LOCUS       NM_021332               1480 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus glucagon-like peptide 1 receptor (Glp1r), mRNA.
ACCESSION   NM_021332 XM_904149
VERSION     NM_021332.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1480)
  AUTHORS   Li,H., Fang,Y., Wang,D., Shi,B. and Thompson,G.J.
  TITLE     Impaired brain glucose metabolism in glucagon-like peptide-1
            receptor knockout mice
  JOURNAL   Nutr Diabetes 14 (1), 86 (2024)
   PUBMED   39389952
  REMARK    GeneRIF: Impaired brain glucose metabolism in glucagon-like
            peptide-1 receptor knockout mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1480)
  AUTHORS   Chang,H., Perkins,M.H., Novaes,L.S., Qian,F., Zhang,T.,
            Neckel,P.H., Scherer,S., Ley,R.E., Han,W. and de Araujo,I.E.
  TITLE     Stress-sensitive neural circuits change the gut microbiome via
            duodenal glands
  JOURNAL   Cell 187 (19), 5393-5412 (2024)
   PUBMED   39121857
REFERENCE   3  (bases 1 to 1480)
  AUTHORS   Huang,K.P., Acosta,A.A., Ghidewon,M.Y., McKnight,A.D.,
            Almeida,M.S., Nyema,N.T., Hanchak,N.D., Patel,N., Gbenou,Y.S.K.,
            Adriaenssens,A.E., Bolding,K.A. and Alhadeff,A.L.
  TITLE     Dissociable hindbrain GLP1R circuits for satiety and aversion
  JOURNAL   Nature 632 (8025), 585-593 (2024)
   PUBMED   38987598
  REMARK    GeneRIF: Dissociable hindbrain GLP1R circuits for satiety and
            aversion.
REFERENCE   4  (bases 1 to 1480)
  AUTHORS   Lu,Y., Wang,L., Luo,F., Savani,R., Rossi,M.A. and Pang,Z.P.
  TITLE     Dorsolateral septum GLP-1R neurons regulate feeding via lateral
            hypothalamic projections
  JOURNAL   Mol Metab 85, 101960 (2024)
   PUBMED   38763494
  REMARK    GeneRIF: Dorsolateral septum GLP-1R neurons regulate feeding via
            lateral hypothalamic projections.
REFERENCE   5  (bases 1 to 1480)
  AUTHORS   Ruska,Y., Csibi,A., Doroghazi,B., Szilvasy-Szabo,A., Mohacsik,P.,
            Kornyei,Z., Denes,A., Kadar,A., Puskar,Z., Hrabovszky,E.,
            Gereben,B., Wittmann,G. and Fekete,C.
  TITLE     Topography of the GLP-1/GLP-1 receptor system in the spinal cord of
            male mice
  JOURNAL   Sci Rep 14 (1), 14403 (2024)
   PUBMED   38909126
  REMARK    GeneRIF: Topography of the GLP-1/GLP-1 receptor system in the
            spinal cord of male mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1480)
  AUTHORS   Scrocchi,L.A., Brown,T.J. and Drucker,D.J.
  TITLE     Leptin sensitivity in nonobese glucagon-like peptide I receptor -/-
            mice
  JOURNAL   Diabetes 46 (12), 2029-2034 (1997)
   PUBMED   9392491
REFERENCE   7  (bases 1 to 1480)
  AUTHORS   Yamato,E., Ikegami,H., Takekawa,K., Fujisawa,T., Nakagawa,Y.,
            Hamada,Y., Ueda,H. and Ogihara,T.
  TITLE     Tissue-specific and glucose-dependent expression of receptor genes
            for glucagon and glucagon-like peptide-1 (GLP-1)
  JOURNAL   Horm Metab Res 29 (2), 56-59 (1997)
   PUBMED   9105899
REFERENCE   8  (bases 1 to 1480)
  AUTHORS   Scrocchi,L.A., Brown,T.J., MaClusky,N., Brubaker,P.L.,
            Auerbach,A.B., Joyner,A.L. and Drucker,D.J.
  TITLE     Glucose intolerance but normal satiety in mice with a null mutation
            in the glucagon-like peptide 1 receptor gene
  JOURNAL   Nat Med 2 (11), 1254-1258 (1996)
   PUBMED   8898756
REFERENCE   9  (bases 1 to 1480)
  AUTHORS   Kershaw,E.E., Chua,S.C. Jr. and Leibel,R.L.
  TITLE     Localization of a (CA)n repeat in glucagon-like peptide-1 receptor
            gene (Glp1r) to proximal mouse chromosome 17 and its linkage to
            other markers
  JOURNAL   Mamm Genome 6 (4), 301-303 (1995)
   PUBMED   7613039
REFERENCE   10 (bases 1 to 1480)
  AUTHORS   Campos,R.V., Lee,Y.C. and Drucker,D.J.
  TITLE     Divergent tissue-specific and developmental expression of receptors
            for glucagon and glucagon-like peptide-1 in the mouse
  JOURNAL   Endocrinology 134 (5), 2156-2164 (1994)
   PUBMED   8156917
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DQ093397.1.
            
            On Aug 8, 2006 this sequence version replaced NM_021332.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ093397.1, DQ093398.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1480
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 15.8 cM"
     gene            1..1480
                     /gene="Glp1r"
                     /gene_synonym="GLP-1R; GLP1Rc"
                     /note="glucagon-like peptide 1 receptor"
                     /db_xref="GeneID:14652"
                     /db_xref="MGI:MGI:99571"
     exon            1..88
                     /gene="Glp1r"
                     /gene_synonym="GLP-1R; GLP1Rc"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..1402
                     /gene="Glp1r"
                     /gene_synonym="GLP-1R; GLP1Rc"
                     /note="GLP-1-R; GLP-1 receptor"
                     /codon_start=1
                     /product="glucagon-like peptide 1 receptor precursor"
                     /protein_id="NP_067307.2"
                     /db_xref="CCDS:CCDS37542.1"
                     /db_xref="GeneID:14652"
                     /db_xref="MGI:MGI:99571"
                     /translation="MASTPSLLRLALLLLGAVGRAGPRPQGTTVSLSETVQKWREYRR
                     QCQRFLTEAPLLATGLFCNRTFDDYACWPDGPPGSFVNVSCPWYLPWASSVLQGHVYR
                     FCTAEGLWLHKDNSSLPWRDLSECEESKRGERNFPEEQLLSLYIIYTVGYALSFSALV
                     IASAILVGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLL
                     SYQDSLGCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVFSEQRIFKLYLSIGWGV
                     PLLFVIPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFIRVICIVVSK
                     LKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTS
                     FQGLMVAILYCFVNNEVQMEFRKCWERWRLEHLNIQRDCSMKPLKCPTSSVSSGATVG
                     SSVYAATCQSSYS"
     exon            89..185
                     /gene="Glp1r"
                     /gene_synonym="GLP-1R; GLP1Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            186..293
                     /gene="Glp1r"
                     /gene_synonym="GLP-1R; GLP1Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            294..412
                     /gene="Glp1r"
                     /gene_synonym="GLP-1R; GLP1Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            413..519
                     /gene="Glp1r"
                     /gene_synonym="GLP-1R; GLP1Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            520..673
                     /gene="Glp1r"
                     /gene_synonym="GLP-1R; GLP1Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            674..833
                     /gene="Glp1r"
                     /gene_synonym="GLP-1R; GLP1Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            834..894
                     /gene="Glp1r"
                     /gene_synonym="GLP-1R; GLP1Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            895..964
                     /gene="Glp1r"
                     /gene_synonym="GLP-1R; GLP1Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1053
                     /gene="Glp1r"
                     /gene_synonym="GLP-1R; GLP1Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1192
                     /gene="Glp1r"
                     /gene_synonym="GLP-1R; GLP1Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1234
                     /gene="Glp1r"
                     /gene_synonym="GLP-1R; GLP1Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1480
                     /gene="Glp1r"
                     /gene_synonym="GLP-1R; GLP1Rc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcccagcc atggccagca ccccaagcct cctgcgcctg gcgctcctgc tgctcggggc
       61 ggtgggcagg gccggccccc gccctcaggg taccacggtg tccctctcag agacggtgca
      121 gaaatggaga gaataccggc ggcagtgcca gcgtttcctc acggaagcgc cactcctggc
      181 cacaggcctc ttctgcaacc ggacctttga tgactatgcc tgctggccgg atgggccccc
      241 aggttccttc gtgaatgtca gctgcccctg gtacctgccc tgggccagta gtgtgctaca
      301 aggccatgtg taccggttct gcacagctga gggtctctgg ctacataagg acaactccag
      361 cctgccctgg agggacctgt cggagtgtga agagtctaag cgaggggaga gaaactttcc
      421 tgaggaacag ctcctgtccc tgtacattat ctacacagtg gggtacgcac tttctttctc
      481 cgccttggtc atcgcttcag ccatccttgt tggcttcaga cacttgcact gcaccaggaa
      541 ctacatccac ctgaacctgt ttgcatcctt catcctccga gcactgtccg tcttcatcaa
      601 agatgctgcc ctcaagtgga tgtatagcac ggctgcccag caacaccagt gggatgggct
      661 cctctcctat caggactctc taggctgccg actggtgttc ctgctcatgc agtactgcgt
      721 ggcagccaac tactactggt tgctggtgga aggcgtgtat ctatacacac tgctggcctt
      781 ctcggtgttc tcggagcagc gcatcttcaa gctgtatctg agcataggct ggggagttcc
      841 gctgctgttc gttatcccat gggggattgt caagtatctc tatgaggacg agggctgctg
      901 gactaggaac tccaatatga actactggct catcatccga ttgcccattc tctttgctat
      961 cggcgtcaac tttcttatct tcatccgtgt catctgcata gtggtctcca aactgaaggc
     1021 taatctcatg tgcaagactg acatcaaatg caggcttgcc aagtccactc tgactctcat
     1081 cccccttctg gggacacatg aagtcatctt tgcctttgtg atggacgaac acgcccgagg
     1141 aaccctacgc ttcatcaagc tgttcacaga actctccttc acttccttcc agggcttgat
     1201 ggtggctatc ctgtactgct ttgtcaacaa tgaggtccag atggagtttc ggaaatgctg
     1261 ggagcgctgg aggctggagc acttgaatat ccagagagac tgcagcatga agcccctcaa
     1321 gtgtcccacc agcagcgtca gcagtggggc cacagtgggc agcagcgtgt acgcagccac
     1381 ctgccagagt tcctacagct gagccccagt gccggtcctc ctgtggtcct tgcttctggc
     1441 tgggtggcca tcccaggtgg gagagatcct ggggataggg
//
