LOCUS       NM_028419               1002 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus glutaredoxin 5 (Glrx5), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_028419
VERSION     NM_028419.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1002)
  AUTHORS   Liu,Y., Wang,Y., Yang,M., Luo,J., Zha,J., Geng,S. and Zeng,W.
  TITLE     Exosomes from hypoxic pretreated ADSCs attenuate ultraviolet
            light-induced skin injury via GLRX5 delivery and ferroptosis
            inhibition
  JOURNAL   Photochem Photobiol Sci 23 (1), 55-63 (2024)
   PUBMED   38100056
  REMARK    GeneRIF: Exosomes from hypoxic pretreated ADSCs attenuate
            ultraviolet light-induced skin injury via GLRX5 delivery and
            ferroptosis inhibition.
REFERENCE   2  (bases 1 to 1002)
  AUTHORS   Petry,S.F., Sharifpanah,F., Sauer,H. and Linn,T.
  TITLE     Differential expression of islet glutaredoxin 1 and 5 with high
            reactive oxygen species production in a mouse model of diabesity
  JOURNAL   PLoS One 12 (5), e0176267 (2017)
   PUBMED   28542222
  REMARK    GeneRIF: Study reports a decrease of Grx expression levels in
            pancreatic islets of diabetic mice which was accompanied by
            declining insulin secretion, increase of reactive oxygen species
            (ROS) production level, and cell cycle alterations. These data
            demonstrate the essential role of the Grx system for the beta-cell
            during metabolic stress which may provide a new target for diabetes
            mellitus type 2 treatment.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1002)
  AUTHORS   Linares,G.R., Xing,W., Govoni,K.E., Chen,S.T. and Mohan,S.
  TITLE     Glutaredoxin 5 regulates osteoblast apoptosis by protecting against
            oxidative stress
  JOURNAL   Bone 44 (5), 795-804 (2009)
   PUBMED   19442627
  REMARK    GeneRIF: Grx5 is an important determinant of osteoblast apoptosis
            and acts via a molecular pathway that involves regulation of ROS
            production, cardiolipin oxidation, caspase activity, Fe-S cluster
            formation, and MnSOD activity.
REFERENCE   4  (bases 1 to 1002)
  AUTHORS   Wingert,R.A., Galloway,J.L., Barut,B., Foott,H., Fraenkel,P.,
            Axe,J.L., Weber,G.J., Dooley,K., Davidson,A.J., Schmid,B.,
            Paw,B.H., Shaw,G.C., Kingsley,P., Palis,J., Schubert,H., Chen,O.,
            Kaplan,J. and Zon,L.I.
  CONSRTM   Tubingen 2000 Screen Consortium
  TITLE     Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for
            vertebrate haem synthesis
  JOURNAL   Nature 436 (7053), 1035-1039 (2005)
   PUBMED   16110529
  REMARK    Erratum:[Nature. 2005 Oct 6;437(7060):920. Schmidt, Bettina
            [corrected to Schmid, Bettina]]
REFERENCE   5  (bases 1 to 1002)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   6  (bases 1 to 1002)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ071975.1, CX243759.1,
            AK013761.1 and CJ265616.1.
            
            On Sep 18, 2015 this sequence version replaced NM_028419.2.
            
            Summary: This gene encodes a mitochondrial protein, which is
            evolutionarily conserved. It is involved in the biogenesis of
            iron-sulfur clusters, which are required for normal iron
            homeostasis. Mutations in the human gene are associated with
            autosomal recessive pyridoxine-refractory sideroblastic anemia.
            [provided by RefSeq, Sep 2015].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK013761.1, AK050883.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                CJ071975.1         2-32
            32-71               CX243759.1         2-41
            72-1001             AK013761.1         2-931
            1002-1002           CJ265616.1         665-665
FEATURES             Location/Qualifiers
     source          1..1002
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 55.04 cM"
     gene            1..1002
                     /gene="Glrx5"
                     /note="glutaredoxin 5"
                     /db_xref="GeneID:73046"
                     /db_xref="MGI:MGI:1920296"
     exon            1..365
                     /gene="Glrx5"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..541
                     /gene="Glrx5"
                     /note="monothiol glutaredoxin-5; glutaredoxin 5 homolog"
                     /codon_start=1
                     /product="glutaredoxin-related protein 5, mitochondrial"
                     /protein_id="NP_082695.1"
                     /db_xref="CCDS:CCDS26154.1"
                     /db_xref="GeneID:73046"
                     /db_xref="MGI:MGI:1920296"
                     /translation="MSASLSRAAAALLRWGRSAGGGGLPGAGVRAASSGGQAEQLDAL
                     VKKDKVVVFLKGTPEQPQCGFSNAVVQILRLHGVRDYAAYNVLDDPELRQGIKDYSNW
                     PTIPQVYLNGEFVGGCDILLQMHQNGDLVEELKKLGIRSALVDEKDQDSK"
     exon            366..1002
                     /gene="Glrx5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      929..934
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Glrx5"
                     /note="hexamer: ATTAAA"
     polyA_site      947
                     /gene="Glrx5"
                     /note="major polyA site"
ORIGIN      
        1 gagagcctct ggtgggccgg ccggacacca cgggctctgt aagccctgga gtggccgcag
       61 aggcggtgga cagcgagcgg gcatgagcgc gtccctgagc cgggcggcgg cggctctgct
      121 gcgctggggg cgaagcgctg gtggcggtgg cctgcccgga gccggcgtgc gggcggcgag
      181 ctcgggcggc caggcggagc agctggacgc gctggtgaag aaggacaagg tggtggtgtt
      241 cctcaagggg acgcccgagc agccccagtg cggcttcagc aacgccgtgg tgcagattct
      301 gcggctgcac ggtgttcgcg actatgcggc ctacaacgtg ctggacgacc cggagctgag
      361 gcaaggtatt aaagactact ccaactggcc aaccatcccg caagtgtacc tcaacggcga
      421 gtttgtgggg ggctgtgaca tccttctgca gatgcatcag aatggggacc tagtggaaga
      481 actgaaaaag ctgggtatcc gctctgccct ggtagatgag aaggaccaag actccaagtg
      541 agggccccgg gccctcgccg agcagagcgc cctctccatc ctcggggcca gaaaagcctt
      601 actgcgtggt ggtgccctgt tgctgtgatg cttgcgctgg gcctcctggc agcaagcggg
      661 caggtgcttt tactttagtc tctggctcag aattccctct ggtgaacgta caaccactgc
      721 actgtaaatc aatgtcgcga tcctgtattg ctataaccgt gatctgttct tacgttgtct
      781 ttattctctg ccggccggct ttgggagtca cttctgattc ttgtttgggt tgtagagatg
      841 gtaaagcccc ctgatgtttt tgtaacttcc tgtaaaaggg aaatgatgga cagaggagaa
      901 aatgtggtgg ctagagttgt tttgtaaaat taaattgcca acacagacgt gtgtgtgagt
      961 cattaaatcc agcaagaaca gctccatagg acgtggagaa ct
//
