LOCUS       NM_183427               3187 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus glycine receptor, alpha 2 subunit (Glra2), transcript
            variant 1, mRNA.
ACCESSION   NM_183427
VERSION     NM_183427.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3187)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3187)
  AUTHORS   Devoght,J., Comhair,J., Morelli,G., Rigo,J.M., D'Hooge,R.,
            Touma,C., Palme,R., Dewachter,I., vandeVen,M., Harvey,R.J.,
            Schiffmann,S.N., Piccart,E. and Brone,B.
  TITLE     Dopamine-mediated striatal activity and function is enhanced in
            GlyRalpha2 knockout animals
  JOURNAL   iScience 26 (8), 107400 (2023)
   PUBMED   37554441
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3187)
  AUTHORS   Tian,Q., Tong,P., Chen,G., Deng,M., Cai,T., Tian,R., Zhang,Z.,
            Xia,K. and Hu,Z.
  TITLE     GLRA2 gene mutations cause high myopia in humans and mice
  JOURNAL   J Med Genet 60 (2), 193-203 (2023)
   PUBMED   35396272
  REMARK    GeneRIF: GLRA2 gene mutations cause high myopia in humans and mice.
REFERENCE   4  (bases 1 to 3187)
  AUTHORS   Vieira,J.R., Shah,B., Dupraz,S., Paredes,I., Himmels,P.,
            Schermann,G., Adler,H., Motta,A., Gartner,L., Navarro-Aragall,A.,
            Ioannou,E., Dyukova,E., Bonnavion,R., Fischer,A., Bonanomi,D.,
            Bradke,F., Ruhrberg,C. and Ruiz de Almodovar,C.
  TITLE     Endothelial PlexinD1 signaling instructs spinal cord
            vascularization and motor neuron development
  JOURNAL   Neuron 110 (24), 4074-4089 (2022)
   PUBMED   36549270
REFERENCE   5  (bases 1 to 3187)
  AUTHORS   Catela,C., Chen,Y., Weng,Y., Wen,K. and Kratsios,P.
  TITLE     Control of spinal motor neuron terminal differentiation through
            sustained Hoxc8 gene activity
  JOURNAL   Elife 11, e70766 (2022)
   PUBMED   35315772
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3187)
  AUTHORS   Adams,R.H., Sato,K., Shimada,S., Tohyama,M., Puschel,A.W. and
            Betz,H.
  TITLE     Gene structure and glial expression of the glycine transporter
            GlyT1 in embryonic and adult rodents
  JOURNAL   J Neurosci 15 (3 Pt 2), 2524-2532 (1995)
   PUBMED   7891186
REFERENCE   7  (bases 1 to 3187)
  AUTHORS   Ware,R.E., Howard,T.A., Kamitani,T., Chang,H.-M., Yeh,E.T.H. and
            Seldin,M.F.
  TITLE     Chromosomal assignment of genes involved in
            glycosylphosphatidylinositol anchor biosynthesis: implications for
            the pathogenesis of paroxysmal nocturnal hemoglobinuria
  JOURNAL   Blood 83 (12), 3753-3757 (1994)
   PUBMED   8204896
REFERENCE   8  (bases 1 to 3187)
  AUTHORS   Matzenbach,B., Maulet,Y., Sefton,L., Courtier,B., Avner,P.,
            Guenet,J.L. and Betz,H.
  TITLE     Structural analysis of mouse glycine receptor alpha subunit genes.
            Identification and chromosomal localization of a novel variant
  JOURNAL   J Biol Chem 269 (4), 2607-2612 (1994)
   PUBMED   7507926
REFERENCE   9  (bases 1 to 3187)
  AUTHORS   Geng,Y., Derry,J.M., Hendrickx,J., Coucke,P., Willems,P.R. and
            Barnard,P.J.
  TITLE     Mapping of a liver phosphorylase kinase alpha-subunit gene on the
            mouse X chromosome
  JOURNAL   Genomics 15 (1), 191-193 (1993)
   PUBMED   8432533
REFERENCE   10 (bases 1 to 3187)
  AUTHORS   Derry,J.M. and Barnard,P.J.
  TITLE     Mapping of the glycine receptor alpha 2-subunit gene and the GABAA
            alpha 3-subunit gene on the mouse X chromosome
  JOURNAL   Genomics 10 (3), 593-597 (1991)
   PUBMED   1679744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK139335.1 and BC068987.1.
            
            On Oct 19, 2017 this sequence version replaced NM_183427.4.
            
            Transcript Variant: Variants 1 and 2 encode the same isoform (a).
            Isoforms and b are the same length but differ in their sequence.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056342.1, AK139335.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-412               AK139335.1         2-413
            413-3187            BC068987.1         1-2775
FEATURES             Location/Qualifiers
     source          1..3187
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 76.75 cM"
     gene            1..3187
                     /gene="Glra2"
                     /note="glycine receptor, alpha 2 subunit"
                     /db_xref="GeneID:237213"
                     /db_xref="MGI:MGI:95748"
     exon            1..592
                     /gene="Glra2"
                     /inference="alignment:Splign:2.1.0"
     CDS             525..1883
                     /gene="Glra2"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; glycine receptor subunit alpha-2"
                     /codon_start=1
                     /product="glycine receptor subunit alpha-2 isoform a
                     precursor"
                     /protein_id="NP_906272.1"
                     /db_xref="CCDS:CCDS41206.1"
                     /db_xref="GeneID:237213"
                     /db_xref="MGI:MGI:95748"
                     /translation="MYRQLVNILTALFAFFLGTNHFREAFCKDHDSRSGKHPSQTLSP
                     SDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQW
                     NDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKV
                     LYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTL
                     PQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSF
                     WINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLE
                     YAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQMKDGTAVKAT
                     PANPLPQPPKDADAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITYKIIRHEDVH
                     KK"
     exon            593..726
                     /gene="Glra2"
                     /inference="alignment:Splign:2.1.0"
     exon            727..794
                     /gene="Glra2"
                     /inference="alignment:Splign:2.1.0"
     exon            795..1018
                     /gene="Glra2"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1101
                     /gene="Glra2"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1239
                     /gene="Glra2"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1454
                     /gene="Glra2"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1604
                     /gene="Glra2"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..3150
                     /gene="Glra2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3128..3133
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Glra2"
                     /note="hexamer: AATAAA"
     polyA_site      3150
                     /gene="Glra2"
                     /note="major polyA site"
ORIGIN      
        1 ctgtagctct cattccagca caggatcgca gcattttttc cctctttccc ccaaacactt
       61 caatatacag agtcttttct tctccctcat ttgcaacttc tttttaaaag agaacatttc
      121 ctaaggagag gggctttgct gaatagaaaa gatataaaac aaaagctaca gcagcctgac
      181 ttccagcgtg gcattgtcac cagccccctt tgcatggtga tgcgattaag gtaacagcat
      241 ttttattatt caggaaaagc agctagggga ttcatcagtt ctgaggcttt gtctctcctg
      301 ggctaactga tggttctgag tcttggtttg acctgaccat gatgcccaag actggcactt
      361 tttgtttttt ctcagcaaac tgtacaaccc caaatctctt tttgattttc aaggaaacta
      421 gattcctgcc agattttgag tctggacaat aaataggcac tttgtcctag tctcctttct
      481 ggaatcattt cgggatattt tccacaacca tcacagaaac aggaatgtac cggcagctag
      541 tgaacatttt gacagccttg tttgcatttt tcttagggac aaaccacttc agggaagctt
      601 tctgcaaaga ccatgactcc aggtctggaa aacatccctc gcagacccta tctccttcag
      661 atttcttgga taaattaatg ggaagaacat caggatatga tgcaagaatc aggccaaatt
      721 ttaaaggtcc tccagtaaac gttacttgca atatttttat caacagtttt ggatcagtca
      781 cagaaaccac catggactac cgagtgaaca tttttctgag acagcagtgg aatgattcac
      841 ggctggcata cagtgagtac ccagatgatt ccctggattt ggatccctca atgttggatt
      901 cgatttggaa accggatttg ttctttgcca atgaaaaggg tgccaatttc catgatgtca
      961 ccactgacaa caagttgttg cggatttcca aaaatggcaa agtgctctac agtattagac
     1021 tcaccttgac tttatcttgt ccaatggacc tgaagaactt tccaatggat gtccagacct
     1081 gtacaatgca gctggagagt tttgggtaca ccatgaatga cctgatattt gagtggttaa
     1141 gtgatggtcc agtacaagtt gctgaaggac tcaccttgcc ccagtttatt ttgaaagaag
     1201 agaaggagct tggttattgc acaaagcatt acaacactgg caagtttacc tgcattgagg
     1261 tcaagtttca cctggagcgc cagatgggct actatttgat ccagatgtac atccccagcc
     1321 tgttgatagt cattttgtcc tgggtctcct tttggataaa catggatgca gcccctgcca
     1381 gggttgccct gggcatcaca acagtcctga caatgactac acagagttca ggttccaggg
     1441 catctctgcc aaaggtctcc tatgtgaaag caattgacat ctggatggcg gtatgccttc
     1501 tctttgtgtt tgctgcctta ctggaatatg cagcagtgaa ctttgtctcc aggcaacata
     1561 aggagttcct tcgtctccgg agacgacaga agaggcagaa taaggaagaa gatgttactc
     1621 gtgaaagtcg ttttaacttc agtggctatg ggatgggtca ctgcctccaa atgaaagatg
     1681 gcacagctgt caaggctaca cctgccaacc cacttccaca accccccaaa gatgcagatg
     1741 ctatcaagaa gaagtttgtg gatcgggcaa aaagaattga caccatatct cgagctgcct
     1801 tcccactggc cttcctcatt ttcaacatct tttactggat cacatacaag atcattcggc
     1861 atgaagatgt ccacaagaaa tagatgtacc ctgttgaccc tggaccttct tgcctaagtg
     1921 ttgtgcttgt aaatacacag taatagtgtc tttatatcgc ttcaacagag aagaacattg
     1981 agggtggggg gagggaaatc acgagggtgg ggtttctggc acctatatga caaaagacag
     2041 gttctatggg aaattaagaa aactgcacaa aattaaggtg ttgcagaatc acatgagcat
     2101 aactcccatc catagtctat agcattgttc tttcagatga tgcatcgctc agacatgatg
     2161 tgcaaggtca agttctcaat ggatgattaa tttatggttt gacttgatga gatttggttc
     2221 tgaaagttta gtttaatgcg cgcgagtacg cgcgtgcgtg cgcgcacaca cacacacaca
     2281 cacacacaca cacacacaca ctgaaaatgc ttaccatctg acaatagtga ctagtctata
     2341 gtaaataatt gaggaccaaa ctttttcagg aaaatgctgc ctcgttttta aaacaagcct
     2401 cctgagctat gacatttaca atgtctgtaa ttagtgtttc acccaagaaa tccttctgtg
     2461 ggttgtaaat tctttctatg taccagaaaa caagataaac acaaatgaca aagaacagat
     2521 ttctactcta ctgtctgtag gtgtccactt tgatattatt tttctttcct agatgtaaat
     2581 tgggggttta ttgtgtgttg cgtaattgat ttactggtat atcctcttaa aacaaatgct
     2641 cattttattt tagatcaagt tagcatacta tgtatatttt tttcactttg gctatattta
     2701 cgtgtgactt taagtgccca agtgtaactt agctattgct gtcgctaagc cacagtattt
     2761 atggagatgg tgtgttgtga ccggtgtagc tcagattagc tcaaacttcc catttctgcc
     2821 ctcattgtag ctgtaactac tagtcctaat gttgactgac cagtaatttg tactttcaat
     2881 ccaagtgaat atcgttttaa atatccttga ctaacttaaa aactttaaaa ctgtactgtg
     2941 attttcataa cccgttgcct ttttggtacc agagctacgt ggtttgaatc ctggctacat
     3001 gttttaagta agaaaaaaaa atgtattttt gcttactcaa aagacaacct gtaaaaatat
     3061 atggaaataa ttacatttta catgtgctgt gaaagggatt attttaaaaa agcatttgtt
     3121 cagtttcaat aaagataagt gtgccactaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     3181 aaaaaaa
//
