LOCUS       NM_001039192            2318 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus glia maturation factor, gamma (Gmfg), transcript
            variant 2, mRNA.
ACCESSION   NM_001039192
VERSION     NM_001039192.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2318)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2318)
  AUTHORS   Li,Y., Tang,Y., Liu,J., Meng,X., Wang,Y., Min,Q., Hong,R.,
            Tsubata,T., Hase,K. and Wang,J.Y.
  TITLE     Glia maturation factor-gamma is involved in S1P-induced marginal
            zone B-cell chemotaxis and optimal IgM production to type II
            T-independent antigen
  JOURNAL   Int Immunol 34 (1), 35-43 (2022)
   PUBMED   34673932
  REMARK    GeneRIF: Glia maturation factor-gamma is involved in S1P-induced
            marginal zone B-cell chemotaxis and optimal IgM production to type
            II T-independent antigen.
REFERENCE   3  (bases 1 to 2318)
  AUTHORS   Aerbajinai,W., Ghosh,M.C., Liu,J., Kumkhaek,C., Zhu,J., Chin,K.,
            Rouault,T.A. and Rodgers,G.P.
  TITLE     Glia maturation factor-gamma regulates murine macrophage iron
            metabolism and M2 polarization through mitochondrial ROS
  JOURNAL   Blood Adv 3 (8), 1211-1225 (2019)
   PUBMED   30971398
  REMARK    GeneRIF: findings suggest that GMFG is an important regulator in
            cellular iron metabolism and macrophage phenotype and could be a
            novel therapeutic target for modulating macrophage function in
            immune and metabolic disorders.
REFERENCE   4  (bases 1 to 2318)
  AUTHORS   Popinako,A., Antonov,M., Dibrova,D., Chemeris,A. and Sokolova,O.S.
  TITLE     Analysis of the interactions between GMF and Arp2/3 complex in two
            binding sites by molecular dynamics simulation
  JOURNAL   Biochem Biophys Res Commun 496 (2), 529-535 (2018)
   PUBMED   29339159
  REMARK    GeneRIF: Gmfg has two separate binding sites on Arp2/3 complex with
            high (site 1) and low (site 2) affinity. X-ray crystallography
            revealed closely located positions of Gmfg in site 1. Molecular
            dynamics simulation allowed determining the binding pocket for Gmfg
            in site 2.
REFERENCE   5  (bases 1 to 2318)
  AUTHORS   Luan,Q. and Nolen,B.J.
  TITLE     Structural basis for regulation of Arp2/3 complex by GMF
  JOURNAL   Nat Struct Mol Biol 20 (9), 1062-1068 (2013)
   PUBMED   23893131
  REMARK    GeneRIF: The GMF-Arp2 interface reveals how the ADF-H actin-binding
            domain in GMF is exploited to specifically recognize Arp2/3 complex
            and not actin.
REFERENCE   6  (bases 1 to 2318)
  AUTHORS   Ydenberg,C.A., Padrick,S.B., Sweeney,M.O., Gandhi,M., Sokolova,O.
            and Goode,B.L.
  TITLE     GMF severs actin-Arp2/3 complex branch junctions by a cofilin-like
            mechanism
  JOURNAL   Curr Biol 23 (12), 1037-1045 (2013)
   PUBMED   23727094
  REMARK    GeneRIF: GMF debranches filaments by a mechanism related to
            cofilin-mediated severing, but in which GMF has evolved to target
            molecular junctions between actin-related proteins in the Arp2/3
            complex and actin subunits in the daughter filament of the branch.
REFERENCE   7  (bases 1 to 2318)
  AUTHORS   Nam,J., Onitsuka,I., Hatch,J., Uchida,Y., Ray,S., Huang,S., Li,W.,
            Zang,H., Ruiz-Lozano,P. and Mukouyama,Y.S.
  TITLE     Coronary veins determine the pattern of sympathetic innervation in
            the developing heart
  JOURNAL   Development 140 (7), 1475-1485 (2013)
   PUBMED   23462468
REFERENCE   8  (bases 1 to 2318)
  AUTHORS   Ikeda,K., Kundu,R.K., Ikeda,S., Kobara,M., Matsubara,H. and
            Quertermous,T.
  TITLE     Glia maturation factor-gamma is preferentially expressed in
            microvascular endothelial and inflammatory cells and modulates
            actin cytoskeleton reorganization
  JOURNAL   Circ Res 99 (4), 424-433 (2006)
   PUBMED   16873721
  REMARK    GeneRIF: GMFG is a novel factor in actin cytoskeleton
            reorganization and is expressed preferentially in microvascular
            endothelial and inflammatory cells in embryonic development.
REFERENCE   9  (bases 1 to 2318)
  AUTHORS   Bourgeois,F., Guimiot,F., Mas,C., Bulfone,A., Levacher,B.,
            Moalic,J.M. and Simonneau,M.
  TITLE     Identification and isolation of a full-length clone of mouse GMFB
            (Gmfb), a putative intracellular kinase regulator, differentially
            expressed in telencephalon
  JOURNAL   Cytogenet Cell Genet 92 (3-4), 304-309 (2001)
   PUBMED   11435704
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK009967.1 and AC149606.6.
            
            On Dec 13, 2019 this sequence version replaced NM_001039192.1.
            
            Transcript Variant: This variant (2) contains an alternate first
            exon compared to variant 1. Variants 1 and 2 encode the same
            isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY709542.1, AK009967.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-627               AK009967.1         1-627
            628-2318            AC149606.6         65114-66804         c
FEATURES             Location/Qualifiers
     source          1..2318
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 16.76 cM"
     gene            1..2318
                     /gene="Gmfg"
                     /gene_synonym="0610039G16Rik; 2310057N07Rik"
                     /note="glia maturation factor, gamma"
                     /db_xref="GeneID:63986"
                     /db_xref="MGI:MGI:1927135"
     exon            1..105
                     /gene="Gmfg"
                     /gene_synonym="0610039G16Rik; 2310057N07Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..531
                     /gene="Gmfg"
                     /gene_synonym="0610039G16Rik; 2310057N07Rik"
                     /note="isoform a is encoded by transcript variant 2;
                     GMF-gamma"
                     /codon_start=1
                     /product="glia maturation factor gamma isoform a"
                     /protein_id="NP_001034281.1"
                     /db_xref="CCDS:CCDS39860.1"
                     /db_xref="GeneID:63986"
                     /db_xref="MGI:MGI:1927135"
                     /translation="MSDSLVVCEVDPELKETLRKFRFRKETNNAAIIMKVDKDRQMVV
                     LEDELQNISPEELKLELPERQPRFVVYSYKYVHDDGRVSYPLCFIFSSPVGCKPEQQM
                     MYAGSKNRLVQTAELTKVFEIRTTDDLTETWLKEKLAFFR"
     exon            106..202
                     /gene="Gmfg"
                     /gene_synonym="0610039G16Rik; 2310057N07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            203..252
                     /gene="Gmfg"
                     /gene_synonym="0610039G16Rik; 2310057N07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            253..302
                     /gene="Gmfg"
                     /gene_synonym="0610039G16Rik; 2310057N07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            303..385
                     /gene="Gmfg"
                     /gene_synonym="0610039G16Rik; 2310057N07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            386..459
                     /gene="Gmfg"
                     /gene_synonym="0610039G16Rik; 2310057N07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            460..2318
                     /gene="Gmfg"
                     /gene_synonym="0610039G16Rik; 2310057N07Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      604..609
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gmfg"
                     /gene_synonym="0610039G16Rik; 2310057N07Rik"
                     /note="hexamer: AATAAA"
     polyA_site      648
                     /gene="Gmfg"
                     /gene_synonym="0610039G16Rik; 2310057N07Rik"
                     /note="major polyA site"
     polyA_site      653
                     /gene="Gmfg"
                     /gene_synonym="0610039G16Rik; 2310057N07Rik"
                     /note="major polyA site"
     regulatory      2299..2304
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gmfg"
                     /gene_synonym="0610039G16Rik; 2310057N07Rik"
                     /note="hexamer: ATTACA"
     polyA_site      2318
                     /gene="Gmfg"
                     /gene_synonym="0610039G16Rik; 2310057N07Rik"
ORIGIN      
        1 gttagaggaa agcttccccc tttcatagcc catccctctc agcctggggt ccccacccct
       61 agaagacaga ggaactgaga agaggcctaa ggacagaaaa acatgtcgga ctccctggtg
      121 gtgtgtgaag tggacccgga gctaaaggaa acattgagga aatttcgttt ccgaaaagag
      181 accaacaatg ccgccatcat aatgaaagtg gacaaagacc ggcagatggt ggtgctggag
      241 gatgaactcc agaacatctc cccagaagaa cttaagttgg aattgccaga gagacagccc
      301 aggtttgtgg tctacagcta caagtacgtg catgatgacg gcagggtgtc ctatcctttg
      361 tgcttcatct tctccagccc cgtgggctgc aagcctgaac aacagatgat gtacgcagga
      421 agtaaaaaca ggctggtgca gacggcggag cttaccaagg tgtttgaaat ccgcaccaca
      481 gacgacctca ccgagacctg gcttaaggaa aagttagctt tctttcgttg acctttgagc
      541 cagggatttg gaatccttac ttctgaaggc tcagattgat aggatatgaa catccaagag
      601 cgaaataaag gttaaaattt caggaactta ataacgacat ggtatctgca aaatctgagc
      661 ctctttgttg gtgccgccgg acagtcccta cagttccaac tttggccggg agggggcgga
      721 cgtttccagc gaaaccaagc tggtcccagg agaacagaca cctgtttctc agaaaccaag
      781 ggagggggga ctatggggtt tccttggatg gaaggtggcc tgggtcccct taaggaattt
      841 ggagaaatgt ttgaatcaat gaagggtcac gcctaagggg ataaagaccc tcgagaggag
      901 agcgcgggca ccctttttct ccacctgttt cccccgctct gggacaagaa ggcatctttg
      961 gcgccaaatg ctacttttct cagccctcag ataggaagaa tttaaaggcc aaaagatgtc
     1021 aaaagatcaa aatgtaattg cttcaggcac tcaggaggat gctgagggat ggatgttttg
     1081 aggttttgct aagcttgaag gcccaggact gtggggagag agaattcaga actctcagtg
     1141 agccccagag ggcttgaaga gtcagggaaa ggatactccc tatacgctag ccttttttct
     1201 ttttctttct tttttcttgg cacatcaggg cattgaattt tctcaaacct ctgtttctct
     1261 ttgaaggaca tgtgttgagc acccaagcca tacagggctc tgagatgggc agtcaccaca
     1321 aagatgaatc atactttctc tgcttctccc agtgtctccc atggctcctc aatcctcaca
     1381 cccaaggccc ctggaactcc ctccctccac ctctttccag gttccccgtt gagaggtggc
     1441 cgttgccatg gtaacaatga cacagtgacc ttgggcctgg gctgtccctc ccccaaccct
     1501 ggtgctctta gacgagccta aaagggaatt ctaaccctgc ctctccctct cagccttcag
     1561 attcttcccc ccttcaatcc gtgttctttt atccccagtc aagacaaacc cttgtcgaga
     1621 agttctgcat agaatatctc taaactgggc tatggagaaa tgcccttagc tttccatgtt
     1681 ctgggacatg tggatcaagc tgtctccgcc ctgctagagg ctccacccca cctatgtttc
     1741 ttctgatcac agcctcagtt cccaatggct ggaggtggga aagagaggtc tggggataag
     1801 aagaggcatc gaggccaagc aaccgccgct ggcttgccga gatcatggaa cttgtcacaa
     1861 cagtcacaac ctcaaatgca taacagctaa ctctcccact gagcgcttcc tacgagtcaa
     1921 ggatctgtgg gcaccatacg ggcatagttt aattaacctc actctgaaga caaagaaacc
     1981 gaggcacaga aggtgaagcc atagactatc ccaggcccaa agaccacact atggtttttt
     2041 tatgcaagaa ctcaacagcc atttcttttc cccctccatc ctcactatcc ttcagagttg
     2101 aactggcttt tcgggtagaa ctgcaaataa cccaatcaga aaggaccatg taggtgactc
     2161 gcccaatcaa gagcaaatct ggaaagcaaa gactaaccaa aggggcggag gggtggttcg
     2221 atgggttcag tcttttaaga agtaccagca ccctgatgtt aacttattta tttacttttt
     2281 aaaattttga tgtattttat tacattgtat ttgtgtgt
//
