LOCUS       NM_020492               2389 bp    mRNA    linear   ROD 07-OCT-2024
DEFINITION  Mus musculus glycine receptor, alpha 1 subunit (Glra1), transcript
            variant 2, mRNA.
ACCESSION   NM_020492 XM_904089
VERSION     NM_020492.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2389)
  AUTHORS   Wiessler,A.L., Hasenmuller,A.S., Fuhl,I., Mille,C., Cortes
            Campo,O., Reinhard,N., Schenk,J., Heinze,K.G., Schaefer,N.,
            Specht,C.G. and Villmann,C.
  TITLE     Role of the Glycine Receptor beta Subunit in Synaptic Localization
            and Pathogenicity in Severe Startle Disease
  JOURNAL   J Neurosci 44 (2), e0837232023 (2024)
   PUBMED   37963764
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2389)
  AUTHORS   Araya,A., Gallegos,S., Maldonado,A., Rivera-Meza,M., Chandra,R.,
            Lobo,M.K. and Aguayo,L.G.
  TITLE     Overexpression of wild type glycine alpha 1 subunit rescues ethanol
            sensitivity in accumbal receptors and reduces binge drinking in
            mice
  JOURNAL   Neuropsychopharmacology 48 (9), 1367-1376 (2023)
   PUBMED   36175550
  REMARK    GeneRIF: Overexpression of wild type glycine alpha 1 subunit
            rescues ethanol sensitivity in accumbal receptors and reduces binge
            drinking in mice.
REFERENCE   3  (bases 1 to 2389)
  AUTHORS   Maynard,S.A., Rostaing,P., Schaefer,N., Gemin,O., Candat,A.,
            Dumoulin,A., Villmann,C., Triller,A. and Specht,C.G.
  TITLE     Identification of a stereotypic molecular arrangement of endogenous
            glycine receptors at spinal cord synapses
  JOURNAL   Elife 10, e74441 (2021)
   PUBMED   34878402
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2389)
  AUTHORS   Araya,A., Gallegos,S., Viveros,R., San Martin,L., Munoz,B.,
            Harvey,R.J., Zeilhofer,H.U. and Aguayo,L.G.
  TITLE     Presence of ethanol-sensitive and ethanol-insensitive glycine
            receptors in the ventral tegmental area and prefrontal cortex in
            mice
  JOURNAL   Br J Pharmacol 178 (23), 4691-4707 (2021)
   PUBMED   34378188
REFERENCE   5  (bases 1 to 2389)
  AUTHORS   Yao,L., Zhang,T.Y., Diao,X.T., Ma,J.J., Bai,H.H., Suo,Z.W.,
            Liu,Y.N., Yang,X. and Hu,X.D.
  TITLE     Functional expression of glycine receptors in DRG neurons of mice
  JOURNAL   Eur J Pharmacol 899, 174034 (2021)
   PUBMED   33727056
  REMARK    GeneRIF: Functional expression of glycine receptors in DRG neurons
            of mice.
REFERENCE   6  (bases 1 to 2389)
  AUTHORS   Ryan,S.G., Dixon,M.J., Nigro,M.A., Kelts,K.A., Markand,O.N.,
            Terry,J.C., Shiang,R., Wasmuth,J.J. and O'Connell,P.
  TITLE     Genetic and radiation hybrid mapping of the hyperekplexia region on
            chromosome 5q
  JOURNAL   Am J Hum Genet 51 (6), 1334-1343 (1992)
   PUBMED   1334371
REFERENCE   7  (bases 1 to 2389)
  AUTHORS   Becker,C.M., Schmieden,V., Tarroni,P., Strasser,U. and Betz,H.
  TITLE     Isoform-selective deficit of glycine receptors in the mouse mutant
            spastic
  JOURNAL   Neuron 8 (2), 283-289 (1992)
   PUBMED   1371219
REFERENCE   8  (bases 1 to 2389)
  AUTHORS   van Rens,G.L., Geurts van Kessel,A.H. and Bloemendal,H.
  TITLE     Localization of the beta A4-crystallin gene (CRYBA4) on human
            chromosome 22 in the region q11.2-->q13.1
  JOURNAL   Cytogenet Cell Genet 61 (3), 180-183 (1992)
   PUBMED   1424806
REFERENCE   9  (bases 1 to 2389)
  AUTHORS   Lane,P.W., Ganser,A.L., Kerner,A.L. and White,W.F.
  TITLE     Spasmodic, a mutation on chromosome 11 in the mouse
  JOURNAL   J Hered 78 (6), 353-356 (1987)
   PUBMED   3429842
REFERENCE   10 (bases 1 to 2389)
  AUTHORS   Lane,P.W. and Eicher,E.M.
  TITLE     Gene order in linkage group XVI of the house mouse
  JOURNAL   J Hered 70 (4), 239-244 (1979)
   PUBMED   489953
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK078258.1, AL596207.10 and AY129229.1.
            
            On Mar 20, 2014 this sequence version replaced NM_020492.3.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1. The
            encoded isoform (2) is shorter, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078258.1, BC131949.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849383,
                                           SAMN01164131 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AK078258.1         1-31
            32-32               AL596207.10        202119-202119       c
            33-874              AK078258.1         33-874
            875-1841            AY129229.1         422-1388
            1842-2389           AK078258.1         1840-2387
FEATURES             Location/Qualifiers
     source          1..2389
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 33.12 cM"
     gene            1..2389
                     /gene="Glra1"
                     /gene_synonym="nmf11; oscillator; ot; spasmodic; spd"
                     /note="glycine receptor, alpha 1 subunit"
                     /db_xref="GeneID:14654"
                     /db_xref="MGI:MGI:95747"
     exon            1..521
                     /gene="Glra1"
                     /gene_synonym="nmf11; oscillator; ot; spasmodic; spd"
                     /inference="alignment:Splign:2.1.0"
     exon            522..649
                     /gene="Glra1"
                     /gene_synonym="nmf11; oscillator; ot; spasmodic; spd"
                     /inference="alignment:Splign:2.1.0"
     exon            650..717
                     /gene="Glra1"
                     /gene_synonym="nmf11; oscillator; ot; spasmodic; spd"
                     /inference="alignment:Splign:2.1.0"
     exon            718..941
                     /gene="Glra1"
                     /gene_synonym="nmf11; oscillator; ot; spasmodic; spd"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1024
                     /gene="Glra1"
                     /gene_synonym="nmf11; oscillator; ot; spasmodic; spd"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1162
                     /gene="Glra1"
                     /gene_synonym="nmf11; oscillator; ot; spasmodic; spd"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1377
                     /gene="Glra1"
                     /gene_synonym="nmf11; oscillator; ot; spasmodic; spd"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1524
                     /gene="Glra1"
                     /gene_synonym="nmf11; oscillator; ot; spasmodic; spd"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..2389
                     /gene="Glra1"
                     /gene_synonym="nmf11; oscillator; ot; spasmodic; spd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaaagaaga tgccagccgg gtctaagggt ctgaggccag ggctctgatc cccacggatt
       61 tcttcctttc atggagctgg ccatctcgac aggaaaataa gggtaaaaat aaagaagaag
      121 aagagtaaag aaagaaagaa aagaagaaaa tatacccacc cccaaacgtg cctcccagcg
      181 ccgcagggag cctccagcga gtagagcttc agccgcgctc ttcccgcccg cagccgggct
      241 ggacgctctc cgtggtgctg aacctgcacg actgccgctg tccgcggtac cttagctgcc
      301 tggctgcaat tctcccccgg ctctgacacc tcgtccctct actccctgcc cccttaaaca
      361 tctggattat tatccccagt ggcgctctct ggcttcgtaa gtgcccatcg aaaacatttt
      421 tgcaccccca taactcgtgg actttacagc actagaatct ggaagatgta cagcttcaat
      481 actctgcgat tctacctttg ggagaccatt gtattcttca gccttgctgc ttccaaagag
      541 gctgaagccg cccgctccgc acccaagcct atgtcaccct cggacttcct ggataagctc
      601 atggggagga cttctgggta tgacgccagg atcaggccca actttaaagg tcctcctgtg
      661 aatgtaagtt gcaacatctt catcaacagt ttcggttcca tcgctgagac aaccatggac
      721 tatagggtca acatcttcct gaggcagcag tggaacgacc cccgtctggc ctacaatgaa
      781 taccctgatg actctctgga ccttgaccca tctatgttgg attccatctg gaagcctgac
      841 ttgttctttg ccaatgagaa gggggcccac ttccacgaaa tcaccacgga caacaaactg
      901 ctaagaatct cccggaatgg caatgtcctc tacagcatca gaatcaccct gacgctggcc
      961 tgccccatgg acctgaagaa tttcccgatg gatgtacaga cgtgtatcat gcaactcgaa
     1021 agctttggat ataccatgaa cgacctcatc tttgagtggc aggagcaagg agctgtgcag
     1081 gtggcagacg gactgaccct gcctcagttt attctgaagg aagagaaaga cctgagatac
     1141 tgcaccaagc actacaacac aggtaaattc acctgcatcg aggcccgatt ccacctggag
     1201 cggcagatgg gctactacct gatccagatg tacatcccca gcctgctcat cgtcatcctg
     1261 tcctggatct ccttctggat caacatggat gctgcaccag ctcgtgtggg gctgggcatc
     1321 accacagtgc tcaccatgac cacacagagc tctggctccc gagcctccct acccaaggtg
     1381 tcctacgtga aagctattga catttggatg gctgtttgcc tgctcttcgt gttctctgcc
     1441 ctgctggagt acgccgccgt caactttgtg tctcggcaac acaaggaact gcttcgattt
     1501 aggaggaaga ggcgacatca caaggatgat gagggtggag aaggccgctt caacttctct
     1561 gcctatggga tgggcccagc ctgtctgcag gccaaggatg gcatctctgt caagggtgcc
     1621 aacaacaaca acaccactaa cccgcctcct gcgccatcca agtccccgga ggagatgcgg
     1681 aaactcttca tccagagagc caagaagatc gacaagatat ctcgcatcgg tttccccatg
     1741 gccttcctca tcttcaacat gttctactgg atcatctata agatcgtccg gagagaggat
     1801 gtccacaaca agtgaaggct ctggggcggg gtggggggct gggagagggt ggtgggagga
     1861 gcacagaggc tgggagccgg gggaggaggg agaaaggaag agcacacacc catccccctc
     1921 caccaagtgc aatagaaacc acaggggtgg atacttccag ggtattgcaa tatccatcta
     1981 gcctccaagg gcatgaggtg ggagggcctt tttgaataca gcaactaggg accatgaggg
     2041 gtggggtggg gatcagggag gggattggga aatcacagct ttcaaaattc aagtccattg
     2101 ggttgagagg ggggtggggt cctgtttgga ggtcagtgct gcctgcccca gaacaggaaa
     2161 gcagtgtaat atataacatt taaccatgct taacattaat gcaaaaccca caagaacaaa
     2221 agatacgtct cttaaatcag cctagtagct gcttaaactc ttaaagtccc caacgtgatg
     2281 gacaatattt cccagagtag aaatggacac aactaagctt gctgtggtat gtgcccccat
     2341 cacaccctta caaatgccat gtctatcttt aaaccggaca cacacatgc
//
