LOCUS       NM_011818               2967 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus germ cell-less, spermatogenesis associated 1 (Gmcl1),
            mRNA.
ACCESSION   NM_011818
VERSION     NM_011818.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2967)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2967)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   3  (bases 1 to 2967)
  AUTHORS   Liebe,B., Petukhova,G., Barchi,M., Bellani,M., Braselmann,H.,
            Nakano,T., Pandita,T.K., Jasin,M., Fornace,A., Meistrich,M.L.,
            Baarends,W.M., Schimenti,J., de Lange,T., Keeney,S.,
            Camerini-Otero,R.D. and Scherthan,H.
  TITLE     Mutations that affect meiosis in male mice influence the dynamics
            of the mid-preleptotene and bouquet stages
  JOURNAL   Exp Cell Res 312 (19), 3768-3781 (2006)
   PUBMED   17010969
REFERENCE   4  (bases 1 to 2967)
  AUTHORS   Maekawa,M., Ito,C., Toyama,Y., Suzuki-Toyota,F., Kimura,T.,
            Nakano,T. and Toshimori,K.
  TITLE     Stage-specific expression of mouse germ cell-less-1 (mGCL-1), and
            multiple deformations during mgcl-1 deficient spermatogenesis
            leading to reduced fertility
  JOURNAL   Arch Histol Cytol 67 (4), 335-347 (2004)
   PUBMED   15700541
REFERENCE   5  (bases 1 to 2967)
  AUTHORS   Masuhara,M., Nagao,K., Nishikawa,M., Kimura,T. and Nakano,T.
  TITLE     Enhanced degradation of MDM2 by a nuclear envelope component, mouse
            germ cell-less
  JOURNAL   Biochem Biophys Res Commun 308 (4), 927-932 (2003)
   PUBMED   12927808
  REMARK    GeneRIF: mGCL-1 is a factor modulating MDM2-p53 axis by enhanced
            degradation of MDM2
REFERENCE   6  (bases 1 to 2967)
  AUTHORS   Kimura,T., Ito,C., Watanabe,S., Takahashi,T., Ikawa,M.,
            Yomogida,K., Fujita,Y., Ikeuchi,M., Asada,N., Matsumiya,K.,
            Okuyama,A., Okabe,M., Toshimori,K. and Nakano,T.
  TITLE     Mouse germ cell-less as an essential component for nuclear
            integrity
  JOURNAL   Mol Cell Biol 23 (4), 1304-1315 (2003)
   PUBMED   12556490
  REMARK    GeneRIF: the mgcl-1 gene product appears to be essential for
            appropriate nuclear-lamina organization, which in turn is essential
            for normal sperm morphogenesis and chromatin remodeling.
REFERENCE   7  (bases 1 to 2967)
  AUTHORS   Nili,E., Cojocaru,G.S., Kalma,Y., Ginsberg,D., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A., Berger,R., Shaklai,S., Amariglio,N.,
            Brok-Simoni,F., Simon,A.J. and Rechavi,G.
  TITLE     Nuclear membrane protein LAP2beta mediates transcriptional
            repression alone and together with its binding partner GCL
            (germ-cell-less)
  JOURNAL   J Cell Sci 114 (Pt 18), 3297-3307 (2001)
   PUBMED   11591818
REFERENCE   8  (bases 1 to 2967)
  AUTHORS   Leatherman,J.L., Kaestner,K.H. and Jongens,T.A.
  TITLE     Identification of a mouse germ cell-less homologue with conserved
            activity in Drosophila
  JOURNAL   Mech Dev 92 (2), 145-153 (2000)
   PUBMED   10727854
REFERENCE   9  (bases 1 to 2967)
  AUTHORS   Kimura,T., Yomogida,K., Iwai,N., Kato,Y. and Nakano,T.
  TITLE     Molecular cloning and genomic organization of mouse homologue of
            Drosophila germ cell-less and its expression in germ lineage cells
  JOURNAL   Biochem Biophys Res Commun 262 (1), 223-230 (1999)
   PUBMED   10448096
REFERENCE   10 (bases 1 to 2967)
  AUTHORS   de la Luna,S., Allen,K.E., Mason,S.L. and La Thangue,N.B.
  TITLE     Integration of a growth-suppressing BTB/POZ domain protein with the
            DP component of the E2F transcription factor
  JOURNAL   EMBO J 18 (1), 212-228 (1999)
   PUBMED   9878064
  REMARK    GeneRIF: Gmcl1 interacts with the DP component of the E2F
            transcription factor.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ122611.1, AF163665.1, AK004716.1 and CX567687.1.
            
            On Nov 15, 2007 this sequence version replaced NM_011818.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF186095.1, AK155238.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                CJ122611.1         1-56
            57-2193             AF163665.1         1-2137
            2194-2942           AK004716.1         2170-2918
            2943-2967           CX567687.1         571-595
FEATURES             Location/Qualifiers
     source          1..2967
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 37.75 cM"
     gene            1..2967
                     /gene="Gmcl1"
                     /gene_synonym="2810049L19Rik; Btbd13; DIP; Gcl; Gcl-1;
                     glc-1; mglc-1"
                     /note="germ cell-less, spermatogenesis associated 1"
                     /db_xref="GeneID:23885"
                     /db_xref="MGI:MGI:1345156"
     exon            1..468
                     /gene="Gmcl1"
                     /gene_synonym="2810049L19Rik; Btbd13; DIP; Gcl; Gcl-1;
                     glc-1; mglc-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..1789
                     /gene="Gmcl1"
                     /gene_synonym="2810049L19Rik; Btbd13; DIP; Gcl; Gcl-1;
                     glc-1; mglc-1"
                     /note="DP-interacting protein; germ cell-less homolog 1"
                     /codon_start=1
                     /product="germ cell-less protein-like 1"
                     /protein_id="NP_035948.3"
                     /db_xref="CCDS:CCDS20316.1"
                     /db_xref="GeneID:23885"
                     /db_xref="MGI:MGI:1345156"
                     /translation="MGALSSRVLRPAGRTEQPEPTPGAGGAARRSDAGEDAGHSFCYC
                     PGGRKRKRSSGTFCYCHPDSETDDDEDEGDEQQRLLNTPRRKKLKSTSKYIYQTLFLN
                     GENSDIKICALGEEWSLHKIYLCQSGYFSSMFSGSWKESSMNIIELEIPDQNIDIEAL
                     QVAFGSLYRDDVLIKPSRVVAILAAACMLQLDGLIQQCGETMKETISVRTVCGYYTSA
                     GTYGLDSVKKKCLEWLLNNLMTHQSVELFKELSINVMKQLIGSSNLFVMQVEMDVYTA
                     LKKWMFLQLVPSWNGSLKQLLTETDVWFSKWKKDFEGTTFLETEQGKPFAPVFRHLRL
                     QYIISDLASARIIEQDSLVPSEWLAAVYKQQWLAMLRAEQDSEVGPQEINKEELEGNS
                     MRCGRKLAKDGEYCWRWTGFNFGFDLLVTYTNRYIIFKRNTLNQPCSGSVSLQPRRSI
                     AFRLRLASFDSSGKLICSRATGYQILTLEKDQEQVVMNLDSRLLIFPLYICCNFLYIS
                     PEKRTESNRHPENPGH"
     exon            469..592
                     /gene="Gmcl1"
                     /gene_synonym="2810049L19Rik; Btbd13; DIP; Gcl; Gcl-1;
                     glc-1; mglc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..689
                     /gene="Gmcl1"
                     /gene_synonym="2810049L19Rik; Btbd13; DIP; Gcl; Gcl-1;
                     glc-1; mglc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            690..787
                     /gene="Gmcl1"
                     /gene_synonym="2810049L19Rik; Btbd13; DIP; Gcl; Gcl-1;
                     glc-1; mglc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            788..900
                     /gene="Gmcl1"
                     /gene_synonym="2810049L19Rik; Btbd13; DIP; Gcl; Gcl-1;
                     glc-1; mglc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            901..966
                     /gene="Gmcl1"
                     /gene_synonym="2810049L19Rik; Btbd13; DIP; Gcl; Gcl-1;
                     glc-1; mglc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1051
                     /gene="Gmcl1"
                     /gene_synonym="2810049L19Rik; Btbd13; DIP; Gcl; Gcl-1;
                     glc-1; mglc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1142
                     /gene="Gmcl1"
                     /gene_synonym="2810049L19Rik; Btbd13; DIP; Gcl; Gcl-1;
                     glc-1; mglc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1280
                     /gene="Gmcl1"
                     /gene_synonym="2810049L19Rik; Btbd13; DIP; Gcl; Gcl-1;
                     glc-1; mglc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1350
                     /gene="Gmcl1"
                     /gene_synonym="2810049L19Rik; Btbd13; DIP; Gcl; Gcl-1;
                     glc-1; mglc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1426
                     /gene="Gmcl1"
                     /gene_synonym="2810049L19Rik; Btbd13; DIP; Gcl; Gcl-1;
                     glc-1; mglc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1572
                     /gene="Gmcl1"
                     /gene_synonym="2810049L19Rik; Btbd13; DIP; Gcl; Gcl-1;
                     glc-1; mglc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1660
                     /gene="Gmcl1"
                     /gene_synonym="2810049L19Rik; Btbd13; DIP; Gcl; Gcl-1;
                     glc-1; mglc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..2944
                     /gene="Gmcl1"
                     /gene_synonym="2810049L19Rik; Btbd13; DIP; Gcl; Gcl-1;
                     glc-1; mglc-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2920..2925
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gmcl1"
                     /gene_synonym="2810049L19Rik; Btbd13; DIP; Gcl; Gcl-1;
                     glc-1; mglc-1"
                     /note="hexamer: AATAAA"
     polyA_site      2944
                     /gene="Gmcl1"
                     /gene_synonym="2810049L19Rik; Btbd13; DIP; Gcl; Gcl-1;
                     glc-1; mglc-1"
                     /note="major polyA site"
ORIGIN      
        1 ttgcgcctgc gccctgcggc gcgcgctttg ttgggagaag gagggggcga ggtctagcga
       61 agccggtccg ctgaggcgct acgggcgggg ctgaggatgg aggtgactgc gttcgcggcg
      121 acggttgggg ctgcgcgcga ggcggcagcg gagtaggcgg tggagatacg ggcatggcgg
      181 ggcggcccct cggtgctccc taggcgccgg agccatgggc gctctcagca gccgggtgct
      241 gcggcccgca gggcgcacag agcagcccga acccacgccc ggggctgggg gcgcggcccg
      301 caggtcggac gccggcgaag atgcgggcca cagcttctgt tactgtccgg gcggccgcaa
      361 gcgcaagcgc agcagcggca cattctgcta ctgtcacccc gactccgaga cagacgacga
      421 cgaggacgag ggcgacgagc agcagaggct gctgaacacg ccgcgcagga aaaaattaaa
      481 gagcacatca aaatacatct accaaacgct gtttttgaat ggtgaaaaca gtgacattaa
      541 gatctgtgct ctaggtgaag agtggagctt acacaaaatc tacttatgtc aatctggcta
      601 cttttctagt atgttcagtg gttcttggaa agaatccagc atgaatatta ttgaactgga
      661 gattcctgac cagaacattg atatagaagc actgcaggtc gcatttggat cactgtatcg
      721 agatgacgtc ttaataaagc ccagcagggt cgttgccatt ttggcagcag cttgcatgct
      781 gcaattggat ggtttgatac agcagtgcgg tgagacaatg aaggagacca tctctgtgag
      841 aactgtgtgt ggctattaca catcggcagg gacctatgga ctagactctg taaagaaaaa
      901 gtgcctcgag tggctgctga acaacctcat gactcaccag agtgtggagc ttttcaaaga
      961 actcagtata aacgtcatga aacagctcat tggttcgtct aacttatttg tgatgcaagt
     1021 ggagatggat gtatatacag ctcttaaaaa gtggatgttc cttcagctgg tgccttcctg
     1081 gaatgggtct ttaaagcagc ttttgacaga aacagatgtc tggttttcaa agtggaaaaa
     1141 agactttgaa gggacgactt tccttgaaac tgagcaggga aaaccatttg cgcccgtgtt
     1201 cagacattta aggctacagt acattatcag tgatctggct tctgcaagga tcattgagca
     1261 ggattctctg gtaccttcag aatggctggc ggcagtgtat aaacagcagt ggctggctat
     1321 gctacgggct gaacaagaca gtgaagtggg gcctcaagaa atcaataaag aagaacttga
     1381 gggaaacagc atgaggtgtg gtcgaaagct tgccaaagat ggtgagtact gctggcgctg
     1441 gacaggcttc aatttcggct ttgacctcct tgtgacttac accaatcgat acatcatttt
     1501 caaacgcaat acgctgaacc agccatgtag tggatctgtc agcttacagc ctcgaaggag
     1561 catagcattt agattgcgct tggcttcttt tgacagtagt gggaaactca tatgcagtag
     1621 agcaactggc taccaaatac tgacgcttga aaaagaccag gagcaagtgg tgatgaactt
     1681 ggacagcaga cttctgatct tccctctgta catctgctgt aacttcttgt atatatcacc
     1741 agaaaaaaga actgagagta atcgtcaccc agaaaaccca ggacactgag gcactcatca
     1801 gtggccagtt ttaacttaat gacctactgc gttcacgtcc aaggtgacta acagtgaccg
     1861 gccttatgaa ctgtgggacc ctggagatgt cctcaccctc attacatttc tatgcacata
     1921 tgaaaaagtt ttttaaaact gagaaagcat ctgtcaaacc atgttaaaag gatatcaact
     1981 cttgctttaa tttagtagca gtaaaaattg ctgtaggtaa atttctcatt tctttgcaac
     2041 aagatataga tttaattttg agcttgaatt tcgatcctat ctaatgttag tgagtttact
     2101 catctgtaaa tgtgttcctg ttttgttaag agaatgctaa ggacggagtt taagtggcca
     2161 atcataaatg ctctttcaat tggtgccttt aaagctgtcc tttcatttgt tcagccacct
     2221 ggtgaagtct tgtgttcagt tgagatcctt tccagaatct tcttcgtttt agccatcaga
     2281 tcccttgtca tggtttggga gattaagctt aagagttggt tttgtttcgt ttttcttttt
     2341 tcttttttta ttctaaatat aagcattttc atattttttt aaactttaac tttcctacag
     2401 ttttaaatga caacaagaat cagcttgagg acttgaaata aacttgaata agggaaatca
     2461 gtttgattct gaggatattc cttcgcctta cgtgcatggt cttgtctggc attctgtgta
     2521 ctcttatgtt atgaattatt tatgtacaga tacatcgtca cacattttca tattctctga
     2581 tagttggaat ttatgtcaaa ttttagttgg gaatcttgtt tcctattaag ctcaggactt
     2641 tataccctct gaactgagtg cctttgagtc acatacataa gtagatttca tggtgaatgt
     2701 acagggggag ctgggaacaa aacagtcgtg ttagaacaac ttaccttgtc aagaataaga
     2761 tgtatgctca tcccgatctg tatgtgttgg tcccttgtgt ttattgctat tgaaaatagc
     2821 ctggatcatt gtcctccagt cagagtaagt gtttttgtgg ttgatgtatg tttttagtat
     2881 ttttttaaat tggaatcatt tttatgtatc tgttcaaata ataaatgctc atttggaaaa
     2941 ggaaaaaaaa aaaaaaaaaa aaaaaaa
//
