LOCUS       NM_146041               1510 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Mus musculus GDP-mannose 4, 6-dehydratase (Gmds), mRNA.
ACCESSION   NM_146041
VERSION     NM_146041.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1510)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1510)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   3  (bases 1 to 1510)
  AUTHORS   Xu,J., Liu,H., Lan,Y. and Jiang,R.
  TITLE     Cis-Repression of Foxq1 Expression Affects Foxf2-Mediated Gene
            Expression in Palate Development
  JOURNAL   Front Cell Dev Biol 9, 665109 (2021)
   PUBMED   33898467
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1510)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1510)
  AUTHORS   Kizuka,Y., Nakano,M., Yamaguchi,Y., Nakajima,K., Oka,R., Sato,K.,
            Ren,C.T., Hsu,T.L., Wong,C.H. and Taniguchi,N.
  TITLE     An Alkynyl-Fucose Halts Hepatoma Cell Migration and Invasion by
            Inhibiting GDP-Fucose-Synthesizing Enzyme FX, TSTA3
  JOURNAL   Cell Chem Biol 24 (12), 1467-1478 (2017)
   PUBMED   29033318
REFERENCE   6  (bases 1 to 1510)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 1510)
  AUTHORS   Sullivan,F.X., Kumar,R., Kriz,R., Stahl,M., Xu,G.Y., Rouse,J.,
            Chang,X.J., Boodhoo,A., Potvin,B. and Cumming,D.A.
  TITLE     Molecular cloning of human GDP-mannose 4,6-dehydratase and
            reconstitution of GDP-fucose biosynthesis in vitro
  JOURNAL   J Biol Chem 273 (14), 8193-8202 (1998)
   PUBMED   9525924
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL645664.8,
            AL645763.6, AL645643.7, AL645697.9 and AL645783.13.
            
            On Mar 21, 2007 this sequence version replaced NM_146041.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031788.1, SRR5189685.130900.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               AL645664.8         130746-130908       c
            164-208             AL645664.8         26717-26761         c
            209-296             AL645664.8         19579-19666         c
            297-406             AL645664.8         17499-17608         c
            407-599             AL645763.6         2875-3067           c
            600-671             AL645763.6         2001-2072           c
            672-704             AL645643.7         1-33
            705-832             AL645643.7         26549-26676
            833-951             AL645697.9         71134-71252         c
            952-1048            AL645697.9         48270-48366         c
            1049-1117           AL645783.13        47477-47545         c
            1118-1510           AL645783.13        46921-47313         c
FEATURES             Location/Qualifiers
     source          1..1510
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 13.52 cM"
     gene            1..1510
                     /gene="Gmds"
                     /note="GDP-mannose 4, 6-dehydratase"
                     /db_xref="GeneID:218138"
                     /db_xref="MGI:MGI:1891112"
     exon            1..163
                     /gene="Gmds"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1180
                     /gene="Gmds"
                     /EC_number="4.2.1.47"
                     /note="GMD; GDP-D-mannose dehydratase"
                     /codon_start=1
                     /product="GDP-mannose 4,6 dehydratase"
                     /protein_id="NP_666153.1"
                     /db_xref="CCDS:CCDS26426.1"
                     /db_xref="GeneID:218138"
                     /db_xref="MGI:MGI:1891112"
                     /translation="MAQAPAKCPSYPGSGDGEMGKLRKVALITGITGQDGSYLAEFLL
                     EKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKP
                     TEIYNLGAQSHVKISFDLAEYTADVDGVGTLRLLDAIKTCGLINSVKFYQASTSELYG
                     KVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFREAYNLFAVNGILFNHESPRRGANF
                     VTRKISRSVAKIYLGQLECFSLGNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATG
                     EVHSVREFVEKSFMHIGKTIVWEGKNENEVGRCKETGKVHVTVDLKYYRPTEVDFLQG
                     DCSKAQQKLNWKPRVAFDELVREMVQADVELMRTNPNA"
     exon            164..208
                     /gene="Gmds"
                     /inference="alignment:Splign:2.1.0"
     exon            209..296
                     /gene="Gmds"
                     /inference="alignment:Splign:2.1.0"
     exon            297..406
                     /gene="Gmds"
                     /inference="alignment:Splign:2.1.0"
     exon            407..599
                     /gene="Gmds"
                     /inference="alignment:Splign:2.1.0"
     exon            600..704
                     /gene="Gmds"
                     /inference="alignment:Splign:2.1.0"
     exon            705..832
                     /gene="Gmds"
                     /inference="alignment:Splign:2.1.0"
     exon            833..951
                     /gene="Gmds"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1048
                     /gene="Gmds"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1117
                     /gene="Gmds"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1510
                     /gene="Gmds"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcccgcggc tcgttccact ccgccttcct ctcggccgca cgctcacccg cctgaggcga
       61 catggctcaa gctcccgcta agtgcccgag ctacccgggc tccggggatg gcgagatggg
      121 caagctcagg aaggtggctc tcatcactgg catcaccgga caggatggtt cgtacttggc
      181 agaattcctg ttggagaaag ggtacgaggt ccatggaata gtacggcgat ctagttcatt
      241 taatacaggt cgaattgaac atttatataa gaatcctcag gctcatattg aaggaaacat
      301 gaagttgcac tatggtgacc tcactgacag cacctgccta gtgaaaatca tcaatgaagt
      361 caagcctaca gagatctata atcttggagc ccagagccat gtcaagatct cctttgactt
      421 agctgagtac accgcagatg ttgatggcgt tggcaccttg cggcttctgg atgcaattaa
      481 aacttgtggc cttataaatt ctgtgaagtt ctaccaggcc tcaacaagtg aactttatgg
      541 aaaagtgcag gaaatacccc agaaggagac cacacctttc tatccgaggt caccctatgg
      601 agcagccaaa ctctatgcct attggattgt ggtgaatttc cgtgaagctt ataatctctt
      661 tgcagtgaat ggaattctct tcaatcatga gagtcccaga agaggagcta attttgttac
      721 tcgaaaaatt agccggtcag tagctaagat ttaccttgga caactggaat gtttcagctt
      781 gggaaatctg gatgccaaac gagactgggg ccatgccaag gactatgtag aggctatgtg
      841 gctcatgttg cagaatgatg agccagagga ctttgtcata gctactgggg aagttcacag
      901 tgtccgtgaa tttgttgaaa agtcattcat gcacatcgga aaaaccattg tgtgggaagg
      961 aaagaatgaa aatgaagtgg gcagatgtaa agagaccggc aaagttcacg tgactgtgga
     1021 tctgaaatac taccgaccga ctgaagtgga ctttctgcag ggagactgct ccaaggctca
     1081 gcagaagcta aactggaagc cccgcgttgc ctttgacgag ctggtgaggg agatggtgca
     1141 ggccgacgtg gagctcatga ggaccaaccc caacgcttga gcccctctgc agagactcga
     1201 ggggcatggt gacagtgcag agccagggaa ccagagtcca gtaactcctg ccaaccatgg
     1261 accctcgacc tcctgtgctg tccctgtatc cagagctggg ccacagaggt ttgtagagcc
     1321 tgggacagga cacaccagag ctaaggccgc attgcttttg tcaaagtctc ctcctctgac
     1381 tggtttcagg aaatcaagaa gtttgaatca catactcatt ttacttgaaa ttatgtcact
     1441 agacaactta tattttggag tcttgagatt gtttttctct tttcttatta aataatcttt
     1501 ctataaacca
//
