LOCUS       NM_175459               7524 bp    mRNA    linear   ROD 07-JAN-2025
DEFINITION  Mus musculus GLIS family zinc finger 3 (Glis3), transcript variant
            1, mRNA.
ACCESSION   NM_175459 NM_172636
VERSION     NM_175459.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7524)
  AUTHORS   Collier,J.B., Kang,H.S., Roh,Y.G., Srivastava,C., Grimm,S.A.,
            Jarmusch,A.K. and Jetten,A.M.
  TITLE     GLIS3: A novel transcriptional regulator of mitochondrial functions
            and metabolic reprogramming in postnatal kidney and polycystic
            kidney disease
  JOURNAL   Mol Metab 90, 102052 (2024)
   PUBMED   39505148
REFERENCE   2  (bases 1 to 7524)
  AUTHORS   Kang,H.S., Grimm,S.A., Liao,X.H. and Jetten,A.M.
  TITLE     GLIS3 expression in the thyroid gland in relation to TSH signaling
            and regulation of gene expression
  JOURNAL   Cell Mol Life Sci 81 (1), 65 (2024)
   PUBMED   38281222
  REMARK    GeneRIF: GLIS3 expression in the thyroid gland in relation to TSH
            signaling and regulation of gene expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7524)
  AUTHORS   Scoville,D.W. and Jetten,A.M.
  TITLE     GLIS3: A Critical Transcription Factor in Islet beta-Cell
            Generation
  JOURNAL   Cells 10 (12), 3471 (2021)
   PUBMED   34943978
  REMARK    GeneRIF: GLIS3: A Critical Transcription Factor in Islet beta-Cell
            Generation.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7524)
  AUTHORS   Niborski,L.L., Paces-Fessy,M., Ricci,P., Bourgeois,A.,
            Magalhaes,P., Kuzma-Kuzniarska,M., Lesaulnier,C., Reczko,M.,
            Declercq,E., Zurbig,P., Doucet,A., Umbhauer,M. and Cereghini,S.
  TITLE     Hnf1b haploinsufficiency differentially affects developmental
            target genes in a new renal cysts and diabetes mouse model
  JOURNAL   Dis Model Mech 14 (5) (2021)
   PUBMED   33737325
REFERENCE   5  (bases 1 to 7524)
  AUTHORS   Akerman,I., Maestro,M.A., De Franco,E., Grau,V., Flanagan,S.,
            Garcia-Hurtado,J., Mittler,G., Ravassard,P., Piemonti,L.,
            Ellard,S., Hattersley,A.T. and Ferrer,J.
  TITLE     Neonatal diabetes mutations disrupt a chromatin pioneering function
            that activates the human insulin gene
  JOURNAL   Cell Rep 35 (2), 108981 (2021)
   PUBMED   33852861
REFERENCE   6  (bases 1 to 7524)
  AUTHORS   Sakai-Kato,K., Ishiguro,A., Mikoshiba,K., Aruga,J. and
            Utsunomiya-Tate,N.
  TITLE     CD spectra show the relational style between Zic-, Gli-, Glis-zinc
            finger protein and DNA
  JOURNAL   Biochim Biophys Acta 1784 (7-8), 1011-1019 (2008)
   PUBMED   18298960
REFERENCE   7  (bases 1 to 7524)
  AUTHORS   Beak,J.Y., Kang,H.S., Kim,Y.S. and Jetten,A.M.
  TITLE     Functional analysis of the zinc finger and activation domains of
            Glis3 and mutant Glis3(NDH1)
  JOURNAL   Nucleic Acids Res 36 (5), 1690-1702 (2008)
   PUBMED   18263616
REFERENCE   8  (bases 1 to 7524)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   9  (bases 1 to 7524)
  AUTHORS   Kim,Y.S., Nakanishi,G., Lewandoski,M. and Jetten,A.M.
  TITLE     GLIS3, a novel member of the GLIS subfamily of Kruppel-like zinc
            finger proteins with repressor and activation functions
  JOURNAL   Nucleic Acids Res 31 (19), 5513-5525 (2003)
   PUBMED   14500813
  REMARK    GeneRIF: The transcription factor, GLIS3, has both repressor and
            activation functions.
REFERENCE   10 (bases 1 to 7524)
  AUTHORS   Kim,Y.S., Lewandoski,M., Perantoni,A.O., Kurebayashi,S.,
            Nakanishi,G. and Jetten,A.M.
  TITLE     Identification of Glis1, a novel Gli-related, Kruppel-like zinc
            finger protein containing transactivation and repressor functions
  JOURNAL   J Biol Chem 277 (34), 30901-30913 (2002)
   PUBMED   12042312
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DQ871027.1, AK087731.1,
            CK640192.1, AC118934.9 and BP768786.1.
            
            On Mar 30, 2015 this sequence version replaced NM_175459.5.
            
            Summary: This gene is a member of the GLI-similar zinc finger
            protein family and encodes a nuclear protein which contains
            multiple C2H2-type zinc finger domains. This protein functions as
            both a repressor and activator of transcription and is specifically
            involved in the transcriptional regulation of insulin. It is
            thought to enhance GLI-RE-dependent transcription by binding to the
            GLI-RE consensus sequence (GACCACCCAC). Mutations in a similar gene
            in human have been associated with neonatal diabetes and congenital
            hypothyroidism (NDH). Alternatively spliced transcript variants
            have been identified. [provided by RefSeq, Mar 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ871027.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3214              DQ871027.1         2-3215
            3215-3230           AK087731.1         766-781
            3231-3917           DQ871027.1         3232-3918
            3918-4192           CK640192.1         29-303
            4193-7008           AC118934.9         73236-76051
            7009-7524           BP768786.1         36-551              c
FEATURES             Location/Qualifiers
     source          1..7524
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 22.88 cM"
     gene            1..7524
                     /gene="Glis3"
                     /gene_synonym="4833409N03Rik; E330013K21Rik"
                     /note="GLIS family zinc finger 3"
                     /db_xref="GeneID:226075"
                     /db_xref="MGI:MGI:2444289"
     exon            1..482
                     /gene="Glis3"
                     /gene_synonym="4833409N03Rik; E330013K21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            483..966
                     /gene="Glis3"
                     /gene_synonym="4833409N03Rik; E330013K21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             579..3386
                     /gene="Glis3"
                     /gene_synonym="4833409N03Rik; E330013K21Rik"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein GLIS3; GLI-similar 3"
                     /codon_start=1
                     /product="zinc finger protein GLIS3 isoform 1"
                     /protein_id="NP_780668.3"
                     /db_xref="CCDS:CCDS37947.1"
                     /db_xref="GeneID:226075"
                     /db_xref="MGI:MGI:2444289"
                     /translation="MNGRSCGMNLHRTSRTPQGPGLLGGQHIPPIRAHAGTPCSSSCA
                     STPSPSIGSLANSLHLKMSSGAGMAPQSNMAASPIHLPALSPRRQLLANGKPQFQVTP
                     AGVMAAPHTIKPKQQEFGDPFSPNPEKGALGFGPQCKSIGKGSCNNLVVTSSPMMVQR
                     LGPISPPASQVSTACKQISPSLPRAVNAANLNRPPSDTRSVILQESLVSTTLSLTESQ
                     SALSVKQEWSQSYRAFPSLSSSHSSQNGTDLGDLLSLPPGTPVSGNSVSNSLPPYLFG
                     MENSHSPYPSPRHSATRAHSTRSKKRALSLSPLSDGIGIDFNTIIRTSPTSLVAYING
                     PRASPANLSPQSEVYGHFLGVRGSCIPQSCAVASGQKGILVASGGHTLPGYGEDGTLE
                     YERMQQLEHGGLQPGPVNNMVLQPGLPGQDGQTANMLKTERLEEFPASALDLPSALPL
                     PLPPPQGPPPPYHAHPHLHHPELLPHTQSLSLAQTGLEEDGEMEDSGGKHCCRWIDCS
                     ALYDQQEELVRHIEKVHIDQRKGEDFTCFWTGCPRRYKPFNARYKLLIHMRVHSGEKP
                     NKCTFEGCKKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDT
                     KPYACQIPGCTKRYTDPSSLRKHVKAHSSREQQARKKLRSSTELHPDLLTDCLAVQPL
                     QPATSPGDAADHTVGHSPGPGPGPGPGAELYSAPIFASNHSTRSGTAAGAGPPPHPVS
                     HPSPGHNVQGSPHNPSSQLPPLTAVDAGAERFAPPTPSPHHISPGRVPAPPSLLQRAQ
                     APHSQQPPGSLLKPYQPETNSSFQPNGIHVHGFYGQLQTFCPPHYPDSQRTVPPSGSC
                     SMVPSFEDCLVPTSMGQAGFDVFHRAFSTHSGITVYDLPSASSSLFGESLRSGPEDPT
                     FLQLSAVDRCPSQLSSVYTEG"
     exon            967..1174
                     /gene="Glis3"
                     /gene_synonym="4833409N03Rik; E330013K21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..2288
                     /gene="Glis3"
                     /gene_synonym="4833409N03Rik; E330013K21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2450
                     /gene="Glis3"
                     /gene_synonym="4833409N03Rik; E330013K21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2561
                     /gene="Glis3"
                     /gene_synonym="4833409N03Rik; E330013K21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..2721
                     /gene="Glis3"
                     /gene_synonym="4833409N03Rik; E330013K21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..2890
                     /gene="Glis3"
                     /gene_synonym="4833409N03Rik; E330013K21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2891..3066
                     /gene="Glis3"
                     /gene_synonym="4833409N03Rik; E330013K21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3067..3249
                     /gene="Glis3"
                     /gene_synonym="4833409N03Rik; E330013K21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3250..7514
                     /gene="Glis3"
                     /gene_synonym="4833409N03Rik; E330013K21Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      7209
                     /gene="Glis3"
                     /gene_synonym="4833409N03Rik; E330013K21Rik"
                     /note="major polyA site"
     regulatory      7458..7463
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Glis3"
                     /gene_synonym="4833409N03Rik; E330013K21Rik"
                     /note="hexamer: AATAAA"
     polyA_site      7491
                     /gene="Glis3"
                     /gene_synonym="4833409N03Rik; E330013K21Rik"
ORIGIN      
        1 acctcggggc cgcggcgggc ccgggtccag gctcgcaccg gcgctctcta gccgcgaccc
       61 agctcaggca gccagcatcc cgagcccggc ccctccaggc gtcgccctcg gccccgagcg
      121 aggatgagca ccccgggcca ggcatgaagt cgcctctcaa ctttgtaaag acatgactgg
      181 agtgtgcctg tgcgtagcgc ggacagggag ctgatgcgga gagtcggccc gctgccctgc
      241 ctcctcctcc cagggccgcc gccgtcgcag cctcgcgcgg gcacacacac ggccctccgg
      301 ccgtagttcc gcgctccggc cacgggcttg gatgcgagtt ttcctttccg aaggaggcag
      361 agccggcgtg gagcgctgag ggggctcagc ctccacccac gcatcgctag tgttgtcacg
      421 agcgggctgg ccgggagaag ggactcgctc gcctagcttt gttgtggaaa tccggttacc
      481 tgacttatca cctatcccat ggataagtta cttgccttgc cttgaaagaa tcaatagtgc
      541 catcggatat tgatcagcgt ggcctcaggg ctctcagaat gaatggaagg tcatgtggca
      601 tgaatctcca ccggacatca agaaccccac aggggcctgg cctactcggt ggtcaacata
      661 tccctcccat cagagcccac gcaggcactc cctgctcctc ttcctgtgcc agcacgccga
      721 gccccagtat tggaagtctt gctaacagtc ttcacctcaa gatgtcctcg ggagcaggga
      781 tggctcctca gagcaacatg gccgcgagtc ccatccatct gcctgccctg agccccagga
      841 gacagttact cgccaatggg aagcctcagt tccaggtcac cccggctggt gtcatggcag
      901 caccacatac tataaagccc aaacagcaag aatttggaga ccccttctct ccaaatcctg
      961 agaaaggggc tcttggcttt gggcctcagt gcaagtccat tggaaaaggc agctgcaaca
     1021 atctagtggt caccagcagt cccatgatgg ttcagcgact gggacccatt tcacctccag
     1081 caagccaggt ctccacagca tgcaagcaga tcagtcctag cttaccgagg gcagtgaatg
     1141 cagccaacct gaatagacct ccttcagata ccaggtccgt tattttgcaa gagtctctgg
     1201 tgtccacgac tttgagtctg acagagagtc aatcagcctt gagtgtgaag caagagtggt
     1261 ctcagagcta cagggctttc ccttcacttt catccagcca cagttcccag aatggcacgg
     1321 acctagggga ccttcttagc ttgcctccag gcacgccagt gtctggcaac agcgtctcca
     1381 actcgttgcc accctacctt ttcggcatgg aaaatagcca ctctccttac cctagccctc
     1441 ggcactcagc aaccagggcc cactccaccc gctctaagaa gagagcattg tccttgtcgc
     1501 cactgtcaga tggcatcggg atcgacttca acactatcat ccgtacttca cccacatcct
     1561 tggtcgccta catcaacgga ccaagagcct ccccagccaa cctgtcccca cagtcagagg
     1621 tctatgggca tttcctgggt gttcgtggca gctgcatccc ccagtcttgt gcagtggcca
     1681 gcgggcagaa aggcatattg gttgccagtg gagggcatac gctgccgggc tatggagagg
     1741 acggtacact ggagtatgaa cgcatgcagc agcttgagca tggtggcctg caacccggac
     1801 ctgtaaacaa catggtgttg cagcctggcc taccgggcca ggatggccag acagccaaca
     1861 tgctcaaaac agagcgcctg gaggagttcc ccgccagtgc cttggacctg ccctctgctc
     1921 tgcctctccc tcttcctccg cctcagggtc ccccaccccc ataccatgcc catccacacc
     1981 ttcatcaccc agagctcctg cctcacaccc aatcgctgtc cctggcccag actggcctgg
     2041 aagaggatgg ggagatggaa gactcagggg ggaagcactg ctgccgttgg atagactgca
     2101 gtgcccttta tgaccagcag gaggaactgg tgaggcacat cgagaaggtc cacatagacc
     2161 aacgcaaggg ggaagacttc acgtgcttct ggactggctg ccctagaaga tacaagcctt
     2221 tcaacgcacg gtataaactg ctgatccaca tgagggtcca ctctggggag aagcccaaca
     2281 agtgtacgtt cgaaggctgc aagaaggcct tttccaggct cgagaacctc aagattcact
     2341 tgcggagcca cacgggtgag aagccatact tgtgccagca tccgggctgc caaaaggcct
     2401 tcagcaattc cagtgaccgt gccaagcacc agaggacaca tcttgacact aaaccttatg
     2461 cttgtcaaat tccaggatgt acaaagcgct acacagaccc aagctccctc agaaagcacg
     2521 tgaaggcaca ttcttcccga gagcagcaag caaggaaaaa gctacggtct agcactgagc
     2581 tccatccaga tctcctcaca gactgcctcg ctgtgcagcc cctgcagcca gccacgtccc
     2641 ctggagatgc tgctgatcat accgtggggc actccccagg gccggggcct gggccagggc
     2701 ctggggctga actctattca gctcccattt tcgccagcaa tcattcaact cgaagtggaa
     2761 cagctgctgg ggctgggcca cccccacatc ctgtcagtca cccttctcca ggacataatg
     2821 tacaggggag cccccacaac ccctcctccc agttacctcc actcacagct gtggacgcag
     2881 gcgctgagag gtttgcacct ccgactccat ctcctcacca catcagcccg ggaagagttc
     2941 cagctcctcc gtcactgctc cagagagcac aggctcccca ctcccagcag ccaccaggct
     3001 cactcctgaa gccctaccag ccagaaacca actcttcttt tcagccaaat ggtatccatg
     3061 tccacggatt ttatggccag ctgcagacat tctgtccccc gcattatcct gattcccaaa
     3121 gaactgtgcc acccagcggc tcctgcagta tggtgccttc ctttgaggac tgcctggtcc
     3181 ccacgtccat gggtcaagcc ggttttgatg ttttccacag agccttctca acacactcag
     3241 gcatcacagt gtacgatttg ccttcagctt cctcaagcct ctttggggaa tctcttcgca
     3301 gtggccctga agaccccacg ttcttgcagc tcagtgctgt ggaccgctgt cctagccagc
     3361 tctcctctgt gtataccgaa ggctgaaagc tcccggggtt ctgcacattt gggacctttg
     3421 agtaactcgt cgcctcttat tttcattctc tcacaagccg tgtgaagaac atcaaccaaa
     3481 tccatggagc cagtaggatt gctaggactg tggaaggcag gactggatag tcagacctgg
     3541 ctttcagaaa tttttgcacc tcttccatct tctcattttg ctgggccagg taaccagcag
     3601 gagtttcttt tcaaagggaa tttagagtct cactttaagg atgcctgtta cttccaggct
     3661 gtcagctctc aaaagacacc aatgaatatg cacaagaacg ggaagaccct tgctaaagac
     3721 tcggagaaga cagccgaggt accagtggca aagtgtgccc atgctctttc gtgtggcaga
     3781 gtgatgcaca gccgtgaacg gtgggggaaa tccatgtcca aagcacgcta cgccttggac
     3841 tctctccaac tctggcttta ccatttgtct tacatagtcc atgctaacta gttacttttc
     3901 agttgcttct ccaatggcaa aataaggttt tatattcagg aaccttcttt gtttttgaac
     3961 tttaaagact tgctatttac atctactttt aaaggaaaaa atatttaaag gtttattcat
     4021 tttgatagaa gtcattacca tttttaatca atcccgggta cgtgtatttt accacagctg
     4081 tagcaagagt taatagtttt gcagtttagt aaaggttatc tgagagaaac agaatagtta
     4141 acacacgcac acgcacatgc acacacacac acacacacac actcacacct gcgtccagga
     4201 ttattgcaag aatcctcata tgctgcgtta taggggtata cacctataat cccagcactc
     4261 agaacgtact ctgagtttga agctaccctg gtctacacag tgcgttccag tccagccagg
     4321 gctaaatagc aaagcaccgt ctcaagaaaa atacctctca tgtatgatgg ctcagcggtt
     4381 ccatcttgga agcctttcca tttgaagggt tcttgcatgg cctttgctcc attcctctgc
     4441 ctgggacaaa acaggggtca cattgagtca catgtgtggg tttgttcaga aagccaaact
     4501 cggggcacct cttgtccagt cactctggtt ctgcccagtt ccctgaggtg atcctgtcat
     4561 ctgccatgtt ctcctctgct ctatgttcat atacactctc tccctttttc cagattgtgg
     4621 tcagatacgc tgacgatctg ccacatttta tcaactctcc tgaaggttct gagaaggcag
     4681 tgttctgcaa ctctgctttg aaagcctaga atttttcaca gagcctaaaa ctgtgatgag
     4741 cctaaataag acatcatttt ctagtgacat ttttagaaaa acactttaaa aggccccgtg
     4801 tcctaaggga aaggatacac aaataggcca agactccaaa ataacctggt cagttccaac
     4861 attctggtcc actcacattg tagatttttt ttcctcttta aaaaaagttg ttttaaatag
     4921 aactaaagcg gaattcttca tgaaactggg ctcagtatct ctttcaatga ggcagttaaa
     4981 cagctcaatg tcagatgtgg gtcctgagac tgtatcctca taggcaggcc tgtgagcctg
     5041 gccccacatt agaagagttc caccgcgtgt cttgcttcct tccaagatgg cactgcatac
     5101 tgaatgggaa gatgaagaac caagtgtggg cgctctctct ctctctctct ctctctctct
     5161 ctctctctct ctctcccttc ccctcccctc actctctaac agcacattgg ttggtcaagt
     5221 gttgccaaag aggccatatt cttgggggga aaactatctt gcaagcttct aagtcccaag
     5281 acttccaatt ccctttgtta ttctgagctt taaggaagga accctgtctg gcttcctcag
     5341 caggtaagct ctcaggctgc tagaaactcc cacccttcca gagctcctgt gtcctctgtc
     5401 acacttggtc aaagcaggaa cacacacact ccaacactgg cttatttgat ggcaaccctc
     5461 atttgacctc tgtcaccctc taaaaagaaa agagacccta ctctcaaaag gagcatctat
     5521 ccattcttaa atcctaaagc ttttacacag cgccccaagc acatttcatt tggatgatga
     5581 ggaaggaaca gatgagaggc accgtggtct tacaaccaat cgtttctact ctgccgtatg
     5641 gatgtgttaa ggaaagagaa atcatagcaa ggaacggaag tacagaccat gcatggcatc
     5701 tctccctgta gtggaggcat gaggcctggg agccaggctt tggactcatg gtggctttcc
     5761 atgtgacact gcttttctgg gtcacctaag taggagggat ccatggagaa cctgtgtcat
     5821 cagggccttc ttactaggtc agacctaccc cagagagacg ttcttgctat cagaaggcat
     5881 gagcagagct aggtcccatg tagcccctca aaggccctcc agaatagtcc caatagccac
     5941 tggtctgggg acagggccta gagtcatgac acatactggc tccttcagag tgttaggttc
     6001 cagaatttct cctcagcatg aatgtgttct tggcttgctt tggccttcac agttccatct
     6061 gtattttgaa acaatgaaag cagagcttga aaacataatt attcccttcc attcctagac
     6121 ccttttagcc ctgatgggta gccattttca taaacatcca aatggaaatt gtcattccaa
     6181 tttcaaaaca ataaagatta gtgctcctga aaacacacaa cccaaagaca attattttag
     6241 tccataaaaa taaaaaggtc attatgaata gagacatagc cttcatccat tgtcataact
     6301 ccctaaagga actacttcaa agcgtcactt gtaatttact ctctgatggg cacacaaatg
     6361 ccatttaaat attccctggg cctgtgagat atggtccctt acacaggtct ccaccacgtg
     6421 acccaggtga ttcttaagtg gaaaacaagg tatttggtag acctcagcag aaagtctccg
     6481 gacaagagtg ttggttacgt ccagtgtcct caagtgatca tctgccaaat gtactagctc
     6541 actaatgcga gcttagaaca gggctaagct gtctccctgt cccagagctc ataccccctt
     6601 cccatcccct attgcctgga agtattgaca gtgctcagtt gtattacttg gtgtttgatt
     6661 tgatttgact gtttagatca atgttgttat tgccatggat aaaataacag agacagagaa
     6721 aaccaaacgc attggagaaa atggcgcgtg ttcaaatgaa gagatttatt ttgtacagac
     6781 agagaagcgt cctcagtaat gttgctgaca taaagcactt tgggggggga ggggagtgga
     6841 aatctgtttt ccataaatca cataggccct tgtacattgt tctatccact catgtagaga
     6901 aatgagctgc gtatatcata ctggatatgg ggccagtttg acggtagggg cacatgtggt
     6961 gcttattgtc gtaaatcttt taaggaatta ggtacacttt tttctattaa tatgtatagt
     7021 tttacgattt gtcacagtta tgtttcatat aatcataagt tattttgtct tgtttcatga
     7081 agtccttttt ttttttttaa tgtcaaaagt aaaatgaagg gattgtatac ttggcacaaa
     7141 ataaaactgg aaatcgaggc tgcccctccc gcctgaagcg ctccttcagc gcgtcggctt
     7201 aaaacacaat ggtaaccggc gttgtttgtt tgtttgtctt attgttctgt tctcttctgt
     7261 caccagcctc ctctgtattg gggatggtga ttataattaa aagcagatgg ggggggaagg
     7321 ggtgtccaag gccagcttta aaatgctgca tcgctttggg ccagaactga agcctggatt
     7381 taattataga tatgaggacg aaatggcagt aaaaatgaat gtctccctga atcctttaca
     7441 tgttgggagt gtccataaat aaaacatgaa gttttatttc atcacattta attaaagctt
     7501 ttatacatgt tttaaaaaaa aaaa
//
