LOCUS       NM_177992               1560 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus guanosine monophosphate reductase 2 (Gmpr2), mRNA.
ACCESSION   NM_177992 NM_134075
VERSION     NM_177992.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1560)
  AUTHORS   Zhang,J., Zhang,W., Zou,D., Chen,G., Wan,T., Zhang,M. and Cao,X.
  TITLE     Cloning and functional characterization of GMPR2, a novel human
            guanosine monophosphate reductase, which promotes the monocytic
            differentiation of HL-60 leukemia cells
  JOURNAL   J Cancer Res Clin Oncol 129 (2), 76-83 (2003)
   PUBMED   12669231
REFERENCE   2  (bases 1 to 1560)
  AUTHORS   Deng,Y., Wang,Z., Ying,K., Gu,S., Ji,C., Huang,Y., Gu,X., Wang,Y.,
            Xu,Y., Li,Y., Xie,Y. and Mao,Y.
  TITLE     NADPH-dependent GMP reductase isoenzyme of human (GMPR2).
            Expression, purification, and kinetic properties
  JOURNAL   Int J Biochem Cell Biol 34 (9), 1035-1050 (2002)
   PUBMED   12009299
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY099107.1, AK075772.1 and BE956837.1.
            
            On or before Nov 3, 2006 this sequence version replaced
            NM_134075.1, NM_177992.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031004.1, BC024109.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                BY099107.1         2-88
            88-1533             AK075772.1         46-1491
            1534-1560           BE956837.1         1-27                c
FEATURES             Location/Qualifiers
     source          1..1560
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..1560
                     /gene="Gmpr2"
                     /gene_synonym="1810008P16Rik; 5730544D12Rik; GMPR 2"
                     /note="guanosine monophosphate reductase 2"
                     /db_xref="GeneID:105446"
                     /db_xref="MGI:MGI:1917903"
     exon            1..150
                     /gene="Gmpr2"
                     /gene_synonym="1810008P16Rik; 5730544D12Rik; GMPR 2"
                     /inference="alignment:Splign:2.1.0"
     exon            151..246
                     /gene="Gmpr2"
                     /gene_synonym="1810008P16Rik; 5730544D12Rik; GMPR 2"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..1206
                     /gene="Gmpr2"
                     /gene_synonym="1810008P16Rik; 5730544D12Rik; GMPR 2"
                     /EC_number="1.7.1.7"
                     /note="guanosine 5'-monophosphate oxidoreductase 2"
                     /codon_start=1
                     /product="GMP reductase 2"
                     /protein_id="NP_818773.1"
                     /db_xref="CCDS:CCDS27124.1"
                     /db_xref="GeneID:105446"
                     /db_xref="MGI:MGI:1917903"
                     /translation="MPHIDNDVKLDFKDVLLRPKRSTLKSRSEVELTRSFSFRNSKQM
                     YSGIPVIAANMDTVGTFEMARVLCKFSLFTAIHKHYSIHQWQEFASQNPDCLECLAAS
                     SGSGSADFEQLEQILEAIPQVKYICLDVANGYSEHFVEFVKDVRKRFPQHTIMAGNVV
                     TGEMVEELILSGADIIKVGIGPGSVCTTRKKTGVGYPQLSAVMECADAAHGLKGHIIS
                     DGGCSCPGDVAKAFGAGADFVMLGGMLAGHSESGGELIERDGKKYKLFYGMSSEMAMK
                     KYSGGVAEYRASEGKIVEVPFKGDVEHTIRDILGGIRSTCTYVGAAKLKELSRRTTFI
                     RVTQQVNPIFSNSQ"
     exon            247..366
                     /gene="Gmpr2"
                     /gene_synonym="1810008P16Rik; 5730544D12Rik; GMPR 2"
                     /inference="alignment:Splign:2.1.0"
     exon            367..450
                     /gene="Gmpr2"
                     /gene_synonym="1810008P16Rik; 5730544D12Rik; GMPR 2"
                     /inference="alignment:Splign:2.1.0"
     exon            451..624
                     /gene="Gmpr2"
                     /gene_synonym="1810008P16Rik; 5730544D12Rik; GMPR 2"
                     /inference="alignment:Splign:2.1.0"
     exon            625..706
                     /gene="Gmpr2"
                     /gene_synonym="1810008P16Rik; 5730544D12Rik; GMPR 2"
                     /inference="alignment:Splign:2.1.0"
     exon            707..813
                     /gene="Gmpr2"
                     /gene_synonym="1810008P16Rik; 5730544D12Rik; GMPR 2"
                     /inference="alignment:Splign:2.1.0"
     exon            814..856
                     /gene="Gmpr2"
                     /gene_synonym="1810008P16Rik; 5730544D12Rik; GMPR 2"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1016
                     /gene="Gmpr2"
                     /gene_synonym="1810008P16Rik; 5730544D12Rik; GMPR 2"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1544
                     /gene="Gmpr2"
                     /gene_synonym="1810008P16Rik; 5730544D12Rik; GMPR 2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1511..1516
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gmpr2"
                     /gene_synonym="1810008P16Rik; 5730544D12Rik; GMPR 2"
                     /note="hexamer: ATTAAA"
     polyA_site      1537
                     /gene="Gmpr2"
                     /gene_synonym="1810008P16Rik; 5730544D12Rik; GMPR 2"
                     /note="major polyA site"
ORIGIN      
        1 agcgcccgaa gctagaattc cttgggtagt cgagtttgca attagcggaa ctcgttcgag
       61 tggccctgaa ggctcatcga ggctgcacgc ggctagttgc taagcaaaag aatctttggt
      121 caactgccac ctgagtcaaa gcaacaggaa ctttgcatca tgcctcatat tgataatgat
      181 gtgaaacttg acttcaagga tgtcctgttg aggcccaaac gcagcactct taagtctcga
      241 agtgaggtag agctcacaag atcattttcg ttccggaact caaagcagat gtacagtggc
      301 atccctgtca ttgctgccaa tatggatacc gtgggcactt ttgaaatggc tagggttctc
      361 tgtaagttct ccctgttcac tgccatccat aagcactaca gcatccatca gtggcaagag
      421 tttgctagcc agaatcctga ctgtcttgag tgtctagctg ccagctcagg ctcaggctct
      481 gctgactttg agcagctgga acagatcctg gaagctattc cccaagtcaa atatatatgc
      541 ctggatgtgg ctaacggcta ctctgaacat tttgttgaat ttgtaaagga tgtacggaag
      601 cgattccccc aacacaccat catggcagga aatgtggtaa caggagagat ggtagaagag
      661 ttaatccttt ctggggctga catcatcaaa gtgggaattg gtcctggctc tgtctgtaca
      721 actcggaaga aaactggagt ggggtatcca cagctcagtg cagtgatgga gtgtgcagat
      781 gctgctcatg gcctcaaagg ccatatcatc tcagatggag gctgcagctg tcctggggat
      841 gtggcaaagg cttttggggc aggggctgac tttgtgatgt tgggtggcat gctggccggg
      901 cacagtgaat caggtggcga actcattgag agagatggca agaaatataa gctcttctac
      961 ggaatgagtt ctgaaatggc catgaagaag tactcaggag gtgtggctga gtacagggcc
     1021 tcagagggaa agatagtaga agtccccttt aaaggcgatg tggaacatac tattcgtgac
     1081 atcctaggag gcatccggtc tacatgcacg tatgtagggg ctgctaaact gaaggaacta
     1141 agccggagaa ctacttttat ccgagtcacc cagcaagtga atccaatctt cagcaattcc
     1201 cagtagaccc aagaagccta ctttcctgag gcagcagcac tgccactgga gcctcccgac
     1261 agggcgtgcc tctcccactg cagcccctgt ggtggtggct gcctaattca gttccagctc
     1321 tcactctact cacccatgcc tctagctgca caatgttatg gcactacggg agaggcgagg
     1381 aaggagacgt gagatcaaca aatgagaccc tggggacagc ccccgaagat taggaagatg
     1441 ctaatccaca cagaaatggc agcccttggt ctggaaaggg aaggctgcgg gaatcatgtt
     1501 aagcagcttc attaaatgac atcatcacgt gtctaaacag cttaaaaaaa aaaaaaaaaa
//
