LOCUS       NM_010297               1411 bp    mRNA    linear   ROD 13-NOV-2023
DEFINITION  Mus musculus glycine receptor, alpha 4 subunit (Glra4), mRNA.
ACCESSION   NM_010297
VERSION     NM_010297.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1411)
  AUTHORS   Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K,
            Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre
            A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt
            AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,
            Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S,
            Wohnoutka P, Hawrylycz MJ, Puelles L and Jones AR.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   2  (bases 1 to 1411)
  AUTHORS   Kunz PA, Burette AC, Weinberg RJ and Philpot BD.
  TITLE     Glycine receptors support excitatory neurotransmitter release in
            developing mouse visual cortex
  JOURNAL   J Physiol 590 (22), 5749-5764 (2012)
   PUBMED   22988142
REFERENCE   3  (bases 1 to 1411)
  AUTHORS   Guo Z, Zhao C, Huang M, Huang T, Fan M, Xie Z, Chen Y, Zhao X, Xia
            G, Geng J and Cheng L.
  TITLE     Tlx1/3 and Ptf1a control the expression of distinct sets of
            transmitter and peptide receptor genes in the developing dorsal
            spinal cord
  JOURNAL   J Neurosci 32 (25), 8509-8520 (2012)
   PUBMED   22723691
REFERENCE   4  (bases 1 to 1411)
  AUTHORS   Buerbank S, Becker K, Becker CM, Brandt N, Engel J, Knipper M,
            Schick B and Dlugaiczyk J.
  TITLE     Developmental regulation of glycine receptors at efferent synapses
            of the murine cochlea
  JOURNAL   Histochem Cell Biol 136 (4), 387-398 (2011)
   PUBMED   21850450
  REMARK    GeneRIF: The distinct developmental regulation of GlyRalpha4 in the
            murine cochlea advocates a contribution of these chloride channels
            to efferent olivocochlear innervation.
REFERENCE   5  (bases 1 to 1411)
  AUTHORS   Majumdar S, Weiss J and Wassle H.
  TITLE     Glycinergic input of widefield, displaced amacrine cells of the
            mouse retina
  JOURNAL   J Physiol 587 (Pt 15), 3831-3849 (2009)
   PUBMED   19528249
  REMARK    GeneRIF: Glycine receptors (GlyRs) of group II cells are dominated
            by the alpha2 subunit; GlyRs of ON-starburst amacrine cells appear
            to be dominated by the alpha4 subunit.
REFERENCE   6  (bases 1 to 1411)
  AUTHORS   Lynch JW.
  TITLE     Native glycine receptor subtypes and their physiological roles
  JOURNAL   Neuropharmacology 56 (1), 303-309 (2009)
   PUBMED   18721822
  REMARK    Review article
REFERENCE   7  (bases 1 to 1411)
  AUTHORS   Prasad T, Wang X, Gray PA and Weiner JA.
  TITLE     A differential developmental pattern of spinal interneuron
            apoptosis during synaptogenesis: insights from genetic analyses of
            the protocadherin-gamma gene cluster
  JOURNAL   Development 135 (24), 4153-4164 (2008)
   PUBMED   19029045
REFERENCE   8  (bases 1 to 1411)
  AUTHORS   Heinze L, Harvey RJ, Haverkamp S and Wassle H.
  TITLE     Diversity of glycine receptors in the mouse retina: localization of
            the alpha4 subunit
  JOURNAL   J Comp Neurol 500 (4), 693-707 (2007)
   PUBMED   17154252
  REMARK    GeneRIF: The alpha4 subunit was localized in the inner plexiform
            layer (IPL) in brightly fluorescent puncta, which represent
            postsynaptically clustered glycine receptors.
REFERENCE   9  (bases 1 to 1411)
  AUTHORS   Harvey RJ, Schmieden V, Von Holst A, Laube B, Rohrer H and Betz H.
  TITLE     Glycine receptors containing the alpha4 subunit in the embryonic
            sympathetic nervous system, spinal cord and male genital ridge
  JOURNAL   Eur J Neurosci 12 (3), 994-1001 (2000)
   PUBMED   10762330
REFERENCE   10 (bases 1 to 1411)
  AUTHORS   Matzenbach B, Maulet Y, Sefton L, Courtier B, Avner P, Guenet JL
            and Betz H.
  TITLE     Structural analysis of mouse glycine receptor alpha subunit genes.
            Identification and chromosomal localization of a novel variant
  JOURNAL   J Biol Chem 269 (4), 2607-2612 (1994)
   PUBMED   7507926
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DQ109809.1 and BC110630.2.
            
            [WARNING] On Nov 22, 2023 this sequence was replaced by
            NM_010297.3.
            
            On Jul 15, 2008 this sequence version replaced NM_010297.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ109809.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-788               DQ109809.1         1-788
            789-1389            BC110630.2         651-1251
            1390-1411           DQ109809.1         1390-1411
FEATURES             Location/Qualifiers
     source          1..1411
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 59.1 cM"
     gene            1..1411
                     /gene="Glra4"
                     /note="glycine receptor, alpha 4 subunit"
                     /db_xref="GeneID:14657"
                     /db_xref="MGI:MGI:95750"
     exon            1..86
                     /gene="Glra4"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..1389
                     /gene="Glra4"
                     /note="glycine receptor subunit alpha-4"
                     /codon_start=1
                     /product="glycine receptor subunit alpha-4 precursor"
                     /protein_id="NP_034427.2"
                     /db_xref="CCDS:CCDS53195.1"
                     /db_xref="GeneID:14657"
                     /db_xref="MGI:MGI:95750"
                     /translation="MTTLVPASLFLLLWTLPGKVLLSVALAKEDVKSGLKGSQPMSPS
                     DFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNVFLRQQWN
                     DPRLAYREYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVL
                     YSIRLTLILSCPMDLKNFPMDIQTCTMQLESFGYTMNDLMFEWLEDAPAVQVAEGLTL
                     PQFILRDEKDLGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSF
                     WINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLE
                     YAAVNFVSRQHKEFMRLRRRQRRQRMEEDIIRESRFYFRGYGLGHCLQARDGGPMEGS
                     SIYSPQPPTPLLKEGETMRKLYVDRAKRIDTISRAVFPFTFLVFNIFYWVVYKVLRSE
                     DIHQAL"
     exon            87..217
                     /gene="Glra4"
                     /inference="alignment:Splign:2.1.0"
     exon            218..285
                     /gene="Glra4"
                     /inference="alignment:Splign:2.1.0"
     exon            286..509
                     /gene="Glra4"
                     /inference="alignment:Splign:2.1.0"
     exon            510..592
                     /gene="Glra4"
                     /inference="alignment:Splign:2.1.0"
     exon            593..733
                     /gene="Glra4"
                     /inference="alignment:Splign:2.1.0"
     exon            734..948
                     /gene="Glra4"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1098
                     /gene="Glra4"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1411
                     /gene="Glra4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccaaggtc cctgcagaat gacaactctt gttccagcaa gcctcttcct tcttctctgg
       61 accttgccag ggaaggtcct gctcagtgtg gctttggcaa aagaggatgt caaatctgga
      121 ctcaaaggat cccagcctat gtccccctct gatttcttgg acaagcttat gggacgaaca
      181 tctggatatg atgctaggat taggcccaat ttcaaaggtc cacctgtgaa tgtgacctgc
      241 aacatcttca tcaacagttt tggctccgtc actgagacca ccatggacta ccgggtaaat
      301 gtcttcttgc ggcagcagtg gaatgaccca cgtctggcct accgagaata tccagatgac
      361 tctctcgacc tagacccatc catgctcgac tctatctgga aaccagacct cttctttgcc
      421 aatgagaaag gggccaactt ccatgaggtg accacagaca acaagttact gcgcatcttc
      481 aagaatggaa atgttctcta cagcatcaga ttgaccctca ttttgtcctg cccaatggac
      541 ctcaagaact tcccaatgga catacagacc tgtacaatgc agctggaaag ctttggctac
      601 accatgaatg acctcatgtt tgagtggcta gaagatgctc ctgctgtcca agtggctgag
      661 gggttgactc taccccaatt tattttgcgg gatgagaagg atctagggta ttgtaccaag
      721 cactacaata caggaaaatt cacttgcatt gaggtaaagt ttcacctgga gcggcagatg
      781 ggctactatc tgattcaaat gtacatcccc agcctactca tcgtcatcct gtcctgggtc
      841 tccttctgga tcaacatgga tgcggcccct gctcgtgtag gccttggcat caccacagtc
      901 ctcaccatga caactcagag ctctggatcc agggcctctt tgcctaaggt gtcctacgta
      961 aaggcaattg acatctggat ggctgtatgc ctgctctttg tatttgctgc cttgcttgag
     1021 tatgctgcag tcaattttgt ctctcgtcag cataaggaat ttatgagact tcgtagaagg
     1081 cagagacgtc agcgtatgga agaagacatc ataagagaga gccgcttcta ttttcgtggc
     1141 tatggcctag gacactgctt acaagcaagg gatggaggtc caatggaagg ttccagcatt
     1201 tatagtcccc aacctccaac ccctcttcta aaggaaggag aaaccatgag gaaactctat
     1261 gtggaccgag ccaagagaat tgacaccatc tccagggctg tcttcccttt tacttttctt
     1321 gtcttcaata tcttctattg ggttgtctat aaagtactaa ggtcagaaga tatccaccag
     1381 gcactgtgaa cagggtggag gctatagtgt a
//
