LOCUS NP_065592 206 aa linear ROD 25-APR-2025 DEFINITION geminin [Mus musculus]. ACCESSION NP_065592 VERSION NP_065592.1 DBSOURCE REFSEQ: accession NM_020567.2 KEYWORDS RefSeq; RefSeq Select. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. REFERENCE 1 (residues 1 to 206) AUTHORS Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A., Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R., Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J., Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z., Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J., Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L., Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J., Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B., Jackson,S.P. and Balmus,G. CONSRTM Sanger Mouse Genetics Project TITLE Genetic determinants of micronucleus formation in vivo JOURNAL Nature 627 (8002), 130-136 (2024) PUBMED 38355793 REFERENCE 2 (residues 1 to 206) AUTHORS Turner,B.R.H., Mellor,C., McElroy,C., Bowen,N., Gu,W., Knill,C. and Itasaki,N. TITLE Non-ubiquitous expression of core spliceosomal protein SmB/B' in chick and mouse embryos JOURNAL Dev Dyn 252 (2), 276-293 (2023) PUBMED 36058892 REFERENCE 3 (residues 1 to 206) AUTHORS Petropoulos,M., Champeris Tsaniras,S., Nikou,S., Maxouri,S., Dionellis,V.S., Kalogeropoulou,A., Karamichali,A., Ioannidis,K., Danalatos,I.R., Obst,M., Naumann,R., Delinasios,G.J., Gorgoulis,V.G., Roukos,V., Anastassiadis,K., Halazonetis,T.D., Bravou,V., Lygerou,Z. and Taraviras,S. TITLE Cdt1 overexpression drives colorectal carcinogenesis through origin overlicensing and DNA damage JOURNAL J Pathol 259 (1), 10-20 (2023) PUBMED 36210634 REFERENCE 4 (residues 1 to 206) AUTHORS Wang,L., Park,J.Y., Liu,F., Olesen,K.M., Hou,S., Peng,J.C., Infield,J., Levesque,A.C., Wang,Y.D., Jin,H., Fan,Y., Connelly,P.J., Pruett-Miller,S.M., Hu,M.G., Hinds,P.W. and Han,Y.G. TITLE A kinase-independent function of cyclin-dependent kinase 6 promotes outer radial glia expansion and neocortical folding JOURNAL Proc Natl Acad Sci U S A 119 (38), e2206147119 (2022) PUBMED 36095192 REFERENCE 5 (residues 1 to 206) AUTHORS Kalogeropoulou,A., Mougkogianni,M., Iliadou,M., Nikolopoulou,E., Flordelis,S., Kanellou,A., Arbi,M., Nikou,S., Nieminuszczy,J., Niedzwiedz,W., Kardamakis,D., Bravou,V., Lygerou,Z. and Taraviras,S. TITLE Intrinsic neural stem cell properties define brain hypersensitivity to genotoxic stress JOURNAL Stem Cell Reports 17 (6), 1395-1410 (2022) PUBMED 35623353 REFERENCE 6 (residues 1 to 206) AUTHORS Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A., Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L., Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E. TITLE BayGenomics: a resource of insertional mutations in mouse embryonic stem cells JOURNAL Nucleic Acids Res 31 (1), 278-281 (2003) PUBMED 12520002 REFERENCE 7 (residues 1 to 206) AUTHORS Yanagi,K., Mizuno,T., You,Z. and Hanaoka,F. TITLE Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a novel intrinsic Cdt1 DNA binding activity JOURNAL J Biol Chem 277 (43), 40871-40880 (2002) PUBMED 12192004 REMARK GeneRIF: role in inhibiting Cdt1-MCM6 interactions as well as a novel intrinsic Cdt1 DNA binding activity REFERENCE 8 (residues 1 to 206) AUTHORS Hemberger,M., Himmelbauer,H., Ruschmann,J., Zeitz,C. and Fundele,R. TITLE cDNA subtraction cloning reveals novel genes whose temporal and spatial expression indicates association with trophoblast invasion JOURNAL Dev Biol 222 (1), 158-169 (2000) PUBMED 10885754 REFERENCE 9 (residues 1 to 206) AUTHORS Kroll,K.L., Salic,A.N., Evans,L.M. and Kirschner,M.W. TITLE Geminin, a neuralizing molecule that demarcates the future neural plate at the onset of gastrulation JOURNAL Development 125 (16), 3247-3258 (1998) PUBMED 9671596 REFERENCE 10 (residues 1 to 206) AUTHORS McGarry,T.J. and Kirschner,M.W. TITLE Geminin, an inhibitor of DNA replication, is degraded during mitosis JOURNAL Cell 93 (6), 1043-1053 (1998) PUBMED 9635433 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY045588.1, AK131959.1 and CF751770.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK131959.1, SRR1660813.427191.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134, SAMN01164135 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## FEATURES Location/Qualifiers source 1..206 /organism="Mus musculus" /strain="C57BL/6" /db_xref="taxon:10090" /chromosome="13" /map="13 10.64 cM" Protein 1..206 /product="geminin" /calculated_mol_wt=23168 Region 1..181 /region_name="Geminin" /note="pfam07412" /db_xref="CDD:462159" Region 1..42 /region_name="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" /note="propagated from UniProtKB/Swiss-Prot (O88513.1)" Site 27 /site_type="acetylation" /note="N6-acetyllysine. /evidence=ECO:0000250|UniProtKB:O75496; propagated from UniProtKB/Swiss-Prot (O88513.1)" Site 36 /site_type="phosphorylation" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:O75496; propagated from UniProtKB/Swiss-Prot (O88513.1)" Site 63 /site_type="phosphorylation" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:O75496; propagated from UniProtKB/Swiss-Prot (O88513.1)" Site 64 /site_type="phosphorylation" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:O75496; propagated from UniProtKB/Swiss-Prot (O88513.1)" Region 79..158 /region_name="Necessary and sufficient for interaction with IDAS and CDT1. /evidence=ECO:0000250" /note="propagated from UniProtKB/Swiss-Prot (O88513.1)" Region 157..206 /region_name="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" /note="propagated from UniProtKB/Swiss-Prot (O88513.1)" Region 167..187 /region_name="Homeodomain binding. /evidence=ECO:0000250" /note="propagated from UniProtKB/Swiss-Prot (O88513.1)" Site 181 /site_type="phosphorylation" /note="Phosphoserine, by CK2. /evidence=ECO:0000250|UniProtKB:O75496; propagated from UniProtKB/Swiss-Prot (O88513.1)" CDS 1..206 /gene="Gmnn" /gene_synonym="Gem" /coded_by="NM_020567.2:133..753" /db_xref="CCDS:CCDS26378.1" /db_xref="GeneID:57441" /db_xref="MGI:MGI:1927344" ORIGIN 1 mnlsmkqkqe gaqenvknsp vprrtlkmiq psadgslvgr enelpkglfk rklwddqlas 61 qtsscgpean enkdvgdltq eafdlisken pssqywkeva eqrrkalyea lkeneklhke 121 ieqkdseiar lrkenkdlae vaehvqymae vierlsnepl dnfespdsqe fdseeeavey 181 seledsgagt caeetvssst darpct //