LOCUS       NM_053108               1335 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Mus musculus glutaredoxin (Glrx), transcript variant 1, mRNA.
ACCESSION   NM_053108
VERSION     NM_053108.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1335)
  AUTHORS   Gong,X., Huang,M. and Chen,L.
  TITLE     NRF1 mitigates motor dysfunction and dopamine neuron degeneration
            in mice with Parkinson's disease by promoting GLRX m6 A methylation
            through upregulation of METTL3 transcription
  JOURNAL   CNS Neurosci Ther 30 (3), e14441 (2024)
   PUBMED   37735974
  REMARK    GeneRIF: NRF1 mitigates motor dysfunction and dopamine neuron
            degeneration in mice with Parkinson's disease by promoting GLRX
            m[6] A methylation through upregulation of METTL3 transcription.
REFERENCE   2  (bases 1 to 1335)
  AUTHORS   Ahn,Y.J., Wang,L., Kim,S., Eber,M.R., Salerno,A.G. and Asmis,R.
  TITLE     Macrophage-restricted overexpression of glutaredoxin 1 protects
            against atherosclerosis by preventing nutrient stress-induced
            macrophage dysfunction and reprogramming
  JOURNAL   Atherosclerosis 387, 117383 (2023)
   PUBMED   38061313
  REMARK    GeneRIF: Macrophage-restricted overexpression of glutaredoxin 1
            protects against atherosclerosis by preventing nutrient
            stress-induced macrophage dysfunction and reprogramming.
REFERENCE   3  (bases 1 to 1335)
  AUTHORS   Zhang,J., Yu,Y., Dang,T., Lal,K. and Wu,H.
  TITLE     The impact of glutaredoxin 1 and glutaredoxin 2 double knockout on
            lens epithelial cell function
  JOURNAL   Exp Eye Res 233, 109521 (2023)
   PUBMED   37277068
  REMARK    GeneRIF: The impact of glutaredoxin 1 and glutaredoxin 2 double
            knockout on lens epithelial cell function.
REFERENCE   4  (bases 1 to 1335)
  AUTHORS   Xia,Y., Xu,Y., Liu,Q., Zhang,J., Zhang,Z., Jia,Q., Tang,Q.,
            Jing,X., Li,J., Chen,J., Xiong,Y., Li,Y. and He,J.
  TITLE     Glutaredoxin 1 regulates cholesterol metabolism and gallstone
            formation by influencing protein S-glutathionylation
  JOURNAL   Metabolism 145, 155610 (2023)
   PUBMED   37277061
  REMARK    GeneRIF: Glutaredoxin 1 regulates cholesterol metabolism and
            gallstone formation by influencing protein S-glutathionylation.
REFERENCE   5  (bases 1 to 1335)
  AUTHORS   Li,C., Chen,X., Zhang,S., Liang,C., Ma,X., Zhang,R. and Yan,H.
  TITLE     Glutaredoxin 1 protects lens epithelial cells from
            epithelial-mesenchymal transition by preventing casein kinase
            1alpha S-glutathionylation during posterior capsular opacification
  JOURNAL   Redox Biol 62, 102676 (2023)
   PUBMED   36989576
  REMARK    GeneRIF: Glutaredoxin 1 protects lens epithelial cells from
            epithelial-mesenchymal transition by preventing casein kinase
            1alpha S-glutathionylation during posterior capsular opacification.
REFERENCE   6  (bases 1 to 1335)
  AUTHORS   Kobayashi,M., Nakamura,H., Yodoi,J. and Shiota,K.
  TITLE     Ontogenesis of anti-oxidative enzymes in mouse embryos and fetuses:
            an immunohistochemical study
  JOURNAL   Ital J Anat Embryol 106 (2 Suppl 2), 137-142 (2001)
   PUBMED   11732570
REFERENCE   7  (bases 1 to 1335)
  AUTHORS   Kobayashi,M., Nakamura,H., Yodoi,J. and Shiota,K.
  TITLE     Immunohistochemical localization of thioredoxin and glutaredoxin in
            mouse embryos and fetuses
  JOURNAL   Antioxid Redox Signal 2 (4), 653-663 (2000)
   PUBMED   11213470
REFERENCE   8  (bases 1 to 1335)
  AUTHORS   Nakamura,T., Ohno,T., Hirota,K., Nishiyama,A., Nakamura,H., Wada,H.
            and Yodoi,J.
  TITLE     Mouse glutaredoxin - cDNA cloning, high level expression in E. coli
            and its possible implication in redox regulation of the DNA binding
            activity in transcription factor PEBP2
  JOURNAL   Free Radic Res 31 (4), 357-365 (1999)
   PUBMED   10517541
  REMARK    Review article
REFERENCE   9  (bases 1 to 1335)
  AUTHORS   Miranda-Vizuete,A., Pedrajas,J.R., Damdimopoulos,A.E. and Spyrou,G.
  TITLE     Cloning and sequencing of mouse glutaredoxin (grx) cDNA
  JOURNAL   DNA Seq 10 (3), 179-182 (1999)
   PUBMED   10647820
REFERENCE   10 (bases 1 to 1335)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY272278.1, AK153086.1 and CO796000.1.
            
            On Apr 4, 2008 this sequence version replaced NM_053108.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054418.1, AF109314.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                BY272278.1         20-40
            22-1319             AK153086.1         2-1299
            1320-1335           CO796000.1         518-533
FEATURES             Location/Qualifiers
     source          1..1335
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 40.95 cM"
     gene            1..1335
                     /gene="Glrx"
                     /gene_synonym="D13Wsu156e; Glrx1; Grx1; TTase"
                     /note="glutaredoxin"
                     /db_xref="GeneID:93692"
                     /db_xref="MGI:MGI:2135625"
     exon            1..290
                     /gene="Glrx"
                     /gene_synonym="D13Wsu156e; Glrx1; Grx1; TTase"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..407
                     /gene="Glrx"
                     /gene_synonym="D13Wsu156e; Glrx1; Grx1; TTase"
                     /EC_number="1.8.4.1"
                     /note="glutaredoxin (thioltransferase); glutaredoxin 1
                     (thioltransferase); TTase-1; thioltransferase-1"
                     /codon_start=1
                     /product="glutaredoxin-1"
                     /protein_id="NP_444338.2"
                     /db_xref="CCDS:CCDS26651.1"
                     /db_xref="GeneID:93692"
                     /db_xref="MGI:MGI:2135625"
                     /translation="MAQEFVNCKIQSGKVVVFIKPTCPYCRKTQEILSQLPFKQGLLE
                     FVDITATNNTSAIQDYLQQLTGARTVPRVFIGKDCIGGCSDLISMQQTGELMTRLKQI
                     GALQL"
     exon            291..419
                     /gene="Glrx"
                     /gene_synonym="D13Wsu156e; Glrx1; Grx1; TTase"
                     /inference="alignment:Splign:2.1.0"
     exon            420..1327
                     /gene="Glrx"
                     /gene_synonym="D13Wsu156e; Glrx1; Grx1; TTase"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1301..1306
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Glrx"
                     /gene_synonym="D13Wsu156e; Glrx1; Grx1; TTase"
                     /note="hexamer: ATTAAA"
     polyA_site      1323
                     /gene="Glrx"
                     /gene_synonym="D13Wsu156e; Glrx1; Grx1; TTase"
                     /note="major polyA site"
ORIGIN      
        1 agctgctggc taagcgccgc tgcattaccg gaccattact ttcaactgca cgttcctccc
       61 tggagaagct gcagcctgtc agcatggctc aggagtttgt gaactgcaag atccagtctg
      121 ggaaggtggt cgtgttcatc aagcccacct gcccctactg cagaaagacc caagaaatcc
      181 tcagtcaact gcctttcaaa caaggtcttc tggagtttgt ggacatcaca gccactaaca
      241 acaccagtgc gattcaagat tatttacaac agctcaccgg agcgagaaca gttcctcggg
      301 tcttcatagg taaagactgc ataggcggat gcagtgatct aatctccatg caacagactg
      361 gggagctgat gactcggctg aagcagattg gagctctgca gttataaaag gggtggcagg
      421 cagagtccat gctgacacag ctgtctaacc atgctgatgg ccagtgcccc tgagagttga
      481 tgtgcatcgc agaggatgtc agtatttcct ggtgactggg atttttcaac aaggcggcct
      541 ttattcttct tttcctcagt gctaaaaact gttgcaattt gcccctaacc atggggccga
      601 gaagcttaac agaccacact ggtttgatta tccattcttc atgtgccaac atgtctctac
      661 ctctaagccc aggttttcca aatccagttg ctctaaatct ccagtggatc tgttgctggt
      721 tttctgctac tgttcgtcag ctgaagtcat tttgcagaag tccactttct aaagaattat
      781 tgaatcaatg gatatcgaaa atttgtttcc tgagtcatgc atcggctcct ctctccctcg
      841 tgcacgcacc cttcccactc ctgcattcac tgcccttact tagccagtgt tctcagcctc
      901 aacctcctac aacccgcaga cgtccacact ggtgtgagga tgctgtttga aaaatcagat
      961 gaactttagc atagttggtc ctcacggagg ccacgttaac ttaggcggca gagcagatgg
     1021 tgcatgcagc tccctctgta aaggtgatta attgtccaga aaatcccaag cagctgtgtg
     1081 ttgatccgag ttagagggcc agaaaaatca aatgtgaaat acaaaattgc aaaattctcc
     1141 ttccaagaat ttttgtgaaa gacgttgttt ctgaaacatt gtcctaaaca gtttcttcca
     1201 tccaaacttt gacattttgc tttgatgtct tgctatgctg tttaattctc atggatctgt
     1261 agatcacttc tctggtctcc agtgaggagg attcattact attaaagatg tatctataga
     1321 taactaaaaa aaaaa
//
