LOCUS       NM_008137               3383 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus guanine nucleotide binding protein, alpha 14 (Gna14),
            mRNA.
ACCESSION   NM_008137
VERSION     NM_008137.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3383)
  AUTHORS   Park,R., Lee,S., Chin,H., Nguyen,A.T. and Lee,D.
  TITLE     Tumor-Promoting Role of GNA14 in Colon Cancer Development
  JOURNAL   Cancers (Basel) 15 (18), 4572 (2023)
   PUBMED   37760541
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3383)
  AUTHORS   Jiang,Z., Yue,W.W.S., Chen,L., Sheng,Y. and Yau,K.W.
  TITLE     Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in
            Intrinsically Photosensitive Retinal Ganglion Cells
  JOURNAL   Cell 175 (3), 652-664 (2018)
   PUBMED   30270038
REFERENCE   3  (bases 1 to 3383)
  AUTHORS   Wang,Q., Yue,W.W.S., Jiang,Z., Xue,T., Kang,S.H., Bergles,D.E.,
            Mikoshiba,K., Offermanns,S. and Yau,K.W.
  TITLE     Synergistic Signaling by Light and Acetylcholine in Mouse Iris
            Sphincter Muscle
  JOURNAL   Curr Biol 27 (12), 1791-1800 (2017)
   PUBMED   28578927
REFERENCE   4  (bases 1 to 3383)
  AUTHORS   Hughes,S., Jagannath,A., Hickey,D., Gatti,S., Wood,M.,
            Peirson,S.N., Foster,R.G. and Hankins,M.W.
  TITLE     Using siRNA to define functional interactions between melanopsin
            and multiple G Protein partners
  JOURNAL   Cell Mol Life Sci 72 (1), 165-179 (2015)
   PUBMED   24958088
REFERENCE   5  (bases 1 to 3383)
  AUTHORS   Chew,K.S., Schmidt,T.M., Rupp,A.C., Kofuji,P. and Trimarchi,J.M.
  TITLE     Loss of gq/11 genes does not abolish melanopsin phototransduction
  JOURNAL   PLoS One 9 (5), e98356 (2014)
   PUBMED   24870805
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3383)
  AUTHORS   Offermanns,S. and Simon,M.I.
  TITLE     G alpha 15 and G alpha 16 couple a wide variety of receptors to
            phospholipase C
  JOURNAL   J Biol Chem 270 (25), 15175-15180 (1995)
   PUBMED   7797501
REFERENCE   7  (bases 1 to 3383)
  AUTHORS   Ceci,J.D., Matsuda,Y., Grubber,J.M., Jenkins,N.A., Copeland,N.G.
            and Chapman,V.M.
  TITLE     Interspecific backcrosses provide an important new tool for
            centromere mapping of mouse chromosomes
  JOURNAL   Genomics 19 (3), 515-524 (1994)
   PUBMED   8188294
REFERENCE   8  (bases 1 to 3383)
  AUTHORS   Wilkie,T.M., Gilbert,D.J., Olsen,A.S., Chen,X.N., Amatruda,T.T.,
            Korenberg,J.R., Trask,B.J., de Jong,P., Reed,R.R., Simon,M.I. et
            al.
  TITLE     Evolution of the mammalian G protein alpha subunit multigene family
  JOURNAL   Nat Genet 1 (2), 85-91 (1992)
   PUBMED   1302014
  REMARK    Review article
REFERENCE   9  (bases 1 to 3383)
  AUTHORS   Wilkie,T.M., Scherle,P.A., Strathmann,M.P., Slepak,V.Z. and
            Simon,M.I.
  TITLE     Characterization of G-protein alpha subunits in the Gq class:
            expression in murine tissues and in stromal and hematopoietic cell
            lines
  JOURNAL   Proc Natl Acad Sci U S A 88 (22), 10049-10053 (1991)
   PUBMED   1946421
REFERENCE   10 (bases 1 to 3383)
  AUTHORS   Strathmann,M., Wilkie,T.M. and Simon,M.I.
  TITLE     Diversity of the G-protein family: sequences from five additional
            alpha subunits in the mouse
  JOURNAL   Proc Natl Acad Sci U S A 86 (19), 7407-7409 (1989)
   PUBMED   2508088
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK128401.1, BY034514.1, AK085444.1 and AK035320.1.
            
            On Nov 14, 2007 this sequence version replaced NM_008137.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK085444.1, AK168498.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                CK128401.1         1-75
            76-95               BY034514.1         117-136
            96-2027             AK085444.1         2-1933
            2028-3383           AK035320.1         868-2223
FEATURES             Location/Qualifiers
     source          1..3383
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 11.29 cM"
     gene            1..3383
                     /gene="Gna14"
                     /gene_synonym="Hg1i"
                     /note="guanine nucleotide binding protein, alpha 14"
                     /db_xref="GeneID:14675"
                     /db_xref="MGI:MGI:95769"
     exon            1..1151
                     /gene="Gna14"
                     /gene_synonym="Hg1i"
                     /inference="alignment:Splign:2.1.0"
     CDS             1028..2095
                     /gene="Gna14"
                     /gene_synonym="Hg1i"
                     /note="heterotrimeric guanine nucleotide-binding protein
                     1i; g alpha-14; G-protein subunit alpha-14"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein subunit
                     alpha-14"
                     /protein_id="NP_032163.3"
                     /db_xref="CCDS:CCDS29685.1"
                     /db_xref="GeneID:14675"
                     /db_xref="MGI:MGI:95769"
                     /translation="MAGCCCLSAEEKESQRISAEIERQLRRDKKDARRELKLLLLGTG
                     ESGKSTFIKQMRIIHGSGYSDEDRKGFTKLVYQNIFTAMQAMIRAMDTLRIQYMCEQN
                     KENAQIIREVEVDKVTALSRDQVAAIKQLWLDPGIQECYDRRREYQLSDSAKYYLTDI
                     ERIAMPSFVPTQQDVLRVRVPTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFES
                     VTSIIFLVALSEYDQVLAECDNENRMEESKALFRTIITYPWFLNSSVILFLNKKDLLE
                     EKIMYSHLISYFPEYTGPKQDVKAARDFILKLYQDQNPDKEKVIYSHFTCATDTENIR
                     FVFAAVKDTILQLNLREFNLV"
     exon            1152..1336
                     /gene="Gna14"
                     /gene_synonym="Hg1i"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1491
                     /gene="Gna14"
                     /gene_synonym="Hg1i"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1620
                     /gene="Gna14"
                     /gene_synonym="Hg1i"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1750
                     /gene="Gna14"
                     /gene_synonym="Hg1i"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1904
                     /gene="Gna14"
                     /gene_synonym="Hg1i"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..3383
                     /gene="Gna14"
                     /gene_synonym="Hg1i"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2359..2364
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gna14"
                     /gene_synonym="Hg1i"
                     /note="hexamer: ATTAAA"
     polyA_site      2379
                     /gene="Gna14"
                     /gene_synonym="Hg1i"
                     /note="major polyA site"
     regulatory      2480..2485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gna14"
                     /gene_synonym="Hg1i"
                     /note="hexamer: AATAAA"
     polyA_site      2506
                     /gene="Gna14"
                     /gene_synonym="Hg1i"
                     /note="major polyA site"
     regulatory      3291..3296
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gna14"
                     /gene_synonym="Hg1i"
                     /note="hexamer: AATACA"
     polyA_site      3317
                     /gene="Gna14"
                     /gene_synonym="Hg1i"
                     /note="major polyA site"
ORIGIN      
        1 aaactacaag ctgacccaag gcttgcacta agcccaaatt gagttgtggc atccgggaag
       61 cagagggagc cagtctagaa accccaagtg tgagcggtgg agaagctggt gggcaaagct
      121 cagcctcagg tgggaaaaga ggcctgagcc tagctgctgg catgcggtgt gtgaacgggc
      181 tgcagacgtt tggctcgggt ctgctagtgc gctgcctcca cccctggcac tgaggctggg
      241 agttgacgaa actccctcac ctgtcggaac ccggatctgg cagcgggaag ggggctggca
      301 gccagtgtct gctggttaca gcaagcttgg caagtggccc tgcctgcact agggcgccac
      361 cgccaaggag gcaggtgtga gactactctg cgacccagcc tcttgttgct atcctttgtc
      421 cccaggcacc gtcggcttgg ggtaggactt caggcaactc ctgcagcctt ggctgcaggt
      481 tcgagacgct ccgccccctc ctgtcacata gagcggtcag tgctggagga accttccatt
      541 ccgcaaaagt ctacgggttg aggttttcgg aactttgcaa acagggacta gctggccctt
      601 tatttgcaag ccaggccaca cctgctgcta gcctgcgaca ccctacagtc ccggagagac
      661 cattctagca gcagcaccga cgccccaact tttgattcgc ggtgtgcgtt gcctacctgg
      721 gtacccagct acagtgtccg gggacgcaca tcttctggag acagcgccaa tcacactgcc
      781 cagttcgctc ttctctccct cccaagcgcg gggttgggtg cctgatcccg gaccacacaa
      841 gcgctcagga ctcgcctgac ctcggaactg ccttcgagaa agcgttagcc taggagatcc
      901 gagcctcttt ctccatacca tagttggttc aggtggtttc ctcttcaaac cttgcgtctg
      961 gcgcggataa tccgcgcggc cgggcgttaa gctccaggtc cctgtcgctc cgtcgaggtg
     1021 gcaagccatg gccggctgct gctgtttgtc tgcggaggag aaagagtctc agcgcatcag
     1081 cgcggagatc gagcggcagc ttcgccgcga caagaaggac gcgcgccggg agctcaagct
     1141 gctgttgctg ggaaccggtg agagtgggaa aagcaccttt atcaagcaga tgaggataat
     1201 ccatgggtct ggctacagtg atgaagatag aaagggcttc acgaagctgg tttaccaaaa
     1261 catattcacg gccatgcaag ccatgatcag agcaatggat accctgagga tacaatacat
     1321 gtgtgagcag aataaggaaa atgcccagat catcagggaa gtggaagtag acaaggtcac
     1381 tgcactctct agagaccagg tggcagccat caagcagctg tggctggatc ccggaatcca
     1441 ggagtgttac gacaggagga gggagtacca gctgtcagac tctgccaaat attacctgac
     1501 ggacattgag cgtatcgcca tgccctcttt cgtgccaaca caacaggatg tgcttcgtgt
     1561 tagagtgccc accactggca tcatagaata tccattcgac ctggaaaaca tcatcttccg
     1621 aatggtggat gttggtggcc agcgatctga acgacggaaa tggattcact gctttgagag
     1681 tgtcacctcc atcattttct tggttgctct gagtgaatat gaccaggttc tggctgagtg
     1741 tgacaatgag aaccgcatgg aggagagcaa agccctgttt agaaccatca tcacctaccc
     1801 ctggtttctg aactcctccg tgattctgtt cttaaacaag aaggatcttc tagaggagaa
     1861 aatcatgtac tctcatctaa ttagctactt cccagagtac acaggaccaa agcaagatgt
     1921 caaagcggcc agggacttta tcctgaagct gtatcaagac cagaatcctg acaaagagaa
     1981 ggttatctat tctcacttca cttgtgctac agacaccgag aatatccgct ttgtgtttgc
     2041 tgctgtcaaa gacacaatcc tacagctaaa cctacgggag ttcaacttgg tgtaaatgga
     2101 gggcctactc ctccgagaca gagggtgatc tgagcccttc ctgcctgatc tacaagtgct
     2161 tctggaccag gacctaagga cattatgtag cccacaggga cagagatggg tagtgcaatg
     2221 tgaaaaatac ttcaccaacc cttttaagtg tctttaattc ttcactgtct aactcttttc
     2281 tcgccttttg gttgaacgat taggtatcat ttttgagtgg ttccccctct cctattttta
     2341 aactagtgtt caacagttat taaaaatcat gcaaaaaaat tcatgcaaca gagggacttg
     2401 ttaatttaca aatcatgcct tcagacctct gagattcatt taggtgactt aaacatcttc
     2461 attggtttga taattttaaa ataaatcttt taagaaactt ttaaaacatt tcttcccctt
     2521 aatgttgaaa tatgactcat gtaacaactt actaaaccac caaagacttc tttctatgcc
     2581 ttttttttgt ttgtttttta attttaaaaa cagggtctta agtagcccag gctggcttcc
     2641 aactcaaatt tgctgtgtaa ttgagcatgg cccttggtcc tcctgcctgg ctgttccatg
     2701 cttagctaag attttcttct tttctgagac agagcctcac atattctttt ctggtctcag
     2761 acatgctatg tggccaagga tgatgacact gggctttcgg ttctcttgta ttcatataca
     2821 caacctattt aaggcagttc tcacactgtt gccaactcct agcattaaga ggtctccaag
     2881 agtgtgattg cacattgata tttacaggtt agtaatgctt ggatggatgt gtcacaggat
     2941 cagttatatg atgcttggga tgggtcccgg gcgttgtgca tgttaggcaa atgttctgcc
     3001 gaccgagcta tatcccaaac caaagatttc tttaaaaagc agttctttcc atgtcaactt
     3061 tctaatccaa attaatatta ttcaaacatt gatttttgcc acaatctgat aaaaccaact
     3121 ttagatactg catgtgtgta tgtcctaatg cgtatggcca ggccttacag cttatggaat
     3181 ggctaaagca gaacttgtta acagatgtca tgtaaacctt gccaaagctc tggtggcaat
     3241 ctccaatgtg ttgtttgaac tgtgcgcgct gtgcctttct ggatactaag aatacactgt
     3301 tctaccctga acaccaacga tgatgtgctt cttagagctc gtggctgatc gttctgttca
     3361 aaagaaaacg ttagttttaa cgg
//
