LOCUS       NP_065592                206 aa            linear   ROD 25-APR-2025
DEFINITION  geminin [Mus musculus].
ACCESSION   NP_065592
VERSION     NP_065592.1
DBSOURCE    REFSEQ: accession NM_020567.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 206)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 206)
  AUTHORS   Turner,B.R.H., Mellor,C., McElroy,C., Bowen,N., Gu,W., Knill,C. and
            Itasaki,N.
  TITLE     Non-ubiquitous expression of core spliceosomal protein SmB/B' in
            chick and mouse embryos
  JOURNAL   Dev Dyn 252 (2), 276-293 (2023)
   PUBMED   36058892
REFERENCE   3  (residues 1 to 206)
  AUTHORS   Petropoulos,M., Champeris Tsaniras,S., Nikou,S., Maxouri,S.,
            Dionellis,V.S., Kalogeropoulou,A., Karamichali,A., Ioannidis,K.,
            Danalatos,I.R., Obst,M., Naumann,R., Delinasios,G.J.,
            Gorgoulis,V.G., Roukos,V., Anastassiadis,K., Halazonetis,T.D.,
            Bravou,V., Lygerou,Z. and Taraviras,S.
  TITLE     Cdt1 overexpression drives colorectal carcinogenesis through origin
            overlicensing and DNA damage
  JOURNAL   J Pathol 259 (1), 10-20 (2023)
   PUBMED   36210634
REFERENCE   4  (residues 1 to 206)
  AUTHORS   Wang,L., Park,J.Y., Liu,F., Olesen,K.M., Hou,S., Peng,J.C.,
            Infield,J., Levesque,A.C., Wang,Y.D., Jin,H., Fan,Y.,
            Connelly,P.J., Pruett-Miller,S.M., Hu,M.G., Hinds,P.W. and Han,Y.G.
  TITLE     A kinase-independent function of cyclin-dependent kinase 6 promotes
            outer radial glia expansion and neocortical folding
  JOURNAL   Proc Natl Acad Sci U S A 119 (38), e2206147119 (2022)
   PUBMED   36095192
REFERENCE   5  (residues 1 to 206)
  AUTHORS   Kalogeropoulou,A., Mougkogianni,M., Iliadou,M., Nikolopoulou,E.,
            Flordelis,S., Kanellou,A., Arbi,M., Nikou,S., Nieminuszczy,J.,
            Niedzwiedz,W., Kardamakis,D., Bravou,V., Lygerou,Z. and
            Taraviras,S.
  TITLE     Intrinsic neural stem cell properties define brain hypersensitivity
            to genotoxic stress
  JOURNAL   Stem Cell Reports 17 (6), 1395-1410 (2022)
   PUBMED   35623353
REFERENCE   6  (residues 1 to 206)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (residues 1 to 206)
  AUTHORS   Yanagi,K., Mizuno,T., You,Z. and Hanaoka,F.
  TITLE     Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a
            novel intrinsic Cdt1 DNA binding activity
  JOURNAL   J Biol Chem 277 (43), 40871-40880 (2002)
   PUBMED   12192004
  REMARK    GeneRIF: role in inhibiting Cdt1-MCM6 interactions as well as a
            novel intrinsic Cdt1 DNA binding activity
REFERENCE   8  (residues 1 to 206)
  AUTHORS   Hemberger,M., Himmelbauer,H., Ruschmann,J., Zeitz,C. and Fundele,R.
  TITLE     cDNA subtraction cloning reveals novel genes whose temporal and
            spatial expression indicates association with trophoblast invasion
  JOURNAL   Dev Biol 222 (1), 158-169 (2000)
   PUBMED   10885754
REFERENCE   9  (residues 1 to 206)
  AUTHORS   Kroll,K.L., Salic,A.N., Evans,L.M. and Kirschner,M.W.
  TITLE     Geminin, a neuralizing molecule that demarcates the future neural
            plate at the onset of gastrulation
  JOURNAL   Development 125 (16), 3247-3258 (1998)
   PUBMED   9671596
REFERENCE   10 (residues 1 to 206)
  AUTHORS   McGarry,T.J. and Kirschner,M.W.
  TITLE     Geminin, an inhibitor of DNA replication, is degraded during
            mitosis
  JOURNAL   Cell 93 (6), 1043-1053 (1998)
   PUBMED   9635433
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY045588.1, AK131959.1 and CF751770.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131959.1, SRR1660813.427191.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..206
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 10.64 cM"
     Protein         1..206
                     /product="geminin"
                     /calculated_mol_wt=23168
     Region          1..181
                     /region_name="Geminin"
                     /note="pfam07412"
                     /db_xref="CDD:462159"
     Region          1..42
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O88513.1)"
     Site            27
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:O75496; propagated from
                     UniProtKB/Swiss-Prot (O88513.1)"
     Site            36
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75496; propagated from
                     UniProtKB/Swiss-Prot (O88513.1)"
     Site            63
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75496; propagated from
                     UniProtKB/Swiss-Prot (O88513.1)"
     Site            64
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75496; propagated from
                     UniProtKB/Swiss-Prot (O88513.1)"
     Region          79..158
                     /region_name="Necessary and sufficient for interaction
                     with IDAS and CDT1. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (O88513.1)"
     Region          157..206
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O88513.1)"
     Region          167..187
                     /region_name="Homeodomain binding. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (O88513.1)"
     Site            181
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:O75496; propagated from
                     UniProtKB/Swiss-Prot (O88513.1)"
     CDS             1..206
                     /gene="Gmnn"
                     /gene_synonym="Gem"
                     /coded_by="NM_020567.2:133..753"
                     /db_xref="CCDS:CCDS26378.1"
                     /db_xref="GeneID:57441"
                     /db_xref="MGI:MGI:1927344"
ORIGIN      
        1 mnlsmkqkqe gaqenvknsp vprrtlkmiq psadgslvgr enelpkglfk rklwddqlas
       61 qtsscgpean enkdvgdltq eafdlisken pssqywkeva eqrrkalyea lkeneklhke
      121 ieqkdseiar lrkenkdlae vaehvqymae vierlsnepl dnfespdsqe fdseeeavey
      181 seledsgagt caeetvssst darpct
//
