LOCUS       NM_133248               2015 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus glomulin, FKBP associated protein (Glmn), transcript
            variant 1, mRNA.
ACCESSION   NM_133248
VERSION     NM_133248.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2015)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2015)
  AUTHORS   Rios,J.J., Denton,K., Russell,J., Kozlitina,J., Ferreira,C.R.,
            Lewanda,A.F., Mayfield,J.E., Moresco,E., Ludwig,S., Tang,M., Li,X.,
            Lyon,S., Khanshour,A., Paria,N., Khalid,A., Li,Y., Xie,X.,
            Feng,J.Q., Xu,Q., Lu,Y., Hammer,R.E., Wise,C.A. and Beutler,B.
  TITLE     Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice
  JOURNAL   J Bone Miner Res 36 (8), 1548-1565 (2021)
   PUBMED   33905568
REFERENCE   3  (bases 1 to 2015)
  AUTHORS   Suzuki,S., Suzuki,T., Mimuro,H., Mizushima,T. and Sasakawa,C.
  TITLE     Shigella hijacks the glomulin-cIAPs-inflammasome axis to promote
            inflammation
  JOURNAL   EMBO Rep 19 (1), 89-101 (2018)
   PUBMED   29191979
  REMARK    GeneRIF: Shigella hijacks the glomulin-cIAP1-cIAP2-inflammasome
            axis to promote inflammation.
REFERENCE   4  (bases 1 to 2015)
  AUTHORS   Suzuki,S., Mimuro,H., Kim,M., Ogawa,M., Ashida,H., Toyotome,T.,
            Franchi,L., Suzuki,M., Sanada,T., Suzuki,T., Tsutsui,H., Nunez,G.
            and Sasakawa,C.
  TITLE     Shigella IpaH7.8 E3 ubiquitin ligase targets glomulin and activates
            inflammasomes to demolish macrophages
  JOURNAL   Proc Natl Acad Sci U S A 111 (40), E4254-E4263 (2014)
   PUBMED   25246571
  REMARK    GeneRIF: Results indicate a bacterial adaptation that hijacks
            inflammasome activation via interactions between IpaH7.8 E3
            ubiquitin ligase and glomulin (GLMN).
REFERENCE   5  (bases 1 to 2015)
  AUTHORS   Tron,A.E., Arai,T., Duda,D.M., Kuwabara,H., Olszewski,J.L.,
            Fujiwara,Y., Bahamon,B.N., Signoretti,S., Schulman,B.A. and
            DeCaprio,J.A.
  TITLE     The glomuvenous malformation protein Glomulin binds Rbx1 and
            regulates cullin RING ligase-mediated turnover of Fbw7
  JOURNAL   Mol Cell 46 (1), 67-78 (2012)
   PUBMED   22405651
REFERENCE   6  (bases 1 to 2015)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   7  (bases 1 to 2015)
  AUTHORS   McIntyre,B.A., Brouillard,P., Aerts,V., Gutierrez-Roelens,I. and
            Vikkula,M.
  TITLE     Glomulin is predominantly expressed in vascular smooth muscle cells
            in the embryonic and adult mouse
  JOURNAL   Gene Expr Patterns 4 (3), 351-358 (2004)
   PUBMED   15053987
  REMARK    GeneRIF: The glomulin expression during murine development (E9.5
            days post-coitum until adulthood) by non-radioactive in situ
            hybridization was studied.
REFERENCE   8  (bases 1 to 2015)
  AUTHORS   Arai,T., Kasper,J.S., Skaar,J.R., Ali,S.H., Takahashi,C. and
            DeCaprio,J.A.
  TITLE     Targeted disruption of p185/Cul7 gene results in abnormal vascular
            morphogenesis
  JOURNAL   Proc Natl Acad Sci U S A 100 (17), 9855-9860 (2003)
   PUBMED   12904573
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY013339.1, AK169045.1 and AC134411.7.
            
            On Jun 17, 2009 this sequence version replaced NM_133248.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Both variants 1 and 2 encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK169045.1, BC003446.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                BY013339.1         1-33
            34-1958             AK169045.1         6-1930
            1959-2015           AC134411.7         129726-129782       c
FEATURES             Location/Qualifiers
     source          1..2015
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 52.23 cM"
     gene            1..2015
                     /gene="Glmn"
                     /gene_synonym="9330160J16Rik; Fap48; Fap68"
                     /note="glomulin, FKBP associated protein"
                     /db_xref="GeneID:170823"
                     /db_xref="MGI:MGI:2141180"
     exon            1..96
                     /gene="Glmn"
                     /gene_synonym="9330160J16Rik; Fap48; Fap68"
                     /inference="alignment:Splign:2.1.0"
     exon            97..171
                     /gene="Glmn"
                     /gene_synonym="9330160J16Rik; Fap48; Fap68"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..1923
                     /gene="Glmn"
                     /gene_synonym="9330160J16Rik; Fap48; Fap68"
                     /note="isoform a is encoded by transcript variant 1;
                     FKBP-associated protein; FAP; FK506-binding
                     protein-associated protein"
                     /codon_start=1
                     /product="glomulin isoform a"
                     /protein_id="NP_573511.2"
                     /db_xref="CCDS:CCDS19505.1"
                     /db_xref="GeneID:170823"
                     /db_xref="MGI:MGI:2141180"
                     /translation="MAVEELQSIIKRCQILEEHDFKEEDFGLFQLAGQRCIEDGYINQ
                     LLEIIQDEKNKTIIKSMGWNLVGPVVRCLLRGREEDKREECFLIFDLLVKLCNPKELL
                     LGLLELIEEPSGKQISQIILLLLQPLQTVIQKLPNNKAYSVGLALSTLWSQLSLLPVP
                     HSEEQIQADDYGLCQCCKALIEFTKPFVEEVISDKENKENAKLKDELLKFCFKGLKCP
                     LLTAQFLEQSEDVGNDPFRCFASEIIGFLSKIGHPVPQIILNHGRKKRTWDYLEFEEE
                     EDKQLAESVASLTYLVFVQGIGIDQLPMVLSPSYLLQLNMEHIEVFLQRTEQSIYSKG
                     LELLETSLLRLEDNSLCYQYLEIKSFLAVPQGLVKVMTLCPIETLRKKGLSMLQLFID
                     KLDSQGKYTLFRCLLNTSNHSGVEAFVIQNIKNQIDLSFKKTYNKWFAGAQLISLLDL
                     VLSLPEGAETDLLQNSDRIMASLNLLRYLVIKDNEDDNQTGLWTELGKIENNFLKPLH
                     IGLNMSKAHYEAEIKNSQQNNQVASMCKGVCSVTVGGEEIPSMPPEMQLKVLHSALFT
                     FDLIESVLARVEELIEIKSKSTSEENVGIK"
     exon            172..297
                     /gene="Glmn"
                     /gene_synonym="9330160J16Rik; Fap48; Fap68"
                     /inference="alignment:Splign:2.1.0"
     exon            298..414
                     /gene="Glmn"
                     /gene_synonym="9330160J16Rik; Fap48; Fap68"
                     /inference="alignment:Splign:2.1.0"
     exon            415..523
                     /gene="Glmn"
                     /gene_synonym="9330160J16Rik; Fap48; Fap68"
                     /inference="alignment:Splign:2.1.0"
     exon            524..761
                     /gene="Glmn"
                     /gene_synonym="9330160J16Rik; Fap48; Fap68"
                     /inference="alignment:Splign:2.1.0"
     exon            762..864
                     /gene="Glmn"
                     /gene_synonym="9330160J16Rik; Fap48; Fap68"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1052
                     /gene="Glmn"
                     /gene_synonym="9330160J16Rik; Fap48; Fap68"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1106
                     /gene="Glmn"
                     /gene_synonym="9330160J16Rik; Fap48; Fap68"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1137
                     /gene="Glmn"
                     /gene_synonym="9330160J16Rik; Fap48; Fap68"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1227
                     /gene="Glmn"
                     /gene_synonym="9330160J16Rik; Fap48; Fap68"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1269
                     /gene="Glmn"
                     /gene_synonym="9330160J16Rik; Fap48; Fap68"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1343
                     /gene="Glmn"
                     /gene_synonym="9330160J16Rik; Fap48; Fap68"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1428
                     /gene="Glmn"
                     /gene_synonym="9330160J16Rik; Fap48; Fap68"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1535
                     /gene="Glmn"
                     /gene_synonym="9330160J16Rik; Fap48; Fap68"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1599
                     /gene="Glmn"
                     /gene_synonym="9330160J16Rik; Fap48; Fap68"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1723
                     /gene="Glmn"
                     /gene_synonym="9330160J16Rik; Fap48; Fap68"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1806
                     /gene="Glmn"
                     /gene_synonym="9330160J16Rik; Fap48; Fap68"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..2015
                     /gene="Glmn"
                     /gene_synonym="9330160J16Rik; Fap48; Fap68"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1939..1944
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Glmn"
                     /gene_synonym="9330160J16Rik; Fap48; Fap68"
                     /note="hexamer: AATAAA"
     polyA_site      1958
                     /gene="Glmn"
                     /gene_synonym="9330160J16Rik; Fap48; Fap68"
                     /note="major polyA site"
     regulatory      1984..1989
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Glmn"
                     /gene_synonym="9330160J16Rik; Fap48; Fap68"
                     /note="hexamer: CATAAA"
     polyA_site      2014
                     /gene="Glmn"
                     /gene_synonym="9330160J16Rik; Fap48; Fap68"
ORIGIN      
        1 gagggtccgg tccgggggcg gggccaggag tgcggcctgc gctacctgaa gtggagaagg
       61 aggaggaggg caagaggcag gcgcgtggat cggcggttca ttacagcatc aaaattagga
      121 aaataattag gaatggctgt ggaggaactt cagagcataa taaaaagatg tcaaatccta
      181 gaagagcatg attttaaaga agaagatttt ggcctctttc agttagcagg tcaaagatgc
      241 attgaagatg gttatataaa ccagctgcta gagattattc aagatgaaaa gaacaagacc
      301 atcattaagt ctatggggtg gaatcttgtt ggtccagttg ttcgatgcct cctgaggggc
      361 agagaagagg ataaaagaga agagtgtttt ctgatatttg atttgctggt gaagttatgt
      421 aatccaaagg aattgttgtt gggtttgctt gaactcattg aagagccctc cggaaaacag
      481 atttcccaaa ttattcttct tttactgcaa ccattacaaa cagttattca gaaacttcct
      541 aacaacaagg catactccgt tggactagca ttgtcaacac tttggagtca gctgtctctt
      601 cttcctgttc cacactcaga agaacaaatt caggcagatg attatggcct ctgtcagtgt
      661 tgtaaggcct tgatagagtt cacgaaacct tttgtggaag aagtaataag tgataaagaa
      721 aacaaagaaa atgcaaaact aaaagatgaa ttactgaaat tttgtttcaa aggcttgaaa
      781 tgccctttgc tgacagcaca attcctcgaa cagtcagaag acgttggaaa tgaccctttt
      841 cggtgttttg catctgaaat aataggattt ttatcaaaaa ttggacaccc tgtcccccaa
      901 attattctta atcatggaag gaaaaaaagg acttgggatt accttgaatt tgaagaagaa
      961 gaagacaaac aactggcaga gtctgtggct tctctgacat atctagtatt tgttcagggc
     1021 atcggtattg atcagctgcc catggtctta agcccatcgt accttctgca gttgaacatg
     1081 gagcatattg aagtgtttct gcaaagaaca gaacagtcta tttactccaa aggattggaa
     1141 cttctggaga ctagcttatt gagattagaa gacaacagcc tatgttatca gtacttagaa
     1201 atcaagagtt ttcttgctgt gcctcagggc ttagtcaaag ttatgacact ttgccccatt
     1261 gagacattga ggaaaaaagg tttatctatg cttcagctgt ttattgacaa gttggattca
     1321 caaggcaaat atacattatt taggtgctta ctaaatacaa gtaatcactc aggagtggaa
     1381 gcctttgtaa ttcaaaacat caaaaatcag attgatttat catttaagaa aacatataac
     1441 aaatggtttg caggagcaca gctgatctct ctgttagacc tggtcctgtc tctccctgag
     1501 ggcgctgaga cagacttact gcagaactca gacaggatta tggcttcatt aaatttattg
     1561 aggtatttgg ttatcaaaga taatgaagat gacaatcaaa ctggattatg gacagaactt
     1621 ggaaaaattg aaaataactt tctaaagcca cttcatatag gacttaatat gtcaaaagca
     1681 cattatgaag cagaaattaa aaacagccaa caaaataacc aagtagcctc aatgtgtaaa
     1741 ggtgtttgtt ccgtgactgt aggtggagaa gaaatccctt ctatgcctcc tgaaatgcag
     1801 cttaaggtct tacattccgc tctcttcaca tttgacttga ttgaaagtgt tctggctcga
     1861 gtagaagaac tcattgaaat caaatcaaag tctacctctg aagaaaatgt tgggataaag
     1921 taaaggttct atttcataaa taaaaaccaa caaaatgctg tttttcatta tactttatac
     1981 caccataaaa atatttacag aaattttact actag
//
