LOCUS       NM_001045540            5287 bp    mRNA    linear   ROD 06-AUG-2023
DEFINITION  Mus musculus predicted gene 12185 (Gm12185), mRNA.
ACCESSION   NM_001045540 XM_886603 XM_896921 XM_896934 XM_979217
VERSION     NM_001045540.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5287)
  AUTHORS   Murillo-Leon M, Muller UB, Zimmermann I, Singh S, Widdershooven P,
            Campos C, Alvarez C, Konen-Waisman S, Lukes N, Ruzsics Z, Howard
            JC, Schwemmle M and Steinfeldt T.
  TITLE     Molecular mechanism for the control of virulent Toxoplasma gondii
            infections in wild-derived mice
  JOURNAL   Nat Commun 10 (1), 1233 (2019)
   PUBMED   30874554
  REMARK    GeneRIF: Study shows that Irgb2-b1CIM is the CIM mice-inherited
            element largely responsible for resistance against virulent
            Eurasian T. gondii strains and demonstrate efficient binding of
            Irgb2-b1CIM only to virulent T. gondii-derived ROP5B but not ROP5A
            and ROP5C.
            Erratum:[Nat Commun. 2019 Apr 4;10(1):1645. PMID: 30948711]
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645849.17.
            
            On Jun 4, 2013 this sequence version replaced NM_001045540.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022776.2, AK145236.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-256               AL645849.17        186650-186905       c
            257-1463            AL645849.17        174901-176107       c
            1464-5287           AL645849.17        164379-168202       c
FEATURES             Location/Qualifiers
     source          1..5287
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 28.89 cM"
     gene            1..5287
                     /gene="Gm12185"
                     /gene_synonym="Irgb2b1"
                     /note="predicted gene 12185"
                     /db_xref="GeneID:620913"
                     /db_xref="MGI:MGI:3652173"
     exon            1..256
                     /gene="Gm12185"
                     /gene_synonym="Irgb2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            257..1463
                     /gene="Gm12185"
                     /gene_synonym="Irgb2b1"
                     /inference="alignment:Splign:2.1.0"
     CDS             279..2786
                     /gene="Gm12185"
                     /gene_synonym="Irgb2b1"
                     /note="Immunity related GTPase, B2-B1 tandem, WSB
                     specific"
                     /codon_start=1
                     /product="interferon inducible GTPase"
                     /protein_id="NP_001039005.1"
                     /db_xref="CCDS:CCDS36142.1"
                     /db_xref="GeneID:620913"
                     /db_xref="MGI:MGI:3652173"
                     /translation="MGQTSSSTSPPKEDPPLTFQVKTKVLSQELIASIESSLEDGNLQ
                     ETVSAISSALGDIEKVPLNIAVMGETGAGKSSLINALQGVGDDEEGAAASTGVVHTTT
                     ERTPYTYTKFPSVTLWDLPSIGSTAFQPHDYLKKIEFEEYDFFIIVSAIRIKQSDIEL
                     AKAIVQMNRGLYFVRTKTDSDLENEKLCNPMRFNRENILKSIRICLSSNLKERFQQEP
                     PVFLVSNFDVSDFDFPKLESTLLSQLPAYKHQIFMSTLQVVINAIVDRKRDMLKQKIW
                     KESIMPRAWATIPSRGLTQKDMEMLQQTLNDYRSSFGLNEASLENIAEDLNVTLEELK
                     ANIKSPHLFSDEPDTSLTEKLLKYIGNPYFSKVFHLQNYFIDTVASDAKIILSKEELF
                     TEQHPPLNTATCQTSTGRTSQITAQLLEFNFKNFFKNFKKESKILSEETITLIESHLE
                     NKNLKEALTVISHALRNIDKAPLNIAVTGETGTGKSSFINALRGISSEEKDAAPTGVI
                     ETTMKRTPYPHPKLPNVTIWDLPGIGSTNFPPQNYLTEMKFGEYDFFIIISATRFKEI
                     DAHLAKAIAKMNIKFYFVRTKIDQDISNEQRSKPKSFNRDSVLKKIKDECLGLLQKVL
                     SSQPPIFLVSNFDVSDFDFPKLETTLLKELPAHKRHLFMMSLHSVTETTIARKRDFLR
                     QKIWLEALKAGLWATIPLGGLVRDKMQKLEETLTLYRSYFGLDEASLENIAKDFNVSV
                     NEIKAHLRSLQLLTKNNDMSFKEKLLKYIEYISCVTGGPLASGLYFSKTYYWQSLFID
                     TVASDAKSLLNKEEFLSEKPGSCLSDLPEYWETGMEL"
     exon            1464..5287
                     /gene="Gm12185"
                     /gene_synonym="Irgb2b1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgtagaga gcaagggcta tgtgtggacc agtaaggaca aagaaactca gggagatccg
       61 actgtccacc ccacggtctc ttcctttcta tgtgtagttc ttcttgggac accagaactc
      121 cacacctcat atcttctctt cttttctctc tgtagacatc ctgaatctga gtttcagttt
      181 tagacaaaga cctttcctga gaggagatcc atcacagaag tgttattgcc accagatcaa
      241 ggtcaccact gctgaggtac cattgacatt tgccaggaat gggtcagact tcctcttcta
      301 catcccctcc aaaggaggat cctcctttga catttcaggt gaaaaccaaa gtcctgtctc
      361 aggaattaat cgcctccatt gaatcatccc tagaggatgg aaaccttcag gaaacagttt
      421 ctgcaatcag cagtgctctg ggtgacatag agaaagtccc actgaacatt gcagtgatgg
      481 gggagactgg ggctggaaag tccagtctca tcaatgctct gcagggagtg ggggatgatg
      541 aagaaggtgc agctgcttcc acaggggtgg tacatacaac cactgagaga acaccataca
      601 cttacacaaa gtttcccagt gtgacactgt gggacctgcc tagcattgga tctactgcct
      661 tccaaccaca tgattatctg aagaaaatcg agtttgagga gtatgacttc ttcattattg
      721 tctctgctat acgtattaaa cagagtgata tagaacttgc caaagctatt gtgcaaatga
      781 atagaggttt gtactttgtt cgaacaaaga cagattctga tctagagaat gaaaaactgt
      841 gtaaccctat gagattcaat agagagaaca tattgaagag tattcgaatt tgcctttcaa
      901 gtaatctcaa agaacgtttc cagcaggagc ctccagtctt cttagtctct aactttgatg
      961 tgtctgactt tgacttccca aagctggaat ccacccttct cagccagctc ccagcctaca
     1021 aacaccaaat attcatgagt actttgcaag ttgttataaa tgccatagta gaccggaaga
     1081 gggatatgct gaaacaaaag atctggaagg aatccataat gccaagagca tgggctacca
     1141 taccatcccg gggactgacc caaaaggaca tggagatgtt gcaacagact ttgaatgact
     1201 atagatcttc ctttggcctg aatgaggcat cactggaaaa catcgctgag gatttgaacg
     1261 tgacactgga ggagctcaag gcaaacatta agtctccaca tttgttctca gatgagccag
     1321 atacatcctt aacagagaaa ctattgaagt acattggaaa tccttacttt tcaaaggttt
     1381 tccacttgca aaattatttc atagacacgg ttgcgagtga tgctaaaatt atcctcagta
     1441 aagaagagct tttcacagag cagcatcctc cactgaacac agctacatgc cagacttcca
     1501 ctggcaggac ttctcagata acggctcaac ttttggaatt caactttaaa aattttttta
     1561 aaaatttcaa gaaggaaagc aaaatcctct ctgaagaaac catcactttg attgaatccc
     1621 atctggagaa taagaacctc aaagaggcac tgactgtgat tagtcatgct ctgcgaaata
     1681 ttgacaaagc cccactgaac attgctgtga ctggagaaac aggaacaggg aaatccagct
     1741 ttatcaatgc cttgagagga ataagtagtg aagaaaaaga tgcagccccc actggggtaa
     1801 tagagacaac catgaagaga actccatacc cacacccaaa gcttcccaat gtgacaatat
     1861 gggacctgcc tggcattggg tcaaccaact tcccaccaca aaactatctg acagaaatga
     1921 agtttggtga gtatgacttc ttcattatca tctcagctac acgcttcaaa gaaattgatg
     1981 cacatctggc caaagccatt gcaaagatga acataaagtt ctactttgtc cgaaccaaga
     2041 tagatcaaga tatcagtaat gaacagagga gtaaacctaa gtctttcaat agagacagtg
     2101 tcttaaagaa aataaaagat gaatgcttgg gtcttctcca gaaggttctc tccagtcagc
     2161 ctccaatctt cctagtctct aactttgatg tgtctgactt tgacttccca aagctggaga
     2221 ccaccctact gaaggaactc ccagcccaca agcgccacct cttcatgatg tccttgcaca
     2281 gtgttactga gactaccatt gcccggaaga gggatttcct cagacagaag atctggctgg
     2341 aggccctgaa ggctggacta tgggccacca ttccacttgg gggcttagtc agagataaaa
     2401 tgcagaagtt ggaagagacc ttgactctct acaggtctta ctttgggctg gatgaagcct
     2461 cactagaaaa tattgccaag gatttcaatg tgtctgtgaa tgaaattaag gcacacctta
     2521 ggtctctcca gttgttaaca aagaacaatg acatgtcctt caaagaaaaa ctgttgaaat
     2581 atattgaata tatttcctgt gttactgggg gaccacttgc ctcaggcctt tactttagta
     2641 agacttacta ctggcaaagt ctcttcattg atactgtggc aagtgatgcc aagtctctcc
     2701 ttaataagga agagtttttg tcagagaagc caggatcgtg cctgtctgac ctccctgaat
     2761 actgggaaac aggaatggag ctgtgaggta ctaacctttg gactggcttc agacatggac
     2821 ttaacgccta cttttagcat cagatatttt ctgggaaaga ccagaggatt aatttctttc
     2881 agagacagaa taccactctg gcaagaaaaa aagagtcatc cccagtataa gcacagtctt
     2941 ccattaaaat atcaccatga gaatttatgg ttgtatacat atgacttgca atattttgtc
     3001 taattaaact gggttctttt gtcccaagga gattccccaa gcagtgccac actctcctaa
     3061 gttaaagaag ttagcagacc gtataaccat ttgtgttttt ctgtatctgc atcattttga
     3121 gaataatgac actaggttgt tgtttcttgc attaatgctt ataccctagg taagcttgtt
     3181 ctccaactcg tttataccta aaataacctg tttgtcgatt ctgtctgaaa tgcggctggt
     3241 tgcctcttct cacacaactt cctccacaac ctggtggtga atctcttcag cctcactctt
     3301 tcccagagtt cctttttctc aggcagttgt ctcacccatt ttttcctgac tctctacgcg
     3361 ccattcagct ctttgtggac agatgatgct ttgacaccat gcacaagagc tgattgacac
     3421 aatcctctct tgaacttcgt tgggggtttg ggaagtacag gggtcacgtt cccagcacac
     3481 atctccacat taggtggtat ggccttagac atagtaggca cacagcacat gggatgatga
     3541 ccattgtcga tgcttcctcc aggaagagct gaggaatgca tggataagta aacacacctg
     3601 gagatctgta cagacacaga cattgtattc cacagccttc accagtcaac gggatgagtt
     3661 tggaatttgg gctgtaggca acacaggctc taattaagtt gtcatttctt gtggtatgaa
     3721 aaaggctcaa caacatctta aaatcccacc tcctctcgat aagaggtgct taacataaga
     3781 gcctataatc tctccctcaa cttccctctc atttctcttt ctctttcctc tcttcttctg
     3841 cctcccactc ttcctcttcg tcctcttcat tcttctcccc tcttctatcc ttacttctcc
     3901 ccctgcttct gtctttcatt tgcccactca cttgtgagac ttagcaaaca cagtatctac
     3961 agagaagact tatagcctgg aaatctttgg aagagttggt attacagctc ctgtccaaac
     4021 agcaagaatt ttctcttctc tcttccctaa ggaatgacaa gggttttatt gtcttggggt
     4081 ttgtttgttt gttttctcta aggacttcaa ttgattataa aggggcattt acagtagaag
     4141 aggtcatctg acatattcaa agccttctgc tgcagagtct cttgtgcaat gcatggaagc
     4201 atcacctgtc aataaaatgc tgttggccaa tgagcaaaag gcaggaagta ataaatgaga
     4261 gtttcagtag gaaagaatgg aattctggga gacagaaaga gtgtgggagc ttttagccag
     4321 aacactgagg aagacaaatt catgaacctg gagataggta actagccaca tggcaggagt
     4381 tagaacagat taagtggaaa agctaagttg tgaactggtt gaggagcaat ccaaaacttt
     4441 tggcctaggc attgatttat atacaataag tctcagttgt tatttctgaa aataaagagg
     4501 ctacatggca aagcttacat tttcatttgg cccactgaat gtctggcaag aactttctta
     4561 aatagccact tcccaccaat ccactgtggt tcaacaattc caggcagggg caagtaacaa
     4621 aggaagaact tcagagaggt tgtttggaag tagctcttat aagaagccct ggctgtgcag
     4681 aaataaacag ctcttcaact gtagcctcag tgcatgaagc tggactcagt ctctgagcca
     4741 agcaagaggc tacctccctg aaagagagag caagggaagc ctgtgtgcta acccagatgc
     4801 tggacctgca ctctcaggac aaaagcctac ctgagggggc tcgtgttaac cagacaactt
     4861 gtggcttgat acccagctcc tgtgggtcca acaccttctc tgagttgggg aatggtctag
     4921 atccagtgag gtagctccca gttacatgga gaaggcagaa acccctcttc tgtaagagag
     4981 aaagactctg aggccaggct agtgcaggag cagaaggtga ctccatgaga tacaactgta
     5041 agacattttc tcaattagtg atcaaggggg aagggcccct tgtgggtggg accatctctt
     5101 ggctggtagt cttagttcta taggagagca ggctgagcaa gccaggggaa gcaagccagt
     5161 aaagaacatc cctccttggc ctctgaatca gctcctgctt cctgacctgc ttgagttcca
     5221 gtcctgactt ccttggtgat aaacagtagt atggaattgt aagctgaata aaccctttcc
     5281 tccccaa
//
