LOCUS       NM_010307               5489 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus guanine nucleotide binding protein, alpha stimulating,
            olfactory type (Gnal), transcript variant 1, mRNA.
ACCESSION   NM_010307
VERSION     NM_010307.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5489)
  AUTHORS   Millett,M., Heuberger,A., Martin Castosa,E., Comite,A., Wagner,P.,
            Hall,D., Gallardo,I., Chambers,N.E., Wagner,L., Reinhardt,J. and
            Moehle,M.S.
  TITLE     Neuron specific quantitation of Galphaolf expression and signaling
            in murine brain tissue
  JOURNAL   Brain Res 1842, 149105 (2024)
   PUBMED   38960060
  REMARK    GeneRIF: Neuron specific quantitation of Galphaolf expression and
            signaling in murine brain tissue.
REFERENCE   2  (bases 1 to 5489)
  AUTHORS   Aissa,H.B., Sala,R.W., Georgescu Margarint,E.L., Frontera,J.L.,
            Varani,A.P., Menardy,F., Pelosi,A., Herve,D., Lena,C. and Popa,D.
  TITLE     Functional abnormalities in the cerebello-thalamic pathways in a
            mouse model of DYT25 dystonia
  JOURNAL   Elife 11, e79135 (2022)
   PUBMED   35699413
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5489)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5489)
  AUTHORS   Melis,C., Beauvais,G., Muntean,B.S., Cirnaru,M.D., Otrimski,G.,
            Creus-Muncunill,J., Martemyanov,K.A., Gonzalez-Alegre,P. and
            Ehrlich,M.E.
  TITLE     Striatal Dopamine Induced ERK Phosphorylation Is Altered in Mouse
            Models of Monogenic Dystonia
  JOURNAL   Mov Disord 36 (5), 1147-1157 (2021)
   PUBMED   33458877
REFERENCE   5  (bases 1 to 5489)
  AUTHORS   Nagai,M.H., Xavier,V.P.S., Gutiyama,L.M., Machado,C.F., Reis,A.H.,
            Donnard,E.R., Galante,P.A.F., Abreu,J.G., Festuccia,W.T. and
            Malnic,B.
  TITLE     Depletion of Ric-8B leads to reduced mTORC2 activity
  JOURNAL   PLoS Genet 16 (5), e1008255 (2020)
   PUBMED   32392211
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5489)
  AUTHORS   Williams,C.J., Schultz,R.M. and Kopf,G.S.
  TITLE     G protein gene expression during mouse oocyte growth and
            maturation, and preimplantation embryo development
  JOURNAL   Mol Reprod Dev 44 (3), 315-323 (1996)
   PUBMED   8858601
REFERENCE   7  (bases 1 to 5489)
  AUTHORS   Justice,M.J., Gilbert,D.J., Kinzler,K.W., Vogelstein,B.,
            Buchberg,A.M., Ceci,J.D., Matsuda,Y., Chapman,V.M., Patriotis,C.,
            Makris,A. et al.
  TITLE     A molecular genetic linkage map of mouse chromosome 18 reveals
            extensive linkage conservation with human chromosomes 5 and 18
  JOURNAL   Genomics 13 (4), 1281-1288 (1992)
   PUBMED   1354644
REFERENCE   8  (bases 1 to 5489)
  AUTHORS   Wilkie,T.M., Gilbert,D.J., Olsen,A.S., Chen,X.N., Amatruda,T.T.,
            Korenberg,J.R., Trask,B.J., de Jong,P., Reed,R.R., Simon,M.I. et
            al.
  TITLE     Evolution of the mammalian G protein alpha subunit multigene family
  JOURNAL   Nat Genet 1 (2), 85-91 (1992)
   PUBMED   1302014
  REMARK    Review article
REFERENCE   9  (bases 1 to 5489)
  AUTHORS   Strathmann,M., Wilkie,T.M. and Simon,M.I.
  TITLE     Diversity of the G-protein family: sequences from five additional
            alpha subunits in the mouse
  JOURNAL   Proc Natl Acad Sci U S A 86 (19), 7407-7409 (1989)
   PUBMED   2508088
REFERENCE   10 (bases 1 to 5489)
  AUTHORS   Jones,D.T. and Reed,R.R.
  TITLE     Golf: an olfactory neuron specific-G protein involved in odorant
            signal transduction
  JOURNAL   Science 244 (4906), 790-795 (1989)
   PUBMED   2499043
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK158831.1 and AC140336.2.
            
            On Dec 24, 2013 this sequence version replaced NM_010307.2.
            
            Transcript Variant: This variant (1) represents the use of an
            alternate promoter, differs in the 5' UTR and initiates translation
            at an alternate start codon compared to variant 2. The encoded
            protein (isoform 1) has a distinct N-terminus and is shorter than
            isoform 2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158831.1, SRR9219379.38016.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1008              AK158831.1         2-1009
            1009-1009           AC140336.2         34831-34831         c
            1010-2136           AK158831.1         1011-2137
            2137-2137           AC140336.2         24942-24942         c
            2138-2754           AK158831.1         2139-2755
            2755-2755           AC140336.2         24324-24324         c
            2756-2932           AK158831.1         2757-2933
            2933-5489           AC140336.2         21590-24146         c
FEATURES             Location/Qualifiers
     source          1..5489
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 39.85 cM"
     gene            1..5489
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /note="guanine nucleotide binding protein, alpha
                     stimulating, olfactory type"
                     /db_xref="GeneID:14680"
                     /db_xref="MGI:MGI:95774"
     exon            1..411
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..1412
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /note="isoform 1 is encoded by transcript variant 1;
                     guanine nucleotide-binding protein G(olf) subunit alpha;
                     adenylate cyclase-stimulating G alpha protein, olfactory
                     type; guanine nucleotide binding protein, alpha 10; G
                     alpha 10; heterotrimeric guanine nucleotide-binding
                     protein 1o"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein G(olf)
                     subunit alpha isoform 1"
                     /protein_id="NP_034437.1"
                     /db_xref="CCDS:CCDS29318.1"
                     /db_xref="GeneID:14680"
                     /db_xref="MGI:MGI:95774"
                     /translation="MGCLGNSSKTAEDQGVDEKERREANKKIEKQLQKERLAYKATHR
                     LLLLGAGESGKSTIVKQMRILHVNGFNPEEKKQKILDIRKNVKDAIVTIVSAMSTIIP
                     PVPLANPENQFRSDYIKSIAPITDFEYSQEFFDHVKKLWDDEGVKACFERSNEYQLID
                     CAQYFLERIDSVSLVDYTPTDQDLLRCRVLTSGIFETRFQVDKVNFHMFDVGGQRDER
                     RKWIQCFNDVTAIIYVAACSSYNMVIREDNNTNRLRESLDLFESIWNNRWLRTISIIL
                     FLNKQDMLAEKVLAGKSKIEDYFPEYANYTVPEDATPDAGEDPKVTRAKFFIRDLFLR
                     ISTATGDGKHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLKQYELL"
     exon            412..484
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /inference="alignment:Splign:2.1.0"
     exon            485..539
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /inference="alignment:Splign:2.1.0"
     exon            540..659
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /inference="alignment:Splign:2.1.0"
     exon            660..757
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /inference="alignment:Splign:2.1.0"
     exon            758..812
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /inference="alignment:Splign:2.1.0"
     exon            813..886
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /inference="alignment:Splign:2.1.0"
     exon            887..945
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1066
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1197
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1265
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..5489
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2733..2738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /note="hexamer: AATAAG"
     polyA_site      2760
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /note="major polyA site"
     regulatory      5450..5455
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /note="hexamer: AATAAT"
     regulatory      5462..5467
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /note="hexamer: AATAAA"
     polyA_site      5467
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
     polyA_site      5489
                     /gene="Gnal"
                     /gene_synonym="2610011C15Rik; 9630020G10Rik; Galphaolf;
                     Gna10; Golf; Hg1o"
                     /note="major polyA site"
ORIGIN      
        1 gtgtgcgctg tttccccagc aggttcctaa gacgacctgc ctttaaggag cgtttccctg
       61 ggcgcgcctg cctcccggcg ccgttagccg ggagcgtgcg gtgggcaggg gagggagaag
      121 cccgtgcgat cgcagatccc cgggagacct ggccgtctct ttcagtatca gagagcggag
      181 acgccgtcgc gggagcgcac atctcggggt ctcgctggct ctggtgcgcc ttcctacttg
      241 cctgaccgca gagcgagcca gcaggcatgg ggtgtttggg caacagcagc aagaccgcgg
      301 aagatcaggg cgtagatgaa aaagaacgcc gcgaggccaa caaaaagatc gagaagcagt
      361 tgcagaaaga gcgcctggct tacaaagcaa ctcaccgcct gctgcttctg ggggctggtg
      421 agtccgggaa aagcactatc gtcaaacaga tgaggatcct gcacgtcaat ggcttcaacc
      481 ccgaggaaaa gaagcagaaa attctggaca tcaggaaaaa tgtcaaagat gcgatcgtga
      541 caatcgtttc agcaatgagt actatcatac ctccagttcc actggccaac cctgagaacc
      601 agttccggtc agattatatc aagagcatag cccctatcac tgactttgaa tattcccagg
      661 agttctttga ccatgtgaag aagctgtggg acgatgaagg agtgaaggcc tgctttgaga
      721 gatccaacga gtaccagctg atcgactgtg cacaatactt cctggaaagg attgacagtg
      781 tcagtctggt tgactacaca cccacagacc aggacctgct cagatgcaga gtgctgacat
      841 caggaatctt tgagacacga ttccaagtgg acaaagtgaa ctttcacatg tttgatgttg
      901 gaggccagag agatgagaga agaaaatgga tccagtgttt taatgatgtc actgcgatca
      961 tttacgtggc ggcctgtagt agctacaaca tggtgatccg ggaagataac aataccaaca
     1021 gacttcggga atcactggac ctgtttgaaa gcatctggaa taacaggtgg ttgcgaacca
     1081 tttctatcat cctattcttg aacaaacaag acatgctggc agaaaaagtc ttggcaggga
     1141 agtcaaaaat cgaagactat ttcccggagt atgccaatta tactgtccct gaagatgcaa
     1201 caccagatgc gggagaagat cccaaagtta caagagcaaa gttctttatc cgggatctgt
     1261 tcttgaggat cagcacagcc acgggtgatg gcaaacatta ctgctaccct cacttcacct
     1321 gcgccgtgga cacagagaac atccgcagag tgttcaacga ttgccgtgac atcatccaga
     1381 gaatgcatct caagcagtac gaactcttgt gagggctacc tacccctcct ccccctaaac
     1441 ctacccctcc tcctcctcct cactgctgcc tcttctccct cttggccacc ccatgaggca
     1501 gcatatctcc ctagcctgcg tgtctgtcca ccctgagcca tggtagggcg tagtgagtgt
     1561 ctagtgtcat caggctgccg tctgtcctgt cctaggtatg cctacatgta accaccaagc
     1621 ctctggctac ctctgttccc caaggtttgg ttctgtgact ttgttttcac cggactaaac
     1681 agccccccca ccaccaattt gtatcactgc gaagccacca actctcactt gggtgacact
     1741 gcagtggatt tttttcgggg tgggaatcta tttatgcttt gattgattgg ttgatgggtc
     1801 gaatcatcag agacagctta gtgaatgggg gagttacatt gttttcaagt tatcaagcat
     1861 gatcacaaaa tcgtccagac agtgccatgc acttgattct tccctttata aaacgtcagg
     1921 ctaccaggtg tctgcccctc ctggtctgca ttggcccaag gcttagaata gatccaagtc
     1981 agcaacagaa taagaggaac tttttcagcc acagttgcaa tggctgtaag ccttgggcat
     2041 ttggagagag cttctgggag ccttttacac ttgggcagaa aacctgccac attcactact
     2101 gcaaatggtg tcctgtttat aaacaagggg tcctctacac ctttacaata gcatagtcat
     2161 tcctatcttc tttctgttgt tgctttaacc agactgtaga gaccccaaga tgtaatactc
     2221 ttttctatgg ctactcaaga atcctccttg tagagttctg tgccttggtg gcggccacac
     2281 ctgtaaggaa acatatccca actgtgtcta gcagtttgca gtccacactg cctgctgctt
     2341 cacagtggga aatcgatagt gtctattcct cttagggtat ttttatcagg ttagtactta
     2401 gggaagactc gttgatttta gaatcgtcca ctttaccagc ggtatcatcc gaacactgaa
     2461 aactatcaca gctacctgct tttactaccc caaacctcag ctgctgcaaa cactggaatg
     2521 acccacttcc aaggcataaa ttacaaccag ttctgttttc agggtactaa gggccccccc
     2581 cccatatgaa atgtttctga tgatcccttc aagttctgta ggcaggagca ggccagcaat
     2641 cccttcatta agttctacac acagtccacc aaacaaaaag ccagtggtca gaggaacgca
     2701 cagtggtgtc gatgttgtat atgactgagg acaataagat ggtgtcttct gaagaggaaa
     2761 tactacaaag ctgcttattc attatctgtc tctctatctg cattgctagg gatgagccca
     2821 gcacctagag catgctagat gagcgctcga ctgccagtcc atatcccagt cataactcca
     2881 gcccccccac aaaaaccttt aaatataaag acaaaataaa tggctgttcc tcacatatgt
     2941 aagacctgca aatgcaacct cgagttactg taggacacct agacacagct cactctgtct
     3001 aagttccgag gctttggggg gtcattctta ggcttaagtt atctgtaaag ctgtccaaag
     3061 ttaagttttt aacagtacaa atagggggga gtgacagcct gcattgctca atcatctctt
     3121 accgttactt caagtttatt ctaaaaactg gcattgtaga atgctctaaa aactcatcct
     3181 ggctgagatg ctcatccatg aaaggataca acacattctt caactcctca tcactgtctt
     3241 cttgtgccat tcactaccat ggcacaaaac ttccatctga agccaggcaa tgaggacaca
     3301 cgcctttaat cccagcactc gggaggcaga ggcaggcgga tctctgagtt cgaggccagc
     3361 ctggtctaca gagtgagttc caggacaact agggctgcac agagaaaccc tgtctcaaac
     3421 aaaacaaaca aacaaacttc catctgtacc aacacatgat atgagagtga ctttcagttc
     3481 tcctgcactc ttaaagcaaa gcaagaagaa aaacttgtgt tcacacacac acacacacac
     3541 acacacacac acacacacac gtgaggtttt tttatactat agtttgcatt actacccagc
     3601 agttccctgc tcactaaatg actattgaaa agttttgttg ggactgacaa agcacatgct
     3661 tagcatgcat aaaacctgag ctcaatcaaa agaaaagaaa tataaataaa gttaagtcat
     3721 tagaaaagat ccaaactcct taagtaagaa aaagaatatg ctttatctga cagaattatt
     3781 acatcatttg ttcttaaatt caaccatcca tgttgaagtt ttagtcatga gcagacattg
     3841 agttcagatg cgataacatg gtctcccgga aagaaaatta cacgtaccta aaaatccaat
     3901 tgcattagca cagaaacaca aaagccttta gtcctactca ttgaatctgt acttttgagc
     3961 atatagcttc ataatctgca agaaactgag agccacttca cagaagtaca gagaagcccc
     4021 aatgtttagg agcacacata gcctcgagtg tgcaccaaag ctgctgggtc cttcctgtgg
     4081 aagaaaggac tgtgtgtcat gcatgcgagt ggtagtgtcc atgacattta cattccatac
     4141 ctatggaacc tttgattata catacgtttc attaaatgaa aagatgaatt tgttgcagag
     4201 aacatgttcc atttttatag catgagaaca gtacagtcaa ccatttattc cgtagtcacg
     4261 ttgaagattc agaatcccca ccatgtacat aggaacaacc agcatttgct ctcctccggg
     4321 acttgcagga ccctcgctgg aagtcctata ggtctttggc tttgattcgt atcaccatac
     4381 acaacagtca ccggctcttc atctcctcat gtgcaacctg cacagtttcc agccacacag
     4441 aaaaggcgag ggcagatgct caaagtgaac taagatgagg atcatgagga agccagccgc
     4501 tgcaccgtac atggtcagca ccgtgtcctc aaacgggagg tagcacttgg acagagcgta
     4561 atctctggat gtcaggctgc cctgggggga gaaacggaaa gtttatgctg cagggtaagt
     4621 ctcaggcata agtctgacct agaagctgtc ttctaggttc cctcatgtgg gtctgggagg
     4681 gaagagacct ctttacccac gaccaagagg cttcaagcat gacatgccaa cactgaccac
     4741 acaggtactg acaaaagaaa gaagccaaag atatgctgac ttgtatgctg acacacccct
     4801 cccctccatt aaaatgcatt ccacacacag tagggcagcc ccagagggag acctagaagc
     4861 atcagaggaa tgagaggatg agcaatgagc gtttccctgc cactggatag cagagcagtc
     4921 tccctgttgc ccagaagtgc ctctgcacct ccgtaggctt ttcactgtag gcagtgtggg
     4981 accaaggtag caaatgtttt cacctacttg aacttgaaag cacaaagggt ccccaccttt
     5041 ttatagccag gcctatgaaa cagtagccta agactgggtg ccagaaccca tggtaacaaa
     5101 gatggtgttt caccgagtca ccacctttca cagacttgga gattctgcac taccatgtgc
     5161 ctggcacatt tagacaataa gagatgacca agtctgctat tgagtagaca actgtttccc
     5221 tcgaaacaga ctggcacttg ctggactcca cctctgctcc tcagagtctc agccctgaag
     5281 ccacattctg cctatttgtc cccagacaga cgactagaga caggtggtgc atccacccag
     5341 agtgcaaaga gggcaattta tttctggctt ttgtgtgttt ttacagattg cagccattaa
     5401 gtagttgatt actgtgttga tttcaatact caagaaagct ttcagataaa ataataataa
     5461 taataaaggt ttacgttacc atgatgaaa
//
