LOCUS       NM_001038592            3603 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus glutaredoxin 2 (Glrx2), transcript variant 1, mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_001038592
VERSION     NM_001038592.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3603)
  AUTHORS   Li,C., Chen,X., Zhang,S., Liang,C., Deng,Q., Li,X. and Yan,H.
  TITLE     Pericyte loss via glutaredoxin2 downregulation aggravates
            diabetes-induced microvascular dysfunction
  JOURNAL   Exp Eye Res 247, 110025 (2024)
   PUBMED   39117135
  REMARK    GeneRIF: Pericyte loss via glutaredoxin2 downregulation aggravates
            diabetes-induced microvascular dysfunction.
REFERENCE   2  (bases 1 to 3603)
  AUTHORS   Chen,X., Chen,Y., Li,C., Li,J., Zhang,S., Liang,C., Deng,Q.,
            Guo,Z., Guo,C. and Yan,H.
  TITLE     Glutaredoxin 2 protects lens epithelial cells from
            epithelial-mesenchymal transition by suppressing mitochondrial
            oxidative stress-related upregulation of integrin-linked kinase
  JOURNAL   Exp Eye Res 234, 109609 (2023)
   PUBMED   37541331
  REMARK    GeneRIF: Glutaredoxin 2 protects lens epithelial cells from
            epithelial-mesenchymal transition by suppressing mitochondrial
            oxidative stress-related upregulation of integrin-linked kinase.
REFERENCE   3  (bases 1 to 3603)
  AUTHORS   Zhang,J., Yu,Y., Dang,T., Lal,K. and Wu,H.
  TITLE     The impact of glutaredoxin 1 and glutaredoxin 2 double knockout on
            lens epithelial cell function
  JOURNAL   Exp Eye Res 233, 109521 (2023)
   PUBMED   37277068
  REMARK    GeneRIF: The impact of glutaredoxin 1 and glutaredoxin 2 double
            knockout on lens epithelial cell function.
REFERENCE   4  (bases 1 to 3603)
  AUTHORS   Guo,Y., Guo,C., Zhang,J., Ning,X. and Yan,H.
  TITLE     The protective mechanism of Grx2 in ultraviolet-B (UVB)-induced
            cataract formation
  JOURNAL   Biochem Biophys Res Commun 613, 107-112 (2022)
   PUBMED   35550196
REFERENCE   5  (bases 1 to 3603)
  AUTHORS   Scalcon,V., Folda,A., Lupo,M.G., Tonolo,F., Pei,N., Battisti,I.,
            Ferri,N., Arrigoni,G., Bindoli,A., Holmgren,A., Coppo,L. and
            Rigobello,M.P.
  TITLE     Mitochondrial depletion of glutaredoxin 2 induces metabolic
            dysfunction-associated fatty liver disease in mice
  JOURNAL   Redox Biol 51, 102277 (2022)
   PUBMED   35290904
  REMARK    GeneRIF: Mitochondrial depletion of glutaredoxin 2 induces
            metabolic dysfunction-associated fatty liver disease in mice.
REFERENCE   6  (bases 1 to 3603)
  AUTHORS   Jurado,J., Prieto-Alamo,M.J., Madrid-Risquez,J. and Pueyo,C.
  TITLE     Absolute gene expression patterns of thioredoxin and glutaredoxin
            redox systems in mouse
  JOURNAL   J Biol Chem 278 (46), 45546-45554 (2003)
   PUBMED   12954614
REFERENCE   7  (bases 1 to 3603)
  AUTHORS   Gladyshev,V.N., Liu,A., Novoselov,S.V., Krysan,K., Sun,Q.A.,
            Kryukov,V.M., Kryukov,G.V. and Lou,M.F.
  TITLE     Identification and characterization of a new mammalian glutaredoxin
            (thioltransferase), Grx2
  JOURNAL   J Biol Chem 276 (32), 30374-30380 (2001)
   PUBMED   11397793
REFERENCE   8  (bases 1 to 3603)
  AUTHORS   Lundberg,M., Johansson,C., Chandra,J., Enoksson,M., Jacobsson,G.,
            Ljung,J., Johansson,M. and Holmgren,A.
  TITLE     Cloning and expression of a novel human glutaredoxin (Grx2) with
            mitochondrial and nuclear isoforms
  JOURNAL   J Biol Chem 276 (28), 26269-26275 (2001)
   PUBMED   11297543
REFERENCE   9  (bases 1 to 3603)
  AUTHORS   Kobayashi,M., Nakamura,H., Yodoi,J. and Shiota,K.
  TITLE     Ontogenesis of anti-oxidative enzymes in mouse embryos and fetuses:
            an immunohistochemical study
  JOURNAL   Ital J Anat Embryol 106 (2 Suppl 2), 137-142 (2001)
   PUBMED   11732570
REFERENCE   10 (bases 1 to 3603)
  AUTHORS   Kobayashi,M., Nakamura,H., Yodoi,J. and Shiota,K.
  TITLE     Immunohistochemical localization of thioredoxin and glutaredoxin in
            mouse embryos and fetuses
  JOURNAL   Antioxid Redox Signal 2 (4), 653-663 (2000)
   PUBMED   11213470
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY226480.1, AK005853.1 and AL592403.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.274128.1,
                                           SRR1660817.282159.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               BY226480.1         1-191
            192-700             AK005853.1         95-603
            701-3603            AL592403.6         55572-58474
FEATURES             Location/Qualifiers
     source          1..3603
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 62.53 cM"
     gene            1..3603
                     /gene="Glrx2"
                     /gene_synonym="1700010P22Rik; Grx2"
                     /note="glutaredoxin 2"
                     /db_xref="GeneID:69367"
                     /db_xref="MGI:MGI:1916617"
     exon            1..191
                     /gene="Glrx2"
                     /gene_synonym="1700010P22Rik; Grx2"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..564
                     /gene="Glrx2"
                     /gene_synonym="1700010P22Rik; Grx2"
                     /note="isoform a is encoded by transcript variant 1;
                     glutaredoxin-2, mitochondrial; thioltransferase"
                     /codon_start=1
                     /product="glutaredoxin-2, mitochondrial isoform a"
                     /protein_id="NP_001033681.1"
                     /db_xref="CCDS:CCDS15343.1"
                     /db_xref="GeneID:69367"
                     /db_xref="MGI:MGI:1916617"
                     /translation="MSWRRAASVGRRLVASGRILAGRRGAAGAAGSGMGNSTSSFWGK
                     STTTPVNQIQETISNNCVVIFSKTSCSYCSMAKKIFHDMNVNYKAVELDMLEYGNQFQ
                     DALHKMTGERTVPRIFVNGRFIGGAADTHRLHKEGKLLPLVHQCYLKKKQEERH"
     exon            192..255
                     /gene="Glrx2"
                     /gene_synonym="1700010P22Rik; Grx2"
                     /inference="alignment:Splign:2.1.0"
     exon            256..432
                     /gene="Glrx2"
                     /gene_synonym="1700010P22Rik; Grx2"
                     /inference="alignment:Splign:2.1.0"
     exon            433..3603
                     /gene="Glrx2"
                     /gene_synonym="1700010P22Rik; Grx2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      679..684
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Glrx2"
                     /gene_synonym="1700010P22Rik; Grx2"
                     /note="hexamer: AATAAA"
     polyA_site      701
                     /gene="Glrx2"
                     /gene_synonym="1700010P22Rik; Grx2"
                     /note="major polyA site"
     regulatory      3578..3583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Glrx2"
                     /gene_synonym="1700010P22Rik; Grx2"
                     /note="hexamer: AATAAA"
     polyA_site      3603
                     /gene="Glrx2"
                     /gene_synonym="1700010P22Rik; Grx2"
ORIGIN      
        1 tggggcggag cgaggccgcc ggaggggcgg gcttccatcg tcgtggtcgc gatcgcctgc
       61 tgctctcccg gaggctgccg gggacctttg gctatgtcct ggcgccgcgc ggcttcggtg
      121 gggaggcggc tggtggcgag cgggaggatc ttggcggggc ggcgtggcgc ggctggagct
      181 gcgggctcgg gaatgggaaa cagcacatcg tcgttttggg ggaagtctac aactactcct
      241 gtgaaccaga tccaagaaac aatttctaac aattgtgtgg tgatcttctc aaaaacatcc
      301 tgctcttact gttccatggc caagaagatt ttccatgaca tgaatgtcaa ctacaaggct
      361 gtggagttgg atatgctgga atatggcaac cagtttcaag atgcgcttca caagatgact
      421 ggggaaagaa ccgttcccag gatatttgtc aatggacgat ttattggagg cgcagcggac
      481 actcacaggc ttcacaaaga agggaaattg ctgcctctgg ttcatcagtg ttatttaaaa
      541 aaaaaacaag aggaaagaca ttgaatgatg tggatagtcg ccataccagt aaatgctagt
      601 tagtgcagtc gtacctttga cttgaggctg ttttcagtgt gtggattgcc ttcataaaga
      661 tgattcagaa taatgaacaa taaattgccc tggacccttc atctcccgat tggccagttt
      721 ttgagcatga gatggtataa aaaaactaaa ggaggtggag ttacatcaaa agtaaagaat
      781 gtttattaag aatttaagaa tcttacagca aagagggagt acgcacttaa actcttgctc
      841 cccatggcat tcaggaatta acttctcacg ttcactagct gtcagggctg aggactgaca
      901 tgtggcttcc ttaaaattta atgtggtaca gatgtgcagt gggttgggat accatatcat
      961 gacaaccctt tatgttctag accaccaaac atactaaata tgtagaattc gatgaagttt
     1021 ctagttgggg catcaagctg ctaatgactt catggtcaga aagcaaaagg tttcaataga
     1081 gtgagagtgg gcttttcaaa cagttcagaa atgttattta gttctgttgc cagttggaca
     1141 ttctaccttt cagaatgtgt atcagctact ggaatttttt ttttttttcc ttttggagac
     1201 agggtcactc tgtagctcag aatggccaca aacgcaaaag tcagtcctcc tacctgtttc
     1261 caggcttgga ttatatgctg agctaccaca cccagcttga gaatgcttaa gagaaacagg
     1321 aattagagtt tagactaacg gtccttgtta tagtccgaac gtgccccacc acagacatca
     1381 tgtgttggaa acacatgaca taacctgata tggtacgcga ggtgaggcct ttacaaagta
     1441 cttaatcctg agggcagatg ggtccgtgct ctattagagt ggttcttgat aaaaggatga
     1501 gtttgtcccc ttacctctcc cgtctttgct cttcctcttc ttcctctgca gtgtcctgat
     1561 acagcaagga aatcctcact agataacctc accttcccga ccgatgacct agagaaagtc
     1621 catctcttct tcataaagta ctcagtctca ggtagtctgt ctgagtccca cagatggagc
     1681 gtccctaaaa tcacttctgt tatcttacta ttctctaact aggaagacac tgttcaaatt
     1741 gacttcattt cagataaact tagcaaacag aattaacctt taagaagtaa tatttaaaag
     1801 aactgaaaac atttccaatg ctttgctagt ctggtcatgg tttccgcctc tggtcaagaa
     1861 tattttaagt gcttaagaaa tgatgcattt cctagcagat tctcagagtc acgttggaaa
     1921 tgttatcaaa tgctgagcct ttctcaggta ggaagaacat ggacttccca gagtgagtgc
     1981 ttcagctttc tggtcaagat agactaggga ctcatgcaga gtttggaggg agacagtggc
     2041 ttgctgtcag agatgtttcc tacgtggact tcaactgcat tttggataac ttgacataga
     2101 agttaagaca gctctcctga tttaagctgt catgttggta ggaaaggaac atggtgtatt
     2161 tttattcctt tattttacac tatatcatga gaaattatat aattttacta tgctctaaaa
     2221 ctcacattat gtatgggaaa ggtgtcactg tttctgttgt cactagtaat cttattagga
     2281 tgtaaggtca aaggcaggtt acttaaatgc acagctacac caaccacgta ataatatggc
     2341 cttggctttg aggagctttt tttgtggtat tcagcctcag acccagggct tgaatagcag
     2401 gcaggtgtgc aggtgccact gacttataaa actttttctt tttttttttt tttacattag
     2461 acttttttaa ttagatattt tctttattta catttcaaat gttatcccct ttcctagttt
     2521 cccctctgaa aattccgtat cccctcccat tccccccaac tcacccactc ccattcctgg
     2581 ccctggcatt cccctatacc ggggcataga accttcacag gaccaagggc ctctcctccc
     2641 attgatgacc aactaggcca tcctctgcta catacgaagc tcgagccatg agtcccacca
     2701 tgtgtttttt ttggttggtg gtttagtccc tgggagctct gggggtactg gtttgttcat
     2761 atttttgttc cttctatggg gcttgcaaac tccttcagct ccttgggtcc tttctctagc
     2821 tacttcattg gggaccctgt gctctgtcca atggatggct atgagcatcc acttctgtat
     2881 ttgtcaggca ctggcagagc ctgtcaggag acagctatat caggctcctg tcagcatgct
     2941 cttgttggca tctgcaatag tgtcgggttt ggtgattgtt aatgggatgg atctccaggt
     3001 ggggcagtct ctggatggtc atttgttcag tttctgctcc atgctttatc tctgtaactc
     3061 cttccatggg tattttgttt tcccttctaa gaaggatcaa agtatccaca ctttggtgtt
     3121 ccttcttctt gagtttcatg tgttttgtga attgtatctt gggtattctg agcttctggg
     3181 ctaatatcca ctgggctaat ataccactta gctatacaac taattcttaa gaatgtttta
     3241 tcagttcttc ctaggcttgt gggaaacaag aggatgtgtg gtacataatt cttggttagg
     3301 gtcagatgtt aaaataaccc agctcttaaa aaatccttat cgtcagaagg ctcaagaata
     3361 tagaaggtaa cagggtatgt taattttcaa ttataagttt atataagaaa taaactctta
     3421 aagccgggca tggtggcgca cgcctttaat cccagcactt gtgaggcaga ggcgggcgga
     3481 tttctgagtt tgaggccagc ctggtctaca gagtgagttc caggacagcc agggctacac
     3541 agagaaaccc tgtctcaaaa aaaaaaaaaa aaaaagaaat aaactcttcc aatgattgct
     3601 taa
//
