LOCUS       NM_001135115            2702 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus predicted gene 12250 (Gm12250), mRNA.
ACCESSION   NM_001135115 XM_905096
VERSION     NM_001135115.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2702)
  AUTHORS   Christgen,S., Place,D.E., Zheng,M., Briard,B., Yamamoto,M. and
            Kanneganti,T.D.
  TITLE     The IFN-inducible GTPase IRGB10 regulates viral replication and
            inflammasome activation during influenza A virus infection in mice
  JOURNAL   Eur J Immunol 52 (2), 285-296 (2022)
   PUBMED   34694641
  REMARK    GeneRIF: The IFN-inducible GTPase IRGB10 regulates viral
            replication and inflammasome activation during influenza A virus
            infection in mice.
REFERENCE   2  (bases 1 to 2702)
  AUTHORS   Ha,H.J., Chun,H.L., Lee,S.Y., Jeong,J.H., Kim,Y.G. and Park,H.H.
  TITLE     Molecular basis of IRGB10 oligomerization and membrane association
            for pathogen membrane disruption
  JOURNAL   Commun Biol 4 (1), 92 (2021)
   PUBMED   33469160
  REMARK    GeneRIF: Molecular basis of IRGB10 oligomerization and membrane
            association for pathogen membrane disruption.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2702)
  AUTHORS   Karki,R., Lee,E., Sharma,B.R., Banoth,B. and Kanneganti,T.D.
  TITLE     IRF8 Regulates Gram-Negative Bacteria-Mediated NLRP3 Inflammasome
            Activation and Cell Death
  JOURNAL   J Immunol 204 (9), 2514-2522 (2020)
   PUBMED   32205422
REFERENCE   4  (bases 1 to 2702)
  AUTHORS   Place,D.E., Briard,B., Samir,P., Karki,R., Bhattacharya,A.,
            Guy,C.S., Peters,J.L., Frase,S., Vogel,P., Neale,G., Yamamoto,M.
            and Kanneganti,T.D.
  TITLE     Interferon inducible GBPs restrict Burkholderia thailandensis
            motility induced cell-cell fusion
  JOURNAL   PLoS Pathog 16 (3), e1008364 (2020)
   PUBMED   32150572
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2702)
  AUTHORS   Lee,Y., Yamada,H., Pradipta,A., Ma,J.S., Okamoto,M., Nagaoka,H.,
            Takashima,E., Standley,D.M., Sasai,M., Takei,K. and Yamamoto,M.
  TITLE     Initial phospholipid-dependent Irgb6 targeting to Toxoplasma gondii
            vacuoles mediates host defense
  JOURNAL   Life Sci Alliance 3 (1), e201900549 (2019)
   PUBMED   31852733
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2702)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   7  (bases 1 to 2702)
  AUTHORS   Khaminets,A., Hunn,J.P., Konen-Waisman,S., Zhao,Y.O.,
            Preukschat,D., Coers,J., Boyle,J.P., Ong,Y.C., Boothroyd,J.C.,
            Reichmann,G. and Howard,J.C.
  TITLE     Coordinated loading of IRG resistance GTPases on to the Toxoplasma
            gondii parasitophorous vacuole
  JOURNAL   Cell Microbiol 12 (7), 939-961 (2010)
   PUBMED   20109161
REFERENCE   8  (bases 1 to 2702)
  AUTHORS   Coers,J., Bernstein-Hanley,I., Grotsky,D., Parvanova,I.,
            Howard,J.C., Taylor,G.A., Dietrich,W.F. and Starnbach,M.N.
  TITLE     Chlamydia muridarum evades growth restriction by the
            IFN-gamma-inducible host resistance factor Irgb10
  JOURNAL   J Immunol 180 (9), 6237-6245 (2008)
   PUBMED   18424746
  REMARK    GeneRIF: C. muridarum has evolved a mechanism to escape the murine
            IFN-gamma response by restricting access of Irgb10 and possibly
            other IRG proteins to the inclusion.
REFERENCE   9  (bases 1 to 2702)
  AUTHORS   Miyairi,I., Tatireddigari,V.R., Mahdi,O.S., Rose,L.A.,
            Belland,R.J., Lu,L., Williams,R.W. and Byrne,G.I.
  TITLE     The p47 GTPases Iigp2 and Irgb10 regulate innate immunity and
            inflammation to murine Chlamydia psittaci infection
  JOURNAL   J Immunol 179 (3), 1814-1824 (2007)
   PUBMED   17641048
  REMARK    GeneRIF: p47 GTPases Irgb10 and Iigp2 act together to confer
            differential susceptibility against murine chlamydial infection.
REFERENCE   10 (bases 1 to 2702)
  AUTHORS   Bernstein-Hanley,I., Coers,J., Balsara,Z.R., Taylor,G.A.,
            Starnbach,M.N. and Dietrich,W.F.
  TITLE     The p47 GTPases Igtp and Irgb10 map to the Chlamydia trachomatis
            susceptibility locus Ctrq-3 and mediate cellular resistance in mice
  JOURNAL   Proc Natl Acad Sci U S A 103 (38), 14092-14097 (2006)
   PUBMED   16959883
  REMARK    GeneRIF: Data use fine structure mapping in congenic fibroblasts
            carrying DNA from the susceptible parent to localize the effect of
            Ctrq-3 to a 1.2-megabase interval of genomic DNA that contains
            Irgb10 and Igtp.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL928857.15.
            
            On Sep 21, 2008 this sequence version replaced XM_905096.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.175358.1, AI122314.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-242               AL928857.15        15752-15993
            243-2702            AL928857.15        19648-22107
FEATURES             Location/Qualifiers
     source          1..2702
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 35.96 cM"
     gene            1..2702
                     /gene="Gm12250"
                     /gene_synonym="Irgb10"
                     /note="predicted gene 12250"
                     /db_xref="GeneID:631323"
                     /db_xref="MGI:MGI:3649299"
     exon            1..242
                     /gene="Gm12250"
                     /gene_synonym="Irgb10"
                     /inference="alignment:Splign:2.1.0"
     exon            243..2702
                     /gene="Gm12250"
                     /gene_synonym="Irgb10"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..1516
                     /gene="Gm12250"
                     /gene_synonym="Irgb10"
                     /note="interferon-gamma-inducible p47 GTPase"
                     /codon_start=1
                     /product="interferon-gamma-inducible GTPase 10"
                     /protein_id="NP_001128587.1"
                     /db_xref="GeneID:631323"
                     /db_xref="MGI:MGI:3649299"
                     /translation="MGQSSSKPDAKAHNMASSLTEFFKNFKMESKIISKETIDSIQSC
                     IQEGDIQKVISIINAALTDIEKAPLNIAVTGETGAGKSTFINALRGIGHEESESAESG
                     AVETTKDRKKYTHPKFPNVTIWDLPGVGTTNFKPEEYLKKMKFQEYDFFLIISSARFR
                     DNEAQLAEAIKKMKKKFYFVRTKIDSDLWNEKKAKPSSYNREKILEVIRSDCVKNLQN
                     ANAASTRVFLVSSFEVAQFDFPSLESTLLEELPAHKRHIFVQCLPTITEPAIDRRRDV
                     LKQTIWLEALKAGASATIPMMSFFNDDIEEFEKILSHYRACFGLDDESLENMAKEWSM
                     SVEELESTIKSPHLLSSEPNESVADKLVKTMEKIFAVTGGFVATGLYFRKSYYMQNYF
                     LDTVTEDAKVLLKKKVFLQDSVDSE"
     regulatory      1876..1881
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gm12250"
                     /gene_synonym="Irgb10"
                     /note="hexamer: ATTAAA"
     polyA_site      1897
                     /gene="Gm12250"
                     /gene_synonym="Irgb10"
                     /note="major polyA site"
     regulatory      1924..1929
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gm12250"
                     /gene_synonym="Irgb10"
                     /note="hexamer: AATATA"
     polyA_site      1945
                     /gene="Gm12250"
                     /gene_synonym="Irgb10"
                     /note="major polyA site"
ORIGIN      
        1 gttctcttcc ctctgttggc ttgattcctg tgaggacagg gcagcagcta gagataaacc
       61 tcagagctct ttatacacag cacagtctct tctgtggtag tcacacagtg cagcacactt
      121 ggacttccaa gtagcaaacg ccggtctgta caggtctgtg tgcatttgct gttcctggtg
      181 cagacggaag ctcttcactg gactcaaggc ttctgccaga aacctctttc tcaaaggagc
      241 tgtgtcctgt gtgcccacaa ccatgggtca gtcttcttct aaacccgatg caaaggctca
      301 caatatggcc tccagcctta ctgaattctt caagaatttc aagatggaaa gcaaaatcat
      361 ttctaaggag accatcgatt caattcagtc atgtatccaa gaaggagaca tccagaaggt
      421 gatttctata atcaatgctg ccttgacaga cattgagaaa gcccccctga acatcgctgt
      481 gacaggggag acaggggcag ggaagtccac gttcattaat gcccttcggg gaataggaca
      541 tgaggaaagt gagtcagctg agagtggagc ggtggagaca accaaggaca ggaagaaata
      601 cacccaccct aagttcccta atgtgaccat ctgggatctc cctggggttg ggacaactaa
      661 cttcaaacca gaagaatatc tgaagaaaat gaagttccag gagtatgatt ttttcctgat
      721 catctcatct gctcgcttta gagataatga agcccagctg gctgaagcaa tcaaaaaaat
      781 gaaaaagaag ttctactttg ttcggaccaa aattgacagt gatttgtgga atgagaagaa
      841 agctaaaccc agttcctaca atagggagaa aatcctggag gtgatccgaa gtgactgtgt
      901 aaagaatctg cagaatgcta acgcagcctc tactcgtgtc ttcttagtct caagctttga
      961 ggtagcacag tttgattttc ctagcctgga gtccaccctt ttggaagagc tgccagcaca
     1021 caagcgccac atcttcgtgc agtgcctccc taccattact gagcctgcta ttgatcgcag
     1081 gagagatgtc ctgaaacaga caatctggct ggaggctctg aaggctggag cgtcggccac
     1141 catccccatg atgtcattct tcaatgacga cattgaggaa tttgagaaga tcctgagcca
     1201 ctacagggct tgctttgggc tagatgatga gtcgctggaa aacatggcca aggagtggtc
     1261 catgtctgtg gaggagctgg agtccaccat taagtcaccc catttgctgt caagtgagcc
     1321 gaatgaatct gtggcggaca agctggtgaa aaccatggag aaaatttttg ccgtcactgg
     1381 cggattcgta gccactggcc tttactttag aaagagttac tatatgcaaa attattttct
     1441 tgacacagtg acagaggatg ctaaagttct acttaagaaa aaagtctttt tgcaggacag
     1501 tgtggactct gagtaaggtt ctaaagatgg agagagtgag gcagttggcc tgggacttag
     1561 gtgactttag tgtcttcagg acgctggaga gacgactgag ggcattcctg aagcaccctg
     1621 gtcaggctgt gatatctcat aggctttgtg acccttgggg gaaatagagg gatcagcatt
     1681 atgtccctcc taacacgagt cttgtacaat gtgctagtgt gaactctctg ggcaaggagt
     1741 tttcagaaat gactgttttt agacagggtc ttactatggc tctcttggat ctccttctct
     1801 acagaagtag accaggctgg ccttgaactc acacagaaat cctcctgcct ctgcctctgc
     1861 ctcttgagtg ctgggattaa aggtatacac taccatactt ggaagatttt tttttttttg
     1921 aaaaatatat atatccacca cacgacttga ttttgtgctg ctttgctgag aacactccca
     1981 ggctgatgat atcatttaca gttttcatat atatggtttg tatatggttc gtataacaga
     2041 gtgtaacaga aaacagtggg gacccatcgc ctgagtcaca gtatttgctg cagcccttct
     2101 gcagaggtgc cattacccaa gacagggatg cagtctgagg tttgcacact ggagagtcct
     2161 cacacgttaa cagacaatgc ttcgtgcatg gatcatgacg gtaggaaatt agaggaaaga
     2221 aactagtggt tgacaaggaa gtcctcaccc aaaatacaga atttccttaa tcatgcgcaa
     2281 agatactcag tcttccatcc agaggctgaa atgtaaatta gcagccatgc cactttcagg
     2341 aagtcgaatt tgcatgtgag attgtagata agcagtttct gtgatgcagt gttggtgtca
     2401 acacaaaatc atgacacagc ccgtggtgtg acctctgaga aaattataca tgcagttact
     2461 ctttgacact ctttaaatat tgccagacag cgcaaacagg tatattaggt tttgggttat
     2521 cagctgtggg actttttaag attgattgtg tctagggact ggaaagatgg ctcagagatt
     2581 taagagcaca tactatcctc atataggaca agagtttggt tctcagcgcc catgccagac
     2641 aactcacaat ttcttataac tccagctctg ggggtggggg tggaggtaga ggtggcgtgg
     2701 gg
//
