LOCUS       NM_175681               4873 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus glucagon-like peptide 2 receptor (Glp2r), mRNA.
ACCESSION   NM_175681 XM_991784
VERSION     NM_175681.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4873)
  AUTHORS   Hunt,J.E., Billeschou,A., Windelov,J.A., Hartmann,B., Ullmer,C.,
            Holst,J.J. and Kissow,H.
  TITLE     Pharmacological activation of TGR5 promotes intestinal growth via a
            GLP-2-dependent pathway in mice
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 318 (5), G980-G987 (2020)
   PUBMED   32308039
REFERENCE   2  (bases 1 to 4873)
  AUTHORS   Fuchs,S., Yusta,B., Baggio,L.L., Varin,E.M., Matthews,D. and
            Drucker,D.J.
  TITLE     Loss of Glp2r signaling activates hepatic stellate cells and
            exacerbates diet-induced steatohepatitis in mice
  JOURNAL   JCI Insight 5 (8), 136907 (2020)
   PUBMED   32191643
  REMARK    GeneRIF: Loss of Glp2r signaling activates hepatic stellate cells
            and exacerbates diet-induced steatohepatitis in mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4873)
  AUTHORS   Yusta,B., Matthews,D., Koehler,J.A., Pujadas,G., Kaur,K.D. and
            Drucker,D.J.
  TITLE     Localization of Glucagon-Like Peptide-2 Receptor Expression in the
            Mouse
  JOURNAL   Endocrinology 160 (8), 1950-1963 (2019)
   PUBMED   31237617
REFERENCE   4  (bases 1 to 4873)
  AUTHORS   Kato,S., Utsumi,D. and Matsumoto,K.
  TITLE     G protein-coupled receptor 40 activation ameliorates dextran
            sulfate sodium-induced colitis in mice via the upregulation of
            glucagon-likepeptide-2
  JOURNAL   J Pharmacol Sci 140 (2), 144-152 (2019)
   PUBMED   31242961
  REMARK    GeneRIF: GPR40 activation ameliorates DSS-induced colitis in mice
            by enhancing GLP-2 production.
REFERENCE   5  (bases 1 to 4873)
  AUTHORS   Taher,J., Baker,C., Alvares,D., Ijaz,L., Hussain,M. and Adeli,K.
  TITLE     GLP-2 Dysregulates Hepatic Lipoprotein Metabolism, Inducing Fatty
            Liver and VLDL Overproduction in Male Hamsters and Mice
  JOURNAL   Endocrinology 159 (9), 3340-3350 (2018)
   PUBMED   30052880
  REMARK    GeneRIF: Lack of Glp2r appears to interfere with VLDL secretion,
            resulting in enhanced hepatic lipid accumulation.
REFERENCE   6  (bases 1 to 4873)
  AUTHORS   Dube,P.E., Forse,C.L., Bahrami,J. and Brubaker,P.L.
  TITLE     The essential role of insulin-like growth factor-1 in the
            intestinal tropic effects of glucagon-like peptide-2 in mice
  JOURNAL   Gastroenterology 131 (2), 589-605 (2006)
   PUBMED   16890611
  REMARK    GeneRIF: GLP-2 in the gut acts by activating receptors on the
            subepithelial myofibroblasts, causing the release of growth
            factors, which in turn stimulate intestinal growth
            Erratum:[Gastroenterology. 2007 Mar;132(3):1208]
REFERENCE   7  (bases 1 to 4873)
  AUTHORS   Shin,E.D., Estall,J.L., Izzo,A., Drucker,D.J. and Brubaker,P.L.
  TITLE     Mucosal adaptation to enteral nutrients is dependent on the
            physiologic actions of glucagon-like peptide-2 in mice
  JOURNAL   Gastroenterology 128 (5), 1340-1353 (2005)
   PUBMED   15887116
  REMARK    Erratum:[Gastroenterology. 2007 Mar;132(3):1208]
REFERENCE   8  (bases 1 to 4873)
  AUTHORS   Orskov,C., Hartmann,B., Poulsen,S.S., Thulesen,J., Hare,K.J. and
            Holst,J.J.
  TITLE     GLP-2 stimulates colonic growth via KGF, released by subepithelial
            myofibroblasts with GLP-2 receptors
  JOURNAL   Regul Pept 124 (1-3), 105-112 (2005)
   PUBMED   15544847
  REMARK    GeneRIF: GLP-2 in the gut acts by activating receptors on the
            subepithelial myofibroblasts, causing the release of growth
            factors, which in turn stimulate intestinal growth
REFERENCE   9  (bases 1 to 4873)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
REFERENCE   10 (bases 1 to 4873)
  AUTHORS   Lovshin,J., Estall,J., Yusta,B., Brown,T.J. and Drucker,D.J.
  TITLE     Glucagon-like peptide (GLP)-2 action in the murine central nervous
            system is enhanced by elimination of GLP-1 receptor signaling
  JOURNAL   J Biol Chem 276 (24), 21489-21499 (2001)
   PUBMED   11262390
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC044746.2 and AL646097.25.
            
            On Oct 23, 2009 this sequence version replaced NM_175681.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC044746.2, AY605231.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2009              BC044746.2         1-2009
            2010-4873           AL646097.25        70028-72891         c
FEATURES             Location/Qualifiers
     source          1..4873
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 41.13 cM"
     gene            1..4873
                     /gene="Glp2r"
                     /gene_synonym="9530092J08Rik; GLP-2"
                     /note="glucagon-like peptide 2 receptor"
                     /db_xref="GeneID:93896"
                     /db_xref="MGI:MGI:2136733"
     exon            1..347
                     /gene="Glp2r"
                     /gene_synonym="9530092J08Rik; GLP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..1820
                     /gene="Glp2r"
                     /gene_synonym="9530092J08Rik; GLP-2"
                     /note="G protein-coupled receptor GLP2R; GLP-2R; GLP-2-R;
                     GLP-2 receptor"
                     /codon_start=1
                     /product="glucagon-like peptide 2 receptor precursor"
                     /protein_id="NP_783612.2"
                     /db_xref="CCDS:CCDS24860.1"
                     /db_xref="GeneID:93896"
                     /db_xref="MGI:MGI:2136733"
                     /translation="MRRLWGPGTPFLALLLLVSIKQVTTGSLLEETVQKWAQYKETCL
                     KDLLEKPSGVFCNGTFDKYVCWPHSFPGNVSVPCPSYLPWWNKESPGRAYRHCLAQGT
                     WQKQENSTDTWQDESECSENHSFKQNVDHYHHTLLSTLQLMYTVGYSLSLISLFLALT
                     LFLFLRKLHCTRNYIHMNLFASFILRALVVLVKDMVFYNSYSRRPDSESGWMSYLSEI
                     SASCRSVQVLLHYFVGTNHLWLLVEGLYLHALLEPTVLPERRLWPKYLVVGWAFPMLF
                     VIPWIFVRASLENTGCWAVNENKKIWWIIRGPILLCVTVNFFIFLKILKLLISKFRAH
                     QMCFRDYKYRLAKSTLLLILLMGVHEFLFTFFTDDQVQGFSRLIRLFIQLTLSSFHGF
                     LVALQYGFASREVKAELRKTWGRFLLARHWGCRACVLGKNFRFLGKCSKKLSEGDGAE
                     TLQKLQSSGVSSHLTAGNLRDHGAQPHRGRGAWPRASSLSESSEGDFTLANTMEEILE
                     ESEI"
     exon            348..438
                     /gene="Glp2r"
                     /gene_synonym="9530092J08Rik; GLP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            439..543
                     /gene="Glp2r"
                     /gene_synonym="9530092J08Rik; GLP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            544..665
                     /gene="Glp2r"
                     /gene_synonym="9530092J08Rik; GLP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            666..778
                     /gene="Glp2r"
                     /gene_synonym="9530092J08Rik; GLP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            779..932
                     /gene="Glp2r"
                     /gene_synonym="9530092J08Rik; GLP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1092
                     /gene="Glp2r"
                     /gene_synonym="9530092J08Rik; GLP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1153
                     /gene="Glp2r"
                     /gene_synonym="9530092J08Rik; GLP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1223
                     /gene="Glp2r"
                     /gene_synonym="9530092J08Rik; GLP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1312
                     /gene="Glp2r"
                     /gene_synonym="9530092J08Rik; GLP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1451
                     /gene="Glp2r"
                     /gene_synonym="9530092J08Rik; GLP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1493
                     /gene="Glp2r"
                     /gene_synonym="9530092J08Rik; GLP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..4873
                     /gene="Glp2r"
                     /gene_synonym="9530092J08Rik; GLP-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2106..2111
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Glp2r"
                     /gene_synonym="9530092J08Rik; GLP-2"
                     /note="hexamer: ATTAAA"
     polyA_site      2132
                     /gene="Glp2r"
                     /gene_synonym="9530092J08Rik; GLP-2"
     regulatory      4852..4857
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Glp2r"
                     /gene_synonym="9530092J08Rik; GLP-2"
                     /note="hexamer: ATTAAA"
     polyA_site      4873
                     /gene="Glp2r"
                     /gene_synonym="9530092J08Rik; GLP-2"
                     /note="major polyA site"
ORIGIN      
        1 gattcggtag atcgctgtag agcaactcag acagtcggcg gcctgaagag gacttgtgca
       61 aacacttcct ctctggacaa ggaggaatgc aggaggccac cgcctgcagt acatcttgga
      121 gtgttggagg gatgtgcctg cacttgtgaa agggcgccag aaggacgagg ccccaaccaa
      181 gcccggcagt gcccagtaga tgcagagagg cgtccctgcc ccgggcgcag ccagtgggca
      241 tccctgcggc ccaggggcct gagtctctcc actcccacgg gatgcgtcgg ctctggggcc
      301 ctgggacgcc cttcctcgcc ctgcttctgc tggtttccat caagcaagtt actacaggat
      361 ctctccttga ggagacagtt cagaagtggg ctcagtataa ggagacgtgt ctgaaagact
      421 tgctcgagaa accttctggt gtattttgta atggaacatt tgataagtac gtgtgctggc
      481 ctcattcttt tcctggaaat gtctctgtcc cctgtccttc atacttacct tggtggaata
      541 aagagagccc aggaagggcc tacagacact gcttggctca ggggacttgg cagaagcaag
      601 agaactccac agatacttgg caggatgagt cagaatgctc agagaaccac agcttcaaac
      661 aaaacgtgga tcactatcac cataccttgt tgtccacctt gcagctgatg tacactgtgg
      721 gctactccct gtctctcatc tccctcttct tggctcttac actcttcttg ttccttcgaa
      781 aactgcactg cacacgcaat tacatccaca tgaacctgtt cgcttcgttc atcctgagag
      841 ctctggttgt ccttgtgaag gacatggtct tctacaactc ttactccagg aggcctgaca
      901 gtgagagtgg atggatgtca tatctgtcag agatttctgc ctcctgccgc tctgtccagg
      961 tcctcctgca ctactttgtg ggcaccaatc acttgtggtt gctggttgaa ggactttacc
     1021 tccatgctct gctggagcca acagtgcttc ctgaaaggcg gctgtggccc aagtacctgg
     1081 tggtgggttg ggccttcccc atgctgtttg ttattccctg gatttttgtc cgagcaagcc
     1141 tggagaatac agggtgctgg gcagtaaatg agaataagaa aatctggtgg atcatcagag
     1201 gacccattct gctttgtgta acagttaatt tcttcatctt cctcaagatt ctcaagcttc
     1261 tcatttctaa gttcagagct catcagatgt gcttcagaga ctacaaatat agactggcaa
     1321 aatcaaccct gctcctcatt cttttgatgg gggttcatga gttcctcttc actttcttca
     1381 ccgacgacca agttcaagga ttttcaagac ttattcgtct cttcatccag ttgaccctga
     1441 gctccttcca tggatttctg gtggccttgc agtacggctt tgccagtaga gaggtgaagg
     1501 cagagctgag aaagacctgg ggccgcttct tattagctcg ccactggggc tgcagagcct
     1561 gtgtcctagg gaagaacttc cggttcctgg ggaaatgttc caagaagctg tcggagggag
     1621 atggtgccga gacactccag aagctgcaat cttcaggtgt cagctcacac ctgaccgctg
     1681 ggaacctgcg ggatcatggg gcacagcctc acaggggccg tggagcttgg ccccgggcaa
     1741 gcagcctgtc tgagagcagc gagggagact tcaccctggc caataccatg gaggagattc
     1801 tggaagagag tgagatctaa gacagggtcc atcaccacag cttggcaact gaggatccct
     1861 aggaaagagg ttgctgagcc cagggtcctc ctctttccat tcactatccc cattttgatg
     1921 tgaagtctct tctgggttat caagctccat atcagtgagt ctatataatg cccacagtcc
     1981 ctcctgcctt tgtcacccta cccccccccc acccccacca tgcatatttt ccagaatgtc
     2041 cgttggtttt gggggccttg ccctaaattc aagtgagtgg aacccaccat gaagaaaaat
     2101 catttattaa atagggttca gtttgtatct ccttcccgtt catggtgtat ggcttccttc
     2161 tagagatgga agtagggtgc actggaaccc cacaggaagc tttaaagtat caagttctgg
     2221 ggaatcacag caaatattct aagagagaaa gtctgagatg aggaccaaga attgaaagag
     2281 ttggacaagc atttgcggaa actcctcacc cttggtaaaa cccaggcagg atggagggag
     2341 cagctactct gcatttgctg ctcatctggg gcacaccact ctccttggac agggtgtgac
     2401 cccatgttgt cccccagacc cctctcctcc tcacttctct tcctgttctg tcaagtctca
     2461 tctccctttc tccatctcag ctctgtttgg ggttgacaga agtttgaatg tcatgatact
     2521 ctatgtgtta ttttctgtcc tcattgctgt gtccaaatgc tgaacaagta gcaatttaag
     2581 ggagcaactg ctatgtggct catagcttga gaacatagtc catcaaggtc gggaaggcat
     2641 ggtggtagga ctatgaggtg gctcatgagg ccaatgttag tgttgtgggc atgtgggcaa
     2701 gcttttgtca acttgacaca aacctaaaca tctctgggag gaaggatcta aactgaggac
     2761 tgtcctccat caggttgtcc tgtaggctgg tctgtgggag cattttcttg attcatggct
     2821 gatgtggaag agtccatccc actgtgggtg gtgccatcca ctagcaggtg gtcctgggtt
     2881 atgtaagaaa gcagatagag tgagccatga tgaacaagcc agtaaaaagc attcctccat
     2941 agttcttgcc tctgctcctc ctggagttca cactctgtct ttactcagtg attggaatgt
     3001 gatatggaag tgtaagccaa attaaccctt tcctccccaa cttgtttttc agtcgtgatg
     3061 tttatcatgg caaaagaaag gagaccagga cagcaattgg tagtagagag tgggctactg
     3121 ttgggacaag cctggccatg ctgttttggg gaggattgta gaagtgtttg gaacctcagg
     3181 ctggaaaagc caccgagtgc tcaaagctta gtgggcttta ctgcaagagc tggacagtta
     3241 gtgttgaggg aaacacagtt gatggagggc tggcttgtgg attttcagag ggaagcaaag
     3301 actctctggg tcgtttgagt ttttcccccc cagtctatag tttctggtca gctgggactg
     3361 acaattccac ttgataagag agcattgtca ttgcaacaga atcttctggg aggaggtatt
     3421 ccttggaatc aaaagctgtg gtctggtggg gaggcagcca ggctgtccat taggctggtg
     3481 gcaaacctgg gcaaaccagg aagtcaggca gcagatagat gctgttgctt aggtaagcct
     3541 ctctgcaaat gtcctaaggc acaatgaaag gcgtgtctcc taggtgattc taaaagcagg
     3601 caagctgaca gtgaagatcc accacgatac tgctacttct ttggcctctg atgctggaag
     3661 cctttggaac gttgtcatta gtcctgttct cctcaccctg gtttcacctg ttctcatgaa
     3721 ctcagcttct accagttcac ttgttctacc attctagggt taggactccc cttccatact
     3781 tagttcacca ctgacccttt gatggtcaga tttcctgctc caggaggcta atccattctt
     3841 catcctacat cagtagtaaa gcccaggtga gggaataagg tgagggaagc cctgtctgag
     3901 tgtggacttg ctgaaggtgg cataagaagc cccaggctct atagctgcca ggctcattgg
     3961 gcctttgtga caatgggaaa taagctggat ttgacctgac ctacagaggc tgaagaggga
     4021 caaccagtca aggccaggct cagttacaca agtcacaaga caagaggaag caaggtgact
     4081 gagggaggaa ctgtttgtgg aaacattgtg cagttggcaa ggagtgatgc ttttttagtg
     4141 ggcaaggtgt atgtgtgtcc atggctgggt atactgcctg gttgagatat gtgtccatgg
     4201 ttgggtatac tgcctggttg agatatgtgt ccatggttgg gtatgttgtc tgggttgggt
     4261 atgtgaccat ggtggggtat gctgtctggg ttgggtatgt gtccatggtg aagtatgctg
     4321 cagtagacag aaatactgct ttgagacttc tcaaacagag ctgccaagct cagcaaagga
     4381 aacttaagac attccattat atgtgaactt agacagtatc catggataat ctccttatac
     4441 aagtttttcc cataatagac ttcatctgga atttgattct gattatacat actttgtgtc
     4501 ttacctggct gttttcttta taaggagact tgaaagcaag gccaggacta aggtgagcca
     4561 ctgatggtgg tcagtcacca ggacaagggt gagccactga cggtggtcag tcacctctga
     4621 taatctcaat gataaaataa gttgtaactt aatacaatat ttaaaaagca actagagtcc
     4681 acaggctact tctaaggata ggatgttggc accagggcag ggaagagtgt gcagaagatg
     4741 aagccccaga atgccggcat agatttcaac catgcccttg tctgcaatgc tgataatgtg
     4801 ttccttttat caatgatttt ggtgttgaac gactgcatta aaacattatt cattaaagta
     4861 tttcgtatcc caa
//
