LOCUS       NM_025508               1584 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus guanosine monophosphate reductase (Gmpr), mRNA.
ACCESSION   NM_025508 XM_913041 XM_922611
VERSION     NM_025508.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1584)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1584)
  AUTHORS   Pang,C.J., Lemsaddek,W., Alhashem,Y.N., Bondzi,C., Redmond,L.C.,
            Ah-Son,N., Dumur,C.I., Archer,K.J., Haar,J.L., Lloyd,J.A. and
            Trudel,M.
  TITLE     Kruppel-like factor 1 (KLF1), KLF2, and Myc control a regulatory
            network essential for embryonic erythropoiesis
  JOURNAL   Mol Cell Biol 32 (13), 2628-2644 (2012)
   PUBMED   22566683
REFERENCE   3  (bases 1 to 1584)
  AUTHORS   Hedstrom,L.
  TITLE     The dynamic determinants of reaction specificity in the IMPDH/GMPR
            family of (beta/alpha)(8) barrel enzymes
  JOURNAL   Crit Rev Biochem Mol Biol 47 (3), 250-263 (2012)
   PUBMED   22332716
  REMARK    Review article
REFERENCE   4  (bases 1 to 1584)
  AUTHORS   Lai,H.C., Klisch,T.J., Roberts,R., Zoghbi,H.Y. and Johnson,J.E.
  TITLE     In vivo neuronal subtype-specific targets of Atoh1 (Math1) in
            dorsal spinal cord
  JOURNAL   J Neurosci 31 (30), 10859-10871 (2011)
   PUBMED   21795538
REFERENCE   5  (bases 1 to 1584)
  AUTHORS   MAGER,J. and MAGASANIK,B.
  TITLE     Guanosine 5'-phosphate reductase and its role in the
            interconversion of purine nucleotides
  JOURNAL   J Biol Chem 235, 1474-1478 (1960)
   PUBMED   14419794
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC154521.2, BY274415.1,
            AK084508.1 and AC154817.2.
            
            On May 7, 2015 this sequence version replaced NM_025508.4.
            
            Summary: A similar gene in human encodes an enzyme that catalyzes
            the irreversible and NADPH-dependent reductive deamination of GMP
            to IMP. The protein also functions in the re-utilization of free
            intracellular bases and purine nucleosides. [provided by RefSeq,
            May 2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010827.2, AK084508.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AC154521.2         16089-16101         c
            14-97               BY274415.1         2-85
            98-1577             AK084508.1         2-1481
            1578-1584           AC154817.2         82335-82341         c
FEATURES             Location/Qualifiers
     source          1..1584
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 21.94 cM"
     gene            1..1584
                     /gene="Gmpr"
                     /gene_synonym="2310004P21Rik; GMPR 1"
                     /note="guanosine monophosphate reductase"
                     /db_xref="GeneID:66355"
                     /db_xref="MGI:MGI:1913605"
     exon            1..300
                     /gene="Gmpr"
                     /gene_synonym="2310004P21Rik; GMPR 1"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..1251
                     /gene="Gmpr"
                     /gene_synonym="2310004P21Rik; GMPR 1"
                     /EC_number="1.7.1.7"
                     /note="guanosine 5'-monophosphate oxidoreductase 1;
                     guanosine monophosphate reductase 1"
                     /codon_start=1
                     /product="GMP reductase 1"
                     /protein_id="NP_079784.1"
                     /db_xref="CCDS:CCDS26482.1"
                     /db_xref="GeneID:66355"
                     /db_xref="MGI:MGI:1913605"
                     /translation="MPRIDADLKLDFKDVLLRPKRSSLKSRSEVDLERTFTFRNSKQT
                     YSGIPIIVANMDTVGTFEMAVVMSQHAMFTAVHKHYSLDDWKCFAETHPECLQHVAVS
                     SGSGQNDLERMSRILEAVPQVKFICLDVANGYSEHFVEFVKLVRSKFPEHTIMAGNVV
                     TGEMVEELILSGADIIKVGVGPGSVCTTRTKTGVGYPQLSAVIECADSAHGLKGHIIS
                     DGGCTCPGDVAKAFGAGADFVMLGGMFSGHTECAGEVIERNGQKLKLFYGMSSDTAMK
                     KHAGGVAEYRASEGKTVEVPYKGDVENTILDILGGLRSTCTYVGAAKLKELSRRATFI
                     RVTQQHNTVFG"
     exon            301..420
                     /gene="Gmpr"
                     /gene_synonym="2310004P21Rik; GMPR 1"
                     /inference="alignment:Splign:2.1.0"
     exon            421..504
                     /gene="Gmpr"
                     /gene_synonym="2310004P21Rik; GMPR 1"
                     /inference="alignment:Splign:2.1.0"
     exon            505..678
                     /gene="Gmpr"
                     /gene_synonym="2310004P21Rik; GMPR 1"
                     /inference="alignment:Splign:2.1.0"
     exon            679..760
                     /gene="Gmpr"
                     /gene_synonym="2310004P21Rik; GMPR 1"
                     /inference="alignment:Splign:2.1.0"
     exon            761..867
                     /gene="Gmpr"
                     /gene_synonym="2310004P21Rik; GMPR 1"
                     /inference="alignment:Splign:2.1.0"
     exon            868..910
                     /gene="Gmpr"
                     /gene_synonym="2310004P21Rik; GMPR 1"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1070
                     /gene="Gmpr"
                     /gene_synonym="2310004P21Rik; GMPR 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1584
                     /gene="Gmpr"
                     /gene_synonym="2310004P21Rik; GMPR 1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1560..1565
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gmpr"
                     /gene_synonym="2310004P21Rik; GMPR 1"
                     /note="hexamer: AATATA"
     polyA_site      1580
                     /gene="Gmpr"
                     /gene_synonym="2310004P21Rik; GMPR 1"
                     /note="major polyA site"
ORIGIN      
        1 ggggcgctcc cttggggcgc ctggcgttgg ggaacggagc tgggggctcc gggtgcgcgg
       61 gcataagaac aaggcgtgcg caccgggttc gcggagcacc agtctgcgca cagccacccg
      121 ggcgccactg tacgcacgcg ccccgcagct cccggctgac gccggccttc gcaccgcctc
      181 cgccgcagga agctaccgcg caccgctagc accatgcccc gcatagacgc ggaccttaaa
      241 ctcgacttca aggatgttct gctgcgacct aagcggagca gcctcaagag ccgatccgag
      301 gtggatcttg agcgaacttt tacatttcga aactcgaagc aaacctactc agggattccc
      361 atcattgtgg ccaacatgga cactgtgggg acatttgaga tggctgtggt gatgtcacag
      421 catgccatgt ttacagccgt tcacaagcac tactccctgg atgactggaa atgttttgcg
      481 gaaacccacc ccgaatgcct gcagcatgta gccgtgagtt ctggcagcgg gcagaatgat
      541 cttgagagga tgagccgcat cttggaagct gtgcctcagg tgaagttcat ctgcctggat
      601 gtggccaatg ggtattcaga gcattttgtg gaattcgtga aactggtccg atccaaattc
      661 cccgaacaca ccatcatggc agggaacgtg gtgaccggag agatggtgga agagctcatc
      721 ctctctggag cagatatcat caaagtggga gtcggaccag gttctgtgtg caccacccga
      781 accaagacag gagtgggcta cccgcagctg agtgcggtga tagagtgtgc tgactccgcc
      841 catggcctca aggggcacat catctctgat ggaggctgca catgtccagg agatgtcgcc
      901 aaagcctttg gagctggtgc agactttgtc atgctgggag gcatgttttc aggccacacc
      961 gagtgtgcag gtgaggtgat cgagaggaac gggcagaagc tgaaactctt ctatggcatg
     1021 agctcagaca cagccatgaa gaaacacgca ggaggcgtcg ccgagtacag ggcctccgag
     1081 ggcaagaccg tggaagtgcc ttacaaaggg gacgtggaga acaccattct ggatatcctt
     1141 ggaggactgc gctccacctg tacctacgtc ggggctgcca agctcaaaga gctcagcagg
     1201 agagccacgt tcatccgggt gacccaacag cacaacacgg tgtttggtta acctcgggga
     1261 tgcagacctc agtgttgagc cgagtggaag cctcctttca ccatgcttcg cccctcccct
     1321 ccttatctgc cttggcaggc tggctgctat cacagatgct gagactgagt ccttgtcctg
     1381 atcttgtagc ccgagacctt ggggcttgcc ctagtgcctg tgtggggccc aggagcaggg
     1441 cgctcgtggg gccccgggtc agctcctaga actcatcgcc tcctggtgtc aaccagccct
     1501 tgcaccctcc tttctgtccg ccgttagttt tctttctaaa ggacaatggt ttcactttta
     1561 atataatgct atgatcttga ctga
//
