LOCUS       NM_174846               4226 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus glycerate kinase (Glyctk), transcript variant 1, mRNA.
ACCESSION   NM_174846
VERSION     NM_174846.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4226)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4226)
  AUTHORS   Sass,J.O., Behringer,S., Fernando,M., Cesaroni,E., Cursio,I.,
            Volpini,A. and Till,C.
  TITLE     d-Glycerate kinase deficiency in a neuropediatric patient
  JOURNAL   Brain Dev 42 (2), 226-230 (2020)
   PUBMED   31837836
REFERENCE   3  (bases 1 to 4226)
  AUTHORS   Jang,C., Hui,S., Lu,W., Cowan,A.J., Morscher,R.J., Lee,G., Liu,W.,
            Tesz,G.J., Birnbaum,M.J. and Rabinowitz,J.D.
  TITLE     The Small Intestine Converts Dietary Fructose into Glucose and
            Organic Acids
  JOURNAL   Cell Metab 27 (2), 351-361 (2018)
   PUBMED   29414685
REFERENCE   4  (bases 1 to 4226)
  AUTHORS   Cazier,J.B., Kaisaki,P.J., Argoud,K., Blaise,B.J., Veselkov,K.,
            Ebbels,T.M., Tsang,T., Wang,Y., Bihoreau,M.T., Mitchell,S.C.,
            Holmes,E.C., Lindon,J.C., Scott,J., Nicholson,J.K., Dumas,M.E. and
            Gauguier,D.
  TITLE     Untargeted metabolome quantitative trait locus mapping associates
            variation in urine glycerate to mutant glycerate kinase
  JOURNAL   J Proteome Res 11 (2), 631-642 (2012)
   PUBMED   22029865
  REMARK    GeneRIF: Data show significant evidence of linkages were obtained
            with NMR signals characterizing the glycerate (LOD10-42) at the
            mutant glycerate kinase locus, which demonstrate the power of
            metabolomics to identify the biological function of genetic
            variants.
REFERENCE   5  (bases 1 to 4226)
  AUTHORS   Thiagarajan,R.D., Georgas,K.M., Rumballe,B.A., Lesieur,E.,
            Chiu,H.S., Taylor,D., Tang,D.T., Grimmond,S.M. and Little,M.H.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4226)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   7  (bases 1 to 4226)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   8  (bases 1 to 4226)
  AUTHORS   Calvo,S.E., Pagliarini,D.J. and Mootha,V.K.
  TITLE     Upstream open reading frames cause widespread reduction of protein
            expression and are polymorphic among humans
  JOURNAL   Proc Natl Acad Sci U S A 106 (18), 7507-7512 (2009)
   PUBMED   19372376
  REMARK    GeneRIF: Includes the study of an upstream ORF in this gene, and
            shows that it functions to reduce protein levels by ~73%.
REFERENCE   9  (bases 1 to 4226)
  AUTHORS   Katayama,H., Kitagawa,Y. and Sugimoto,E.
  TITLE     Purification of rat liver glycerate kinase and studies of its
            enzymatic and immunological properties
  JOURNAL   J Biochem 88 (3), 765-773 (1980)
   PUBMED   6252205
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY111608.1, AK052709.1, AK049425.1 and BB747408.1.
            
            On Feb 24, 2006 this sequence version replaced NM_174846.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052709.1, SRR1660813.182303.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                BY111608.1         2-71
            71-2259             AK052709.1         10-2198
            2260-2960           AK049425.1         2241-2941
            2961-4094           AK052709.1         2900-4033
            4095-4106           BB747408.1         387-398
            4107-4226           AK052709.1         4034-4153
FEATURES             Location/Qualifiers
     source          1..4226
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 57.46 cM"
     gene            1..4226
                     /gene="Glyctk"
                     /gene_synonym="6230410P16Rik; C430006L12"
                     /note="glycerate kinase"
                     /db_xref="GeneID:235582"
                     /db_xref="MGI:MGI:2444085"
     exon            1..650
                     /gene="Glyctk"
                     /gene_synonym="6230410P16Rik; C430006L12"
                     /inference="alignment:Splign:2.1.0"
     CDS             274..1845
                     /gene="Glyctk"
                     /gene_synonym="6230410P16Rik; C430006L12"
                     /EC_number="2.7.1.31"
                     /codon_start=1
                     /product="glycerate kinase"
                     /protein_id="NP_777271.3"
                     /db_xref="CCDS:CCDS23469.1"
                     /db_xref="GeneID:235582"
                     /db_xref="MGI:MGI:2444085"
                     /translation="MAAALQVLPCLLRAPSRPLLWGPPVARMTSGMALAEQARQLFDS
                     AVGAVQPGPMLQRTLSLDPSGRQLKVRDRTFQLRENLYLVGFGKAVLGMAAAAEELLA
                     QHLVQGVISVPKGIRAAMEHAGKKEMLLKPHSRIQVFEGAEDNLPDRDALRAALTIQQ
                     LAEGLTADDLLLVLISGGGSALLPAPIPPVTLEEKQMLTKLLAARGATIQELNTIRKA
                     LSQLKGGGLAQAAYPAQVISLILSDVIGDPLEVIASGPTVASTHSVQDCLHILNHYGL
                     RAALPRSVKTVLSRADSDPHGPHTCGHVLNVIIGSNSLALAEAQRQAEVLGYHAMVLS
                     TAMQGDVKRVARFYGLLARVAAAHLTPSLAERPLEEEAELHQLAAELQLPDLQLEEAL
                     EAVVKAKGPVCLLAGGEPTVQLQGSGKGGRNQELALHVGVELGRQPLGPIDVLFLSGG
                     TDGQDGPTKVAGAWVMSDLISQASAESLDIATSLANNDSYTFFCRFRGGTHLLHTGLT
                     GTNVMDVHLLILHPQ"
     exon            651..802
                     /gene="Glyctk"
                     /gene_synonym="6230410P16Rik; C430006L12"
                     /inference="alignment:Splign:2.1.0"
     exon            803..978
                     /gene="Glyctk"
                     /gene_synonym="6230410P16Rik; C430006L12"
                     /inference="alignment:Splign:2.1.0"
     exon            979..4226
                     /gene="Glyctk"
                     /gene_synonym="6230410P16Rik; C430006L12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4199..4204
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Glyctk"
                     /gene_synonym="6230410P16Rik; C430006L12"
                     /note="hexamer: AATAAA"
     regulatory      4204..4209
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Glyctk"
                     /gene_synonym="6230410P16Rik; C430006L12"
                     /note="hexamer: AATAAA"
     polyA_site      4217
                     /gene="Glyctk"
                     /gene_synonym="6230410P16Rik; C430006L12"
     polyA_site      4225
                     /gene="Glyctk"
                     /gene_synonym="6230410P16Rik; C430006L12"
                     /note="major polyA site"
ORIGIN      
        1 ggacttggag cagagtgtcc agaagactgg tgtgtggtct acagaagagg acgtggctgg
       61 gcatcagggc tgggctttca gggctggtgt aagatcaggt ttgctgcagg cttcatgact
      121 tctccaggtt tcatttcagg ttatggagtc cgccagtcct gagccctcgg aggggtggcc
      181 atgatggatg gtggggttct gtccgtggcc tcactccttc tcctccctct ctaggcagct
      241 atggacacga ggctgtgctg agagaagcgg ggcatggctg cggccctaca ggtcttgccc
      301 tgtctcctcc gagccccatc ccgtccactc ctctgggggc ccccagtggc ccggatgacc
      361 agtggtatgg ctttggcaga acaggcacgg cagctgtttg atagtgcagt gggtgctgtg
      421 cagccaggcc ccatgctgca gaggacactg tccctggatc ctagtggcag acagctgaag
      481 gtgcgggacc ggactttcca gctgcgggaa aacctctacc tagtgggctt cggcaaggcc
      541 gtactgggca tggcagctgc tgccgaggag ctgctggctc agcatcttgt gcagggtgtg
      601 atcagcgtac ccaaggggat ccgagccgct atggaacatg ctggaaagaa agagatgctg
      661 ctgaagccac acagccgcat ccaggtgttc gagggcgccg aggacaactt accggatcgg
      721 gatgcactcc gggccgcgct gaccatccag cagctggcag aggggctcac tgcagatgac
      781 ctgctgctgg tgctcatctc aggtgggggc tcagccctgc tgcctgctcc tatcccacct
      841 gtcacactgg aggagaaaca gatgctcacc aagctgctgg cagcccgagg agccacgatc
      901 caggagctga acaccatccg caaggccctg tcgcagctga agggtggagg gctggctcag
      961 gctgcctatc ctgctcaggt gataagcctc atcttgtcag atgtgattgg ggaccctttg
     1021 gaagtgattg ccagtggccc tacggtggcc agcacccaca gtgtgcaaga ctgcctgcat
     1081 attctcaacc actatggcct ccgtgctgct cttccccgct ctgtgaagac tgtgctctcc
     1141 cgagctgact ctgaccccca tggaccacac acctgtggcc acgtcctcaa tgtgatcatc
     1201 ggctctaact ctctggcgct ggctgaggct cagaggcaag ccgaggtgct gggctaccat
     1261 gccatggtgt tgagcacagc catgcagggt gatgtaaaaa gagtggctcg gttctacggg
     1321 ctgctagccc gggtggctgc agcccacctc actccatcct tggctgagcg tcccttggag
     1381 gaggaggcgg aactccatca gctggcagct gagctccagc tcccggacct gcagctggag
     1441 gaggctctgg aagcggtggt aaaggctaaa gggccggtct gcctcctggc tggtggtgag
     1501 cccacggtgc agctgcaggg atctggcaag ggcggtcgga accaagaact ggccttgcac
     1561 gtgggagtgg agctgggaag gcagccactg ggacctattg atgtgctatt tttgagtgga
     1621 ggcactgatg ggcaggatgg gcctacaaag gtggccgggg cctgggtcat gtctgatctc
     1681 atcagccagg cttctgctga gagcctggac atcgccacct ccctcgccaa taacgactca
     1741 tacactttct tttgccgctt ccggggagga acacatttgc tgcacacagg gttgacaggg
     1801 accaatgtta tggatgtcca cctcctgatt cttcatcctc agtgatggtg tcgctcaccg
     1861 tgtgagagtg tagaagaggc cttcaagggc agggcctctt aggaaggtca agggccgatt
     1921 cccaggcccc actgtgccgc aggacttttc ctccgttgct ctgcccgcct ccctcggatc
     1981 tactctatgc ttgttccccc aactagatta gaagatgggg gcttctttct acccctagtt
     2041 tctgtcatga cagcaggtag ccctgaggcc cagcaggagc ttcttggcca gtcacagttc
     2101 tcattttctc cctggatgcc ttcctgccca ggtcctcagc ctgtctcttc catggagcga
     2161 aggtagggca ctgaaaataa agagaatgtt gtgtgtgggg gtctcagctc atctcccctc
     2221 agcacctctt tccatagcac agatcctcgg ggagctgctg ggcagggacc cgtggtgtgg
     2281 ccccagcagt ggtgccagta ccttgaagag tttctcatac cctttttggc tgggtgcaca
     2341 ctcagggtct gctgatggca atctgtgaca attgaatctg tctcctagca gtgtcaatgt
     2401 gggttaacag gacaggctta tagttgccta cttaaccctg actccctgtg gtagaaacct
     2461 gatcatggtt tctcctctcc tgctgttgcc tgactgggtg gagacgatcc acttgtcacc
     2521 acggctcttc cttctgtatt tggaccactc tcagctttcc ccctcaccct ctggctatca
     2581 aggggtttct tcaggccgca ggcattgcac ttgttctcct gtgcccactt ttcccaggct
     2641 aaacattcca tgttccattg tcgctcctcc gggtacccag ttgggaccct ggtgccagca
     2701 tttcagtgtg tgtctcagca ctagaatggt aggtcagagc agtgaaggac ctcagcagtc
     2761 cctcacccca tcctgtcata gctggcagag gtgagtcact tggcttggcc tgcagccact
     2821 ggcctggttt acctcgagcc ctcttgttcc acatcagagc cctctgttgg cttatcctca
     2881 ccgtacgcca cggctccaat ccctatatga gcgagcaata gaatcacata ggaataaaaa
     2941 gccatagaga acagtgaggc ctggggcggc ccctgtgggc ccttcttcca tcgtgagggt
     3001 gtgaggggct ctaggtcaga gctgatgtgt cctgggaagg gcctcccatc tccactgggc
     3061 tctggacagt ctagctagaa gttgggccat ggcttgcaga cctggctcct gtgtgtgttc
     3121 ctaagactga gaaggaggta agcaaggtga gctggctctg aggaccagac aggcttaggg
     3181 aagtggagtg gtttgtacca tttctttcct tctgtccttg tgcacaggat cagagactct
     3241 ggggattttg tctttacgct ggggttctgg tatcctctag gagtggctct gtccccgtgt
     3301 tcttgacctt gggaacgtat tcccattgga cactgagttg caggccagag cttcaggaga
     3361 agagcttttc agccgcatcc ttggtgtctc tgtgaggtaa acacgtgagc agtggacact
     3421 ggtgtcagaa tgcatccaca gtgtacccat gggtgctttt cagagtaggt ttgctcgtgg
     3481 ggaccactgt caccattgcc tgctgagggc ttcacatata ggtagagtct ttttgttgga
     3541 ggctccccgt gtctgccttg gtcactttcc tgtacctatg ctctcagagt ctgggggcca
     3601 gggtctgaat tgggccccat tatagcaaac agtttgtggg cataaccttc tatatttgct
     3661 cacctattta tctggtcatt ctagatgata gaaataaaca aattcctcac agttagagct
     3721 caataggact gttttttttg tttttttctc tccatcaata tcaagtatgg agccaggcct
     3781 ggtgcacagg cctataatcc caggtacacg agaggactct cagagtattg agagctcatg
     3841 gctagcctga gctacagagt gaaagccagc ctaggcaact aagagagatc ccattttaaa
     3901 gacctttaaa aagggtcggg cagtggtggt gcacgctttt aataccagca cttgggaggc
     3961 agaggcaggc ggatctcttg agtgtttgag gccagcccaa tctacagagt gagttccagg
     4021 acatccagtg ctacccagag agaacccctg tctcaccaag aacagcagca gcagcagcag
     4081 cagcagcagc agcagcagca gcagcaacaa caacaacaac aacaagaggt ctgggaatgt
     4141 ggtcaatgat actattctag catgtgtgaa gccctgggtt gagttcccag cactgaaaaa
     4201 taaaataaat aaatgaatga atggct
//
