LOCUS       NM_010306               3294 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus G protein subunit alpha i3 (Gnai3), mRNA.
ACCESSION   NM_010306
VERSION     NM_010306.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3294)
  AUTHORS   Hartig,E.I., Day,M., Jarysta,A. and Tarchini,B.
  TITLE     Proteins required for stereocilia elongation during mammalian hair
            cell development ensure precise and steady heights during adult
            life
  JOURNAL   Proc Natl Acad Sci U S A 121 (40), e2405455121 (2024)
   PUBMED   39320919
REFERENCE   2  (bases 1 to 3294)
  AUTHORS   Jarysta,A., Tadenev,A.L.D., Day,M., Krawchuk,B., Low,B.E.,
            Wiles,M.V. and Tarchini,B.
  TITLE     Inhibitory G proteins play multiple roles to polarize sensory hair
            cell morphogenesis
  JOURNAL   Elife 12, 88186 (2024)
   PUBMED   38651641
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3294)
  AUTHORS   Schroper,T., Mehrkens,D., Leiss,V., Tellkamp,F., Engelhardt,S.,
            Herzig,S., Birnbaumer,L., Nurnberg,B. and Matthes,J.
  TITLE     Protective effects of Galphai3 deficiency in a murine heart-failure
            model of beta1-adrenoceptor overexpression
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 397 (4), 2401-2420 (2024)
   PUBMED   37843590
  REMARK    GeneRIF: Protective effects of Galphai3 deficiency in a murine
            heart-failure model of beta1-adrenoceptor overexpression.
REFERENCE   4  (bases 1 to 3294)
  AUTHORS   Li,Y., Chai,J.L., Shi,X., Feng,Y., Li,J.J., Zhou,L.N., Cao,C. and
            Li,K.R.
  TITLE     Galphai1/3 mediate Netrin-1-CD146-activated signaling and
            angiogenesis
  JOURNAL   Theranostics 13 (7), 2319-2336 (2023)
   PUBMED   37153740
  REMARK    GeneRIF: Galphai1/3 mediate Netrin-1-CD146-activated signaling and
            angiogenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3294)
  AUTHORS   Akturk,A., Day,M. and Tarchini,B.
  TITLE     RGS12 polarizes the GPSM2-GNAI complex to organize and elongate
            stereocilia in sensory hair cells
  JOURNAL   Sci Adv 8 (42), eabq2826 (2022)
   PUBMED   36260679
REFERENCE   6  (bases 1 to 3294)
  AUTHORS   Rock,B., Xin,L. and Niederhuber,J.E.
  TITLE     71.67 T lymphocyte activation is accompanied by the down-regulation
            of three G alpha genes
  JOURNAL   Cell Immunol 164 (2), 316-321 (1995)
   PUBMED   7656338
REFERENCE   7  (bases 1 to 3294)
  AUTHORS   Wilkie,T.M., Gilbert,D.J., Olsen,A.S., Chen,X.N., Amatruda,T.T.,
            Korenberg,J.R., Trask,B.J., de Jong,P., Reed,R.R., Simon,M.I. et
            al.
  TITLE     Evolution of the mammalian G protein alpha subunit multigene family
  JOURNAL   Nat Genet 1 (2), 85-91 (1992)
   PUBMED   1302014
  REMARK    Review article
REFERENCE   8  (bases 1 to 3294)
  AUTHORS   Strathmann,M., Wilkie,T.M. and Simon,M.I.
  TITLE     Diversity of the G-protein family: sequences from five additional
            alpha subunits in the mouse
  JOURNAL   Proc Natl Acad Sci U S A 86 (19), 7407-7409 (1989)
   PUBMED   2508088
REFERENCE   9  (bases 1 to 3294)
  AUTHORS   Blatt,C., Eversole-Cire,P., Cohn,V.H., Zollman,S., Fournier,R.E.,
            Mohandas,L.T., Nesbitt,M., Lugo,T., Jones,D.T., Reed,R.R. et al.
  TITLE     Chromosomal localization of genes encoding guanine
            nucleotide-binding protein subunits in mouse and human
  JOURNAL   Proc Natl Acad Sci U S A 85 (20), 7642-7646 (1988)
   PUBMED   2902634
REFERENCE   10 (bases 1 to 3294)
  AUTHORS   Jones,D.T. and Reed,R.R.
  TITLE     Molecular cloning of five GTP-binding protein cDNA species from rat
            olfactory neuroepithelium
  JOURNAL   J Biol Chem 262 (29), 14241-14249 (1987)
   PUBMED   2820999
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY126665.1, AK169285.1 and BP765831.1.
            
            On Aug 13, 2013 this sequence version replaced NM_010306.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004566.1, AK169285.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                BY126665.1         2-26
            26-3251             AK169285.1         1-3226
            3252-3294           BP765831.1         11-53               c
FEATURES             Location/Qualifiers
     source          1..3294
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.83 cM"
     gene            1..3294
                     /gene="Gnai3"
                     /gene_synonym="Galphai3; Gnai-3; Hg1a"
                     /note="G protein subunit alpha i3"
                     /db_xref="GeneID:14679"
                     /db_xref="MGI:MGI:95773"
     exon            1..265
                     /gene="Gnai3"
                     /gene_synonym="Galphai3; Gnai-3; Hg1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..1212
                     /gene="Gnai3"
                     /gene_synonym="Galphai3; Gnai-3; Hg1a"
                     /note="guanine nucleotide-binding protein G(k) subunit
                     alpha; g(i) alpha-3; guanine nucleotide binding protein,
                     alpha inhibiting 3; guanine nucleotide-binding protein
                     G(i) subunit alpha; heterotrimeric guanine
                     nucleotide-binding protein 1a; guanine nucleotide binding
                     protein (G protein), alpha inhibiting 3"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein G(i) subunit
                     alpha-3"
                     /protein_id="NP_034436.1"
                     /db_xref="CCDS:CCDS17751.1"
                     /db_xref="GeneID:14679"
                     /db_xref="MGI:MGI:95773"
                     /translation="MGCTLSAEDKAAVERSKMIDRNLREDGEKAAKEVKLLLLGAGES
                     GKSTIVKQMKIIHEDGYSEDECKQYKVVVYSNTIQSIIAIIRAMGRLKIDFGESARAD
                     DARQLFVLAGSAEEGVMTSELAGVIKRLWRDGGVQACFSRSREYQLNDSASYYLNDLD
                     RISQTNYIPTQQDVLRTRVKTTGIVETHFTFKELYFKMFDVGGQRSERKKWIHCFEGV
                     TAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEE
                     KIKRSPLTICYPEYTGSNTYEEAAAYIQCQFEDLNRRKDTKEVYTHFTCATDTKNVQF
                     VFDAVTDVIIKNNLKECGLY"
     exon            266..308
                     /gene="Gnai3"
                     /gene_synonym="Galphai3; Gnai-3; Hg1a"
                     /inference="alignment:Splign:2.1.0"
     exon            309..450
                     /gene="Gnai3"
                     /gene_synonym="Galphai3; Gnai-3; Hg1a"
                     /inference="alignment:Splign:2.1.0"
     exon            451..608
                     /gene="Gnai3"
                     /gene_synonym="Galphai3; Gnai-3; Hg1a"
                     /inference="alignment:Splign:2.1.0"
     exon            609..737
                     /gene="Gnai3"
                     /gene_synonym="Galphai3; Gnai-3; Hg1a"
                     /inference="alignment:Splign:2.1.0"
     exon            738..867
                     /gene="Gnai3"
                     /gene_synonym="Galphai3; Gnai-3; Hg1a"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1021
                     /gene="Gnai3"
                     /gene_synonym="Galphai3; Gnai-3; Hg1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1231
                     /gene="Gnai3"
                     /gene_synonym="Galphai3; Gnai-3; Hg1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..3273
                     /gene="Gnai3"
                     /gene_synonym="Galphai3; Gnai-3; Hg1a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3121..3126
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnai3"
                     /gene_synonym="Galphai3; Gnai-3; Hg1a"
                     /note="hexamer: AATAAA"
     polyA_site      3146
                     /gene="Gnai3"
                     /gene_synonym="Galphai3; Gnai-3; Hg1a"
                     /note="major polyA site"
     regulatory      3232..3237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnai3"
                     /gene_synonym="Galphai3; Gnai-3; Hg1a"
                     /note="hexamer: ATTAAA"
     polyA_site      3268
                     /gene="Gnai3"
                     /gene_synonym="Galphai3; Gnai-3; Hg1a"
                     /note="major polyA site"
ORIGIN      
        1 aaacagcaca catccggttc ttccgggagc taggggagct gacggagaag gccaccgccc
       61 agcagaagac ccgtctccgc cggtgtgtgg cgattcccgc ggtgtgtgtg agtgagcccg
      121 ggcccggtcc cctctcccgc cgccgccatg ggctgcacgt tgagcgccga ggacaaggcg
      181 gcggtggagc ggagcaagat gatcgaccgc aacttgcggg aggacgggga gaaagcggcc
      241 aaagaagtga agctgctgct gctcggcgct ggagaatctg gtaaaagtac catcgtgaaa
      301 cagatgaaaa tcattcatga ggacggctat tcagaggacg aatgtaaaca gtataaagta
      361 gttgtctaca gcaatactat tcagtccatc attgcaatca tacgagccat gggacggttg
      421 aagattgatt ttggggaatc tgccagagca gatgatgccc gacagttatt tgttttagct
      481 gggagtgctg aagaaggagt catgacttca gaactagcag gcgtgattaa acgtttatgg
      541 cgagatggcg gggtacaggc atgctttagc aggtccaggg aatatcagct caatgattct
      601 gcttcatact acctaaatga tttggataga atatcccaga ccaactacat tccaactcag
      661 caagatgttc ttcggacaag agtgaagact acaggcattg tggagaccca cttcaccttc
      721 aaggaactct acttcaaaat gtttgatgta ggtggccaaa gatccgaacg aaaaaagtgg
      781 attcactgtt ttgagggagt gacagcaatt atcttttgtg tggctctcag tgattacgac
      841 cttgttctgg ctgaggatga ggaaatgaac cgaatgcatg aaagcatgaa attgtttgac
      901 agcatttgta acaacaaatg gtttacagac acttcaatca ttctctttct taataagaaa
      961 gacctttttg aggaaaaaat aaagaggagt ccattaacaa tctgttatcc agaatacaca
     1021 ggttccaata catacgaaga ggcagctgct tacattcagt gccagtttga agatctgaac
     1081 cgaagaaaag ataccaagga ggtctacact cacttcacct gtgccacaga caccaaaaat
     1141 gtgcagtttg tttttgatgc tgttacggat gtcatcatta aaaacaactt aaaggaatgt
     1201 gggctttatt gagaggatgg catagtaaaa gctattacag ggaggagtgt tgagaccaga
     1261 tgtcatctac tgtctcttgg gtcagcagca cgcatgacag gaccaaggaa tggcagcaac
     1321 acgcagaatc ttagctagcg ctctccagca gtcttctcta ttagggaatg tctaattggc
     1381 atgagatgtt caaatcagac ctgggattgg acaactgtaa agtatgactg gatcgtcagg
     1441 gcgtcgcttg gactctgtaa tctaatgttt agggcatatt gaagttgagg tgctgccttc
     1501 cagaacttaa acatgtagct cactttcccc catctttttg acaaatgacc agtagttaat
     1561 ttctaaggtt tttcttatca agagaagaat acttaaaaac tcttccttgt ttgcaaaaga
     1621 aacttctgag gactgagtct taactatgca cacaatgtca ccagacatct tgaaactatt
     1681 cctcttagta ggaactgttt gtttttaact cttggaatgg tcgggagtaa tatttcaata
     1741 attaaaattc ttcctggtta ttgggactat attaatagag cttttcggaa tgaaatttat
     1801 gttactgtca tgtttaaagt accacaatgg tttctaaaca gcattcacct tggagagttc
     1861 tacagtacga ttcctgctct cattgcttta cgcttacggt tggaagttgt atttgtcggg
     1921 gttaaccttg tttgtgctga ttaccaaatt actagatgaa tactgatgta gtgtgttaaa
     1981 ctgcttcttg gacacacgca ggatagccgt caatgagatg cagatgctaa attgagaacc
     2041 agtggcttgc tgctacaggt ctactaagtt gaccacatgg aatcttgcct gtttgtctcg
     2101 gtcatgggga ggttttgaat aagatgcccc ttgttttcca tcttcgtggc cttttttgtt
     2161 aggagacatc taaaagtgta ttaacagtgc atgcttttcc tttgtaaatg tggtgccaaa
     2221 tccctgtttg ccatcgtttt tactgtagca atgttaactg tagtagtagt ccttactata
     2281 ttctttttct aaaacttgca tttggggact ttttccacct tgtcgtgtac agatttgaat
     2341 ctgttacagt tggcagcagt attaaaacaa acggtgagtg aagagcctac ggttgctccg
     2401 tgcataacta gttctttctg gggatcctgt ctgtctcttt tttcccctga cctctgtctg
     2461 agagtggatt tattaggtag aaaagtgtct ttgaaagtct agctccttga tgtaatagta
     2521 ttaccaagtc aggactgagg gctttatgtg cagtccgtgt acaagaggaa agtcacaatc
     2581 cggctttcgg atgtgtacag tttgcttgtg ctgagagcta cagtcctttt gtacagtata
     2641 tatcaaatgt cattaaacac tgagtggaca ctgagggaca gcaaacaatg catttggagc
     2701 atttcagatc agtagtttga tcagtgcctt ttgaggtcca gtcgctgtgg ctcggatcca
     2761 ttcatctcta tgttacctcc tactcgtttg aaagaaggtt gatggtcaga actgcttcag
     2821 aagcaagcca cggtgatcag tgcctttgtt ggcagctttt acaattttta attcttacgt
     2881 gttttgcaaa atcattatta tgcagacagt ataactgtta tcttacaaat atttcgttag
     2941 ggctaggaaa atgtcacttg aaagaaagaa aagtattgat ttcaatcggc gattgactca
     3001 attcccacaa tgtaggggct aataagtctt actctgaatt tatctttcct ttgttgtatt
     3061 ctgtaatata agaacatctg gtgaaatatt gttttcataa tttttctata ctttgggttt
     3121 aataaaatgg tgttgataat ctaaaatatt agataatcca aatttaattt tacttcagaa
     3181 tgcattttgt attttcattt gaatctgtct attttttaaa cctttctgtt aattaaaaat
     3241 agaagttctt cacttctttg tctctgcaca ccaaaaaaaa aaaaaaaaaa aaaa
//
