LOCUS       NM_001407606            3678 bp    mRNA    linear   ROD 07-AUG-2023
DEFINITION  Mus musculus predicted gene 4924 (Gm4924), transcript variant 2,
            mRNA.
ACCESSION   NM_001407606 XM_017314182
VERSION     NM_001407606.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3678)
  AUTHORS   Ferreira PTM, Oliveira-Scussel ACM, Sousa RAP, Gomes BQ, Felix JE,
            Silva RJ, Millian IB, Assuncao TSF, Teixeira SC, Gomes MLM, Silva
            MV, Barbosa BF, Rodrigues Junior V, Mineo JR, Oliveira CJF, Ferro
            EAV and Gomes AO.
  TITLE     Macrophage Migration Inhibitory Factor contributes to drive
            phenotypic and functional macrophages activation in response to
            Toxoplasma gondii infection
  JOURNAL   Immunobiology 228 (3), 152357 (2023)
   PUBMED   36857907
  REMARK    GeneRIF: Macrophage Migration Inhibitory Factor contributes to
            drive phenotypic and functional macrophages activation in response
            to Toxoplasma gondii infection.
REFERENCE   2  (bases 1 to 3678)
  AUTHORS   Vandenbark AA, Meza-Romero R, Wiedrick J, Gerstner G, Seifert H,
            Kent G, Piechycna M, Benedek G, Bucala R and Offner H.
  TITLE     'Near Cure' treatment of severe acute EAE in MIF-1-deficient female
            and male mice with a bifunctional MHCII-derived molecular construct
  JOURNAL   Cell Immunol 378, 104561 (2022)
   PUBMED   35738135
  REMARK    GeneRIF: ''Near Cure'' treatment of severe acute EAE in
            MIF-1-deficient female and male mice with a bifunctional
            MHCII-derived molecular construct.
REFERENCE   3  (bases 1 to 3678)
  AUTHORS   Nikulina K, Bodeker M, Warren J, Matthews P and Margolis TP.
  TITLE     A novel Kruppel related factor consisting of only a KRAB domain is
            expressed in the murine trigeminal ganglion
  JOURNAL   Biochem Biophys Res Commun 348 (3), 839-849 (2006)
   PUBMED   16904636
  REMARK    GeneRIF: Novel murine Kruppel-related factor MIF1 expressed in
            trigeminal ganglion contains a Kruppel-associated box (KRAB) domain
            but lacks a zinc-finger motif.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160865.10 and AC158606.14.
            
            On Jun 6, 2022 this sequence version replaced XM_017314182.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784643.1197207.1,
                                           SRR17784644.619153.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-407               AC160865.10        168986-169392
            408-534             AC158606.14        75126-75252         c
            535-595             AC158606.14        74865-74925         c
            596-3678            AC158606.14        64180-67262         c
FEATURES             Location/Qualifiers
     source          1..3678
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..3678
                     /gene="Gm4924"
                     /gene_synonym="EG237412; Mif1"
                     /note="predicted gene 4924"
                     /db_xref="GeneID:237412"
                     /db_xref="MGI:MGI:3643133"
     exon            1..407
                     /gene="Gm4924"
                     /gene_synonym="EG237412; Mif1"
                     /inference="alignment:Splign:2.1.0"
     CDS             285..3305
                     /gene="Gm4924"
                     /gene_synonym="EG237412; Mif1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     inhibitor of four 1"
                     /codon_start=1
                     /product="predicted gene 4924 isoform 2"
                     /protein_id="NP_001394535.1"
                     /db_xref="GeneID:237412"
                     /db_xref="MGI:MGI:3643133"
                     /translation="MTSISCLRLRKEWGTAPLCENILVDVTVQPVPLLLLLLQGKDLV
                     TYEDVHVNFTQEEWALLDPSQKSLYKDVMLETYRNLTAIGYKWEDFNIEEHCKCPKRH
                     ERYIICHSGFKPCEDKQYKKKQCTLVSPRTIRQCVVVPTMRRHDDCDTDLQLTGFLTS
                     MAAHHQTNTGEKPYEYKEYRNSSVYTGSLCTCHVAHKIGKYYAYNQCDKTLSSSSSLL
                     GCEKILVGKGSDKSEPCTKGFNHHRYLQTHKRTNSEDLYEYNQHDKDFRSNSSVKLHE
                     RTHLEIELYEDNQSEKAFATHSLHQVPRSHTREERYGYDQCGNTFACLSYLQIHERIS
                     LEKPFECNQCSKAFAYKRHLHRHEKIHTGEKPYGCNQCGKAFVYNSYLQRHKRSHTGE
                     KPYECHQCGKAFSRNSHLYRHERSHTGEKPYGCNKCGKAFGRNSTLQRHERSHNGEKP
                     YGCNKCGKAFGRNSTLQRHERSHNGEKPYERKQCDKAFAQNSHLFHHEVNCTQEKSYG
                     CSQCGKAFAYNSLLQRHERSHTGEKPYECNKCGKAFSQNSHLHKHERSHTGEKPYGRK
                     QCDKAFAQNSHLFHHEINCTQEKSYGCSQCGKAFAYNSHLQRHERSHTGEKPYECNKC
                     GKAFSQNSHLHKHERSHTGEKPYGRKQCDKAFAQNSHLFHHEINCTQEKSYGCSQCGK
                     AFAYNSQLQRHERSHTGEKPYECNKCGKAFGHYSNLQRHERNHTGEKPYECKKCGKAF
                     SQNSHLHKHERSHTEEKPYGRKQCDKDFAQKNLLHSHERNLSGQKPCEYNQSGKAFAQ
                     NSHLFHHEIDHTQEKSYGCSQCGKAFAYNSQLQRHERSHTGEKPYGCNKCGKAFAQKN
                     NLHSHERSHTGEKPYECKKCGKAFSQNSHLHKHERSHTGEKPYGRKQCDKAFAQNSHL
                     FHHEINCTQEKSYGCSQCGKAFGRYSNLQRHERSHTGEKPYECNKCGKAFSQNSHLHK
                     HERSHTGEKPYECNQCLKAFACKSNLYRHERRHT"
     exon            408..534
                     /gene="Gm4924"
                     /gene_synonym="EG237412; Mif1"
                     /inference="alignment:Splign:2.1.0"
     exon            535..595
                     /gene="Gm4924"
                     /gene_synonym="EG237412; Mif1"
                     /inference="alignment:Splign:2.1.0"
     exon            596..3678
                     /gene="Gm4924"
                     /gene_synonym="EG237412; Mif1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acttccggtc tgccatgctg gaggctagga tacagtgctg agaaaggggc tcctggtatt
       61 gcgtggtaca ctgctaccca ctggcgggag ctgaaaagag agtggggaga gctcggaatc
      121 tgcgccatgg tgagaggggc cgccatcccc atacggggag gagtcgcggg agcccgcatg
      181 gcgttcgttc cggggttcgc gaaccggcag cgagtcggtg cccccgtgag gtcccgtgag
      241 ttccgtgggg tccctgcacc tcccaggcaa gagcagatcc ctgaatgact tcgatcagct
      301 gcctgcgcct gcgcaaagaa tggggaacgg cgcctttgtg tgaaaacatc cttgttgacg
      361 tcaccgtgca gccagtgcct ctgctgcttt tattattgca agggaaggat ctagtaacct
      421 atgaggatgt gcatgtgaac tttactcaag aggaatgggc tttgctggat ccttcccaga
      481 agagtctcta caaagatgtg atgctggaaa cctacaggaa cctcacggct ataggctata
      541 aatgggaaga cttcaatatt gaagaacatt gtaaatgtcc taaaagacat gaaaggtata
      601 tcatctgtca ctctggattc aagccatgtg aggataagca atataaaaag aagcaatgta
      661 cccttgtctc tcccagaaca attagacaat gtgtagtagt tcccactatg agaagacatg
      721 atgactgtga tacagattta cagttaactg gttttctaac ttccatggca gcccatcacc
      781 aaactaacac tggagagaaa ccttatgagt acaaggaata cagaaattca tctgtctata
      841 ctggttcact ttgcacctgt catgtggctc acaaaatagg gaaatattat gcatataacc
      901 agtgtgataa aaccctgagt tcttccagtt ctcttctagg atgtgaaaaa attctggtgg
      961 gaaaaggaag tgataaatct gagccatgta ctaaaggctt taaccatcat aggtatcttc
     1021 aaacacataa aagaaccaat agtgaagatc tctatgaata taatcaacat gataaagact
     1081 ttagatctaa ttcatctgta aaattacatg aaagaactca tttggaaatt gaactttatg
     1141 aagataatca aagtgaaaaa gcctttgcaa ctcatagtct tcatcaagta cctagatctc
     1201 atactagaga ggaaaggtat ggatatgatc aatgtggtaa tacctttgcc tgtcttagtt
     1261 atcttcaaat acatgaaaga attagtttgg agaaaccctt tgaatgtaat caatgtagta
     1321 aagcttttgc atataaaaga catcttcaca ggcatgaaaa gattcatact ggagagaaac
     1381 cctatggatg caatcagtgt ggtaaagcct ttgtatataa cagttatctc caaaggcata
     1441 aaagaagtca tactggagag aaaccctatg aatgtcatca atgtggtaaa gccttttcac
     1501 ggaacagtca tctttaccgg catgaaagaa gtcatactgg agagaaacca tatggatgta
     1561 ataaatgtgg taaagccttt gggcgcaaca gtactcttca aaggcatgaa agaagtcata
     1621 atggagagaa accatatgga tgtaataaat gtggtaaagc ctttgggcgc aacagtactc
     1681 ttcaaaggca tgaaagaagt cataatggag agaaacctta tgaacgtaaa caatgtgata
     1741 aagcctttgc acagaatagt catcttttcc atcatgaagt aaactgtact caagaaaaat
     1801 cctatggatg tagtcaatgt ggtaaagcct ttgcatataa cagtcttctt caaaggcatg
     1861 aaaggagtca tactggagag aaaccttacg aatgtaataa atgtggtaaa gccttttcac
     1921 aaaacagtca tcttcataag catgaaagaa gtcatactgg ggagaaacct tatgggcgta
     1981 aacaatgtga taaagccttt gcacagaata gtcatctttt ccatcatgaa ataaactgta
     2041 ctcaagaaaa atcctatgga tgtagtcaat gtggtaaagc ctttgcatat aacagtcatc
     2101 ttcaaaggca tgaaagaagt catactggag agaaacctta cgaatgtaat aaatgtggta
     2161 aagccttttc acaaaacagt catcttcata agcatgaaag aagtcatact ggggagaaac
     2221 cttatggacg taaacaatgt gataaagcct ttgcacagaa tagtcatctt ttccatcatg
     2281 aaataaactg tactcaagaa aaatcctatg gatgtagtca atgtggtaaa gcctttgcat
     2341 ataacagtca acttcaaagg catgaaagaa gtcatactgg agagaagcct tacgaatgta
     2401 ataaatgtgg taaagccttt gggcattata gtaatcttca aaggcatgaa agaaatcaca
     2461 ctggagagaa accttatgaa tgtaagaaat gtggtaaagc cttttcacaa aacagtcatc
     2521 ttcataagca cgaaagaagt catactgagg agaaacctta tggacgtaaa caatgtgata
     2581 aagactttgc acagaagaat cttcttcaca gtcacgaaag aaatctttct gggcaaaagc
     2641 cctgtgaata taatcaaagt ggtaaagcct ttgcacagaa tagtcatctt ttccatcatg
     2701 aaatagacca tactcaagaa aaatcctatg gatgtagtca atgtggtaaa gcctttgcat
     2761 ataacagtca acttcaaagg catgaaagaa gtcatactgg agagaaacca tatggatgta
     2821 ataaatgtgg taaagccttt gcacagaaga ataatcttca cagtcatgaa agaagtcaca
     2881 ctggagagaa accttatgaa tgtaagaaat gtggtaaagc cttttcacaa aacagtcatc
     2941 ttcataagca cgaaagaagt cataccgggg agaaacctta tgggcgtaaa caatgtgata
     3001 aagcctttgc acagaatagt catcttttcc atcatgaaat aaactgtact caagaaaaat
     3061 cctatggatg tagtcaatgt ggtaaagcct ttgggcgtta cagtaatctt caaaggcatg
     3121 aaagaagtca tactggagag aaaccttatg aatgtaataa atgtggtaaa gccttttcac
     3181 aaaacagtca tcttcataag catgaaagaa gtcatactgg ggagaaaccc tatgaatgta
     3241 atcaatgttt gaaagccttt gcgtgcaaaa gtaaccttta caggcatgaa agaagacata
     3301 cttgagagaa acactatgga tgtaaacagt gtggtgaggt ctttttacag aatagtcatc
     3361 ttcataggca tgaaaaagtc atactgagcc aaaagcttat gcatttaatc aatgtgataa
     3421 agcctttgca tgttatagca attttcagaa gcatgacagc attcatgctt gtaaaaaagt
     3481 cataaaacta atgagtgagg taaagccttg cattccacat acatttttcc cattgagcta
     3541 tctctggggc ctgagtaagg tttgtagaaa cagttcatca ttaaagtaat gtctcattta
     3601 caaattgtaa acatattgtc atccaaggat ttaagaacaa acaatttgaa taataaaatt
     3661 agttacaagt gaaactga
//
