes the longer isoform (2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.220668.1, BC078439.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AK035952.1         2-39
            39-2958             BC078439.1         1-2920
            2959-2960           AC140336.2         24284-24285         c
            2961-3117           BC078439.1         2921-3077
            3118-5654           AC140336.2         21590-24126         c
FEATURES             Location/Qualifiers
     source          1..5654
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 39.85 cM"
     gene            1..5654
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /note="guanine nucleotide binding protein, alpha
                     stimulating, olfactory type"
                     /db_xref="GeneID:14680"
                     /db_xref="MGI:MGI:95774"
     exon            1..576
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /inference="alignment:Splign:2.1.0"
     CDS             231..1577
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /note="isoform 2 is encoded by transcript variant 2;
                     guanine nucleotide-binding protein G(olf) subunit alpha;
                     adenylate cyclase-stimulating G alpha protein, olfactory
                     type; guanine nucleotide binding protein, alpha 10; G
                     alpha 10; heterotrimeric guanine nucleotide-binding
                     protein 1o"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein G(olf)
                     subunit alpha isoform 2"
                     /protein_id="NP_796111.2"
                     /db_xref="CCDS:CCDS29317.1"
                     /db_xref="GeneID:14680"
                     /db_xref="MGI:MGI:95774"
                     /translation="MGLCYSLRPLLFGSPEDTPCAASEPCAEDAQPSAAPAPASIPAP
                     APVGTLLRRGGGRIVANARPPGELQSRRRQEQLRAEEREAAKEARKVSRGIDRMLREQ
                     KRDLQQTHRLLLLGAGESGKSTIVKQMRILHVNGFNPEEKKQKILDIRKNVKDAIVTI
                     VSAMSTIIPPVPLANPENQFRSDYIKSIAPITDFEYSQEFFDHVKKLWDDEGVKACFE
                     RSNEYQLIDCAQYFLERIDSVSLVDYTPTDQDLLRCRVLTSGIFETRFQVDKVNFHMF
                     DVGGQRDERRKWIQCFNDVTAIIYVAACSSYNMVIREDNNTNRLRESLDLFESIWNNR
                     WLRTISIILFLNKQDMLAEKVLAGKSKIEDYFPEYANYTVPEDATPDAGEDPKVTRAK
                     FFIRDLFLRISTATGDGKHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLKQYELL"
     exon            577..649
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /inference="alignment:Splign:2.1.0"
     exon            650..704
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /inference="alignment:Splign:2.1.0"
     exon            705..824
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /inference="alignment:Splign:2.1.0"
     exon            825..922
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /inference="alignment:Splign:2.1.0"
     exon            923..977
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1051
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1110
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1231
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1362
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1430
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..5654
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2898..2903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /note="hexamer: AATAAG"
     polyA_site      2925
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /note="major polyA site"
     regulatory      5615..5620
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /note="hexamer: AATAAT"
     regulatory      5627..5632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /note="hexamer: AATAAA"
     polyA_site      5632
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
     polyA_site      5654
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /note="major polyA site"
ORIGIN      
        1 ccttggtcag ctccgcctgc ttggggcgct ctcaggtgcg agctcgcgcc tgggacgttc
       61 gaaggatgca caatggccct tcggggcagt gaggggccgt ggtcccccag ccggacccac
      121 cgcagccacg ccccgcagct ggcgccccag ggtccgagtg cagcgctgcc tccggcgtcg
      181 gcgggagccc cggtctgacc cgcggggact tgcccgcgcc ccgcgccccg atgggcctat
      241 gctacagcct gcggccgctg ctcttcggga gcccagagga caccccgtgt gcggcctcgg
      301 aaccctgcgc agaggatgct cagcccagcg ccgccccggc ccctgcctcg atcccagccc
      361 cggctcccgt agggaccctg ctccggcgtg gcggcggccg gatcgtcgcg aacgcgcggc
      421 cgccaggcga gctgcagagc cgccggcgac aggagcagct acgagccgag gagcgcgagg
      481 cggctaaaga ggcgaggaaa gtcagccggg gcatcgaccg catgctgcgc gagcagaagc
      541 gggacctgca gcagacgcac cggctcctgc tgctgggggc tggtgagtcc gggaaaagca
      601 ctatcgtcaa acagatgagg atcctgcacg tcaatggctt caaccccgag gaaaagaagc
      661 agaaaattct ggacatcagg aaaaatgtca aagatgcgat cgtgacaatc gtttcagcaa
      721 tgagtactat catacctcca gttccactgg ccaaccctga gaaccagttc cggtcagatt
      781 atatcaagag catagcccct atcactgact ttgaatattc ccaggagttc tttgaccatg
      841 tgaagaagct gtgggacgat gaaggagtga aggcctgctt tgagagatcc aacgagtacc
      901 agctgatcga ctgtgcacaa tacttcctgg aaaggattga cagtgtcagt ctggttgact
      961 acacacccac agaccaggac ctgctcagat gcagagtgct gacatcagga atctttgaga
     1021 cacgattcca agtggacaaa gtgaactttc acatgtttga tgttggaggc cagagagatg
     1081 agagaagaaa atggatccag tgttttaatg atgtcactgc gatcatttac gtggcggcct
     1141 gtagtagcta caacatggtg atccgggaag ataacaatac caacagactt cgggaatcac
     1201 tggacctgtt tgaaagcatc tggaataaca ggtggttgcg aaccatttct atcatcctat
     1261 tcttgaacaa acaagacatg ctggcagaaa aagtcttggc agggaagtca aaaatcgaag
     1321 actatttccc ggagtatgcc aattatactg tccctgaaga tgcaacacca gatgcgggag
     1381 aagatcccaa agttacaaga gcaaagttct ttatccggga tctgttcttg aggatcagca
     1441 cagccacggg tgatggcaaa cattactgct accctcactt cacctgcgcc gtggacacag
     1501 agaacatccg cagagtgttc aacgattgcc gtgacatcat ccagagaatg catctcaagc
     1561 agtacgaact cttgtgaggg ctacctaccc ctcctccccc taaacctacc cctcctcctc
     1621 ctcctcactg ctgcctcttc tccctcttgg ccaccccatg aggcagcata tctccctagc
     1681 ctgcgtgtct gtccaccctg agccatggta gggcgtagtg agtgtctagt gtcatcaggc
     1741 tgccgtctgt cctgtcctag gtatgcctac atgtaaccac caagcctctg gctacctctg
     1801 ttccccaagg tttggttctg tgactttgtt ttcaccggac taaacagccc ccccaccacc
     1861 aatttgtatc actgcgaagc caccaactct cacttgggtg acactgcagt ggattttttt
     1921 cggggtggga atctatttat gctttgattg attggttgat gggtcgaatc atcagagaca
     1981 gcttagtgaa tgggggagtt acattgtttt caagttatca agcatgatca caaaatcgtc
     2041 cagacagtgc catgcacttg attcttccct ttataaaacg tcaggctacc aggtgtctgc
     2101 ccctcctggt ctgcattggc ccaaggctta gaatagatcc aagtcagcaa cagaataaga
     2161 ggaacttttt cagccacagt tgcaatggct gtaagccttg ggcatttgga gagagcttct
     2221 gggagccttt tacacttggg cagaaaacct gccacattca ctactgcaaa tggtgtcctg
     2281 tttataaaca aggggtcctc tacaccttta caatagcata gtcattccta tcttctttct
     2341 gttgttgctt taaccagact gtagagaccc caagatgtaa tactcttttc tatggctact
     2401 caagaatcct ccttgtagag ttctgtgcct tggtggcggc cacacctgta aggaaacata
     2461 tcccaactgt gtctagcagt ttgcagtcca cactgcctgc tgcttcacag tgggaaatcg
     2521 atagtgtcta ttcctcttag ggtattttta tcaggttagt acttagggaa gactcgttga
     2581 ttttagaatc gtccacttta ccagcggtat catccgaaca ctgaaaacta tcacagctac
     2641 ctgcttttac taccccaaac ctcagctgct gcaaacactg gaatgaccca cttccaaggc
     2701 ataaattaca accagttctg ttttcagggt actaagggcc ccccccccat atgaaatgtt
     2761 tctgatgatc ccttcaagtt ctgtaggcag gagcaggcca gcaatccctt cattaagttc
     2821 tacacacagt ccaccaaaca aaaagccagt ggtcagagga acgcacagtg gtgtcgatgt
     2881 tgtatatgac tgaggacaat aagatggtgt cttctgaaga ggaaatacta caaagctgct
     2941 tattcattat ctgtctctct atctgcattg ctagggatga gcccagcacc tagagcatgc
     3001 tagatgagcg ctcgactgcc agtccatatc ccagtcataa ctccagcccc cccacaaaaa
     3061 cctttaaata taaagacaaa ataaatggct gttcctcaca tatgtaagac ctgcaaatgc
     3121 aacctcgagt tactgtagga cacctagaca cagctcactc tgtctaagtt ccgaggcttt
     3181 ggggggtcat tcttaggctt aagttatctg taaagctgtc caaagttaag tttttaacag
     3241 tacaaatagg ggggagtgac agcctgcatt gctcaatcat ctcttaccgt tacttcaagt
     3301 ttattctaaa aactggcatt gtagaatgct ctaaaaactc atcctggctg agatgctcat
     3361 ccatgaaagg atacaacaca ttcttcaact cctcatcact gtcttcttgt gccattcact
     3421 accatggcac aaaacttcca tctgaagcca ggcaatgagg acacacgcct ttaatcccag
     3481 cactcgggag gcagaggcag gcggatctct gagttcgagg ccagcctggt ctacagagtg
     3541 agttccagga caactagggc tgcacagaga aaccctgtct caaacaaaac aaacaaacaa
     3601 acttccatct gtaccaacac atgatatgag agtgactttc agttctcctg cactcttaaa
     3661 gcaaagcaag aagaaaaact tgtgttcaca cacacacaca cacacacaca cacacacaca
     3721 cacacgtgag gtttttttat actatagttt gcattactac ccagcagttc cctgctcact
     3781 aaatgactat tgaaaagttt tgttgggact gacaaagcac atgcttagca tgcataaaac
     3841 ctgagctcaa tcaaaagaaa agaaatataa ataaagttaa gtcattagaa aagatccaaa
     3901 ctccttaagt aagaaaaaga atatgcttta tctgacagaa ttattacatc atttgttctt
     3961 aaattcaacc atccatgttg aagttttagt catgagcaga cattgagttc agatgcgata
     4021 acatggtctc ccggaaagaa aattacacgt acctaaaaat ccaattgcat tagcacagaa
     4081 acacaaaagc ctttagtcct actcattgaa tctgtacttt tgagcatata gcttcataat
     4141 ctgcaagaaa ctgagagcca cttcacagaa gtacagagaa gccccaatgt ttaggagcac
     4201 acatagcctc gagtgtgcac caaagctgct gggtccttcc tgtggaagaa aggactgtgt
     4261 gtcatgcatg cgagtggtag tgtccatgac atttacattc catacctatg gaacctttga
     4321 ttatacatac gtttcattaa atgaaaagat gaatttgttg cagagaacat gttccatttt
     4381 tatagcatga gaacagtaca gtcaaccatt tattccgtag tcacgttgaa gattcagaat
     4441 ccccaccatg tacataggaa caaccagcat ttgctctcct ccgggacttg caggaccctc
     4501 gctggaagtc ctataggtct ttggctttga ttcgtatcac catacacaac agtcaccggc
     4561 tcttcatctc ctcatgtgca acctgcacag tttccagcca cacagaaaag gcgagggcag
     4621 atgctcaaag tgaactaaga tgaggatcat gaggaagcca gccgctgcac cgtacatggt
     4681 cagcaccgtg tcctcaaacg ggaggtagca cttggacaga gcgtaatctc tggatgtcag
     4741 gctgccctgg ggggagaaac ggaaagttta tgctgcaggg taagtctcag gcataagtct
     4801 gacctagaag ctgtcttcta ggttccctca tgtgggtctg ggagggaaga gacctcttta
     4861 cccacgacca agaggcttca agcatgacat gccaacactg accacacagg tactgacaaa
     4921 agaaagaagc caaagatatg ctgacttgta tgctgacaca cccctcccct ccattaaaat
     4981 gcattccaca cacagtaggg cagccccaga gggagaccta gaagcatcag aggaatgaga
     5041 ggatgagcaa tgagcgtttc cctgccactg gatagcagag cagtctccct gttgcccaga
     5101 agtgcctctg cacctccgta ggcttttcac tgtaggcagt gtgggaccaa ggtagcaaat
     5161 gttttcacct acttgaactt gaaagcacaa agggtcccca cctttttata gccaggccta
     5221 tgaaacagta gcctaagact gggtgccaga acccatggta acaaagatgg tgtttcaccg
     5281 agtcaccacc tttcacagac ttggagattc tgcactacca tgtgcctggc acatttagac
     5341 aataagagat gaccaagtct gctattgagt agacaactgt ttccctcgaa acagactggc
     5401 acttgctgga ctccacctct gctcctcaga gtctcagccc tgaagccaca ttctgcctat
     5461 ttgtccccag acagacgact agagacaggt ggtgcatcca cccagagtgc aaagagggca
     5521 atttatttct ggcttttgtg tgtttttaca gattgcagcc attaagtagt tgattactgt
     5581 gttgatttca atactcaaga aagctttcag ataaaataat aataataata aaggtttacg
     5641 ttaccatgat gaaa
//
