LOCUS       NM_008138               2227 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus G protein subunit alpha i2 (Gnai2), transcript variant
            1, mRNA.
ACCESSION   NM_008138 XM_980919
VERSION     NM_008138.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2227)
  AUTHORS   Deng,X., Zeng,Y. and Ding,D.
  TITLE     MiR-30c-5p-Targeted Regulation of GNAI2 Improves Neural Function
            Injury and Inflammation in Cerebral Ischemia-Reperfusion Injury
  JOURNAL   Appl Biochem Biotechnol 196 (8), 5235-5248 (2024)
   PUBMED   38153649
  REMARK    GeneRIF: MiR-30c-5p-Targeted Regulation of GNAI2 Improves Neural
            Function Injury and Inflammation in Cerebral Ischemia-Reperfusion
            Injury.
REFERENCE   2  (bases 1 to 2227)
  AUTHORS   Jarysta,A., Tadenev,A.L.D., Day,M., Krawchuk,B., Low,B.E.,
            Wiles,M.V. and Tarchini,B.
  TITLE     Inhibitory G proteins play multiple roles to polarize sensory hair
            cell morphogenesis
  JOURNAL   Elife 12, 88186 (2024)
   PUBMED   38651641
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2227)
  AUTHORS   Weiss,J., Vacher,H., Trouillet,A.C., Leinders-Zufall,T., Zufall,F.
            and Chamero,P.
  TITLE     Sensing and avoiding sick conspecifics requires Galphai2+
            vomeronasal neurons
  JOURNAL   BMC Biol 21 (1), 152 (2023)
   PUBMED   37424020
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2227)
  AUTHORS   Dietschi,Q., Tuberosa,J., Fodoulian,L., Boillat,M., Kan,C.,
            Codourey,J., Pauli,V., Feinstein,P., Carleton,A. and Rodriguez,I.
  TITLE     Clustering of vomeronasal receptor genes is required for
            transcriptional stability but not for choice
  JOURNAL   Sci Adv 8 (46), eabn7450 (2022)
   PUBMED   36383665
REFERENCE   5  (bases 1 to 2227)
  AUTHORS   Akturk,A., Day,M. and Tarchini,B.
  TITLE     RGS12 polarizes the GPSM2-GNAI complex to organize and elongate
            stereocilia in sensory hair cells
  JOURNAL   Sci Adv 8 (42), eabq2826 (2022)
   PUBMED   36260679
  REMARK    GeneRIF: RGS12 polarizes the GPSM2-GNAI complex to organize and
            elongate stereocilia in sensory hair cells.
REFERENCE   6  (bases 1 to 2227)
  AUTHORS   Degen,S.J., Gilbert,D.J., Jenkins,N.A. and Copeland,N.G.
  TITLE     Assignment of the gene coding for hepatocyte growth factor-like
            protein to mouse chromosome 9
  JOURNAL   Genomics 13 (4), 1368-1369 (1992)
   PUBMED   1354648
REFERENCE   7  (bases 1 to 2227)
  AUTHORS   Wilkie,T.M., Gilbert,D.J., Olsen,A.S., Chen,X.N., Amatruda,T.T.,
            Korenberg,J.R., Trask,B.J., de Jong,P., Reed,R.R., Simon,M.I. et
            al.
  TITLE     Evolution of the mammalian G protein alpha subunit multigene family
  JOURNAL   Nat Genet 1 (2), 85-91 (1992)
   PUBMED   1302014
  REMARK    Review article
REFERENCE   8  (bases 1 to 2227)
  AUTHORS   De Maeyer-Guignard,J. and De Maeyer,E.
  TITLE     Linkage analysis of the Gi alpha 2 gene on mouse chromosome 9
  JOURNAL   Mamm Genome 3 (10), 601-603 (1992)
   PUBMED   1421769
REFERENCE   9  (bases 1 to 2227)
  AUTHORS   Strathmann,M. and Simon,M.I.
  TITLE     G protein diversity: a distinct class of alpha subunits is present
            in vertebrates and invertebrates
  JOURNAL   Proc Natl Acad Sci U S A 87 (23), 9113-9117 (1990)
   PUBMED   2123549
REFERENCE   10 (bases 1 to 2227)
  AUTHORS   Strathmann,M., Wilkie,T.M. and Simon,M.I.
  TITLE     Diversity of the G-protein family: sequences from five additional
            alpha subunits in the mouse
  JOURNAL   Proc Natl Acad Sci U S A 86 (19), 7407-7409 (1989)
   PUBMED   2508088
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ134826.1, AK167388.1 and CF951009.1.
            
            On Jun 16, 2018 this sequence version replaced NM_008138.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159222.1, AK167388.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 CJ134826.1         2-2
            2-2178              AK167388.1         3-2179
            2179-2227           CF951009.1         251-299
FEATURES             Location/Qualifiers
     source          1..2227
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 58.43 cM"
     gene            1..2227
                     /gene="Gnai2"
                     /gene_synonym="Galphai2; Gia; Gnai-2; Hg1c"
                     /note="G protein subunit alpha i2"
                     /db_xref="GeneID:14678"
                     /db_xref="MGI:MGI:95772"
     exon            1..244
                     /gene="Gnai2"
                     /gene_synonym="Galphai2; Gia; Gnai-2; Hg1c"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1194
                     /gene="Gnai2"
                     /gene_synonym="Galphai2; Gia; Gnai-2; Hg1c"
                     /note="adenylate cyclase-inhibiting G alpha protein;
                     heterotrimeric guanine nucleotide-binding protein 1c;
                     guanine nucleotide binding protein (G protein), alpha
                     inhibiting 2"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein G(i) subunit
                     alpha-2"
                     /protein_id="NP_032164.2"
                     /db_xref="CCDS:CCDS23502.1"
                     /db_xref="GeneID:14678"
                     /db_xref="MGI:MGI:95772"
                     /translation="MGCTVSAEDKAAAERSKMIDKNLREDGEKAAREVKLLLLGAGES
                     GKSTIVKQMKIIHEDGYSEEECRQYRAVVYSNTIQSIMAIVKAMGNLQIDFADPQRAD
                     DARQLFALSCAAEEQGMLPEDLSGVIRRLWADHGVQACFGRSREYQLNDSAAYYLNDL
                     ERIAQSDYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEG
                     VTAIIFCVALSAYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFE
                     EKITQSSLTICFPEYTGANKYDEAASYIQSKFEDLNKRKDTKEIYTHFTCATDTKNVQ
                     FVFDAVTDVIIKNNLKDCGLF"
     exon            245..287
                     /gene="Gnai2"
                     /gene_synonym="Galphai2; Gia; Gnai-2; Hg1c"
                     /inference="alignment:Splign:2.1.0"
     exon            288..429
                     /gene="Gnai2"
                     /gene_synonym="Galphai2; Gia; Gnai-2; Hg1c"
                     /inference="alignment:Splign:2.1.0"
     exon            430..590
                     /gene="Gnai2"
                     /gene_synonym="Galphai2; Gia; Gnai-2; Hg1c"
                     /inference="alignment:Splign:2.1.0"
     exon            591..719
                     /gene="Gnai2"
                     /gene_synonym="Galphai2; Gia; Gnai-2; Hg1c"
                     /inference="alignment:Splign:2.1.0"
     exon            720..849
                     /gene="Gnai2"
                     /gene_synonym="Galphai2; Gia; Gnai-2; Hg1c"
                     /inference="alignment:Splign:2.1.0"
     exon            850..1003
                     /gene="Gnai2"
                     /gene_synonym="Galphai2; Gia; Gnai-2; Hg1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1217
                     /gene="Gnai2"
                     /gene_synonym="Galphai2; Gia; Gnai-2; Hg1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..2191
                     /gene="Gnai2"
                     /gene_synonym="Galphai2; Gia; Gnai-2; Hg1c"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2163..2168
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnai2"
                     /gene_synonym="Galphai2; Gia; Gnai-2; Hg1c"
                     /note="hexamer: AATAAA"
     polyA_site      2173
                     /gene="Gnai2"
                     /gene_synonym="Galphai2; Gia; Gnai-2; Hg1c"
     polyA_site      2191
                     /gene="Gnai2"
                     /gene_synonym="Galphai2; Gia; Gnai-2; Hg1c"
                     /note="major polyA site"
ORIGIN      
        1 agtcgctcgg aactgcggac ctgagagctt cccgcagagg gccggcggtg ggagcggagt
       61 gggtcgggcg gggccgagcc gggccgtggg ccgtgtgggg gccaggccgg gccggcggac
      121 ggcaggatgg gctgcaccgt gagcgccgag gacaaggcgg cagccgagcg ctctaaaatg
      181 atcgacaaga acctgcggga ggacggcgag aaggcggcgc gggaggtgaa gttgcttctg
      241 ttaggtgctg gagagtcagg gaagagcacc atcgtcaagc agatgaagat catccatgaa
      301 gatggctact cagaagagga gtgccggcag taccgtgccg tggtctacag caacaccatc
      361 cagtctatca tggccatcgt gaaggccatg ggcaacctgc agatcgactt tgctgatccc
      421 cagcgtgcgg atgatgccag gcagctgttc gccctgtcct gtgctgcaga ggaacaaggg
      481 atgcttcctg aagacctgtc cggtgtcatc cggaggctct gggctgacca cggtgtgcaa
      541 gcctgctttg gccgctcacg agaataccag ctcaatgact cagccgctta ctacctgaat
      601 gatctggagc gcattgcaca gagtgactac atccctacac agcaggatgt gctgcggacc
      661 cgtgtgaaga ccacgggcat cgtggaaaca cacttcacct tcaaggactt acacttcaag
      721 atgtttgatg tgggtggtca gcggtctgag cgcaagaagt ggatccactg ctttgagggc
      781 gtcacggcca tcatcttctg tgtcgccttg agcgcttatg acttggtgct ggctgaggat
      841 gaggagatga accgcatgca tgagagcatg aagctgtttg acagcatctg caacaacaag
      901 tggttcacag acacctccat catcctcttc ctcaacaaga aggacctgtt tgaagaaaag
      961 atcacacaga gctccctgac catctgtttc cctgagtaca cgggggccaa caagtacgac
     1021 gaggcagcca gctacatcca gagcaagttt gaggatctaa ataagcgcaa agacaccaag
     1081 gagatctaca cgcacttcac gtgcgccacc gacaccaaga acgtgcagtt tgtgttcgat
     1141 gccgtcactg acgtcatcat caagaacaac ctgaaggact gtggcctctt ctgaggggca
     1201 gtggacctgg caggatgggc caccgctgac tgtgctcccc actacccctg aggaagatgg
     1261 gggcaagaag accatgttcc ctgcctgttc ccccagctgc ttctcccatc ttttctctct
     1321 gttctcagct cccctgtccc ctccctcggc tctagacttg ggggaggggt tgccacaggc
     1381 ctcccagtct aaaacccacc tttgtctgag gtgccgggag tagccatggt acccccttcc
     1441 tgggcatccg ttcgggtttt ctaaccgttg tcttgttctg gggtgagcgg ggagcgcatg
     1501 cagagatccc aaggcctatg tctggagggt accaactcct ccagcctaga cccctggctt
     1561 tgtccaacac cagccctgac ccaagtccaa atgtttacag ggagcctcct gcctacccca
     1621 ctctctgccg ctcggaggcc ccaaaggaaa aagcacaaga agcgtgagag ataccgccat
     1681 tcctggagac aaagcccacc tgctcattct cgtagcttta aagaaaaaga aaaaggaaaa
     1741 ataaggaaaa ctgcaaatct agaaaacttt ttagagaaac ctatttaaaa ctgtcaggtc
     1801 ctgaccagca cccccacccc agcccagccc cagccccacc cctttccagc gattccgtgc
     1861 cttgagtgtg tctgcgtgtt tacacccatc cctctttggg cggccccctg ctctgccctc
     1921 cacggaattg gattccaagg gctgttccag acaactgcca acgtcactga gggccctgct
     1981 ctgaagccct gggccctggc tccattaacc taaatgtagc tccttagcgc taatctagga
     2041 accgccgctg cctgctgagg gccaggcccc tcacgccctc gccccaggcc cgggtcctcc
     2101 agcgttgaac acttccttgc ttttttcaca tgttttatgg aattgttcac atgatttgaa
     2161 ataataaaat gtagaaagaa aacaccaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2221 aaaaaaa
//
