LOCUS       NM_010304               1974 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus guanine nucleotide binding protein, alpha 15 (Gna15),
            mRNA.
ACCESSION   NM_010304
VERSION     NM_010304.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1974)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1974)
  AUTHORS   Jiang,Z., Yue,W.W.S., Chen,L., Sheng,Y. and Yau,K.W.
  TITLE     Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in
            Intrinsically Photosensitive Retinal Ganglion Cells
  JOURNAL   Cell 175 (3), 652-664 (2018)
   PUBMED   30270038
REFERENCE   3  (bases 1 to 1974)
  AUTHORS   Wang,Q., Yue,W.W.S., Jiang,Z., Xue,T., Kang,S.H., Bergles,D.E.,
            Mikoshiba,K., Offermanns,S. and Yau,K.W.
  TITLE     Synergistic Signaling by Light and Acetylcholine in Mouse Iris
            Sphincter Muscle
  JOURNAL   Curr Biol 27 (12), 1791-1800 (2017)
   PUBMED   28578927
REFERENCE   4  (bases 1 to 1974)
  AUTHORS   Sato,T., Kawasaki,T., Mine,S. and Matsumura,H.
  TITLE     Functional Role of the C-Terminal Amphipathic Helix 8 of Olfactory
            Receptors and Other G Protein-Coupled Receptors
  JOURNAL   Int J Mol Sci 17 (11), 1930 (2016)
   PUBMED   27869740
  REMARK    GeneRIF: Data indicate that the hydrophobic core buried between
            helix 8 and TM1-2 of olfactory receptor (mOR-S6) is important for
            the activation of both G protein alpha 15 (Galpha15).
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1974)
  AUTHORS   Ray,J.P., Staron,M.M., Shyer,J.A., Ho,P.C., Marshall,H.D.,
            Gray,S.M., Laidlaw,B.J., Araki,K., Ahmed,R., Kaech,S.M. and
            Craft,J.
  TITLE     The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling,
            Differentiation, and Metabolism of T Helper 1 and Follicular B
            Helper T Cells
  JOURNAL   Immunity 43 (4), 690-702 (2015)
   PUBMED   26410627
REFERENCE   6  (bases 1 to 1974)
  AUTHORS   Thia,K.Y., Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and Smyth,M.J.
  TITLE     The natural killer cell serine protease gene Lmet1 maps to mouse
            chromosome 10
  JOURNAL   Immunogenetics 41 (1), 47-49 (1995)
   PUBMED   7806275
REFERENCE   7  (bases 1 to 1974)
  AUTHORS   Mallo,M., Steingrimsson,E., Copeland,N.G., Jenkins,N.A. and
            Gridley,T.
  TITLE     Genomic organization, alternative polyadenylation, and chromosomal
            localization of Grg, a mouse gene related to the groucho transcript
            of the Drosophila Enhancer of split complex
  JOURNAL   Genomics 21 (1), 194-201 (1994)
   PUBMED   7916324
REFERENCE   8  (bases 1 to 1974)
  AUTHORS   Brott,B.K., Alessandrini,A., Largaespada,D.A., Copeland,N.G.,
            Jenkins,N.A., Crews,C.M. and Erikson,R.L.
  TITLE     MEK2 is a kinase related to MEK1 and is differentially expressed in
            murine tissues
  JOURNAL   Cell Growth Differ 4 (11), 921-929 (1993)
   PUBMED   8297798
REFERENCE   9  (bases 1 to 1974)
  AUTHORS   Wilkie,T.M., Gilbert,D.J., Olsen,A.S., Chen,X.N., Amatruda,T.T.,
            Korenberg,J.R., Trask,B.J., de Jong,P., Reed,R.R., Simon,M.I. et
            al.
  TITLE     Evolution of the mammalian G protein alpha subunit multigene family
  JOURNAL   Nat Genet 1 (2), 85-91 (1992)
   PUBMED   1302014
  REMARK    Review article
REFERENCE   10 (bases 1 to 1974)
  AUTHORS   Wilkie,T.M., Scherle,P.A., Strathmann,M.P., Slepak,V.Z. and
            Simon,M.I.
  TITLE     Characterization of G-protein alpha subunits in the Gq class:
            expression in murine tissues and in stromal and hematopoietic cell
            lines
  JOURNAL   Proc Natl Acad Sci U S A 88 (22), 10049-10053 (1991)
   PUBMED   1946421
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC005439.1.
            
            On Aug 28, 2003 this sequence version replaced NM_010304.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005439.1, SRR7652917.1302534.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1974
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..1974
                     /gene="Gna15"
                     /gene_synonym="Galpha15; G[a]15; Hg1l"
                     /note="guanine nucleotide binding protein, alpha 15"
                     /db_xref="GeneID:14676"
                     /db_xref="MGI:MGI:95770"
     exon            1..416
                     /gene="Gna15"
                     /gene_synonym="Galpha15; G[a]15; Hg1l"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..1396
                     /gene="Gna15"
                     /gene_synonym="Galpha15; G[a]15; Hg1l"
                     /note="g alpha-15; G-protein subunit alpha-15;
                     heterotrimeric guanine nucleotide-binding protein 1l"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein subunit
                     alpha-15"
                     /protein_id="NP_034434.1"
                     /db_xref="CCDS:CCDS24060.1"
                     /db_xref="GeneID:14676"
                     /db_xref="MGI:MGI:95770"
                     /translation="MARSLTWGCCPWCLTEEEKTAARIDQEINRILLEQKKQEREELK
                     LLLLGPGESGKSTFIKQMRIIHGVGYSEEDRRAFRLLIYQNIFVSMQAMIDAMDRLQI
                     PFSRPDSKQHASLVMTQDPYKVSTFEKPYAVAMQYLWRDAGIRACYERRREFHLLDSA
                     VYYLSHLERISEDSYIPTAQDVLRSRMPTTGINEYCFSVKKTKLRIVDVGGQRSERRK
                     WIHCFENVIALIYLASLSEYDQCLEENDQENRMEESLALFSTILELPWFKSTSVILFL
                     NKTDILEDKIHTSHLATYFPSFQGPRRDAEAAKSFILDMYARVYASCAEPQDGGRKGS
                     RARRFFAHFTCATDTQSVRSVFKDVRDSVLARYLDEINLL"
     exon            417..601
                     /gene="Gna15"
                     /gene_synonym="Galpha15; G[a]15; Hg1l"
                     /inference="alignment:Splign:2.1.0"
     exon            602..756
                     /gene="Gna15"
                     /gene_synonym="Galpha15; G[a]15; Hg1l"
                     /inference="alignment:Splign:2.1.0"
     exon            757..885
                     /gene="Gna15"
                     /gene_synonym="Galpha15; G[a]15; Hg1l"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1015
                     /gene="Gna15"
                     /gene_synonym="Galpha15; G[a]15; Hg1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1169
                     /gene="Gna15"
                     /gene_synonym="Galpha15; G[a]15; Hg1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1962
                     /gene="Gna15"
                     /gene_synonym="Galpha15; G[a]15; Hg1l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1940..1945
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gna15"
                     /gene_synonym="Galpha15; G[a]15; Hg1l"
                     /note="hexamer: AATAAA"
     polyA_site      1962
                     /gene="Gna15"
                     /gene_synonym="Galpha15; G[a]15; Hg1l"
                     /note="major polyA site"
ORIGIN      
        1 gctggagctt ccaccaccga cctgtctggc gggcagggcc aggtctgggc aagttggagg
       61 gggcgggaag cagcacccag gtccccgccc tgtttccagc acccaggcct cttgaagccc
      121 ttgcctgggc tcccacaggc cctaggcagg gacacggagg gccctggggt gacctccacc
      181 cccacctcca ctccatccgg agaagaaaga gtcccacagt tgggctctgc aggccctgtg
      241 atgtcacctg gtggtctgtg aagcgcccac catggcccgg tccctgactt ggggctgctg
      301 tccctggtgc ctgacagagg aggagaagac tgccgccaga atcgaccagg agatcaacag
      361 gattttgttg gaacagaaaa aacaagagcg cgaggaattg aaactcctgc tgttggggcc
      421 tggtgagagc gggaagagta cgttcatcaa gcagatgcgc atcattcacg gtgtgggcta
      481 ctcggaggag gaccgcagag ccttccggct gctcatctac cagaacatct tcgtctccat
      541 gcaggccatg atagatgcga tggaccggct gcagatcccc ttcagcaggc ctgacagcaa
      601 gcagcacgcc agcctagtga tgacccagga cccctataaa gtgagcacat tcgagaagcc
      661 atatgcagtg gccatgcagt acctgtggcg ggacgcgggc atccgtgcat gctacgagcg
      721 aaggcgtgaa ttccaccttc tggactccgc ggtgtattac ctgtcacacc tggagcgcat
      781 atcagaggac agctacatcc ccactgcgca agacgtgctg cgcagtcgca tgcccaccac
      841 aggcatcaat gagtactgct tctccgtgaa gaaaaccaaa ctgcgcatcg tggatgttgg
      901 tggccagagg tcagagcgta ggaaatggat tcactgtttc gagaacgtga ttgccctcat
      961 ctacctggcc tccctgagcg agtatgacca gtgcctagag gagaacgatc aggagaaccg
     1021 catggaggag agtctcgctc tgttcagcac gatcctagag ctgccctggt tcaagagcac
     1081 ctcggtcatc ctcttcctca acaagacgga catcctggaa gataagattc acacctccca
     1141 cctggccaca tacttcccca gcttccaggg accccggcga gacgcagagg ccgccaagag
     1201 cttcatcttg gacatgtatg cgcgcgtgta cgcgagctgc gcagagcccc aggacggtgg
     1261 caggaaaggc tcccgcgcgc gccgcttctt cgcacacttc acctgtgcca cggacacgca
     1321 aagcgtccgc agcgtgttca aggacgtgcg ggactcggtg ctggcccggt acctggacga
     1381 gatcaacctg ctgtgacgcg ggacagggaa ccccaagcgc gacgcggtcg tggcgaggac
     1441 atacctcccc ctggtggccg cgcgtggaac tgcaggtcca ggagctgcca agtggggaag
     1501 ccagcccaca gggagagagt ccctgcttcc tactgggccc ccaagcccag ctcccctgta
     1561 atttattccc tcgcccttct tctagttgtt ggagaaagga catgagccgg gtctttaacc
     1621 ccagcgctcc ggaggcagag gcaggaggat ttctgtgagt tccaggacca tgttttcaaa
     1681 aacaaacaaa accggataga actgtccggg accttgtgac ttcccagggg ccctgttcac
     1741 atcttcctgt ggggaccatt tcatcttacc aaaggggaaa ccgaggtcgg caagatggct
     1801 ggtgagagtg ccttgccacc aagcctgaca actggacttc aggacctgtt cagtggacag
     1861 agagagggag cggagtccta ggagaagttc tctatctcct caggcgtgca tggtggtgac
     1921 acacctaccc acacagataa ataaatgtaa tttaaaaaca aaaaaaaaaa aaaa
//
