LOCUS       NM_025374               1958 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus glyoxalase 1 (Glo1), transcript variant 1, mRNA.
ACCESSION   NM_025374 XM_992039
VERSION     NM_025374.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1958)
  AUTHORS   Dobariya,P., Xie,W., Rao,S.P., Xie,J., Seelig,D.M., Vince,R.,
            Lee,M.K. and More,S.S.
  TITLE     Deletion of Glyoxalase 1 Exacerbates Acetaminophen-Induced
            Hepatotoxicity in Mice
  JOURNAL   Antioxidants (Basel) 13 (6), 648 (2024)
   PUBMED   38929087
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1958)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1958)
  AUTHORS   Lu,K.J., Yang,C.H., Sheu,J.R., Chung,C.L., Jayakumar,T., Chen,C.M.
            and Hsieh,C.Y.
  TITLE     Overexpressing glyoxalase 1 attenuates acute
            hyperglycemia-exacerbated neurological deficits of ischemic stroke
            in mice
  JOURNAL   Transl Res 261, 57-68 (2023)
   PUBMED   37419278
  REMARK    GeneRIF: Overexpressing glyoxalase 1 attenuates acute
            hyperglycemia-exacerbated neurological deficits of ischemic stroke
            in mice.
REFERENCE   4  (bases 1 to 1958)
  AUTHORS   Prevenzano,I., Leone,A., Longo,M., Nicolo,A., Cabaro,S.,
            Collina,F., Panarese,I., Botti,G., Formisano,P., Napoli,R.,
            Beguinot,F., Miele,C. and Nigro,C.
  TITLE     Glyoxalase 1 knockdown induces age-related beta-cell dysfunction
            and glucose intolerance in mice
  JOURNAL   EMBO Rep 23 (7), e52990 (2022)
   PUBMED   35620868
  REMARK    GeneRIF: Glyoxalase 1 knockdown induces age-related beta-cell
            dysfunction and glucose intolerance in mice.
REFERENCE   5  (bases 1 to 1958)
  AUTHORS   Hirai,S., Miwa,H., Tanaka,T., Toriumi,K., Kunii,Y., Shimbo,H.,
            Sakamoto,T., Hino,M., Izumi,R., Nagaoka,A., Yabe,H., Nakamachi,T.,
            Shioda,S., Dan,T., Miyata,T., Nishito,Y., Suzuki,K., Miyashita,M.,
            Tomoda,T., Hikida,T., Horiuchi,J., Itokawa,M., Arai,M. and Okado,H.
  TITLE     High-sucrose diets contribute to brain angiopathy with impaired
            glucose uptake and psychosis-related higher brain dysfunctions in
            mice
  JOURNAL   Sci Adv 7 (46), eabl6077 (2021)
   PUBMED   34757783
REFERENCE   6  (bases 1 to 1958)
  AUTHORS   Rubinstein,P., Vienne,K. and Hoecker,G.F.
  TITLE     The location of the C3 and GLO (glyoxalase 1) loci of the IXth
            linkage group in mice
  JOURNAL   J Immunol 122 (6), 2584-2589 (1979)
   PUBMED   448134
REFERENCE   7  (bases 1 to 1958)
  AUTHORS   Leinwand,L., Nichols,E. and Ruddle,F.H.
  TITLE     Assignment of the gene for glyoxylase I to mouse chromosome 17 by
            somatic cell genetics
  JOURNAL   Biochem Genet 16 (7-8), 659-666 (1978)
   PUBMED   569476
REFERENCE   8  (bases 1 to 1958)
  AUTHORS   Lalley,P.A., Minna,J.D. and Francke,U.
  TITLE     Conservation of autosomal gene synteny groups in mouse and man
  JOURNAL   Nature 274 (5667), 160-163 (1978)
   PUBMED   662012
REFERENCE   9  (bases 1 to 1958)
  AUTHORS   Minna,J.D., Bruns,G.A., Krinsky,A.H., Lalley,P.A., Francke,U. and
            Gerald,P.S.
  TITLE     Assignment of a Mus musculus gene for triosephosphate isomerase to
            chromosome 6 and for glyoxalase-I to chromosome 17 using somatic
            cell hybrids
  JOURNAL   Somatic Cell Genet 4 (2), 241-252 (1978)
   PUBMED   566476
REFERENCE   10 (bases 1 to 1958)
  AUTHORS   Meo,T., Douglas,T. and Rijnbeek,A.M.
  TITLE     Glyoxalase I polymorphism in the mouse: a new genetic marker linked
            to H-2
  JOURNAL   Science 198 (4314), 311-313 (1977)
   PUBMED   910130
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY312309.1, AK049703.1 and BP769280.1.
            
            On Jan 18, 2008 this sequence version replaced NM_025374.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049703.1, SRR1660813.204538.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                BY312309.1         3-46
            45-1935             AK049703.1         2-1892
            1936-1958           BP769280.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..1958
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 15.69 cM"
     gene            1..1958
                     /gene="Glo1"
                     /gene_synonym="0610009E22Rik; 1110008E19Rik;
                     2510049H23Rik; Glo-1; Glo-1r; Glo-1s; Glo1-r; Glo1-s;
                     GLY1; Qglo"
                     /note="glyoxalase 1"
                     /db_xref="GeneID:109801"
                     /db_xref="MGI:MGI:95742"
     exon            1..192
                     /gene="Glo1"
                     /gene_synonym="0610009E22Rik; 1110008E19Rik;
                     2510049H23Rik; Glo-1; Glo-1r; Glo-1s; Glo1-r; Glo1-s;
                     GLY1; Qglo"
                     /inference="alignment:Splign:2.1.0"
     exon            193..275
                     /gene="Glo1"
                     /gene_synonym="0610009E22Rik; 1110008E19Rik;
                     2510049H23Rik; Glo-1; Glo-1r; Glo-1s; Glo1-r; Glo1-s;
                     GLY1; Qglo"
                     /inference="alignment:Splign:2.1.0"
     exon            276..416
                     /gene="Glo1"
                     /gene_synonym="0610009E22Rik; 1110008E19Rik;
                     2510049H23Rik; Glo-1; Glo-1r; Glo-1s; Glo1-r; Glo1-s;
                     GLY1; Qglo"
                     /inference="alignment:Splign:2.1.0"
     exon            417..484
                     /gene="Glo1"
                     /gene_synonym="0610009E22Rik; 1110008E19Rik;
                     2510049H23Rik; Glo-1; Glo-1r; Glo-1s; Glo1-r; Glo1-s;
                     GLY1; Qglo"
                     /inference="alignment:Splign:2.1.0"
     exon            485..574
                     /gene="Glo1"
                     /gene_synonym="0610009E22Rik; 1110008E19Rik;
                     2510049H23Rik; Glo-1; Glo-1r; Glo-1s; Glo1-r; Glo1-s;
                     GLY1; Qglo"
                     /inference="alignment:Splign:2.1.0"
     exon            575..1940
                     /gene="Glo1"
                     /gene_synonym="0610009E22Rik; 1110008E19Rik;
                     2510049H23Rik; Glo-1; Glo-1r; Glo-1s; Glo1-r; Glo1-s;
                     GLY1; Qglo"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1912..1917
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Glo1"
                     /gene_synonym="0610009E22Rik; 1110008E19Rik;
                     2510049H23Rik; Glo-1; Glo-1r; Glo-1s; Glo1-r; Glo1-s;
                     GLY1; Qglo"
                     /note="hexamer: AATAAA"
     polyA_site      1940
                     /gene="Glo1"
                     /gene_synonym="0610009E22Rik; 1110008E19Rik;
                     2510049H23Rik; Glo-1; Glo-1r; Glo-1s; Glo1-r; Glo1-s;
                     GLY1; Qglo"
                     /note="major polyA site"
ORIGIN      
        1 ttggcctgtc actcagccga ctgcaaaggc gtcccccggg ccttgtggag cgtgtggtcc
       61 gctggcctgt ttgctactag ggcaggttgg tgattctcca gggcagccat ggcagagcca
      121 cagccggcgt ccagtggcct cactgatgag accgctttca gctgctgctc cgatccagac
      181 cctagcacca aggattttct actgcagcaa acgatgctaa gaattaagga tcctaagaag
      241 tccctggatt tttatacgag ggttcttgga ctgaccctcc tgcagaagct tgacttccct
      301 gctatgaagt tctcgctcta cttcttagct tatgaggata agaacgatat ccccaaggac
      361 aagtccgaga agacagcatg gacgttttcc agaaaagcca cccttgagct cacgcacaac
      421 tggggcactg aagatgacga gactcagagt taccacaacg gcaactcgga ccctcgtgga
      481 tttggtcaca ttgggattgc cgttcctgat gtctacagtg cctgtaagag atttgaagaa
      541 ctaggtgtca agtttgtgaa gaagcctgat gacgggaaaa tgaaaggact ggcgttcatt
      601 caagaccctg acggctactg gattgagatt ctgaatccta acaaaatagc aacgattatt
      661 tagtttcggg agaatgtgcc tttgaggtat gggggacagc gggaacaaag cggcgtggaa
      721 aagaaacagc gtgattcaag atgctgcggc gaccagaagc gttggggact gatgggtctc
      781 tctgctccag ttcaaatcct cctgaaaccc ttttcattgt cctgattcag tgggttttta
      841 aaaatctccc ctctgttttg ccaacctaat tttcaagtag caatttatct tatgaccttg
      901 acaaagttgt gtgactttac atttaagata ataattagaa cagctccctt tagagatcac
      961 agttgctact gcctgtctct taaagactgc tcaagtctgt ttctgattca tcatttagaa
     1021 ttttgtttca aatgtttctt tttggggtct gttaccttct ggggtttcag ttcctcagaa
     1081 ataactttcc ataatgggaa gtacagagca gtgaacagaa atgagatttt tttgtgtgta
     1141 cttcaaacag catagtgttt atcttacaaa agagaaggta ctcctgagag caattcggaa
     1201 tcatgctgac aaggacacag atagaaatac taattttctt tttttctttt ttcttttttt
     1261 ttgtatgtat aaagtacttt cagaattcaa ggactaactt tacttttctg ggaatacgga
     1321 ggaggaaggg attagacaat gggccatgct gtagcatcct ttatgtaaat aatgagtact
     1381 gtggttacga cagacaaagc cacctgattg gtctgaaggc ttgggcggtc agtgtttcta
     1441 gtagctgggt tatgcctatg cctcatggta cctcctgccc tactgaggaa cctgccggga
     1501 gtctggccta tgctctctgc tcacacttgg gcttgaatac cacagagaaa gaagcacaga
     1561 ggtcaatagt acaaggctgc tctaggggac acctgtgagt gagccccaca ttggagggag
     1621 tcttccccac cccatggtct tcatgatgct tgtaatcacg tagcatgtta tgttcagtgc
     1681 tgagtcagat gtcgggcatt agctctgtgg tcttccctgc tgacaggatt aatggattct
     1741 cagaggtgat ttgaagactc aacaactgga ggacaaaacc caatttgagg tcagactgca
     1801 gcgaagtttc ctgcctgctg cagtggaaga cgggcgtggg caatgccaag cgctacacag
     1861 ctatgggcac ttggtgatct atgtgagcag tttaaacaca tcataggctg aaataaagct
     1921 aacactgttt agtacataaa aaaaaaaaaa aaaaaaaa
//
