LOCUS       NM_010302               1880 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus guanine nucleotide binding protein, alpha 12 (Gna12),
            mRNA.
ACCESSION   NM_010302 XM_917088
VERSION     NM_010302.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1880)
  AUTHORS   Tak,J., An,Q., Lee,S.G., Lee,C.H. and Kim,S.G.
  TITLE     Galpha12 and endoplasmic reticulum stress-mediated pyroptosis in a
            single cycle of dextran sulfate-induced mouse colitis
  JOURNAL   Sci Rep 14 (1), 6335 (2024)
   PUBMED   38491049
  REMARK    GeneRIF: Galpha12 and endoplasmic reticulum stress-mediated
            pyroptosis in a single cycle of dextran sulfate-induced mouse
            colitis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1880)
  AUTHORS   Tak,J., Joo,M.S., Kim,Y.S., Park,H.W., Lee,C.H., Park,G.C.,
            Hwang,S. and Kim,S.G.
  TITLE     Dual regulation of NEMO by Nrf2 and miR-125a inhibits ferroptosis
            and protects liver from endoplasmic reticulum stress-induced injury
  JOURNAL   Theranostics 14 (5), 1841-1859 (2024)
   PUBMED   38505605
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1880)
  AUTHORS   Tak,J., Kim,Y.S., Kim,T.H., Park,G.C., Hwang,S. and Kim,S.G.
  TITLE     Galpha12 overexpression in hepatocytes by ER stress exacerbates
            acute liver injury via ROCK1-mediated miR-15a and ALOX12
            dysregulation
  JOURNAL   Theranostics 12 (4), 1570-1588 (2022)
   PUBMED   35198058
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1880)
  AUTHORS   van den Bos,E., Ambrosy,B., Horsthemke,M., Walbaum,S., Bachg,A.C.,
            Wettschureck,N., Innamorati,G., Wilkie,T.M. and Hanley,P.J.
  TITLE     Knockout mouse models reveal the contributions of G protein
            subunits to complement C5a receptor-mediated chemotaxis
  JOURNAL   J Biol Chem 295 (22), 7726-7742 (2020)
   PUBMED   32332099
REFERENCE   5  (bases 1 to 1880)
  AUTHORS   Sakaguchi,T., Takefuji,M., Wettschureck,N., Hamaguchi,T., Amano,M.,
            Kato,K., Tsuda,T., Eguchi,S., Ishihama,S., Mori,Y., Yura,Y.,
            Yoshida,T., Unno,K., Okumura,T., Ishii,H., Shimizu,Y., Bando,Y.K.,
            Ohashi,K., Ouchi,N., Enomoto,A., Offermanns,S., Kaibuchi,K. and
            Murohara,T.
  TITLE     Protein Kinase N Promotes Stress-Induced Cardiac Dysfunction
            Through Phosphorylation of Myocardin-Related Transcription Factor A
            and Disruption of Its Interaction With Actin
  JOURNAL   Circulation 140 (21), 1737-1752 (2019)
   PUBMED   31564129
REFERENCE   6  (bases 1 to 1880)
  AUTHORS   Rambhatla,L., Patel,B., Dhanasekaran,N. and Latham,K.E.
  TITLE     Analysis of G protein alpha subunit mRNA abundance in
            preimplantation mouse embryos using a rapid, quantitative RT-PCR
            approach
  JOURNAL   Mol Reprod Dev 41 (3), 314-324 (1995)
   PUBMED   8588930
REFERENCE   7  (bases 1 to 1880)
  AUTHORS   Clegg,C.H., Koeiman,N.R., Jenkins,N.A., Gilbert,D.J., Copeland,N.G.
            and Neubauer,M.G.
  TITLE     Structural features of the murine gene encoding the RI beta subunit
            of cAMP-dependent protein kinase
  JOURNAL   Mol Cell Neurosci 5 (2), 153-164 (1994)
   PUBMED   8032683
REFERENCE   8  (bases 1 to 1880)
  AUTHORS   Wilkie,T.M., Gilbert,D.J., Olsen,A.S., Chen,X.N., Amatruda,T.T.,
            Korenberg,J.R., Trask,B.J., de Jong,P., Reed,R.R., Simon,M.I. et
            al.
  TITLE     Evolution of the mammalian G protein alpha subunit multigene family
  JOURNAL   Nat Genet 1 (2), 85-91 (1992)
   PUBMED   1302014
  REMARK    Review article
REFERENCE   9  (bases 1 to 1880)
  AUTHORS   Strathmann,M.P. and Simon,M.I.
  TITLE     G alpha 12 and G alpha 13 subunits define a fourth class of G
            protein alpha subunits
  JOURNAL   Proc Natl Acad Sci U S A 88 (13), 5582-5586 (1991)
   PUBMED   1905812
REFERENCE   10 (bases 1 to 1880)
  AUTHORS   Strathmann,M., Wilkie,T.M. and Simon,M.I.
  TITLE     Diversity of the G-protein family: sequences from five additional
            alpha subunits in the mouse
  JOURNAL   Proc Natl Acad Sci U S A 86 (19), 7407-7409 (1989)
   PUBMED   2508088
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC158914.4.
            
            On Nov 17, 2006 this sequence version replaced NM_010302.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M63659.1, SRR7974084.14832.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-438               AC158914.4         143893-144330       c
            439-654             AC158914.4         99296-99511         c
            655-705             AC158914.4         76489-76539         c
            706-1880            AC158914.4         73843-75017         c
FEATURES             Location/Qualifiers
     source          1..1880
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 79.3 cM"
     gene            1..1880
                     /gene="Gna12"
                     /gene_synonym="Galpha12"
                     /note="guanine nucleotide binding protein, alpha 12"
                     /db_xref="GeneID:14673"
                     /db_xref="MGI:MGI:95767"
     exon            1..438
                     /gene="Gna12"
                     /gene_synonym="Galpha12"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..1275
                     /gene="Gna12"
                     /gene_synonym="Galpha12"
                     /note="g alpha-12; G-protein subunit alpha-12"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein subunit
                     alpha-12"
                     /protein_id="NP_034432.1"
                     /db_xref="CCDS:CCDS19825.1"
                     /db_xref="GeneID:14673"
                     /db_xref="MGI:MGI:95767"
                     /translation="MSGVVRTLSRCLLPAEAGARERRAGAARDAEREARRRSRDIDAL
                     LARERRAVRRLVKILLLGAGESGKSTFLKQMRIIHGREFDQKALLEFRDTIFDNILKG
                     SRVLVDARDKLGIPWQHSENEKHGMFLMAFENKAGLPVEPATFQLYVPALSALWRDSG
                     IREAFSRRSEFQLGESVKYFLDNLDRIGQLNYFPSKQDILLARKATKGIVEHDFVIKK
                     IPFKMVDVGGQRSQRQKWFQCFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFE
                     TIVNNKLFFNVSIILFLNKMDLLVEKVKSVSIKKHFPDFKGDPHRLEDVQRYLVQCFD
                     RKRRNRSKPLFHHFTTAIDTENIRFVFHAVKDTILQENLKDIMLQ"
     exon            439..654
                     /gene="Gna12"
                     /gene_synonym="Galpha12"
                     /inference="alignment:Splign:2.1.0"
     exon            655..705
                     /gene="Gna12"
                     /gene_synonym="Galpha12"
                     /inference="alignment:Splign:2.1.0"
     exon            706..1880
                     /gene="Gna12"
                     /gene_synonym="Galpha12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcggggcggc ggcggcggac gcagcctgag ggagcggcgg gcggggcggc gcctggcccg
       61 gcagggccgc gccggctgag gggcgtccat ggcgcgcggg ccccagcggg gcgcggccgc
      121 ggcctgaggg cggccatgtc cggggtggtg cggaccctta gccgctgctt gctgccggcc
      181 gaggccggag cccgcgagcg cagggcgggc gcggcgcgcg acgcggagcg cgaggcccga
      241 cggcgcagcc gcgacatcga cgcgctgctg gcccgcgagc ggcgcgcggt gcggcggctg
      301 gtcaagatcc tgctgctggg cgccggcgag agcggcaagt ccaccttcct caagcagatg
      361 cgcatcatcc acggccggga gttcgaccag aaggcgctgc tggagttccg cgacaccatc
      421 ttcgacaaca tccttaaggg ttcgagggtt cttgtggacg ctcgagacaa gctcggcatt
      481 ccctggcagc actctgagaa cgagaagcac gggatgtttc tgatggcctt cgagaacaag
      541 gcagggctgc ctgtggagcc tgccaccttc cagctctacg tgccagccct gagtgccctc
      601 tggagagact cggggatcag ggaagccttc agccgcagaa gcgagttcca gctgggtgaa
      661 tcagtgaagt acttcctgga taacttggac cggattggcc agctgaacta cttccccagt
      721 aagcaagaca tcctgctggc tagaaaggcc accaagggaa tcgtggaaca tgacttcgtt
      781 ataaagaaaa tcccatttaa gatggtggat gtgggcggcc agaggtcaca gcgccagaag
      841 tggttccagt gcttcgacgg catcacatct atcctgttca tggtgtcctc gagcgagtat
      901 gaccaggtcc tcatggagga caggcgcacc aaccggctgg tggagtccat gaacatcttc
      961 gagaccatcg tcaacaacaa gctcttcttc aacgtctcca tcatcctctt cctcaacaag
     1021 atggacctcc tggtggagaa ggtgaagtct gtgagcatta agaagcactt cccagatttc
     1081 aagggcgacc cgcaccggct ggaggacgtc cagcgctacc tggtgcagtg cttcgacagg
     1141 aagcgcagga accgcagcaa gcccctgttc caccacttca ccaccgccat agacaccgag
     1201 aacatccgct tcgtgtttca tgctgtgaag gacacgatcc tgcaggagaa cctgaaagac
     1261 atcatgctgc agtgagagac agcccctccc tctgctgtcc tctcggcctc tggggctgtg
     1321 gccgcccacg tggttctggt gtgtctgccg cctgcatgga cctgcagtgg gcatctcgaa
     1381 tccacaccat ctaatacctg gctcaagagt gctggactac cagccacacc agcgagctcc
     1441 gggcaagagg acgcgggagt gtcagtgata gctactgaat cggggactgt gagactactg
     1501 aatccacacc atcactctgc tgttgatctg taaaacctgg ggacacagct ttcgcctctc
     1561 tacagaaact cttccttgtt gacacagtta accaaggttc aggtgtacgc agacacacgc
     1621 gtgctctcat taatgacaga aacccaaccc cagctggcct tgcagccggc tctcccctct
     1681 gccgtgcagg ttctcactga gtcacactaa ctcgggagct tggcctcaca ctaggctgta
     1741 aagagcatgc gatgctgcta agctcaccgt gtccaagccc aggcctcagt gccacctccc
     1801 agagtgaaca cacagcctta gcatcgtgcc agcaccctcc gagtctcgca aaggcgcagg
     1861 cggggtcagg tgtccacact
//
