LOCUS       NM_001013761            4354 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus geminin coiled-coil domain containing (Gmnc),
            transcript variant 1, mRNA.
ACCESSION   NM_001013761 XM_155938 XM_359237
VERSION     NM_001013761.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4354)
  AUTHORS   Kaplani,K., Lalioti,M.E., Vassalou,S., Lokka,G., Parlapani,E.,
            Kritikos,G., Lygerou,Z. and Taraviras,S.
  TITLE     Ependymal cell lineage reprogramming as a potential therapeutic
            intervention for hydrocephalus
  JOURNAL   EMBO Mol Med 16 (11), 2725-2748 (2024)
   PUBMED   39468302
REFERENCE   2  (bases 1 to 4354)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4354)
  AUTHORS   Moreau,M.X., Saillour,Y., Elorriaga,V., Bouloudi,B., Delberghe,E.,
            Deutsch Guerrero,T., Ochandorena-Saa,A., Maeso-Alonso,L.,
            Marques,M.M., Marin,M.C., Spassky,N., Pierani,A. and Causeret,F.
  TITLE     Repurposing of the multiciliation gene regulatory network in fate
            specification of Cajal-Retzius neurons
  JOURNAL   Dev Cell 58 (15), 1365-1382 (2023)
   PUBMED   37321213
REFERENCE   4  (bases 1 to 4354)
  AUTHORS   Ortiz-Alvarez,G., Fortoul,A., Srivastava,A., Moreau,M.X.,
            Bouloudi,B., Mailhes-Hamon,C., Delgehyr,N., Faucourt,M., Bahin,M.,
            Blugeon,C., Breau,M., Geli,V., Causeret,F., Meunier,A. and
            Spassky,N.
  TITLE     p53/p21 pathway activation contributes to the ependymal fate
            decision downstream of GemC1
  JOURNAL   Cell Rep 41 (11), 111810 (2022)
   PUBMED   36516767
REFERENCE   5  (bases 1 to 4354)
  AUTHORS   Li,Q., Han,Z., Singh,N., Terre,B., Fame,R.M., Arif,U., Page,T.D.,
            Zahran,T., Abdeltawab,A., Huang,Y., Cao,P., Wang,J., Lu,H.,
            Lidov,H.G.W., Surendran,K., Wu,L., Virga,J.Q., Zhao,Y.T.,
            Schuller,U., Wechsler-Reya,R.J., Lehtinen,M.K., Roy,S., Liu,Z.,
            Stracker,T.H. and Zhao,H.
  TITLE     Disruption of GMNC-MCIDAS multiciliogenesis program is critical in
            choroid plexus carcinoma development
  JOURNAL   Cell Death Differ 29 (8), 1596-1610 (2022)
   PUBMED   35322202
REFERENCE   6  (bases 1 to 4354)
  AUTHORS   Terre,B., Piergiovanni,G., Segura-Bayona,S., Gil-Gomez,G.,
            Youssef,S.A., Attolini,C.S., Wilsch-Brauninger,M., Jung,C.,
            Rojas,A.M., Marjanovic,M., Knobel,P.A., Palenzuela,L.,
            Lopez-Rovira,T., Forrow,S., Huttner,W.B., Valverde,M.A., de
            Bruin,A., Costanzo,V. and Stracker,T.H.
  TITLE     GEMC1 is a critical regulator of multiciliated cell differentiation
  JOURNAL   EMBO J 35 (9), 942-960 (2016)
   PUBMED   26933123
  REMARK    GeneRIF: The authors found that GEMC1-deficient mice are growth
            impaired, develop hydrocephaly with a high penetrance, and are
            infertile, due to defects in the formation of multiciliated cells
            in the brain, respiratory tract, and germline.
REFERENCE   7  (bases 1 to 4354)
  AUTHORS   Arbi,M., Pefani,D.E., Kyrousi,C., Lalioti,M.E., Kalogeropoulou,A.,
            Papanastasiou,A.D., Taraviras,S. and Lygerou,Z.
  TITLE     GemC1 controls multiciliogenesis in the airway epithelium
  JOURNAL   EMBO Rep 17 (3), 400-413 (2016)
   PUBMED   26882546
  REMARK    GeneRIF: GemC1 directly transactivates the promoters of MCIDAS and
            FOXJ1.
REFERENCE   8  (bases 1 to 4354)
  AUTHORS   Kyrousi,C., Arbi,M., Pilz,G.A., Pefani,D.E., Lalioti,M.E.,
            Ninkovic,J., Gotz,M., Lygerou,Z. and Taraviras,S.
  TITLE     Mcidas and GemC1 are key regulators for the generation of
            multiciliated ependymal cells in the adult neurogenic niche
  JOURNAL   Development 142 (21), 3661-3674 (2015)
   PUBMED   26395491
  REMARK    GeneRIF: Results suggest that Mcidas and GemC1 are key players in
            the generation of multiciliated ependymal cells of the adult
            neurogenic niche.
REFERENCE   9  (bases 1 to 4354)
  AUTHORS   Wu,J., Bao,J., Kim,M., Yuan,S., Tang,C., Zheng,H., Mastick,G.S.,
            Xu,C. and Yan,W.
  TITLE     Two miRNA clusters, miR-34b/c and miR-449, are essential for normal
            brain development, motile ciliogenesis, and spermatogenesis
  JOURNAL   Proc Natl Acad Sci U S A 111 (28), E2851-E2857 (2014)
   PUBMED   24982181
REFERENCE   10 (bases 1 to 4354)
  AUTHORS   Balestrini,A., Cosentino,C., Errico,A., Garner,E. and Costanzo,V.
  TITLE     GEMC1 is a TopBP1-interacting protein required for chromosomal DNA
            replication
  JOURNAL   Nat Cell Biol 12 (5), 484-491 (2010)
   PUBMED   20383140
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154565.2, AK160719.1 and BC086669.1.
            
            On Oct 25, 2013 this sequence version replaced NM_001013761.1.
            
            Transcript Variant: This variant (1) represents the shortest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC086669.1, CK634140.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMN00849381,
                                    SAMN00849385 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AC154565.2         114632-114663       c
            33-245              AK160719.1         2-214
            246-4354            BC086669.1         1-4109
FEATURES             Location/Qualifiers
     source          1..4354
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 18.56 cM"
     gene            1..4354
                     /gene="Gmnc"
                     /gene_synonym="Gemc1; Gm1778; Gm606"
                     /note="geminin coiled-coil domain containing"
                     /db_xref="GeneID:239789"
                     /db_xref="MGI:MGI:2685452"
     exon            1..180
                     /gene="Gmnc"
                     /gene_synonym="Gemc1; Gm1778; Gm606"
                     /inference="alignment:Splign:2.1.0"
     exon            181..311
                     /gene="Gmnc"
                     /gene_synonym="Gemc1; Gm1778; Gm606"
                     /inference="alignment:Splign:2.1.0"
     exon            312..486
                     /gene="Gmnc"
                     /gene_synonym="Gemc1; Gm1778; Gm606"
                     /inference="alignment:Splign:2.1.0"
     exon            487..575
                     /gene="Gmnc"
                     /gene_synonym="Gemc1; Gm1778; Gm606"
                     /inference="alignment:Splign:2.1.0"
     exon            576..692
                     /gene="Gmnc"
                     /gene_synonym="Gemc1; Gm1778; Gm606"
                     /inference="alignment:Splign:2.1.0"
     exon            693..4329
                     /gene="Gmnc"
                     /gene_synonym="Gemc1; Gm1778; Gm606"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4312..4317
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gmnc"
                     /gene_synonym="Gemc1; Gm1778; Gm606"
                     /note="hexamer: AATAAA"
     polyA_site      4329
                     /gene="Gmnc"
                     /gene_synonym="Gemc1; Gm1778; Gm606"
                     /note="major polyA site"
ORIGIN      
        1 cttttatttc ccagttctgt ggttaaggtc tcctgttaca gacggagggg actgatgata
       61 taattgttta tgagccagca gaacacattt ataggtagta gtgaggtttc cagagagtaa
      121 tgagacgtta aatgttagag acagtggtgc acgattctgg ctaagaaatt tcatctcaag
      181 taagaaaaag tgactcgctg aagaaggcgt tcgtgtgagc tcacagatga gcatgatgct
      241 tgacaaaaac tgagcagtga tgagaatcac ggactgggca acaagaggct atggaagatg
      301 ctgtgttcca gaacagcatt ctgccttgcc aagatcagta ttttgtagga ggccagagtt
      361 ataattgccc gtattccact acaacgtcag aatctggtgt tgacgtttcc aaggagactt
      421 gggtctcttt ctgggctgct ggtctcctgg acaacactga gctccagcaa gcaccacaag
      481 tgctggaatc gccctctgag ttaagtttcc ctgttctgga ctcatgttca tgggaagagg
      541 ctcagctctc atctcagctc tacagaaata aacagctcca ggatactcta ctgcagaagg
      601 aggaagaact tgctaggcta catgaagaga ataatcacct cagacaatac ctgaattcta
      661 ctttggttaa acgtctggaa gagaaggcca agaagttgct gtcatcagat gagttttcca
      721 aagtgtttgg aaaactcaga aaagagaaga ggaaacccaa agaacacaga cactcccctg
      781 ctgagattcc ccagttcaaa actgccaaga gaaacctctc cacagagttt tctaactgtg
      841 aggaacaacc tgggccccat gtggacccct gggttcttca aacccttggg ttaaaagacc
      901 tcaacaccat tgatgacact ctaccagcta actacagtgc caccacctct catcccagag
      961 cagttcccag tatttcctct ctgtttgtac atgatgcaaa tggctatgca aatgtcccca
     1021 gagatctaca cctcgactat gtaggtcagg gaacacatgg ctcacatacc acctccatcc
     1081 accaggaaga ttgtcacagt tttcctaggc tttctaatcc tccagtgagg gtgcagactc
     1141 ttccttacca cactgcagat gtgtcaccca acaagacaga gatggccttt tccacatctt
     1201 tgagccctca ctgtaatgtg aaaactcact ccttccacca gggacaagcc tttgtgcgtc
     1261 gagatgagga aggaggttgg aagtttacct gggtccctaa gcagacctag tgactccttt
     1321 cttctatcac agaacactgc caggacttct gtctgtaaag acctcttgca tatggacttg
     1381 accattgata acacagcagc tctagcctgc ctcctgccac tgccactgtt cctttaggct
     1441 acacacatca acttgcaggg tatggtggtc aataaaccac actgttagcg atctgttctt
     1501 cctttattca ttcttgacct gtttacaggc tcatacctgc cctcggcttt ctctcattgc
     1561 ctgaggcctg gaaatatatt ttctaatttc ctgtatagtt tttcaagaca aaactgtcct
     1621 tttccaatta tggaccgttt aacagcatat cattttccac cagattgtct aaacatggct
     1681 tctattcctc ctctgcttgt ctttgtgtct gaagatgacc cttagaatga gtcccaattc
     1741 tatttcacat acttgctact ggatatccac agatggggct tctgcccttt agcattactg
     1801 aagactcagg gtcaatataa gtaacactct gttcatggaa gatcaaataa ttaaatgtcc
     1861 catggtaatg ttgtcaaaga atctcttaaa gaaagctaac ctcaccgata agcaatacca
     1921 atgacagatt atagcagtca aaagaactac ttttatctct tttaatgtgt catgtgttat
     1981 attaatctct attggtacct gacattgttt ctttgagcag tatgatgcaa catattttga
     2041 gggactttaa ttaaaataaa gaataggaaa ggtttcccgg actacaccga gctgacatcc
     2101 ccttcactgg aactgtagtc ttgcttaact ttgacattgt cttatccttg ttcatcctcc
     2161 attctgcatt ccattaaaac atgtatagaa tacttagtat ccatgtcaga caaggtaagg
     2221 tcacatatgt cccaagacct acacaagtgc acaagttaac cttctcaaag ctatttcatt
     2281 tgtgtgaagg ttcagtgttt ctgcctctag aatataggcg ttaggctagg aaaccacttg
     2341 cattctgagt ggagtgtgcg ttgcatttgc tttagtccaa aatggcatcc cattctattc
     2401 ttccctttaa ctttgataag tgatgcagat attatgtagg gtgaacctta tatacaacca
     2461 aaacaagaaa aatgaatata agcaatatgc atattgctta tataatatat atatatatat
     2521 atacatatat atatatatat ataatcatca caattctgtt ctcatcatga tattcttcag
     2581 cataagccag ttttgtgtgt tagtgtagcc tagtggaaag tcattggcat ctaccaatag
     2641 atacgtattc attttcaagc tgtgcatagc ttgaatgcaa atcctgacat caaggattca
     2701 tcgctttcta gattaaagaa acatttccac atgtttgttt cctttgcacc ctgatcttgt
     2761 gagaattaag catgtatcat ggacacacat ccatattgtc tgcatacagt ccactgctat
     2821 ttctctcgtc cccattcctt ctcaacctgt cacttcacag aaaacatgtc tgaaatgtgt
     2881 actgtctgta agtttttgta agaaggacgt tcttttgatt tttgctcttt gttctctgtt
     2941 ttagtttgat cacaaaaatc aaagaacctg tgttataatt tctattgcca atcagtttta
     3001 tttactatca ttgaaggcac tggtactcgc tggggtgttt tcataactta tggaacaata
     3061 gaactattaa aagctttctt ttcagaggaa tgccttttac attttagtat ccacatccct
     3121 ggtgggtgac atcaatctca ttttagaata acaaagtgaa cattagaatt gattgtatgt
     3181 tgctctgcta ggaattgagt aaaccatgca attattttga aagtcaaata aacagagaac
     3241 caaattaact aaaagatatt tatattgcat tgtttaagca ctgtattgtg tgatgtatgc
     3301 caagaagaaa ttctcaagtt cagcactgtg cattgggcac aaagaacagc tacatacata
     3361 acacagcttt tgagatcatt tcaaatcaac ttggtctcat cctggtgtat agaagttaga
     3421 tcccattgat aacgtgttta gacttataat atgaaaggtg gtaacagagg aattaccaca
     3481 tatttttgca attatatctg caagtttctg atatttattt gagttatata taggctatca
     3541 ttttgttgct gtgtaagaaa tttgaaattt tattatgtga gtacatgttc tgactttaaa
     3601 ggttgatctt ctctctccag caatccactt aatatcttac aagaaaaaaa tgataaaaac
     3661 tgtccctttc tgaatgtgat gggtactttc atatggtgca aatgatttcc aacattagct
     3721 atttctccat ctgggttgta accataacct tctttatttg cattaatttt gtaacatgtt
     3781 tatatctgga ttactatcat tggcacttag ggttattgat tatttccttt ttccaggtat
     3841 ataactgaga cttttaaata atctgtggcc taaaaaggtt caaatgccta atgaatacaa
     3901 ttgtcttaaa cataacatca tataagaatt ttaatctaat gttgatgttt aatcatatta
     3961 tattaactat ccaaaagttt atacaatgta ttttgatgat caatatctct aactcctccc
     4021 ttttccatct tctccaccct taactccata tgcacccaag atctctgttt tgggatattt
     4081 atgaataaat ctgataggct tagttcttaa aacatatagc ataggtatgt ttttcagtat
     4141 gttttaaatc ttcattttga cagaggtaca taagcattta gttttaattc ttacaaagac
     4201 tatctacaaa tatcaagcac gatttactac ttggagtgta aattctacga tttatttttg
     4261 attggaacaa tttctaatta tataagtcaa ctttgtaatc aatctatgac taataaatga
     4321 gaaaacttaa aaaaaaaaaa aaaaaaaaaa aaaa
//
