LOCUS       NM_020567                995 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus geminin (Gmnn), mRNA.
ACCESSION   NM_020567
VERSION     NM_020567.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 995)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 995)
  AUTHORS   Turner,B.R.H., Mellor,C., McElroy,C., Bowen,N., Gu,W., Knill,C. and
            Itasaki,N.
  TITLE     Non-ubiquitous expression of core spliceosomal protein SmB/B' in
            chick and mouse embryos
  JOURNAL   Dev Dyn 252 (2), 276-293 (2023)
   PUBMED   36058892
REFERENCE   3  (bases 1 to 995)
  AUTHORS   Petropoulos,M., Champeris Tsaniras,S., Nikou,S., Maxouri,S.,
            Dionellis,V.S., Kalogeropoulou,A., Karamichali,A., Ioannidis,K.,
            Danalatos,I.R., Obst,M., Naumann,R., Delinasios,G.J.,
            Gorgoulis,V.G., Roukos,V., Anastassiadis,K., Halazonetis,T.D.,
            Bravou,V., Lygerou,Z. and Taraviras,S.
  TITLE     Cdt1 overexpression drives colorectal carcinogenesis through origin
            overlicensing and DNA damage
  JOURNAL   J Pathol 259 (1), 10-20 (2023)
   PUBMED   36210634
REFERENCE   4  (bases 1 to 995)
  AUTHORS   Wang,L., Park,J.Y., Liu,F., Olesen,K.M., Hou,S., Peng,J.C.,
            Infield,J., Levesque,A.C., Wang,Y.D., Jin,H., Fan,Y.,
            Connelly,P.J., Pruett-Miller,S.M., Hu,M.G., Hinds,P.W. and Han,Y.G.
  TITLE     A kinase-independent function of cyclin-dependent kinase 6 promotes
            outer radial glia expansion and neocortical folding
  JOURNAL   Proc Natl Acad Sci U S A 119 (38), e2206147119 (2022)
   PUBMED   36095192
REFERENCE   5  (bases 1 to 995)
  AUTHORS   Kalogeropoulou,A., Mougkogianni,M., Iliadou,M., Nikolopoulou,E.,
            Flordelis,S., Kanellou,A., Arbi,M., Nikou,S., Nieminuszczy,J.,
            Niedzwiedz,W., Kardamakis,D., Bravou,V., Lygerou,Z. and
            Taraviras,S.
  TITLE     Intrinsic neural stem cell properties define brain hypersensitivity
            to genotoxic stress
  JOURNAL   Stem Cell Reports 17 (6), 1395-1410 (2022)
   PUBMED   35623353
REFERENCE   6  (bases 1 to 995)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 995)
  AUTHORS   Yanagi,K., Mizuno,T., You,Z. and Hanaoka,F.
  TITLE     Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a
            novel intrinsic Cdt1 DNA binding activity
  JOURNAL   J Biol Chem 277 (43), 40871-40880 (2002)
   PUBMED   12192004
  REMARK    GeneRIF: role in inhibiting Cdt1-MCM6 interactions as well as a
            novel intrinsic Cdt1 DNA binding activity
REFERENCE   8  (bases 1 to 995)
  AUTHORS   Hemberger,M., Himmelbauer,H., Ruschmann,J., Zeitz,C. and Fundele,R.
  TITLE     cDNA subtraction cloning reveals novel genes whose temporal and
            spatial expression indicates association with trophoblast invasion
  JOURNAL   Dev Biol 222 (1), 158-169 (2000)
   PUBMED   10885754
REFERENCE   9  (bases 1 to 995)
  AUTHORS   Kroll,K.L., Salic,A.N., Evans,L.M. and Kirschner,M.W.
  TITLE     Geminin, a neuralizing molecule that demarcates the future neural
            plate at the onset of gastrulation
  JOURNAL   Development 125 (16), 3247-3258 (1998)
   PUBMED   9671596
REFERENCE   10 (bases 1 to 995)
  AUTHORS   McGarry,T.J. and Kirschner,M.W.
  TITLE     Geminin, an inhibitor of DNA replication, is degraded during
            mitosis
  JOURNAL   Cell 93 (6), 1043-1053 (1998)
   PUBMED   9635433
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY045588.1, AK131959.1 and CF751770.1.
            
            On Dec 21, 2006 this sequence version replaced NM_020567.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131959.1, SRR1660813.427191.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                BY045588.1         1-27
            28-975              AK131959.1         2-949
            976-995             CF751770.1         461-480
FEATURES             Location/Qualifiers
     source          1..995
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 10.64 cM"
     gene            1..995
                     /gene="Gmnn"
                     /gene_synonym="Gem"
                     /note="geminin"
                     /db_xref="GeneID:57441"
                     /db_xref="MGI:MGI:1927344"
     exon            1..125
                     /gene="Gmnn"
                     /gene_synonym="Gem"
                     /inference="alignment:Splign:2.1.0"
     exon            126..183
                     /gene="Gmnn"
                     /gene_synonym="Gem"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..753
                     /gene="Gmnn"
                     /gene_synonym="Gem"
                     /codon_start=1
                     /product="geminin"
                     /protein_id="NP_065592.1"
                     /db_xref="CCDS:CCDS26378.1"
                     /db_xref="GeneID:57441"
                     /db_xref="MGI:MGI:1927344"
                     /translation="MNLSMKQKQEGAQENVKNSPVPRRTLKMIQPSADGSLVGRENEL
                     PKGLFKRKLWDDQLASQTSSCGPEANENKDVGDLTQEAFDLISKENPSSQYWKEVAEQ
                     RRKALYEALKENEKLHKEIEQKDSEIARLRKENKDLAEVAEHVQYMAEVIERLSNEPL
                     DNFESPDSQEFDSEEEAVEYSELEDSGAGTCAEETVSSSTDARPCT"
     exon            184..261
                     /gene="Gmnn"
                     /gene_synonym="Gem"
                     /inference="alignment:Splign:2.1.0"
     exon            262..397
                     /gene="Gmnn"
                     /gene_synonym="Gem"
                     /inference="alignment:Splign:2.1.0"
     exon            398..480
                     /gene="Gmnn"
                     /gene_synonym="Gem"
                     /inference="alignment:Splign:2.1.0"
     exon            481..591
                     /gene="Gmnn"
                     /gene_synonym="Gem"
                     /inference="alignment:Splign:2.1.0"
     exon            592..977
                     /gene="Gmnn"
                     /gene_synonym="Gem"
                     /inference="alignment:Splign:2.1.0"
     regulatory      947..952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gmnn"
                     /gene_synonym="Gem"
                     /note="hexamer: AATAAA"
     polyA_site      977
                     /gene="Gmnn"
                     /gene_synonym="Gem"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgtcagc taccgggtcg gcgggttagt ctgcaggttc gggtcgttct ggcgtcgttg
       61 aatccggtgt ggtgccaggg ccttgtgcgg ctctcacgct cgccgggaac tgagcattgc
      121 tgtctctgaa aaatgaatct cagtatgaag cagaagcagg agggagccca agagaatgtg
      181 aagaatagtc ctgtcccaag gagaacgctg aagatgatcc agccttctgc agatggatct
      241 cttgttggca gagaaaatga gttgccaaaa ggcttgttca aaaggaagct ttgggatgac
      301 cagctagcat ctcagacttc aagctgtggt ccagaagcta atgaaaataa ggatgttgga
      361 gacctcaccc aggaagcctt tgatcttata agtaaagaga acccatcttc tcagtattgg
      421 aaagaagtgg cagagcagcg gaggaaagct ctctacgaag cgctgaaaga gaatgagaaa
      481 cttcataaag aaattgaaca aaaggacagt gagattgccc gcctgagaaa ggagaataaa
      541 gacttggcag aagtagctga gcacgtgcag tacatggcgg aggtaatcga gaggctgagt
      601 aatgaacctc tggataactt tgaatcaccg gatagtcagg aatttgattc tgaagaagaa
      661 gctgttgagt attcagaact ggaagactca ggagctggga cgtgtgctga agagactgtg
      721 tcttcctcca cggatgctag gccgtgtaca tgaggtgtgg gacgcactgc cagcgttgcc
      781 ctttagtata gctcttggta aactaactac acggtgcaag tgctggaagc caggtttgaa
      841 tcctggggct atcactatgt taaaatacag atagtgtgta tttttaatcc gttttatgta
      901 aatagcattt tcatttttgt cagtgtcaga tataaactgt atattaaata aacttcaatt
      961 tcctgttgaa cattgtaaaa aaaaaaaaaa aaaaa
//
