LOCUS       NM_177910               1772 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Mus musculus GDP-mannose pyrophosphorylase B (Gmppb), transcript
            variant 1, mRNA.
ACCESSION   NM_177910
VERSION     NM_177910.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1772)
  AUTHORS   Schurig,M.K., Umeh,O., Henze,H., Jung,M.J., Gresing,L.,
            Blanchard,V., von Maltzahn,J., Hubner,C.A. and Franzka,P.
  TITLE     Consequences of GMPPB deficiency for neuromuscular development and
            maintenance
  JOURNAL   Front Mol Neurosci 17, 1356326 (2024)
   PUBMED   38419795
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1772)
  AUTHORS   Liu,Z., Wang,Y., Yang,F., Yang,Q., Mo,X., Burstein,E., Jia,D.,
            Cai,X.T. and Tu,Y.
  TITLE     GMPPB-congenital disorders of glycosylation associate with
            decreased enzymatic activity of GMPPB
  JOURNAL   Mol Biomed 2 (1), 13 (2021)
   PUBMED   35006422
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1772)
  AUTHORS   Franzka,P., Henze,H., Jung,M.J., Schuler,S.C., Mittag,S.,
            Biskup,K., Liebmann,L., Kentache,T., Morales,J., Martinez,B.,
            Katona,I., Herrmann,T., Huebner,A.K., Hennings,J.C., Groth,S.,
            Gresing,L., Horstkorte,R., Marquardt,T., Weis,J., Kaether,C.,
            Mutchinick,O.M., Ori,A., Huber,O., Blanchard,V., von Maltzahn,J.
            and Hubner,C.A.
  TITLE     GMPPA defects cause a neuromuscular disorder with
            alpha-dystroglycan hyperglycosylation
  JOURNAL   J Clin Invest 131 (9) (2021)
   PUBMED   33755596
REFERENCE   4  (bases 1 to 1772)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC137678.11.
            
            On Aug 13, 2022 this sequence version replaced NM_177910.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158470.1, AK148125.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-355               AC137678.11        61818-62172
            356-436             AC137678.11        62288-62368
            437-485             AC137678.11        62456-62504
            486-628             AC137678.11        62642-62784
            629-787             AC137678.11        62978-63136
            788-866             AC137678.11        63221-63299
            867-994             AC137678.11        63376-63503
            995-1177            AC137678.11        63587-63769
            1178-1772           AC137678.11        63853-64447
FEATURES             Location/Qualifiers
     source          1..1772
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.07 cM"
     gene            1..1772
                     /gene="Gmppb"
                     /gene_synonym="E430010H19"
                     /note="GDP-mannose pyrophosphorylase B"
                     /db_xref="GeneID:331026"
                     /db_xref="MGI:MGI:2660880"
     exon            1..355
                     /gene="Gmppb"
                     /gene_synonym="E430010H19"
                     /inference="alignment:Splign:2.1.0"
     exon            356..436
                     /gene="Gmppb"
                     /gene_synonym="E430010H19"
                     /inference="alignment:Splign:2.1.0"
     exon            437..485
                     /gene="Gmppb"
                     /gene_synonym="E430010H19"
                     /inference="alignment:Splign:2.1.0"
     exon            486..628
                     /gene="Gmppb"
                     /gene_synonym="E430010H19"
                     /inference="alignment:Splign:2.1.0"
     exon            629..787
                     /gene="Gmppb"
                     /gene_synonym="E430010H19"
                     /inference="alignment:Splign:2.1.0"
     exon            788..866
                     /gene="Gmppb"
                     /gene_synonym="E430010H19"
                     /inference="alignment:Splign:2.1.0"
     exon            867..994
                     /gene="Gmppb"
                     /gene_synonym="E430010H19"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1177
                     /gene="Gmppb"
                     /gene_synonym="E430010H19"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1772
                     /gene="Gmppb"
                     /gene_synonym="E430010H19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1534..1539
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gmppb"
                     /gene_synonym="E430010H19"
                     /note="hexamer: AATAAT"
     polyA_site      1554
                     /gene="Gmppb"
                     /gene_synonym="E430010H19"
                     /note="major polyA site"
     polyA_site      1772
                     /gene="Gmppb"
                     /gene_synonym="E430010H19"
ORIGIN      
        1 aactccggac cagccggtct ccaaccagtt cctcgtcttc tgttctggct gatcctggac
       61 cccacatcag ggtagagcag gggggcgagg tgacaccaga gttggtcagt ctagttggtg
      121 aaacgtgcag gtcagggcac ggcgttggga gtgcgcggca ggggtcggtc aggcggcctg
      181 taagtacttt ggaccgatag atccacttct aacatctgca gacgccatga aggcactgat
      241 cttggtggga gggtatggga cacggttgcg gccgctgacg ttgagcactc cgaagccatt
      301 ggtggacttc tgcaataagc ccatcttgct gcatcaagtg gaggcgcttg ctgcggcagg
      361 tgtggaccac gtgatcctgg cagtgagcta catgtcacag atgttggaga aggaaatgaa
      421 ggcacaagag caaaggcttg gaatccgaat ctctatgtct catgaagagg agcctttggg
      481 gacagctggg cctctggcgt tggcccgaga cctactatct gagactgccg accctttctt
      541 cgttctcaac agtgatgtga tatgtgattt ccccttccaa gccatggtgc agtttcatcg
      601 gcaccatggc caagagggct ccatcttggt taccaaggtg gaagagcctt ccaagtatgg
      661 tgtggtggta tgtgaggctg acacaggccg catccaccgt tttgttgaga agccacaggt
      721 gtttgtgtcc aataagatca acgcaggcat gtacatcctg agccctgctg tgctgcagcg
      781 catccagctg aagcctacat ccattgagaa ggagatcttc ccagttatgg ccaaggaggg
      841 gcagctatat gccatggagc tgcagggctt ctggatggac attggacagc ccaaggattt
      901 cctcactggc atgtgcctct tcctacaatc gctgagacag aagcatccag agagactgta
      961 ctcaggccct ggcattgtgg ggaatgtact tgtggaccca agtgcccgta tcggtcagaa
     1021 ctgcagcatt ggccccaatg taagcctggg tcctggtgtg gtggtggagg atggtgtgtg
     1081 catccggcga tgcacagtgc ttcgtgatgc tcacatccgc tcccattcct ggcttgagtc
     1141 atgcatcgtg ggctggcgct gccgtgtggg ccaatgggtg cgcatggaga atgtaacagt
     1201 gctgggtgaa gatgtcatag ttaatgatga actgtacctc aatggagcca gcgtgctgcc
     1261 ccacaagtct atcggggagt cagtaccaga acctcgtatt atcatgtgaa ggatatggag
     1321 ggctggccaa gcatccactt tgccatcagc agggtaggac tcaatgcttc acgaggccct
     1381 ggacttggtg ccatttgtct agggaggagt ggatgactct gaagctgtcg gacttctgcc
     1441 ttctggtggg gacagacatg gacaggaccc tgctgggtgt aacccacaag cccccactcc
     1501 ctcaagaaga gcgggcccag ggctgtttgg aataataatt taatgctcac tgtagcctgg
     1561 actggaagtc aagctcaggc tcccaccagc gaggctacac acaggcagat gggtgggtgg
     1621 aagtggtaag agtgagggtg atgggtaaac agggcccggt ctgcggctga tggcggagct
     1681 tccaggatgg cctaggcagc tgaggacatg gcgcttgtgt tggctgcctt gtcccagtcc
     1741 tctacagata caatggtggc tttgcagaag aa
//
