LOCUS       NM_001403310            2310 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus glycosyltransferase 8 domain containing 1 (Glt8d1),
            transcript variant 10, mRNA.
ACCESSION   NM_001403310
VERSION     NM_001403310.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2310)
  AUTHORS   Yang,C.P., Li,X., Wu,Y., Shen,Q., Zeng,Y., Xiong,Q., Wei,M.,
            Chen,C., Liu,J., Huo,Y., Li,K., Xue,G., Yao,Y.G., Zhang,C., Li,M.,
            Chen,Y. and Luo,X.J.
  TITLE     Comprehensive integrative analyses identify GLT8D1 and CSNK2B as
            schizophrenia risk genes
  JOURNAL   Nat Commun 9 (1), 838 (2018)
   PUBMED   29483533
  REMARK    GeneRIF: GLT8D1 and CSNK2B knockdown promote the proliferation and
            inhibit the differentiation abilities of neural stem cells, and
            alter morphology and synaptic transmission of mouse neurons.
            Erratum:[Nat Commun. 2018 Nov 16;9(1):4905. doi:
            10.1038/s41467-018-07401-9.. PMID: 30446647]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2310)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154727.2.
            
            Summary: This gene encodes a member of the glycosyltransferase
            family. The encoded protein is a type II transmembrane protein
            containing a glycosyltransferase 8 domain in the lumenal
            (C-terminal) portion. The specific function of this protein has not
            been determined. Two alternatively spliced variants encoding the
            same isoform have been described. [provided by RefSeq, Sep 2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422601.1159680.1,
                                           SRR13422600.1575550.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-744               AC154727.2         112567-113310
            745-840             AC154727.2         115409-115504
            841-894             AC154727.2         117173-117226
            895-993             AC154727.2         117347-117445
            994-1207            AC154727.2         119368-119581
            1208-1325           AC154727.2         120449-120566
            1326-1410           AC154727.2         120795-120879
            1411-1523           AC154727.2         121011-121123
            1524-1690           AC154727.2         121578-121744
            1691-1803           AC154727.2         121835-121947
            1804-2310           AC154727.2         122199-122705
FEATURES             Location/Qualifiers
     source          1..2310
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 19.09 cM"
     gene            1..2310
                     /gene="Glt8d1"
                     /gene_synonym="2410004H05Rik; 5430414N14Rik"
                     /note="glycosyltransferase 8 domain containing 1"
                     /db_xref="GeneID:76485"
                     /db_xref="MGI:MGI:1923735"
     exon            1..744
                     /gene="Glt8d1"
                     /gene_synonym="2410004H05Rik; 5430414N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            745..840
                     /gene="Glt8d1"
                     /gene_synonym="2410004H05Rik; 5430414N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            841..894
                     /gene="Glt8d1"
                     /gene_synonym="2410004H05Rik; 5430414N14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             879..1994
                     /gene="Glt8d1"
                     /gene_synonym="2410004H05Rik; 5430414N14Rik"
                     /note="isoform 1 is encoded by transcript variant 10;
                     glycosyltransferase 8 domain-containing protein 1"
                     /codon_start=1
                     /product="glycosyltransferase 8 domain-containing protein
                     1 isoform 1"
                     /protein_id="NP_001390239.1"
                     /db_xref="GeneID:76485"
                     /db_xref="MGI:MGI:1923735"
                     /translation="MSFRKVNIIIWVLAVVLFLLVLHHNFLSLSSLLKNDISDSGIVG
                     LQPIDFVASAHQHPVSERQEEIPVVIAASEDRLGGTIAAINSVHQNTRSNVMFYIVTF
                     NSTADHLRSWLNSGSLKSIRYKIVNFDTKLLEGKVKQDPDQGESMKPLTFARFYLPIL
                     VPSAKKAIYMDDDVIVQGDILALYNTPLKPGHAAAFSEDCDSASTKVIIRGAGNQYNY
                     IGYLDYKKERIRKLSMKASTCSFNPGVFVANLTEWKRQNVTNQLEKWMKLNVEEGLYS
                     RTLAGSITTPPLLIVFYQQHSTIDPMWNVRHLGSSAGKRYSPQFVKAAKLLHWNGHFK
                     PWGRTASYADVWEKWYIPDPTGKFSLIRRHMDTSNIK"
     exon            895..993
                     /gene="Glt8d1"
                     /gene_synonym="2410004H05Rik; 5430414N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1207
                     /gene="Glt8d1"
                     /gene_synonym="2410004H05Rik; 5430414N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1325
                     /gene="Glt8d1"
                     /gene_synonym="2410004H05Rik; 5430414N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1410
                     /gene="Glt8d1"
                     /gene_synonym="2410004H05Rik; 5430414N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1523
                     /gene="Glt8d1"
                     /gene_synonym="2410004H05Rik; 5430414N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1690
                     /gene="Glt8d1"
                     /gene_synonym="2410004H05Rik; 5430414N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1803
                     /gene="Glt8d1"
                     /gene_synonym="2410004H05Rik; 5430414N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..2310
                     /gene="Glt8d1"
                     /gene_synonym="2410004H05Rik; 5430414N14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2286..2291
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Glt8d1"
                     /gene_synonym="2410004H05Rik; 5430414N14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2310
                     /gene="Glt8d1"
                     /gene_synonym="2410004H05Rik; 5430414N14Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcggcggcca ctcctcccag cgcaggtaag ggcgactgcg cccagcctcg gaaggcgacg
       61 attcgtctga cgcggctcta acctgacctg tcagtgcgtg gcgggatccc cggagcgcct
      121 caccacgtcc ccatcactcc taagcgtaag gaggctacta atgatctcta gagttaggga
      181 agataacgaa gccacattct ccagggaaag gagactgcct cggagaagag ctgcgaggcc
      241 caagtcgccc cacatctcgt ggattgagct tccgtgcccc tatgtagagg gtcccaaatt
      301 cggcctaact ttttggttgc cggtttccat ggctcattcc caggccagtc cctcttggta
      361 aagaccagcc aagggccggg cgtggtggcg cacgccttta atcccagcac tcgggaggca
      421 gaggcaggtg gatttctgag ttcgaggcca gcctggtcta caaagtgagc tccaggacag
      481 ccagggctat acagagaaaa cccgtctcga aaaaccaaaa aaaaaaaaaa aaaaagacca
      541 gccaaggggt tcccttaacc ctgtctttca agggttgtgt atttcaaagc gtgagccctt
      601 ccctcatgac tgagctagat ggggtgccga attcagacag accattctgg ggatcccatc
      661 ctctggggcc cgctgcctct gtggactctg ctgtgcatgc agtcaggcac agatggcgag
      721 atgctagaca ctctagactg ggagccctga gagtttcttc taaacagacc aaggaacccg
      781 gaaagacatg ccaggaaaga cagcatgatg agacttattc tgaaatccgg tccttttcat
      841 ggttaatttc taatgtttgt gtaagacaga agaaaaggat gtcattccgt aaagtgaaca
      901 tcatcatctg ggtcctggct gttgttctct tcttactggt tttgcaccat aacttcctca
      961 gcttgagcag tttgttaaag aatgacattt cagattcggg aattgtgggg cttcagccca
     1021 tagactttgt cgccagtgct catcagcatc cagtgagtga gaggcaagag gagattcccg
     1081 tggttattgc tgcctctgaa gacaggctgg gtgggaccat tgcagccata aacagcgttc
     1141 atcaaaacac gcgctccaat gtgatgtttt acattgttac attcaacagc acagcagacc
     1201 atctccggtc ctggcttaac agtggttcct tgaaaagcat caggtacaaa attgtaaatt
     1261 ttgacactaa acttttggaa gggaaagtaa agcaggatcc tgaccagggg gagtccatga
     1321 aaccattaac ctttgcaagg ttctacttgc caattctggt tcccagtgca aagaaagcca
     1381 tatacatgga tgatgatgtc attgtacaag gtgacatact tgccttgtac aatacaccac
     1441 tgaagccagg acatgctgct gcgttttcag aagattgtga ctcagcctcc actaaagtca
     1501 tcatccgggg agcagggaac cagtacaatt acattggtta tcttgactat aaaaaggaaa
     1561 gaattcgtaa actttccatg aaagccagca cctgttcctt taatcctgga gtttttgttg
     1621 caaacttgac tgaatggaaa agacagaatg taactaacca gttggaaaaa tggatgaagc
     1681 tcaatgtaga agagggatta tacagcagaa ctctggcagg cagcatcacc acacctcctc
     1741 tgcttatcgt attttatcag cagcattcca ccattgaccc tatgtggaat gtccgccatc
     1801 ttggttccag tgctggaaaa cggtactcac cccagtttgt aaaagctgcc aagttacttc
     1861 actggaatgg tcacttcaag ccttggggaa gaactgcttc atatgctgat gtttgggaaa
     1921 agtggtatat tccagaccca acaggaaaat tcagtttaat ccgaagacat atggatacct
     1981 caaacataaa gtgaactaca atttaagcta attgcgtcac tcaggaaact ctggaagaca
     2041 cactatgtgg gaaggtaaca gttgtagggc ttgagtttct ctataccaac cacagaaaac
     2101 acttcagctg ggtagaagtc atagatatcc agatgactac cacggctcca tctgccttac
     2161 caaatgtttg ctttactata ctgctgactt gaaggacaga gaactccagc atttaactgc
     2221 atctagctgc tgtaggtagg aactgctgtt tggttttagt tttgtacctt gtggcctggt
     2281 ttgtaaataa aatctacatt ttccaataga
//
