LOCUS       NM_198101               3945 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus Gem-interacting protein (Gmip), mRNA.
ACCESSION   NM_198101 XM_195711
VERSION     NM_198101.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3945)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3945)
  AUTHORS   Ota,H., Hikita,T., Sawada,M., Nishioka,T., Matsumoto,M., Komura,M.,
            Ohno,A., Kamiya,Y., Miyamoto,T., Asai,N., Enomoto,A., Takahashi,M.,
            Kaibuchi,K., Sobue,K. and Sawamoto,K.
  TITLE     Speed control for neuronal migration in the postnatal brain by
            Gmip-mediated local inactivation of RhoA
  JOURNAL   Nat Commun 5, 4532 (2014)
   PUBMED   25074242
  REMARK    GeneRIF: Gmip serves as a brake for the RhoA-mediated movement of
            neuronal somata, highlighting the significance of speed control in
            the well-organized neuronal migration and the maintenance of
            neuronal circuits in the postnatal brain.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3945)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 3945)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   5  (bases 1 to 3945)
  AUTHORS   Funatsu,N., Inoue,T. and Nakamura,S.
  TITLE     Gene expression analysis of the late embryonic mouse cerebral
            cortex using DNA microarray: identification of several region- and
            layer-specific genes
  JOURNAL   Cereb Cortex 14 (9), 1031-1044 (2004)
   PUBMED   15142957
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC057037.1.
            
            On Dec 17, 2003 this sequence version replaced XM_195711.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057037.1, SRR7652917.874860.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3945
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 33.88 cM"
     gene            1..3945
                     /gene="Gmip"
                     /gene_synonym="5031419I10Rik"
                     /note="Gem-interacting protein"
                     /db_xref="GeneID:78816"
                     /db_xref="MGI:MGI:1926066"
     exon            1..134
                     /gene="Gmip"
                     /gene_synonym="5031419I10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..3031
                     /gene="Gmip"
                     /gene_synonym="5031419I10Rik"
                     /codon_start=1
                     /product="GEM-interacting protein"
                     /protein_id="NP_932769.1"
                     /db_xref="CCDS:CCDS22350.1"
                     /db_xref="GeneID:78816"
                     /db_xref="MGI:MGI:1926066"
                     /translation="MDSAETELTPAPEGRKRYSDIFQSLDNLEISLGNVTFDPLAGDP
                     VRREDLEPDKADTATVVTEENSEASSWRDLSPEGPAPLTEEELDLRLIRTKGGVDAAL
                     EYAKAWSRYAKELLAWTDKRANYELEFAKSIMKLAEAGKVSILQQSQMPLQYIYTLFL
                     EHDLSLGALALETVAQQKRDYYQPLAAKRMEIEKWRKEFKEQWLKEQKRMNEAVQALR
                     RSELQYIQRREDLRARSQGSPEDPPSQASPGSNKQQERRRRSREEAQAKAHEAEALYQ
                     ACVREANSRQQDLETTKRRIVSHVRKLVLQGDEVLRRVTLGLFELRGAQAERGPRSFS
                     ALAECCVPFEPGQRYQEFVRTLQPGAPPPPSPAFCFQEFTAVVHSFPQDTKKKFSGPL
                     PPRLEEEGSPEPGPWEVASLGSQGIPGSDVDSVGGGSESRSLDSPTSSPGAGARRLVK
                     ASSTGTESSDDFEERDPDLGDGIENGVGSPFRKWTLSTAAQTHRLRRLRGPAKCRECE
                     AFMVSGTECEECFLTCHKRCLETLLILCGHRRLPARMSLFGVDFLQLPRDFPEEVPFV
                     ITRCTAEIEHRALGLQGIYRVSGSRVRVERLCQAFENGRALVELSGNSPHDITSVLKR
                     FLQELTDPVVPFHLYDAFISLAKTLHADPGDDPGTPNPSPEIIRSLKTLLVQLPDSNY
                     STLRHLVAHLFRVAARFEENKMSANNLGIVFGPTLLRPPDGPRATGASPVACLLDSGH
                     QAQLVEFLIVHYEQIFGMDELPLASEPLTQDPGLAPACLESSPQHPASLLAQDTQPLT
                     IALDSSPDPKHHSALEKCPEVTPPELATLQRDQREEEVEDTRDGAGDGSSHCPEDLAL
                     GAQSRGHFSRQPVKYSRGGVRPVTHQLSSLALVASKLCEETPVTVSAVHRGSLRVRGL
                     GPAAACPEGSPLRRNPLPKHFEITQETARLLSKLNSDAVSRTTCCADPEPEESEEHL"
     exon            135..219
                     /gene="Gmip"
                     /gene_synonym="5031419I10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            220..307
                     /gene="Gmip"
                     /gene_synonym="5031419I10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            308..365
                     /gene="Gmip"
                     /gene_synonym="5031419I10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            366..491
                     /gene="Gmip"
                     /gene_synonym="5031419I10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            492..556
                     /gene="Gmip"
                     /gene_synonym="5031419I10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            557..664
                     /gene="Gmip"
                     /gene_synonym="5031419I10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            665..745
                     /gene="Gmip"
                     /gene_synonym="5031419I10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            746..916
                     /gene="Gmip"
                     /gene_synonym="5031419I10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1054
                     /gene="Gmip"
                     /gene_synonym="5031419I10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1251
                     /gene="Gmip"
                     /gene_synonym="5031419I10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1361
                     /gene="Gmip"
                     /gene_synonym="5031419I10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1439
                     /gene="Gmip"
                     /gene_synonym="5031419I10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1517
                     /gene="Gmip"
                     /gene_synonym="5031419I10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1672
                     /gene="Gmip"
                     /gene_synonym="5031419I10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1861
                     /gene="Gmip"
                     /gene_synonym="5031419I10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..1999
                     /gene="Gmip"
                     /gene_synonym="5031419I10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2196
                     /gene="Gmip"
                     /gene_synonym="5031419I10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2584
                     /gene="Gmip"
                     /gene_synonym="5031419I10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2585..2651
                     /gene="Gmip"
                     /gene_synonym="5031419I10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2652..3925
                     /gene="Gmip"
                     /gene_synonym="5031419I10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3565..3570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gmip"
                     /gene_synonym="5031419I10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3605
                     /gene="Gmip"
                     /gene_synonym="5031419I10Rik"
                     /note="major polyA site"
     regulatory      3893..3898
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gmip"
                     /gene_synonym="5031419I10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3925
                     /gene="Gmip"
                     /gene_synonym="5031419I10Rik"
                     /note="major polyA site"
ORIGIN      
        1 accactgggt cggcagaggc aggaaatcgg gctggtcccg ggcggcgcgc agccctgtcc
       61 ctttctcagc attgccgcgc gttccccacc ccaccccctg cccccgggca tcgccatgga
      121 ctcagcggag acagagctaa ccccagctcc tgagggcagg aagagataca gtgacatctt
      181 ccagagcctg gacaacctcg agatatcatt ggggaacgta acttttgatc ccctggctgg
      241 agaccctgta cgcagagaag acctggagcc tgacaaagct gacacagcca cagtggtgac
      301 tgaggagaac agtgaagcca gtagttggcg ggatctctcc ccagaaggtc ctgcacccct
      361 cacagaggaa gaactggatt tgcgactcat tcggaccaag ggtggtgtag atgctgccct
      421 ggagtatgct aaagcatgga gccgctatgc caaggaactg ctggcctgga cagacaagag
      481 agccaactac gagctcgagt ttgctaagag tatcatgaag ctcgctgagg ctggcaaggt
      541 gtccattctc cagcagagcc aaatgccact ccagtacatc tacaccttgt ttctggagca
      601 tgacctcagc ctgggagccc tggccctgga gacagtggcc caacagaaga gagactacta
      661 ccagcctctg gcggccaaaa ggatggaaat tgagaagtgg aggaaggaat tcaaggaaca
      721 gtggctgaag gagcagaagc gcatgaatga ggcagtgcag gcactgcggc gctccgagct
      781 ccagtacatt caacgcagag aggacctgag ggcacgctcc caggggtccc ctgaggaccc
      841 tccttcccag gcatctcctg gatccaacaa gcaacaggag cgcagacggc gctcccgaga
      901 ggaggcacag gccaaggcgc atgaggcgga ggctctgtac caggcctgtg tccgggaggc
      961 caattctcgc cagcaggatc tggagaccac caagcggcgg atagtgtcac atgtgcgcaa
     1021 gctggtgctg caaggagacg aagtgcttag gcgggtgacg ctgggtctgt ttgagctgcg
     1081 aggggcgcag gcagagcgag gaccccgctc cttctctgct ctggctgagt gctgtgtgcc
     1141 ctttgaacct ggccagcgct accaggagtt tgttcggaca ctgcagcctg gggccccacc
     1201 gccgccatct ccggccttct gcttccagga gttcacagct gtggtgcaca gtttccctca
     1261 ggacacaaaa aagaagtttt cggggcctct acctccaagg ctggaggagg agggttcccc
     1321 tgagcctggc ccttgggagg ttgccagctt aggcagccag ggaatcccag gcagtgatgt
     1381 ggacagtgta ggtggtggca gtgagtcccg gtctttggat tctcccactt ccagcccagg
     1441 tgctggggcc cgccgacttg taaaggcttc gtccacaggc acggagtcct ccgatgactt
     1501 tgaggagcga gaccctgatc tgggggatgg gatagagaat ggagtaggca gcccgttcag
     1561 gaagtggaca ctgtccacag ctgctcaaac ccaccgactg cggcggctgc ggggcccagc
     1621 caagtgcaga gaatgtgaag ccttcatggt cagcgggaca gaatgtgaag agtgcttttt
     1681 gacctgtcac aagcgctgcc tggagaccct cctcatcctt tgtggacacc ggcggcttcc
     1741 ggcccggatg tccctctttg gggttgactt cctacagctc cccagagatt tccctgagga
     1801 ggttcccttt gtgattacca gatgcacagc tgagatagag caccgtgccc tgggcttgca
     1861 gggtatctat cgggtcagcg ggtctcgggt acgtgtggag cggctgtgcc aggcctttga
     1921 gaatggccga gcactggtcg agctgtccgg gaactctcct cacgatatca ccagcgttct
     1981 caagcgattt cttcaggagc tcactgatcc cgtggtcccc ttccacttgt acgacgcctt
     2041 catctctctg gcaaagaccc tgcatgcaga ccctggggac gaccctggga cccccaaccc
     2101 cagccctgag attattcgct cgctgaagac cctcttggtg cagctgcctg actctaacta
     2161 cagtaccctg cgacacctgg tggcccatct gttcagggtg gctgctcggt ttgaagaaaa
     2221 caagatgtct gccaacaatc tgggaattgt atttgggcct acactgctgc ggccaccaga
     2281 tggacccagg gccaccggtg ccagccctgt ggcctgtctg ctggactccg gtcaccaggc
     2341 tcagctggtt gagttcctca ttgtgcacta tgagcagatc tttggaatgg atgagctccc
     2401 tctggcctcg gagcctctga cccaagaccc tggcttggct cctgcatgcc ttgaatccag
     2461 tccccagcac ccagcctcac ttcttgccca agacacacag cccctgacca tagccttgga
     2521 ttccagccca gaccccaaac accacagtgc cttggagaag tgccccgagg tcacacctcc
     2581 tgagcttgca actctgcaga gggaccagag ggaggaggag gtggaagaca ccagagatgg
     2641 ggcaggggat gggtccagcc actgccctga ggacttggcc ctgggagcac aatcccgggg
     2701 ccacttcagc cgccagccag tgaagtattc ccggggaggt gtgaggccag ttactcatca
     2761 actctccagc ctggctctgg tggcctccaa gctgtgtgag gagactcctg tcactgtctc
     2821 agcagtgcac cgaggtagtt tgagggtacg aggtttgggc cctgctgctg cctgccctga
     2881 aggcagcccc ctgcgccgga accctctgcc caagcacttt gagatcaccc aggagacagc
     2941 ccgacttctc tccaagctga acagtgatgc tgtgtccagg accacctgtt gtgctgaccc
     3001 agagcctgag gagtctgaag agcacctctg accacctacc atcctgaggg acccagaact
     3061 gaattgatgg tccctgaccc aacctggtga ccaaaccaat tcagtggggt gtggggagag
     3121 acggggttac cagtgagttc cggtaatgaa gattacctac ctgtgggagt cccaagacac
     3181 ttggttgaag tgtcccatca tctccctgcc agaggagatt taaacagcta ggcaacacag
     3241 gtgcaggtgt ttcggggtca agactcaatg gtcaatacag atcagtagat ccttggggac
     3301 tacccgagtc tctgacctct gagacgggtg tcttgactat ttcagtcata atggctcctg
     3361 gccctactac acttgcagca gtaacagact cccaagttag caggtggctg cagcccagcc
     3421 ctgtctcctt ttaatttgtt tgtttgtttg tttgttttaa gctaagtctc actgtgtagc
     3481 tctggctggt ctggagctcc ctttgtgagc cacaaatcct ctgcctccca agtgctggct
     3541 aaatctgtgt tcttacaacc tccaaataaa accatatcct gctgccggca ggagggctga
     3601 ccgcagtggt gcttgctgta aagcctcaca tttgttggac ctcccagagc cacttagtgg
     3661 aaggagagag cccatcccta caaattgtct gacctgtgca catgcacaaa taaaagaaaa
     3721 ttttaattta aaaaaaaaaa tccgctgggc ggtagtgcca cacacctcta cttgatccta
     3781 gcactcagga gatagaggca ggaggatctc tgagttttat gccagccagg tgtacagaga
     3841 aagttccagg acagccaggg ctacacagag aaaccctgtt tcagaaaaac aaaataaaat
     3901 aagataaatc ttgtctgttc ttgcaaaaaa aaaaaaaaaa aaaaa
//
