LOCUS       NM_022023               4171 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus glia maturation factor, beta (Gmfb), mRNA.
ACCESSION   NM_022023
VERSION     NM_022023.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4171)
  AUTHORS   Bellver-Sanchis,A., Geng,Q., Navarro,G., Avila-Lopez,P.A.,
            Companys-Alemany,J., Marsal-Garcia,L., Larramona-Arcas,R., Miro,L.,
            Perez-Bosque,A., Ortuno-Sahagun,D., Banerjee,D.R., Choudhary,B.S.,
            Soriano,F.X., Poulard,C., Pallas,M., Du,H.N. and Grinan-Ferre,C.
  TITLE     G9a Inhibition Promotes Neuroprotection through GMFB Regulation in
            Alzheimer's Disease
  JOURNAL   Aging Dis 15 (1), 311-337 (2024)
   PUBMED   37307824
  REMARK    GeneRIF: G9a Inhibition Promotes Neuroprotection through GMFB
            Regulation in Alzheimer's Disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4171)
  AUTHORS   Yin,G., Zeng,W., Li,R., Zeng,M., Chen,R., Liu,Y., Jiang,R. and
            Wang,Y.
  TITLE     Glia Maturation Factor-beta Supports Liver Regeneration by
            Remodeling Actin Network to Enhance STAT3 Proliferative Signals
  JOURNAL   Cell Mol Gastroenterol Hepatol 14 (5), 1123-1145 (2022)
   PUBMED   35953024
  REMARK    GeneRIF: Glia Maturation Factor-beta Supports Liver Regeneration by
            Remodeling Actin Network to Enhance STAT3 Proliferative Signals.
REFERENCE   3  (bases 1 to 4171)
  AUTHORS   Tan,L., Yu,M., Li,Y., Xue,S., Chen,J., Zhai,Y., Fang,X., Liu,J.,
            Liu,J., Wu,X., Xu,H. and Shen,Q.
  TITLE     Overexpression of Long Non-coding RNA 4933425B07Rik Causes Urinary
            Malformations in Mice
  JOURNAL   Front Cell Dev Biol 9, 594640 (2021)
   PUBMED   33681192
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4171)
  AUTHORS   Ahmed,M.E., Selvakumar,G.P., Kempuraj,D., Raikwar,S.P.,
            Thangavel,R., Bazley,K., Wu,K., Khan,O., Khan,A., Zaheer,S.,
            Iyer,S., Burton,C., James,D. and Zaheer,A.
  TITLE     Glia Maturation Factor (GMF) Regulates Microglial Expression
            Phenotypes and the Associated Neurological Deficits in a Mouse
            Model of Traumatic Brain Injury
  JOURNAL   Mol Neurobiol 57 (11), 4438-4450 (2020)
   PUBMED   32737763
  REMARK    GeneRIF: Glia Maturation Factor (GMF) Regulates Microglial
            Expression Phenotypes and the Associated Neurological Deficits in a
            Mouse Model of Traumatic Brain Injury.
REFERENCE   5  (bases 1 to 4171)
  AUTHORS   Ahmed,M.E., Selvakumar,G.P., Kempuraj,D., Raikwar,S.P.,
            Thangavel,R., Bazley,K., Wu,K., Khan,O., Kukulka,K., Bussinger,B.,
            Dubova,I., Zaheer,S., Govindarajan,R., Iyer,S., Burton,C., James,D.
            and Zaheer,A.
  TITLE     Neuroinflammation Mediated by Glia Maturation Factor Exacerbates
            Neuronal Injury in an in vitro Model of Traumatic Brain Injury
  JOURNAL   J Neurotrauma 37 (14), 1645-1655 (2020)
   PUBMED   32200671
  REMARK    GeneRIF: Neuroinflammation Mediated by Glia Maturation Factor
            Exacerbates Neuronal Injury in an in vitro Model of Traumatic Brain
            Injury.
REFERENCE   6  (bases 1 to 4171)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (bases 1 to 4171)
  AUTHORS   Zaheer,A., Yang,B., Cao,X. and Lim,R.
  TITLE     Decreased copper-zinc superoxide dismutase activity and increased
            resistance to oxidative stress in glia maturation factor-null
            astrocytes
  JOURNAL   Neurochem Res 29 (8), 1473-1480 (2004)
   PUBMED   15260123
REFERENCE   8  (bases 1 to 4171)
  AUTHORS   Kaimori,J.Y., Takenaka,M., Nakajima,H., Hamano,T., Horio,M.,
            Sugaya,T., Ito,T., Hori,M., Okubo,K. and Imai,E.
  TITLE     Induction of glia maturation factor-beta in proximal tubular cells
            leads to vulnerability to oxidative injury through the p38 pathway
            and changes in antioxidant enzyme activities
  JOURNAL   J Biol Chem 278 (35), 33519-33527 (2003)
   PUBMED   12791701
  REMARK    GeneRIF: proteinuria induction of GMF-beta in renal proximal
            tubular cells may play a critical role in the progression of renal
            diseases by enhancing oxidative injuries
REFERENCE   9  (bases 1 to 4171)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 4171)
  AUTHORS   Bourgeois,F., Guimiot,F., Mas,C., Bulfone,A., Levacher,B.,
            Moalic,J.M. and Simonneau,M.
  TITLE     Identification and isolation of a full-length clone of mouse GMFB
            (Gmfb), a putative intracellular kinase regulator, differentially
            expressed in telencephalon
  JOURNAL   Cytogenet Cell Genet 92 (3-4), 304-309 (2001)
   PUBMED   11435704
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093043.6.
            
            On May 17, 2008 this sequence version replaced NM_022023.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF297220.1, SRR1660811.162469.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AC093043.6         9778-9919
            143-239             AC093043.6         14538-14634
            240-289             AC093043.6         15793-15842
            290-339             AC093043.6         16372-16421
            340-422             AC093043.6         17033-17115
            423-496             AC093043.6         17703-17776
            497-4171            AC093043.6         20197-23871
FEATURES             Location/Qualifiers
     source          1..4171
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 24.32 cM"
     gene            1..4171
                     /gene="Gmfb"
                     /gene_synonym="3110001H22Rik; 3110001O16Rik; D14Ertd630e"
                     /note="glia maturation factor, beta"
                     /db_xref="GeneID:63985"
                     /db_xref="MGI:MGI:1927133"
     exon            1..142
                     /gene="Gmfb"
                     /gene_synonym="3110001H22Rik; 3110001O16Rik; D14Ertd630e"
                     /inference="alignment:Splign:2.1.0"
     exon            143..239
                     /gene="Gmfb"
                     /gene_synonym="3110001H22Rik; 3110001O16Rik; D14Ertd630e"
                     /inference="alignment:Splign:2.1.0"
     exon            240..289
                     /gene="Gmfb"
                     /gene_synonym="3110001H22Rik; 3110001O16Rik; D14Ertd630e"
                     /inference="alignment:Splign:2.1.0"
     exon            290..339
                     /gene="Gmfb"
                     /gene_synonym="3110001H22Rik; 3110001O16Rik; D14Ertd630e"
                     /inference="alignment:Splign:2.1.0"
     exon            340..422
                     /gene="Gmfb"
                     /gene_synonym="3110001H22Rik; 3110001O16Rik; D14Ertd630e"
                     /inference="alignment:Splign:2.1.0"
     exon            423..496
                     /gene="Gmfb"
                     /gene_synonym="3110001H22Rik; 3110001O16Rik; D14Ertd630e"
                     /inference="alignment:Splign:2.1.0"
     exon            497..4171
                     /gene="Gmfb"
                     /gene_synonym="3110001H22Rik; 3110001O16Rik; D14Ertd630e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      627..632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gmfb"
                     /gene_synonym="3110001H22Rik; 3110001O16Rik; D14Ertd630e"
                     /note="hexamer: CATAAA"
     polyA_site      652
                     /gene="Gmfb"
                     /gene_synonym="3110001H22Rik; 3110001O16Rik; D14Ertd630e"
     regulatory      4149..4154
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gmfb"
                     /gene_synonym="3110001H22Rik; 3110001O16Rik; D14Ertd630e"
                     /note="hexamer: AATAAA"
     polyA_site      4171
                     /gene="Gmfb"
                     /gene_synonym="3110001H22Rik; 3110001O16Rik; D14Ertd630e"
                     /note="major polyA site"
ORIGIN      
        1 gggccacggc ggccgcgtcc ttaggtgggg gaggctgagc ggtgcgccag ccgaaacagg
       61 aagggagttg gctgccgagc cattcttaaa ggggcccaag agatcgcacg gcaacgggcc
      121 gctgacgacc ggaaggaaaa tgagtgagtc tttggtggtt tgtgatgttg ctgaagattt
      181 agtggaaaag ctgagaaagt ttcgttttcg aaaagaaacc cacaatgctg ctattataat
      241 gaagattgac aaggatgaac gcctggtggt gctggatgag gagctcgagg gtgtctctcc
      301 agatgaactt aaagacgaac tacccgagcg gcagcctcgc ttcattgtgt atagttataa
      361 ataccaacat gatgatggca gagtctcgta cccgctctgc tttattttct ccagtcctgt
      421 cgggtgtaag cctgagcagc agatgatgta cgctgggagt aagaacaagc tagtccagac
      481 tgccgagcta accaaggtat ttgaaataag aaacactgaa gatctaactg aagaatggtt
      541 acgtgagaaa cttggatttt tccactaatg tgaacttctg tgtttctaaa gtatttatgt
      601 attaacctga ccatactgga accagacata aatagttatt tatgcctaaa aatgcactgt
      661 tacttacagt ttgtttcctg cagtaaagaa aaattcttca tttgtgcagt ttgaacaaag
      721 gggaaatcat cttcatagta atgagacgtt gtgaagtgtt cctgcatctg tcattgttag
      781 ggggactact tttctccagg gatgctttgc acccttttga ctaatttcta taatttatga
      841 ttcagaattt gtaactgttt gcagacacta taggaaggtg ggtattagac tgtgatagac
      901 aacagttcct cctctgacca ctcctgggta ctggcagttt ataagtgcaa gtagcatttt
      961 atcacctgtc acatcattgc ggttcatttg ggactgaagc gtaagtgacc gattctgagc
     1021 cttgagtaga gatgtagtgg gacctctgtt gaactctccg ccagttttcc tcctctcttg
     1081 ggttcctgta tctttgcaat caagtgtaga atcttcatca atcactcctc cttaaggtcc
     1141 ggaagttgat ttttatggta gagttaggat tgttaggttt tcttcttatg gagaatagca
     1201 tctgaatctt agaaactggg agctctataa tcaagggctt cgttcttggt tatgtcactg
     1261 gcagggagct tagactgtag cttggtaaca ctgcaaagca cctcctaata tgttaatact
     1321 gtgcctttga ttggtcagct ttaccattag cttaagactg ctacactgcc agtgttctag
     1381 atttggtgaa attaatactt ttttaaaggg ttcaaataaa acaattttct aatatatata
     1441 attaaaattt gtaataaacc aacttgttac ttttaaaatt ccaactatct gcccaaagtt
     1501 atgatagtag gtgagagtta taatttgggg tatatttgct attagttttg tgccatatgt
     1561 aagcattatt taaacattgg ccacaattaa taacaacaca tcaatagatg tcataccttt
     1621 tatcctaaat gtcagaagaa attctaatat gaactaagcc agtcacagtt tgatgacacc
     1681 atcatcagga agcaagattt ctaatctact tggaattctt aagtttcact taagaaaaca
     1741 atgtaagaaa tgctgaatag taatttgact taaagagaca agttaagaga ctgtagagac
     1801 gaccaaattc ttatattaag aaggtagtga ttttgattgg gcattggtgg cacataacat
     1861 ttaatcctgg catttgggag gcagagacag gcagatctct gagttcaaga ccagcctggt
     1921 ctgcagaagc aagttccagg gtaaccaagg ctaaacagat gaacaccctg ctcccctaaa
     1981 aagaaaaaaa tagcaaaaca tctttatgtt ggcatgtgtt cattgcatag tatttgtctc
     2041 atttagggct ttgtgccggt tttactggag ggaagatagc tggaactgtc acagtagagt
     2101 ggagtgtgtt gtattcccaa ctgtgtgctc actagcctgt atgtcaggaa gcaattgcaa
     2161 gtgctagagg aggtgatcat attggttcat gaatggaaaa gtccctttat ttcagtgtcc
     2221 agagagcaag aaaacttcat ctaagaagtt taggacttca ttatacaggt attttggtat
     2281 gagctagaga ataacttgct tataatccca caggaatgca gatgagaccc aagtaaaggg
     2341 ggactttgat gtctctgact gatgcacata agggttcgtt tcacctggtt atagaagcac
     2401 gctttcagaa gcagtgctac aagtctacgt tttaaattca gttctttatt ttggcttgca
     2461 tatttaaatc agtttttgaa atttccaagt ctttcataga gtgaatggcc ctgacctgcc
     2521 acacacagga ctcttagtct ctagttcaag cagcaacacc agtggtgagc agctttcctt
     2581 ttcaagcttg tctgactctt acctgtagat gggtcgtttg taaggtagca cactgagttg
     2641 gggcattaat agaacatggt tattctgtct gtccttagac aagtttgtaa gtcctgtgcc
     2701 ctgcagtgtt catgaaatat ttatgtaagt ttccctttag ctaaaattta cagtattttt
     2761 cttattcttt ttctgctgtt ccgtaaagag tatgtccaga tttcataatt ccaggttttt
     2821 tacactccat gtctttcagc aacaaccatt cccactcagc cttaatctta atctttcctt
     2881 tttggaagcc actcttcccg ggaacctttt aagcaagcat tgctttggaa atttctgatc
     2941 ttactaagtt gtgcatagca tctaatgtca gaaccgacta ggaatcacaa tgtatatgtc
     3001 atgtggtttt ggtgacaaca tgagtgacac atgaagaggg gtattctcag gttaccgtgc
     3061 tgcaattcca aaaggtctga gttttaaaca gtgatttgtt ctggtattga cacaattatg
     3121 ttaggaaaaa agctggttga ctgttttgtt taattgactt ctaaactatg tttgaattgt
     3181 ctgaggagtt tactggatgc ttagcgcagt taaacattct cgtcctgtga gagaaacatt
     3241 ctcttgtagg agaggtgttg cagattgtga ttataaaata atttgtagca aaaatatgtg
     3301 ttagcatttt ccctcccttt ttgtctccta ttttcaggag acaaacttag ccataaactg
     3361 aatcctggtc tgacacttcc acaaatggtt tccagttaga ggagtttatt gccaaattaa
     3421 acttggctct tttcccactt agatagaaac taagaaagct gcacataaga aatgtttgga
     3481 cacttgtaaa actcaagtga ctacattaat ctgtatgtaa actagtgagc agacacatcc
     3541 ataagaattg aaatgccaat atttgggaag tagagagtaa cttatatcct atcagatcta
     3601 ttgagtgtta atatggtagc actctgtatt tgttctgtag actgataata ctggaatcca
     3661 taaagtttga gcctttacaa cttatgtaaa gaaatgttgc aaacatttct ggatgagtct
     3721 tactttgtat ctccagaaga atgtagatgt ctcctaggcc tcctcgtgct gatggttctg
     3781 agctgaatat ttcttggtag gccatgtgac acttcagatc agtgatccta ctcctgtaat
     3841 gttaggacaa ttatattacg cttatgatag aaacagtttc ttgcttttcg gaatattatt
     3901 acttgaatac cacttgagat cattagcatg ccaggaaaag tccattgatt ttgatggtcc
     3961 aatgtaatct cattcaggag gcttgaaaca ttggtggttt agtcttgtga attttaacag
     4021 ttctctgtca ttgtttaaga aaaccaacaa ctggcactac ttcttaagct gtggtttcag
     4081 tctctgctag ttcataccgc atgtttattt tggagtcttt tggtaagcat ggtgcttgta
     4141 ctggtttaaa taaaatgcta acatgaaaga a
//
