LOCUS       NM_010301               3404 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus guanine nucleotide binding protein, alpha 11 (Gna11),
            mRNA.
ACCESSION   NM_010301 NM_177795
VERSION     NM_010301.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3404)
  AUTHORS   Ay,B., Cyr,S.M., Klovdahl,K., Zhou,W., Tognoni,C.M., Iwasaki,Y.,
            Rhee,E.P., Dedeoglu,A., Simic,P. and Bastepe,M.
  TITLE     Galpha11 deficiency increases fibroblast growth factor 23 levels in
            a mouse model of familial hypocalciuric hypercalcemia
  JOURNAL   JCI Insight 9 (9), e178993 (2024)
   PUBMED   38530370
  REMARK    GeneRIF: Galpha11 deficiency increases fibroblast growth factor 23
            levels in a mouse model of familial hypocalciuric hypercalcemia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3404)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3404)
  AUTHORS   Goodwin,A.T., John,A.E., Joseph,C., Habgood,A., Tatler,A.L.,
            Susztak,K., Palmer,M., Offermanns,S., Henderson,N.C. and
            Jenkins,R.G.
  TITLE     Stretch regulates alveologenesis and homeostasis via mesenchymal
            Galphaq/11-mediated TGFbeta2 activation
  JOURNAL   Development 150 (9) (2023)
   PUBMED   37102682
REFERENCE   4  (bases 1 to 3404)
  AUTHORS   Stamatiades,G.A., Toufaily,C., Kim,H.K., Zhou,X., Thompson,I.R.,
            Carroll,R.S., Chen,M., Weinstein,L.S., Offermanns,S., Boehm,U.,
            Bernard,D.J. and Kaiser,U.B.
  TITLE     Deletion of Galphaq/11 or Galphas Proteins in Gonadotropes
            Differentially Affects Gonadotropin Production and Secretion in
            Mice
  JOURNAL   Endocrinology 163 (2) (2022)
   PUBMED   34864945
  REMARK    GeneRIF: Deletion of Galphaq/11 or Galphas Proteins in Gonadotropes
            Differentially Affects Gonadotropin Production and Secretion in
            Mice.
REFERENCE   5  (bases 1 to 3404)
  AUTHORS   Wilson,E.A., Sun,H., Cui,Z., Jahnke,M.T., Pandey,M., Metzger,P.,
            Gavrilova,O., Chen,M. and Weinstein,L.S.
  TITLE     Gqalpha/G11alpha deficiency in dorsomedial hypothalamus leads to
            obesity resulting from decreased energy expenditure and impaired
            sympathetic nerve activity
  JOURNAL   Am J Physiol Endocrinol Metab 320 (2), E270-E280 (2021)
   PUBMED   33166186
REFERENCE   6  (bases 1 to 3404)
  AUTHORS   Wilkie,T.M., Gilbert,D.J., Olsen,A.S., Chen,X.N., Amatruda,T.T.,
            Korenberg,J.R., Trask,B.J., de Jong,P., Reed,R.R., Simon,M.I. et
            al.
  TITLE     Evolution of the mammalian G protein alpha subunit multigene family
  JOURNAL   Nat Genet 1 (2), 85-91 (1992)
   PUBMED   1302014
  REMARK    Review article
REFERENCE   7  (bases 1 to 3404)
  AUTHORS   Taylor,S.J., Chae,H.Z., Rhee,S.G. and Exton,J.H.
  TITLE     Activation of the beta 1 isozyme of phospholipase C by alpha
            subunits of the Gq class of G proteins
  JOURNAL   Nature 350 (6318), 516-518 (1991)
   PUBMED   1707501
REFERENCE   8  (bases 1 to 3404)
  AUTHORS   Smrcka,A.V., Hepler,J.R., Brown,K.O. and Sternweis,P.C.
  TITLE     Regulation of polyphosphoinositide-specific phospholipase C
            activity by purified Gq
  JOURNAL   Science 251 (4995), 804-807 (1991)
   PUBMED   1846707
REFERENCE   9  (bases 1 to 3404)
  AUTHORS   Strathmann,M. and Simon,M.I.
  TITLE     G protein diversity: a distinct class of alpha subunits is present
            in vertebrates and invertebrates
  JOURNAL   Proc Natl Acad Sci U S A 87 (23), 9113-9117 (1990)
   PUBMED   2123549
REFERENCE   10 (bases 1 to 3404)
  AUTHORS   Strathmann,M., Wilkie,T.M. and Simon,M.I.
  TITLE     Diversity of the G-protein family: sequences from five additional
            alpha subunits in the mouse
  JOURNAL   Proc Natl Acad Sci U S A 86 (19), 7407-7409 (1989)
   PUBMED   2508088
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159474.9, AK143685.1 and CD741377.1.
            
            On Jun 23, 2018 this sequence version replaced NM_010301.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143685.1, M55411.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               AC159474.9         30714-30829
            117-3378            AK143685.1         2-3263
            3379-3404           CD741377.1         1-26                c
FEATURES             Location/Qualifiers
     source          1..3404
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..3404
                     /gene="Gna11"
                     /gene_synonym="Dsk7; E430025L19; g alpha-11; Hg1k"
                     /note="guanine nucleotide binding protein, alpha 11"
                     /db_xref="GeneID:14672"
                     /db_xref="MGI:MGI:95766"
     exon            1..371
                     /gene="Gna11"
                     /gene_synonym="Dsk7; E430025L19; g alpha-11; Hg1k"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..1315
                     /gene="Gna11"
                     /gene_synonym="Dsk7; E430025L19; g alpha-11; Hg1k"
                     /note="G-protein subunit alpha-11; heterotrimeric guanine
                     nucleotide-binding protein 1k"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein subunit
                     alpha-11"
                     /protein_id="NP_034431.1"
                     /db_xref="CCDS:CCDS24061.1"
                     /db_xref="GeneID:14672"
                     /db_xref="MGI:MGI:95766"
                     /translation="MTLESMMACCLSDEVKESKRINAEIEKQLRRDKRDARRELKLLL
                     LGTGESGKSTFIKQMRIIHGAGYSEEDKRGFTKLVYQNIFTAMQAMVRAMETLKILYK
                     YEQNKANALLIREVDVEKVTTFEHQYVNAIKTLWSDPGVQECYDRRREFQLSDSAKYY
                     LTDVDRIATVGYLPTQQDVLRVRVPTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIH
                     CFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKK
                     DLLEDKILHSHLVDYFPEFDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDT
                     ENIRFVFAAVKDTILQLNLKEYNLV"
     exon            372..556
                     /gene="Gna11"
                     /gene_synonym="Dsk7; E430025L19; g alpha-11; Hg1k"
                     /inference="alignment:Splign:2.1.0"
     exon            557..711
                     /gene="Gna11"
                     /gene_synonym="Dsk7; E430025L19; g alpha-11; Hg1k"
                     /inference="alignment:Splign:2.1.0"
     exon            712..840
                     /gene="Gna11"
                     /gene_synonym="Dsk7; E430025L19; g alpha-11; Hg1k"
                     /inference="alignment:Splign:2.1.0"
     exon            841..970
                     /gene="Gna11"
                     /gene_synonym="Dsk7; E430025L19; g alpha-11; Hg1k"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1124
                     /gene="Gna11"
                     /gene_synonym="Dsk7; E430025L19; g alpha-11; Hg1k"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..3386
                     /gene="Gna11"
                     /gene_synonym="Dsk7; E430025L19; g alpha-11; Hg1k"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3363..3368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gna11"
                     /gene_synonym="Dsk7; E430025L19; g alpha-11; Hg1k"
                     /note="hexamer: AATAAA"
     polyA_site      3381
                     /gene="Gna11"
                     /gene_synonym="Dsk7; E430025L19; g alpha-11; Hg1k"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgcagcc gtgcggcccc tcccattggc cgcgccgcct gcccgtcccg gggcccgtgg
       61 cagcgcttca ggtcctcggg cgccggcgct cggtggcgac ggctgcgggt agcggcggcg
      121 gcggcggctg cgctgcacgg cgcggacggt ggacgcgcct ctggggccgg gccgtggcct
      181 tcggggaacc gggaagaggt agggccgggc cggcggcagc cggaggaccg cgacgatgac
      241 tctggagtcc atgatggcgt gttgcctgag cgacgaggtg aaggagtcga agcgcatcaa
      301 cgcggagatc gagaaacagc tgcggcggga caagcgcgac gcccggcgcg agctcaagct
      361 gctgctactt ggcactggcg agagcgggaa gagtaccttc atcaagcaga tgcgcatcat
      421 ccacggggcc ggctactcgg aggaggacaa gcgcggcttc accaagttgg tgtaccagaa
      481 catctttacc gccatgcagg ccatggtgcg cgccatggag acgctcaaga tcctctacaa
      541 gtatgagcag aacaaggcca atgcactcct gatccgggag gtcgatgtgg agaaggtcac
      601 aacttttgag caccagtatg tgaatgccat caagacgctg tggagtgacc ctggtgtcca
      661 ggagtgttac gatcgcaggc gggagttcca gctatctgac tcggctaagt actacttgac
      721 ggacgtggac cgcatcgcca cagtaggcta cctgcccacc cagcaggatg tgctgcgggt
      781 acgcgtgccc accactggca tcatcgagta cccgtttgac ctggagaaca tcatcttcag
      841 gatggtggat gtgggcgggc agaggtcaga gcgcaggaag tggatccatt gctttgagaa
      901 cgtgacttcc atcatgttct tggtggcact aagcgagtat gaccaagtcc tggtggagtc
      961 agacaatgag aaccgcatgg aggagagcaa ggccctgttc cgcacaatca tcacctaccc
     1021 ctggttccag aactcgtctg tcattctctt cctcaacaag aaggaccttc tagaagacaa
     1081 gatcctgcac tcacacttgg tcgattactt ccctgagttt gatgggccac agagggatgc
     1141 acaggccgca cgcgagttca ttctgaagat gtttgtggac ctgaaccctg acagcgacaa
     1201 aatcatctac tcccacttca cgtgtgccac cgacaccgag aacatccgct ttgtgttcgc
     1261 agctgtgaag gacaccatcc tgcagctgaa cctgaaggag tacaacctgg tgtgaccgcg
     1321 gcatggctgc caccagggcc agcttcctcc gcatccggtc acccaaaccg agggacctgg
     1381 gcacacgggg gctggggcac atctctcttc ccgctcactt cctgtccctg tccctcttcc
     1441 tcaagggcag agtggcctca tttcggcctt gactcaatgt ggcttgaggt tttttttttt
     1501 cttagaaaac aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aagatacatg aacagcagtg
     1561 tgccctcccc agagataccc ccacagccac aaggctatta agatcagggc cactgcagcc
     1621 caagcccaag tcctgagttt gacttctccc ccaggaaagc tggaggcttg gggaccatgg
     1681 actacccatt ttctaagtta ttgatatccc gtatgccctc agggctcgca ccatccccct
     1741 agactcccaa gaagtggggg tgggcggccc ctgtgcctac cctgggaagt gcctaatcgt
     1801 tttttgtttt gtttttgttt ttgaagaaaa gagaaatatt ctccactctg acttggcagc
     1861 caggtgacac actacagggt ctagtgacca taacccctgt gttcccctgc tgcaggcagg
     1921 gcctgctgtt ggtgaagtgg ggggtgggga gattaagtcc ccaagacccg ctgctcactg
     1981 acatggctag gaaaggccct ggggaccctg agggactacg tggagttggg cagctggaag
     2041 gactgtccaa gtctatgtgg ttcagcaaga ctcgccctcc ccaaacccag tcaagagcgg
     2101 ggtgcacagg ggcctcttcc aaatattctc aggtccgtac ccagacatgg gcagtggccc
     2161 caccccacgc actggtccct ggccatagtc actgcacctt gcctgttgcc tcctaaacta
     2221 gaggaccagc gtataggagg tgatggccat gaccagagag gacataggca ggcccctgct
     2281 gctcatatac actacagtgt ctatctgtct gtctgtcaga tttctttact ttttgcacgt
     2341 gcgttctggg cttggatagc cagccacgcc tttgtcctgc ctgccaagct ggactccagg
     2401 ccccagagtg cccatgcact cagacacacg ccaatctggg cagtggccac attgccatcc
     2461 caggcagaag gaaacaaggg accatgggca tgacagagcc ctagagtatg atgggtggcc
     2521 atgatgatca cccacattcc tggcctccag cccgtggatt cccccacctt cccacactag
     2581 gctcctctcc tgtctccagt tgagggtccg atctgtgcca tcccatacac tacagagcta
     2641 catggatggc agggtcatcc tatgagagac ccaggtcctc atagtaggca tctgtgttgc
     2701 acaataggaa gagaagttgg gactgtacag gtgtctgagg ctggaccacc ccaagccggc
     2761 aaagtgttag cctctcttga gcagtatgtg ccaagtgtgc tgggccacag tggccacagc
     2821 caaaccccgg ggcagcaacc agctcaccca agtggtgagt ggcaggttct gctcagggga
     2881 aatgtgtcag ggccccttgg ggctgtgtgc cacacaggtc aggatgggga ccccagactc
     2941 cctacttctg tcctggtcct caccaaggaa tggcctgatt gcaggggaca cactggtttc
     3001 tttgtgtcca ccttggtgca ctgggagtgc caaccaccat ccagcacctg gtccagggag
     3061 ccaagcctgg cctgtggtgg ctgccagcgg ctgctgtgac ccttgtatat tacagtccta
     3121 atttcaaact tcagcctatt taagagaaca ctcaaaacac tatttttaat cctcgtcctt
     3181 tgtgaagcat gttcccgtgt gagggggagg ctcaggcaca cagctcagtg ccaggctcct
     3241 acaggccctc ggccatggac gccagggtgc aagcagcagg tcggggccct gaccccttaa
     3301 cccagagggt cttgctgaag ccaccttttc atatctttct cttgaattct gttttaaatc
     3361 ggaataaatt ttgttcctaa actctgaaaa aaaaaaaaaa aaaa
//
