LOCUS       NP_065238                449 aa            linear   ROD 07-OCT-2024
DEFINITION  glycine receptor subunit alpha-1 isoform 2 precursor [Mus
            musculus].
ACCESSION   NP_065238 XP_909182
VERSION     NP_065238.2
DBSOURCE    REFSEQ: accession NM_020492.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 449)
  AUTHORS   Wiessler,A.L., Hasenmuller,A.S., Fuhl,I., Mille,C., Cortes
            Campo,O., Reinhard,N., Schenk,J., Heinze,K.G., Schaefer,N.,
            Specht,C.G. and Villmann,C.
  TITLE     Role of the Glycine Receptor beta Subunit in Synaptic Localization
            and Pathogenicity in Severe Startle Disease
  JOURNAL   J Neurosci 44 (2), e0837232023 (2024)
   PUBMED   37963764
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 449)
  AUTHORS   Araya,A., Gallegos,S., Maldonado,A., Rivera-Meza,M., Chandra,R.,
            Lobo,M.K. and Aguayo,L.G.
  TITLE     Overexpression of wild type glycine alpha 1 subunit rescues ethanol
            sensitivity in accumbal receptors and reduces binge drinking in
            mice
  JOURNAL   Neuropsychopharmacology 48 (9), 1367-1376 (2023)
   PUBMED   36175550
  REMARK    GeneRIF: Overexpression of wild type glycine alpha 1 subunit
            rescues ethanol sensitivity in accumbal receptors and reduces binge
            drinking in mice.
REFERENCE   3  (residues 1 to 449)
  AUTHORS   Maynard,S.A., Rostaing,P., Schaefer,N., Gemin,O., Candat,A.,
            Dumoulin,A., Villmann,C., Triller,A. and Specht,C.G.
  TITLE     Identification of a stereotypic molecular arrangement of endogenous
            glycine receptors at spinal cord synapses
  JOURNAL   Elife 10, e74441 (2021)
   PUBMED   34878402
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 449)
  AUTHORS   Araya,A., Gallegos,S., Viveros,R., San Martin,L., Munoz,B.,
            Harvey,R.J., Zeilhofer,H.U. and Aguayo,L.G.
  TITLE     Presence of ethanol-sensitive and ethanol-insensitive glycine
            receptors in the ventral tegmental area and prefrontal cortex in
            mice
  JOURNAL   Br J Pharmacol 178 (23), 4691-4707 (2021)
   PUBMED   34378188
REFERENCE   5  (residues 1 to 449)
  AUTHORS   Yao,L., Zhang,T.Y., Diao,X.T., Ma,J.J., Bai,H.H., Suo,Z.W.,
            Liu,Y.N., Yang,X. and Hu,X.D.
  TITLE     Functional expression of glycine receptors in DRG neurons of mice
  JOURNAL   Eur J Pharmacol 899, 174034 (2021)
   PUBMED   33727056
  REMARK    GeneRIF: Functional expression of glycine receptors in DRG neurons
            of mice.
REFERENCE   6  (residues 1 to 449)
  AUTHORS   Ryan,S.G., Dixon,M.J., Nigro,M.A., Kelts,K.A., Markand,O.N.,
            Terry,J.C., Shiang,R., Wasmuth,J.J. and O'Connell,P.
  TITLE     Genetic and radiation hybrid mapping of the hyperekplexia region on
            chromosome 5q
  JOURNAL   Am J Hum Genet 51 (6), 1334-1343 (1992)
   PUBMED   1334371
REFERENCE   7  (residues 1 to 449)
  AUTHORS   Becker,C.M., Schmieden,V., Tarroni,P., Strasser,U. and Betz,H.
  TITLE     Isoform-selective deficit of glycine receptors in the mouse mutant
            spastic
  JOURNAL   Neuron 8 (2), 283-289 (1992)
   PUBMED   1371219
REFERENCE   8  (residues 1 to 449)
  AUTHORS   van Rens,G.L., Geurts van Kessel,A.H. and Bloemendal,H.
  TITLE     Localization of the beta A4-crystallin gene (CRYBA4) on human
            chromosome 22 in the region q11.2-->q13.1
  JOURNAL   Cytogenet Cell Genet 61 (3), 180-183 (1992)
   PUBMED   1424806
REFERENCE   9  (residues 1 to 449)
  AUTHORS   Lane,P.W., Ganser,A.L., Kerner,A.L. and White,W.F.
  TITLE     Spasmodic, a mutation on chromosome 11 in the mouse
  JOURNAL   J Hered 78 (6), 353-356 (1987)
   PUBMED   3429842
REFERENCE   10 (residues 1 to 449)
  AUTHORS   Lane,P.W. and Eicher,E.M.
  TITLE     Gene order in linkage group XVI of the house mouse
  JOURNAL   J Hered 70 (4), 239-244 (1979)
   PUBMED   489953
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK078258.1, AL596207.10 and AY129229.1.
            
            On or before Dec 7, 2005 this sequence version replaced
            XP_909182.1, NP_065238.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1. The
            encoded isoform (2) is shorter, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078258.1, BC131949.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849383,
                                           SAMN01164131 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 33.12 cM"
     Protein         1..449
                     /product="glycine receptor subunit alpha-1 isoform 2
                     precursor"
                     /note="glycine receptor subunit alpha-1; glycine receptor
                     48 kDa subunit; glycine receptor strychnine-binding
                     subunit"
                     /calculated_mol_wt=48408
     sig_peptide     1..28
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3336
     Region          7..438
                     /region_name="LIC"
                     /note="Cation transporter family protein; TIGR00860"
                     /db_xref="CDD:273305"
     Site            66
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000305; propagated from
                     UniProtKB/Swiss-Prot (Q64018.2)"
     Site            251..272
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64018.2)"
     Site            278..298
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64018.2)"
     Site            289
                     /site_type="other"
                     /note="Important for obstruction of the ion pore in the
                     closed conformation.
                     /evidence=ECO:0000250|UniProtKB:O93430; propagated from
                     UniProtKB/Swiss-Prot (Q64018.2)"
     Site            310..330
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64018.2)"
     Region          383..402
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64018.2)"
     Site            418..438
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64018.2)"
     CDS             1..449
                     /gene="Glra1"
                     /gene_synonym="nmf11; oscillator; ot; spasmodic; spd"
                     /coded_by="NM_020492.4:466..1815"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS24715.1"
                     /db_xref="GeneID:14654"
                     /db_xref="MGI:MGI:95747"
ORIGIN      
        1 mysfntlrfy lwetivffsl aaskeaeaar sapkpmspsd fldklmgrts gydarirpnf
       61 kgppvnvscn ifinsfgsia ettmdyrvni flrqqwndpr layneypdds ldldpsmlds
      121 iwkpdlffan ekgahfheit tdnkllrisr ngnvlysiri tltlacpmdl knfpmdvqtc
      181 imqlesfgyt mndlifewqe qgavqvadgl tlpqfilkee kdlryctkhy ntgkftciea
      241 rfhlerqmgy yliqmyipsl livilswisf winmdaapar vglgittvlt mttqssgsra
      301 slpkvsyvka idiwmavcll fvfsalleya avnfvsrqhk ellrfrrkrr hhkddeggeg
      361 rfnfsaygmg paclqakdgi svkgannnnt tnpppapsks peemrklfiq rakkidkisr
      421 igfpmaflif nmfywiiyki vrredvhnk
//
