LOCUS       NM_008133               3158 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus glutamate dehydrogenase 1 (Glud1), mRNA; nuclear gene
            for mitochondrial product.
ACCESSION   NM_008133 XM_912892 XM_922525 XM_922533 XM_922535
VERSION     NM_008133.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3158)
  AUTHORS   Soro-Arnaiz,I., Fitzgerald,G., Cherkaoui,S., Zhang,J.,
            Gilardoni,P., Ghosh,A., Bar-Nur,O., Masschelein,E., Maechler,P.,
            Zamboni,N., Poms,M., Cremonesi,A., Garcia-Canaveras,J.C., De
            Bock,K. and Morscher,R.J.
  TITLE     GLUD1 determines murine muscle stem cell fate by controlling
            mitochondrial glutamate levels
  JOURNAL   Dev Cell 59 (21), 2850-2865 (2024)
   PUBMED   39121856
REFERENCE   2  (bases 1 to 3158)
  AUTHORS   Lee,P., Kim,J., Choi,I.Y., Pal,R., Hui,D., Marcario,J.K.,
            Michaelis,M.L. and Michaelis,E.K.
  TITLE     Increases in anterograde axoplasmic transport in neurons of the
            hyper-glutamatergic, glutamate dehydrogenase 1 (Glud1) transgenic
            mouse: Effects of glutamate receptors on transport
  JOURNAL   J Neurochem 168 (5), 719-727 (2024)
   PUBMED   38124277
  REMARK    GeneRIF: Increases in anterograde axoplasmic transport in neurons
            of the hyper-glutamatergic, glutamate dehydrogenase 1 (Glud1)
            transgenic mouse: Effects of glutamate receptors on transport.
REFERENCE   3  (bases 1 to 3158)
  AUTHORS   Xing,L., Gkini,V., Nieminen,A.I., Zhou,H.C., Aquilino,M.,
            Naumann,R., Reppe,K., Tanaka,K., Carmeliet,P., Heikinheimo,O.,
            Paabo,S., Huttner,W.B. and Namba,T.
  TITLE     Functional synergy of a human-specific and an ape-specific
            metabolic regulator in human neocortex development
  JOURNAL   Nat Commun 15 (1), 3468 (2024)
   PUBMED   38658571
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3158)
  AUTHORS   Piot,L., Heroven,C., Bossi,S., Zamith,J., Malinauskas,T.,
            Johnson,C., Wennagel,D., Stroebel,D., Charrier,C., Aricescu,A.R.,
            Mony,L. and Paoletti,P.
  TITLE     GluD1 binds GABA and controls inhibitory plasticity
  JOURNAL   Science 382 (6677), 1389-1394 (2023)
   PUBMED   38060673
  REMARK    GeneRIF: GluD1 binds GABA and controls inhibitory plasticity.
REFERENCE   5  (bases 1 to 3158)
  AUTHORS   Herzig,S., Li,L., Jimenez-Sanchez,C., Martinou,J.C. and Maechler,P.
  TITLE     Screening for new inhibitors of the human Mitochondrial Pyruvate
            Carrier and their effects on hepatic glucose production and
            diabetes
  JOURNAL   Biochim Biophys Acta Gen Subj 1867 (12), 130492 (2023)
   PUBMED   37871770
REFERENCE   6  (bases 1 to 3158)
  AUTHORS   Serikawa,T., Montagutelli,X., Simon-Chazottes,D. and Guenet,J.L.
  TITLE     Polymorphisms revealed by PCR with single, short-sized, arbitrary
            primers are reliable markers for mouse and rat gene mapping
  JOURNAL   Mamm Genome 3 (2), 65-72 (1992)
   PUBMED   1617216
REFERENCE   7  (bases 1 to 3158)
  AUTHORS   Tzimagiorgis,G. and Moschonas,N.K.
  TITLE     Molecular cloning, structure and expression analysis of a
            full-length mouse brain glutamate dehydrogenase cDNA
  JOURNAL   Biochim Biophys Acta 1089 (2), 250-253 (1991)
   PUBMED   1711373
REFERENCE   8  (bases 1 to 3158)
  AUTHORS   Tzimagiorgis,G., Adamson,M.C., Kozak,C.A. and Moschonas,N.K.
  TITLE     Chromosomal mapping of glutamate dehydrogenase gene sequences to
            mouse chromosomes 7 and 14
  JOURNAL   Genomics 10 (1), 83-88 (1991)
   PUBMED   2045113
REFERENCE   9  (bases 1 to 3158)
  AUTHORS   Bessis,A., Simon-Chazottes,D., Devillers-Thiery,A., Guenet,J.L. and
            Changeux,J.P.
  TITLE     Chromosomal localization of the mouse genes coding for alpha 2,
            alpha 3, alpha 4 and beta 2 subunits of neuronal nicotinic
            acetylcholine receptor
  JOURNAL   FEBS Lett 264 (1), 48-52 (1990)
   PUBMED   2338144
REFERENCE   10 (bases 1 to 3158)
  AUTHORS   Miret-Duvaux,O., Frederic,F., Simon,D., Guenet,J.L., Hanauer,A.,
            Delhaye-Bouchaud,N. and Mariani,J.
  TITLE     Glutamate dehydrogenase in cerebellar mutant mice: gene
            localization and enzyme activity in different tissues
  JOURNAL   J Neurochem 54 (1), 23-29 (1990)
   PUBMED   2293612
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK150637.1, AK089152.1 and AK161876.1.
            
            On Mar 21, 2009 this sequence version replaced NM_008133.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150637.1, BC052724.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                AK150637.1         2-99
            99-1654             AK089152.1         2-1557
            1655-2800           AK150637.1         1655-2800
            2801-3158           AK161876.1         1937-2294
FEATURES             Location/Qualifiers
     source          1..3158
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 20.8 cM"
     gene            1..3158
                     /gene="Glud1"
                     /gene_synonym="Gdh-X; Glud; Gludl"
                     /note="glutamate dehydrogenase 1"
                     /db_xref="GeneID:14661"
                     /db_xref="MGI:MGI:95753"
     exon            1..616
                     /gene="Glud1"
                     /gene_synonym="Gdh-X; Glud; Gludl"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..1848
                     /gene="Glud1"
                     /gene_synonym="Gdh-X; Glud; Gludl"
                     /EC_number="1.4.1.3"
                     /note="glutamate dehydrogenase 1, mitochondrial; GDH 1"
                     /codon_start=1
                     /product="glutamate dehydrogenase 1, mitochondrial
                     precursor"
                     /protein_id="NP_032159.1"
                     /db_xref="CCDS:CCDS26935.1"
                     /db_xref="GeneID:14661"
                     /db_xref="MGI:MGI:95753"
                     /translation="MYRRLGEALLLSRAGPAALGSAAADSAALLGWARGQPSAAPQPG
                     LTPVARRHYSEAAADREDDPNFFKMVEGFFDRGASIVEDKLVEDLKTRESEEQKRNRV
                     RGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDE
                     VKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGPG
                     IDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGV
                     FHGIENFINEASYMSILGMTPGFGDKTFVVQGFGNVGLHSMRYLHRFGAKCVGVGESD
                     GSIWNPDGIDPKELEDFKLQHGSILGFPKAKVYEGSILEADCDILIPAASEKQLTKSN
                     APRVKAKIIAEGANGPTTPEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVS
                     YGRLTFKYERDSNYHLLMSVQESLERKFGKHGGTIPVVPTAEFQDRISGASEKDIVHS
                     GLAYTMERSARQIMRTAMKYNLGLDLRTAAYVNAIEKVFKVYNEAGVTFT"
     exon            617..697
                     /gene="Glud1"
                     /gene_synonym="Gdh-X; Glud; Gludl"
                     /inference="alignment:Splign:2.1.0"
     exon            698..753
                     /gene="Glud1"
                     /gene_synonym="Gdh-X; Glud; Gludl"
                     /inference="alignment:Splign:2.1.0"
     exon            754..817
                     /gene="Glud1"
                     /gene_synonym="Gdh-X; Glud; Gludl"
                     /inference="alignment:Splign:2.1.0"
     exon            818..912
                     /gene="Glud1"
                     /gene_synonym="Gdh-X; Glud; Gludl"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1092
                     /gene="Glud1"
                     /gene_synonym="Gdh-X; Glud; Gludl"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1230
                     /gene="Glud1"
                     /gene_synonym="Gdh-X; Glud; Gludl"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1368
                     /gene="Glud1"
                     /gene_synonym="Gdh-X; Glud; Gludl"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1449
                     /gene="Glud1"
                     /gene_synonym="Gdh-X; Glud; Gludl"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1573
                     /gene="Glud1"
                     /gene_synonym="Gdh-X; Glud; Gludl"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1665
                     /gene="Glud1"
                     /gene_synonym="Gdh-X; Glud; Gludl"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1728
                     /gene="Glud1"
                     /gene_synonym="Gdh-X; Glud; Gludl"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..3158
                     /gene="Glud1"
                     /gene_synonym="Gdh-X; Glud; Gludl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3009..3014
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Glud1"
                     /gene_synonym="Gdh-X; Glud; Gludl"
                     /note="hexamer: ATTAAA"
     polyA_site      3032
                     /gene="Glud1"
                     /gene_synonym="Gdh-X; Glud; Gludl"
                     /note="major polyA site"
     regulatory      3080..3085
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Glud1"
                     /gene_synonym="Gdh-X; Glud; Gludl"
                     /note="hexamer: TATAAA"
     polyA_site      3112
                     /gene="Glud1"
                     /gene_synonym="Gdh-X; Glud; Gludl"
ORIGIN      
        1 ccgtcctccc ggtggggcga caagcggcgc aggggagggg acagccagac aagcaggaag
       61 ccgcggctta aaagggcagc tcgcgcccag cccttcctcc ccgcggtcca ggcctgcgag
      121 ctccggtctt tacagctccc gccgcactcg cctcagcccg ccgccgccgc catgtaccgc
      181 cgtctgggcg aagcgctgct gctgtcccgc gccgggcccg ctgccctggg ctctgcggct
      241 gcagactcag ccgcgctgct gggctgggcc cgcggacagc cctccgccgc cccgcaaccc
      301 gggctcacgc cggtcgcccg gcgccactac agcgaagcgg ccgccgaccg cgaagacgac
      361 cccaacttct tcaagatggt ggagggcttc ttcgaccgcg gcgccagcat cgtagaggac
      421 aagctggtgg aagacctgaa gacccgggag agcgaggagc agaagcggaa ccgggtgcgc
      481 ggcatcctga ggatcatcaa gccctgcaac catgtgttga gcctctcctt ccccatccgg
      541 cgcgacgacg gctcctggga ggtcatcgaa ggctaccggg cccagcacag ccagcaccgc
      601 acgccctgca agggaggtat ccgttacagc actgacgtga gtgtggatga agtaaaagca
      661 ctggcttcct taatgacata caagtgcgct gtggtcgatg taccgtttgg aggtgctaaa
      721 gcaggcgtta agatcaaccc caagaactat acagataatg aattagaaaa aattacacgg
      781 aggttcacta tggagctggc caagaagggt tttattggtc ctggcattga tgtgcctgcc
      841 ccagacatga gcacgggtga gcgggagatg tcctggatcg ctgacaccta tgccagcacc
      901 atagggcact atgatatcaa tgcgcatgcc tgtgttactg ggaaacccat cagtcaagga
      961 ggcatccacg ggcgcatctc cgctactggc cggggtgtct tccatggaat tgaaaacttc
     1021 atcaatgagg cttcttacat gagcatttta ggaatgacac caggctttgg cgataagaca
     1081 tttgttgttc agggatttgg taatgtgggc ctgcactcta tgagatattt acatcgtttt
     1141 ggtgctaaat gtgttggtgt tggagagtct gatgggagta tatggaatcc ggatgggatt
     1201 gacccaaaag aactggaaga cttcaagttg caacatggat caattctggg cttccccaaa
     1261 gccaaggtct atgaaggaag catcttggag gctgactgtg acattctgat tcctgccgcc
     1321 agcgagaagc agttgaccaa atccaatgca cccagagtca aagccaagat cattgctgaa
     1381 ggtgccaatg ggccaaccac tccagaggct gataagattt tcctggaaag aaacatcatg
     1441 gttattcccg atctctactt aaatgctgga ggagtaacag tgtcttactt tgagtggcta
     1501 aagaatctaa atcatgtcag ctacggccga ttgaccttca aatatgaaag ggactctaac
     1561 taccacttgc tcatgtctgt tcaagagagt ttagagagaa agtttggaaa gcatggtgga
     1621 actattcctg tggtccccac agcagagttc caggacagga tatcgggtgc atctgagaaa
     1681 gacattgtgc actctggctt ggcctacaca atggagagat ctgccaggca aattatgcgc
     1741 acagccatga agtataacct gggattggac ctgagaacag ctgcctatgt caatgctatc
     1801 gagaaagtct tcaaggtgta caatgaagct ggtgtgacct tcacatagac agctcacagc
     1861 cgacttcttt accacctctt cacctataat ttctgcagac ctgtcacaag tttccatata
     1921 accatagaaa tctgttcttg tgactcatta gttaacggac actgttctga acaagtcagt
     1981 tggaatcagc cccttaagag aaagagatta agttagagga tcatgtacaa gctgatggta
     2041 taaaagtagg aatcacgtgt atccaagcca gttaggtggt ttgcttttag gtaaagtctt
     2101 gctcctgtgc tgtcttgctc tgggcccttc ccagcagagt cagtgctgtt gccagggaag
     2161 gagtcaggag cagtcagtca cttcttgaca tgtctgggaa ctccgacaca tataagaagt
     2221 aggtgtgtgg cgttttccaa aggtggcatg gtcctcaaat gagttattgt ggttttacat
     2281 caaaaaaaaa taactcagtt ttctaagttg caaacaaaaa taaaagctat gtctcatgta
     2341 ttttattctc tcagaataaa ccagtacatg ctgctgtaat aaattgcctt caaccactta
     2401 agcctaacct ttactcaagc agtgaacacc taaaatagaa gaaatggaag aagctagttt
     2461 tttatactat aaaacagtat cacttgtagc ttattggccc tgcatcattg tccagcagaa
     2521 ataaagtagc actatggggc gctctcctca gacctgcaag ggacaaggga ctcttgggaa
     2581 ctggtaatgc agtccagaga gtacagtaac cactttacca tgaaaactac ttgttcttcc
     2641 catttgaagg tctattctgt tgagtaattg aaccataatt caaatcgagt gtcccagaaa
     2701 aaaagacttg ggctccctgt ttggagtctg gcaggcttcg agcacgagcc agtggccagg
     2761 ctcaacctgt gtgtcccctt ccaaggcttt gcattctgct caccgcttca ccagcagcag
     2821 gctagagact gcctgcctgg gcttgacttt tgtttggggg gttattggcc agggcttttg
     2881 aacaggaatg tcccacagaa gtaccagaca ttatttatat aaggatgaac gctttttttt
     2941 aacagtaccc tttcagaaat ttctaactac tttgtaactg catgattaac ttggtgataa
     3001 aagcagttat taaaagtcta ccttttccaa aatgtatgtt tcttttctgt gttttcatat
     3061 ttaataatct gttagtaaat ataaaacggt aattgaggtt cagaaatttt cataactgtc
     3121 tatgtcactg ctttctgtta acaagctctt caaatttt
//
