LOCUS       NM_001033300            4567 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus guanine monophosphate synthetase (Gmps), mRNA.
ACCESSION   NM_001033300 XM_130877 XM_916395
VERSION     NM_001033300.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4567)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4567)
  AUTHORS   Holzer,K., Drucker,E., Roessler,S., Dauch,D., Heinzmann,F.,
            Waldburger,N., Eiteneuer,E.M., Herpel,E., Breuhahn,K., Zender,L.,
            Schirmacher,P., Ori,A. and Singer,S.
  TITLE     Proteomic Analysis Reveals GMP Synthetase as p53 Repression Target
            in Liver Cancer
  JOURNAL   Am J Pathol 187 (2), 228-235 (2017)
   PUBMED   27939741
REFERENCE   3  (bases 1 to 4567)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   4  (bases 1 to 4567)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   5  (bases 1 to 4567)
  AUTHORS   Zoref-Shani,E., Shainberg,A. and Sperling,O.
  TITLE     Characterization of purine nucleotide metabolism in primary rat
            muscle cultures
  JOURNAL   Biochim Biophys Acta 716 (3), 324-330 (1982)
   PUBMED   6180773
REFERENCE   6  (bases 1 to 4567)
  AUTHORS   Spector,T.
  TITLE     Studies with GMP synthetase from Ehrlich ascites cells.
            Purification, properties, and interactions with nucleotide analogs
  JOURNAL   J Biol Chem 250 (18), 7372-7376 (1975)
   PUBMED   240826
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK143197.1, AK049755.1, CN528611.1 and AK136966.1.
            
            On Jan 28, 2006 this sequence version replaced NM_001033300.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC138411.1, AK049755.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2237              AK143197.1         2-2238
            2238-2711           AK049755.1         2202-2675
            2712-2922           CN528611.1         503-713
            2923-3898           AK049755.1         2890-3865
            3899-4567           AK136966.1         1221-1889
FEATURES             Location/Qualifiers
     source          1..4567
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 30.08 cM"
     gene            1..4567
                     /gene="Gmps"
                     /gene_synonym="670032; Gm9479"
                     /note="guanine monophosphate synthetase"
                     /db_xref="GeneID:229363"
                     /db_xref="MGI:MGI:2448526"
     exon            1..168
                     /gene="Gmps"
                     /gene_synonym="670032; Gm9479"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..2223
                     /gene="Gmps"
                     /gene_synonym="670032; Gm9479"
                     /EC_number="6.3.5.2"
                     /note="GMP synthase; GMP synthetase; glutamine
                     amidotransferase"
                     /codon_start=1
                     /product="GMP synthase [glutamine-hydrolyzing]"
                     /protein_id="NP_001028472.2"
                     /db_xref="CCDS:CCDS17383.1"
                     /db_xref="GeneID:229363"
                     /db_xref="MGI:MGI:2448526"
                     /translation="MALCNGDSKPENAGGDLKDGSHHYEGAVVILDAGAQYGKVIDRR
                     VRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPILG
                     ICYGMQMMNKVFGGTVHKKSVREDGVFNISMDNTCSLFRGLQKEEIVLLTHGDSVDKV
                     ADGFKVVARSGNIVAGIANESKKLYGVQFHPEVGLTENGKVILKNFLYDIAGCSGNFT
                     VQNRELECIREIKEKVGTSKVLVLLSGGVDSTVCTALLNRALNQDQVIAVHIDNGFMR
                     KRESQSVEEALKKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPE
                     EKRKIIGDTFVKIANEVIGEMSLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHH
                     NDTELIRKLREEGKVIEPLKDFHKDEVRILGRELDLPEELVSRHPFPGPGLAIRVICA
                     EEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLMQITSLHSLN
                     AFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNINRVVYIFGP
                     PVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILRESGFAGKISQMPVILTPLHFDRDP
                     LQKQPSCQRSVVIRTFITSDFMTGVPATPGNEIPVEVVLKMVTEIKKIPGISRIMYDL
                     TSKPPGTTEWE"
     exon            169..350
                     /gene="Gmps"
                     /gene_synonym="670032; Gm9479"
                     /inference="alignment:Splign:2.1.0"
     exon            351..465
                     /gene="Gmps"
                     /gene_synonym="670032; Gm9479"
                     /inference="alignment:Splign:2.1.0"
     exon            466..563
                     /gene="Gmps"
                     /gene_synonym="670032; Gm9479"
                     /inference="alignment:Splign:2.1.0"
     exon            564..667
                     /gene="Gmps"
                     /gene_synonym="670032; Gm9479"
                     /inference="alignment:Splign:2.1.0"
     exon            668..861
                     /gene="Gmps"
                     /gene_synonym="670032; Gm9479"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1027
                     /gene="Gmps"
                     /gene_synonym="670032; Gm9479"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1179
                     /gene="Gmps"
                     /gene_synonym="670032; Gm9479"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1353
                     /gene="Gmps"
                     /gene_synonym="670032; Gm9479"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1459
                     /gene="Gmps"
                     /gene_synonym="670032; Gm9479"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1575
                     /gene="Gmps"
                     /gene_synonym="670032; Gm9479"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1701
                     /gene="Gmps"
                     /gene_synonym="670032; Gm9479"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1817
                     /gene="Gmps"
                     /gene_synonym="670032; Gm9479"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1948
                     /gene="Gmps"
                     /gene_synonym="670032; Gm9479"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2121
                     /gene="Gmps"
                     /gene_synonym="670032; Gm9479"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..4567
                     /gene="Gmps"
                     /gene_synonym="670032; Gm9479"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2222..2227
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gmps"
                     /gene_synonym="670032; Gm9479"
                     /note="hexamer: AATAAA"
     polyA_site      2242
                     /gene="Gmps"
                     /gene_synonym="670032; Gm9479"
                     /note="major polyA site"
     regulatory      2541..2546
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gmps"
                     /gene_synonym="670032; Gm9479"
                     /note="hexamer: AACAAA"
     polyA_site      2563
                     /gene="Gmps"
                     /gene_synonym="670032; Gm9479"
     regulatory      2869..2874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gmps"
                     /gene_synonym="670032; Gm9479"
                     /note="hexamer: AATATA"
     polyA_site      2889
                     /gene="Gmps"
                     /gene_synonym="670032; Gm9479"
     regulatory      3903..3908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gmps"
                     /gene_synonym="670032; Gm9479"
                     /note="hexamer: AAGAAA"
     polyA_site      3922
                     /gene="Gmps"
                     /gene_synonym="670032; Gm9479"
     polyA_site      3983
                     /gene="Gmps"
                     /gene_synonym="670032; Gm9479"
     regulatory      4359..4364
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gmps"
                     /gene_synonym="670032; Gm9479"
                     /note="hexamer: AATAAA"
     regulatory      4363..4368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gmps"
                     /gene_synonym="670032; Gm9479"
                     /note="hexamer: AATAAA"
     polyA_site      4379
                     /gene="Gmps"
                     /gene_synonym="670032; Gm9479"
     polyA_site      4393
                     /gene="Gmps"
                     /gene_synonym="670032; Gm9479"
ORIGIN      
        1 agggcctgcg cgcgcttctg tgttctgagg ccgctgttag gttccgggct gctcttgttc
       61 ttcacgcttc tgccggtccc ggtgttgagc ctctggcgtc caggccttgc cagcagtctg
      121 cacccgcggc gttggtcccc gatggccctg tgcaacggag attccaagcc ggagaatgct
      181 ggaggagatc ttaaggatgg ttctcaccat tacgaaggag ctgttgtcat tctggatgct
      241 ggagcccagt atgggaaagt cattgaccga agagtgcggg agctctttgt gcagtctgaa
      301 atcttcccat tggaaacacc agccttcgcc ataaaggaac aaggatttcg ggctattatc
      361 atatctggag gacctaattc tgtgtatgca gaggatgctc cctggtttga tccagcaata
      421 tttaccattg gcaagcctat tctaggaatt tgctatggca tgcagatgat gaataaagtc
      481 tttggaggca ctgtgcataa aaaaagtgtt agagaggatg gagttttcaa cattagtatg
      541 gataatacgt gttcattatt caggggcctg cagaaggaag aaattgtttt acttacacat
      601 ggagacagtg tagacaaagt tgctgatgga ttcaaggttg tagcacgttc tgggaacatt
      661 gtggcaggta tagccaatga atctaaaaag ctatacggtg tacagttcca ccctgaagtt
      721 gggcttacag aaaatgggaa ggtaatactg aagaatttcc tgtatgatat agctggatgc
      781 agtgggaact ttactgtgca gaaccgagaa cttgaatgca ttcgagagat taaagagaaa
      841 gtaggaacat caaaagtgtt ggttttactc agtggtggtg tagattcaac tgtttgtaca
      901 gctttgctaa atcgtgcttt gaaccaagat caagtcattg ctgtacacat tgataatggc
      961 tttatgagaa aacgagaaag ccaatctgtt gaagaggccc tcaaaaagct tggaattcaa
     1021 gtcaaagtga taaatgctgc tcattccttc tacaatggaa caactactct accaatctca
     1081 gatgaagaca ggaccccacg gaaaagaatt agcaaaacat taaatatgac aacaagtcct
     1141 gaggagaaaa gaaaaattat tggtgatact ttcgttaaga ttgccaatga agtaattgga
     1201 gaaatgagtc tgaagcccga ggaggttttt ctcgcccaag gcactttacg gcctgatcta
     1261 atcgaaagtg cgtcccttgt tgccagtggt aaagccgaac tcatcaaaac ccaccacaac
     1321 gacacagaac ttatcaggaa gttaagggaa gagggaaaag taatagaacc tctgaaagat
     1381 tttcataaag atgaagtcag gattttaggc agagagcttg acctgccaga agaattggtt
     1441 tccaggcatc cttttccagg tcctggcctg gcaatcagag taatatgtgc tgaagaacct
     1501 tatatttgta aagacttccc tgaaaccaac aatattttga aaatagtagc tgatttttct
     1561 gcaagtgtta agaagcctca tacactgtta caaagagtca aagcctgcac aacagaagag
     1621 gaccaggaga agctcatgca aattacaagt ctgcattcac tcaatgcttt cttgctgcca
     1681 attaagactg taggtgtaca gggtgactgt cgttcttaca gttatgtgtg tggaatctca
     1741 agtaaagatg aacctgactg ggaatctctt attttccttg ccagacttat acctcgaatg
     1801 tgtcataaca ttaacagagt tgtctatatc tttggtccac cagttaaaga gcctcctaca
     1861 gatgttactc caactttttt gacaacagga gtgctcagta ctttacgcca agctgatttt
     1921 gaggcccata acattctcag ggagtctggg tttgctggga aaatcagcca gatgccagtg
     1981 attttgaccc ctttacattt cgatagagat ccacttcaga agcagccttc atgccagagg
     2041 tctgtggtta ttcgaacctt tattactagt gacttcatga ctggtgtacc tgcaacacct
     2101 ggcaatgaga ttcctgtaga ggtggtgcta aagatggtca ctgagataaa gaagattcct
     2161 ggaatttcta gaattatgta tgacctaact tcaaagcccc cgggaaccac tgagtgggag
     2221 taataaatgc tttgttgagg aactgtgtgt aactgaggct cattagaaac cacttgttaa
     2281 tggtatgcag tactgtgaaa aatgttcgtg aaacagctac ttcatatctg agctctcata
     2341 gcagtgatcc atggcttagt gtggagctga ggatgattaa aatggaagga agcgttagtg
     2401 tgtctgggta aataatcatg gcaccattgc ccaagtgcag acagattgtt cttacttttg
     2461 cctcagttat gtatagacca ttgatatctg tatataacga tggatgacca gcttctgtct
     2521 gcttgctagg aactgttaga aacaaaacac cctttaatta ccagtgtgac tttctgtgtg
     2581 tgccttttgg agagtccaat ttttttttta gttttttttt ttttttttct tcagcaggtg
     2641 aggaaaccct atttatgcca tagaaaggta taataaaggt attttgactt tttttttttt
     2701 tttttttttt tgtgtgtcat gacacaagga aagtaaaatg taagatgctt caaagatgta
     2761 gcataccagg gatttattat ggaaggagtt taatgatacc ccagccctgg gtaaaaagga
     2821 actgacgacg tttcctacgg atgccatgct tttcactgtc atcttgttaa tatataagca
     2881 agagctttat ccttctggcc ctgtgtcact agttcctaca tctgtgtaca aagagtattt
     2941 aatctctcct caaggctgtc tgagaacttg ttctttttct ttgggagagg gaatgtttct
     3001 attacttagg aaagagctgt gtaaaaggac acccaaggtc tggtctatag acaggtttgt
     3061 tattccttgc taagaagtct tgactgatgc agggtatttg ccaacatctt ttctactaac
     3121 ttctggagaa ggttcaagac cagggcagga cttgattcca ttgccaatag ttctcacagg
     3181 ttctttatga cagccataca agcctgagaa agtaggcagt acaaagttaa gttctaaaaa
     3241 atagtaccat gtttctctca cttgctttta ccccaggttg cagtctgttg tctggtttag
     3301 aagatctttt ctattacttc agtaccagtt tctacttagg attcagtgtt aaatgaaaac
     3361 aaaagtggaa gtcatctttt tgactagtct atagatagcc agaaactgct gctgaaccaa
     3421 gaggaaaaga tctctaacag cagacatcca cactggaaac actatttgtc ttctacaaaa
     3481 gctgaagtgt tcattgtccc agtgagaaag ttctgatggc tttctaaaag gaagatgtgg
     3541 ttgatagatt taggcagatt gagggttctg ttatttctga gtgggaactg ccaagtacag
     3601 aatgtttacc aaagtatcag tgcatgtttg attacataga aaaccttgtt ctagcaaaag
     3661 tatctgctgt acacagcaag aatcaggaag aatatgggat gttctaaccc tgaagttttt
     3721 tgtggcatac tgatcactgc tggtcaggtg atcatatatt ctgggaagag ctgcttattt
     3781 gtgactttag cattctggac gtttgtggta tatagaatac tcagaaagat tggagttaaa
     3841 atgtatgtag tgtttttctc atatgttctc ttagatgact ttatgtaatc cttaatgctg
     3901 aaaagaaaat ttctcccaaa aatatctgta catcatatag aaactttgtg agactgagag
     3961 ctaattttca tgtttactat ctatttttct atgtggttat tttgcctgtc acaatagttc
     4021 atgtgggcca ttgaaaatag ttacagtcaa gaagacaaac aagcttaact tggaaattgt
     4081 taccagtgac tttaagaacc aactgggagg ggagggagct attcttctgt taagtgtatt
     4141 ccagccctaa aagctcatat ggccttacag gctatttact ttttgcttgg atagtaacat
     4201 ttatcgctcg atatcctggg cagttttggc ttatactatt agttatttgg gacacttaca
     4261 taattgtgtt ttatttcttc gtaactatta gagtaagcga gatctgtgaa aatgtgattt
     4321 attctaaaat tggcagacca gaaaacattt aaaagccgaa taaataaatc ctagacctat
     4381 cttagggaac ctatcagtga tggtctgtct atgggatata acaacctcat atatattttt
     4441 ttttactttt attttagttt ttagttttaa gagtaattta ttatatatat atgagtacac
     4501 tgtagctgtc ttcagacaca cagaagaggg catcagatcc cattactgat ggttgtgagc
     4561 tactatg
//
